Gene

KWMTBOMO10127  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005559

Annotation

Mesencephalic_astrocyte-derived_neurotrophic_factor_[Operophtera_brumata]

Location

Bomo_Chr17(+):2807660-2808861      View in EpiBrowser

Full name

Mesencephalic astrocyte-derived neurotrophic factor homolog      

Alternative Name

MANF/CDNF-like protein

Location in the cell

Cytoplasmic   Reliability : 1.047 Extracellular   Reliability : 1.221 Nuclear   Reliability : 1.058

CDS

ATGTTTAAATTTAGTCTGTTTCATTTATTATTTTTGGCTACGGCTGTGCAGGTGGTCCTATCACTTCGAGAAGGTGATTGCGAAGTGTGTGTGAAAACTGTAGAGAAGTTTGCCGCCACGCTATCAGATGATGTGAAGAAAGACCCTAAAAAAATCGAGGCAGAGTTCAAAAAGTTCTGTAAAGGTTCAAAGAACAAAGAAAATAGATTTTGTTACTATTTAGGAGGTCTCGAAGAGTCAGCCACCGGCATTTTGGGAGAATTGTCAAAGCCCTTAAGTTGGTCTATGCCCGCCGATAAAATATGTGAAAAATTGAAGAAAAAAGATGCACAAATCTGTGACCTAAGGTTCGACAAACAAATCGATCTAAATAATGTTGATTTGAAGAAACTAAAAGTACGTGACTTGAAGAAGATTCTGAACGACTGGGATGAGGTCTGCGATGGTTGCATCGAGAAGACTGACTTCATTAAGAGAATAGAAGAGTTAAAACCCAAATACATGGGTAGATCTGACCTCTAA

Protein

MFKFSLFHLLFLATAVQVVLSLREGDCEVCVKTVEKFAATLSDDVKKDPKKIEAEFKKFCKGSKNKENRFCYYLGGLEESATGILGELSKPLSWSMPADKICEKLKKKDAQICDLRFDKQIDLNNVDLKKLKVRDLKKILNDWDEVCDGCIEKTDFIKRIEELKPKYMGRSDL

Description

Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).
Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels.

Similarity

Belongs to the ARMET family.

Keywords

Complete proteome   Developmental protein   Disulfide bond   Reference proteome   Secreted   Signal  

Feature

chain  Mesencephalic astrocyte-derived neurotrophic factor homolog

Uniprot

H9J7R7   A0A2A4JJE9   A0A2H1X351   S4PMQ7   A0A0L7LI18   I4DJI8   + More
A0A194QS16   A0A194QCA9   D0AB74   L7X1Q4   E2C291   A0A0C9R7W3   E2AE78   A0A151JUW8   F4X474   A0A151XGE3   A0A0J7NR01   G3KA07   G3K9Z2   G3K9Y1   A0A151I442   A0A158N9J0   A0A195E294   A0A151IKU5   A0A154PE43   G3KA16   G3K9Y3   A0A034W5R9   Q06K58   A0A0K8WDX3   E9IW56   Q295V5   B4GFM7   B4PR07   W8BRN2   A0A3B0KFL8   A0A1J1HY79   B4QX46   B3M2I7   Q9XZ63   A0A0L0C459   A0A0A1X2W9   B4IBX2   A0A1L8DP97   B4K5R6   A0A1B0GGX4   A0A1W4WD19   B4NIN8   B3P113   A0A1I8N9T0   V9IJJ8   A0A088AAX0   A0A1L8EES2   A0A1L8EFA0   A0A1A9YRR4   A0A026WEW4   A0A1A9WPC6   A0A2A3EGF1   B4JT39   K7J4L9   A0A1B0A659   A0A1A9UF17   A0A1I8PTP7   A0A1B0GDL6   A0A182JC74   B4LX78   A0A0N0BE19   A0A182KFN9   A0A0L7RG63   V5I9M8   U5EVT5   A0A182P5T3   A0A182UU45   A0A182TEL9   A0A182LFT1   A0A182WRJ5   Q7QD98   A0A182HU81   Q1HRA5   A0A2J7Q5Y6   A0A182W066   A0A0M3QXH5   A0A182LTD9   A0A182N638   A0A182Y4A9   A0A0T6B570   A0A084VRC1   A0A182Q4C9   A0A2M4C1Y4   A0A2M4C1T3   D2A3Y7   A0A023EHN4   A0A182T0F8   A0A1Y1LP31   A0A2M3Z3V6   A0A2M3ZE43   W5JF83   A0A182F7D8   A0A232ELV6   A0A182RNR1  

Pubmed

19121390    23622113    26227816    22651552    26354079    23674305    + More
20798317    21719571    21841803    21347285    25348373    16952314    21282665    15632085    17994087    24495485    10597048    10731132    12537572    12537569    19164766    26108605    25830018    25315136    24508170    30249741    20075255    20966253    12364791    14747013    17210077    17204158    17510324    25244985    24438588    18362917    19820115    24945155    28004739    20920257    23761445    28648823   

EMBL

BABH01020219    NWSH01001365    PCG71532.1    PCG71533.1    ODYU01013053    SOQ59707.1    + More
GAIX01003430    JAA89130.1    JTDY01000993    KOB75173.1    AK401456    BAM18078.1    KQ461155    KPJ08313.1    KQ459232    KPJ02620.1    FP102339    CBH09269.1    KC469893    AGC92708.2    GL452091    EFN77938.1    GBYB01004120    JAG73887.1    GL438827    EFN68311.1    KQ981713    KYN37339.1    GL888628    EGI58742.1    KQ982169    KYQ59472.1    LBMM01002387    KMQ94890.1    JN174824    JN174825    JN174826    JN174827    JN174828    JN174829    JN174831    JN174832    JN174833    JN174834    JN174835    JN174836    JN174837    JN174839    JN174840    JN174841    JN174842    AEN68167.1    AEN68168.1    AEN68169.1    AEN68170.1    AEN68171.1    AEN68172.1    AEN68174.1    AEN68175.1    AEN68176.1    AEN68177.1    AEN68178.1    AEN68179.1    AEN68180.1    AEN68182.1    AEN68183.1    AEN68184.1    AEN68185.1    JN174804    JN174806    JN174807    JN174808    JN174809    JN174810    JN174811    JN174812    JN174813    JN174814    JN174815    JN174816    JN174817    JN174818    JN174819    JN174820    JN174821    JN174822    AEN68147.1    AEN68149.1    AEN68150.1    AEN68151.1    AEN68152.1    AEN68153.1    AEN68154.1    AEN68155.1    AEN68156.1    AEN68157.1    AEN68158.1    AEN68159.1    AEN68160.1    AEN68161.1    AEN68162.1    AEN68163.1    AEN68164.1    AEN68165.1    JN174802    JN174803    AEN68145.1    AEN68146.1    KQ976461    KYM84703.1    ADTU01009655    KQ979814    KYN19019.1    KQ977161    KYN05236.1    KQ434886    KZC10087.1    JN174830    JN174838    AEN68173.1    AEN68181.1    JN174805    JN174823    AEN68148.1    AEN68166.1    GAKP01009320    GAKP01009318    JAC49632.1    DQ835360    ABI20165.1    GDHF01006605    GDHF01003085    JAI45709.1    JAI49229.1    GL766449    EFZ15213.1    CM000070    EAL28603.1    CH479182    EDW34412.1    CM000160    EDW97329.1    GAMC01002596    GAMC01002595    JAC03961.1    OUUW01000008    SPP84526.1    CVRI01000030    CRK92514.1    CM000364    EDX12700.1    CH902617    EDV43440.1    AF132912    AE014297    AY061080    JRES01000936    KNC27070.1    GBXI01008840    JAD05452.1    CH480827    EDW44880.1    GFDF01005808    JAV08276.1    CH933806    EDW15128.1    AJWK01000848    CH964272    EDW83752.1    CH954181    EDV49132.1    JR050541    AEY61303.1    GFDG01001577    JAV17222.1    GFDG01001576    JAV17223.1    KK107260    QOIP01000001    EZA54206.1    RLU26419.1    KZ288267    PBC30081.1    CH916373    EDV94929.1    AAZX01007478    CCAG010011953    CH940650    EDW66730.1    KQ435844    KOX71268.1    KQ414601    KOC69726.1    GALX01002660    JAB65806.1    GANO01001723    JAB58148.1    AAAB01008859    EAA07858.3    APCN01000612    DQ440189    CH477432    ABF18222.1    EAT41046.1    NEVH01017543    PNF23998.1    CP012526    ALC45879.1    AXCM01000884    LJIG01009820    KRT82315.1    ATLV01015601    KE525023    KFB40515.1    AXCN02000193    GGFJ01009857    MBW58998.1    GGFJ01009787    MBW58928.1    KQ971348    EFA05582.1    GAPW01005046    JAC08552.1    GEZM01056251    JAV72757.1    GGFM01002451    MBW23202.1    GGFM01006031    MBW26782.1    ADMH02001371    ETN62746.1    NNAY01003488    OXU19340.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000008237    + More
UP000000311    UP000078541    UP000007755    UP000075809    UP000036403    UP000078540    UP000005205    UP000078492    UP000078542    UP000076502    UP000001819    UP000008744    UP000002282    UP000268350    UP000183832    UP000000304    UP000007801    UP000000803    UP000037069    UP000001292    UP000009192    UP000092461    UP000192221    UP000007798    UP000008711    UP000095301    UP000005203    UP000092443    UP000053097    UP000279307    UP000091820    UP000242457    UP000001070    UP000002358    UP000092445    UP000078200    UP000095300    UP000092444    UP000075880    UP000008792    UP000053105    UP000075881    UP000053825    UP000075885    UP000075903    UP000075902    UP000075882    UP000076407    UP000007062    UP000075840    UP000008820    UP000235965    UP000075920    UP000092553    UP000075883    UP000075884    UP000076408    UP000030765    UP000075886    UP000007266    UP000075901    UP000000673    UP000069272    UP000215335    UP000075900   

PRIDE

H9J7R7    B4GFM7    B3M2I7    Q9XZ63    B4NIN8    B4JT39    + More
B4LX78   

Pfam

PF10208   Armet

Interpro

IPR036361   SAP_dom_sf        + More
IPR019345   Armet_prot       
IPR002048   EF_hand_dom       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF68906   SSF68906       

Gene 3D

1.10.720.30    

ProteinModelPortal

H9J7R7   A0A2A4JJE9   A0A2H1X351   S4PMQ7   A0A0L7LI18   I4DJI8   + More
A0A194QS16   A0A194QCA9   D0AB74   L7X1Q4   E2C291   A0A0C9R7W3   E2AE78   A0A151JUW8   F4X474   A0A151XGE3   A0A0J7NR01   G3KA07   G3K9Z2   G3K9Y1   A0A151I442   A0A158N9J0   A0A195E294   A0A151IKU5   A0A154PE43   G3KA16   G3K9Y3   A0A034W5R9   Q06K58   A0A0K8WDX3   E9IW56   Q295V5   B4GFM7   B4PR07   W8BRN2   A0A3B0KFL8   A0A1J1HY79   B4QX46   B3M2I7   Q9XZ63   A0A0L0C459   A0A0A1X2W9   B4IBX2   A0A1L8DP97   B4K5R6   A0A1B0GGX4   A0A1W4WD19   B4NIN8   B3P113   A0A1I8N9T0   V9IJJ8   A0A088AAX0   A0A1L8EES2   A0A1L8EFA0   A0A1A9YRR4   A0A026WEW4   A0A1A9WPC6   A0A2A3EGF1   B4JT39   K7J4L9   A0A1B0A659   A0A1A9UF17   A0A1I8PTP7   A0A1B0GDL6   A0A182JC74   B4LX78   A0A0N0BE19   A0A182KFN9   A0A0L7RG63   V5I9M8   U5EVT5   A0A182P5T3   A0A182UU45   A0A182TEL9   A0A182LFT1   A0A182WRJ5   Q7QD98   A0A182HU81   Q1HRA5   A0A2J7Q5Y6   A0A182W066   A0A0M3QXH5   A0A182LTD9   A0A182N638   A0A182Y4A9   A0A0T6B570   A0A084VRC1   A0A182Q4C9   A0A2M4C1Y4   A0A2M4C1T3   D2A3Y7   A0A023EHN4   A0A182T0F8   A0A1Y1LP31   A0A2M3Z3V6   A0A2M3ZE43   W5JF83   A0A182F7D8   A0A232ELV6   A0A182RNR1  

PDB

2KVD     E-value=8.93547e-36,     Score=372

KEGG

101744776    K22556 mesencephalic astrocyte-derived neurotrophic factor | (RefSeq) mesencephalic astrocyte-derive

GO

GO:0005509   GO:0005576   GO:0005783   GO:0042417   GO:0031175   GO:0070050   GO:0001963   GO:0012505   GO:0016021   GO:0071542   GO:0005615  

PANTHER

PTHR12990  

Subcellular location

Secreted  

SignalP

Position:   1 - 21,         Likelihood:  0.987648

 

 

Length:

173

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.754289999999999

Exp number, first 60 AAs:

0.75181

Total prob of N-in:

0.01296

outside

1  -  173

 

 

Pi

21.191097

Theta

23.224438

Tajima's D

-0.535689

CLR

0.943882

CSRT

0.234438278086096

Interpretation

Uncertain