Gene

KWMTBOMO10115  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005557

Annotation

ATP_binding_protein_[Bombyx_mori]

Location

Bomo_Chr17(+):2408095-2409922      View in EpiBrowser

Full name

Cancer-related nucleoside-triphosphatase homolog       + More
Cancer-related nucleoside-triphosphatase      

Alternative Name

Nucleoside triphosphate phosphohydrolase

Location in the cell

Mitochondrial   Reliability : 1.143 Nuclear   Reliability : 1.047

CDS

ATGTCTAAAAATCCTAATACAACAATAAGGTTTTTTATATTAACAGGCGATCCTGGCATCGGTAAAACTACTCTGACCAAGAAAATATCTTCGCTCTTAGAAGCAGAAGGTGTAAAAGTTAATGGTTTTATTACTGAAGAAGTCAGAAATAAAGGAGTAAGAGAAGGCTTCGATGTGGTTACTAGTGCAGGAGTCAGGGGCCGTTTGGCTAGGGACCAAGATCTCATCACTATCCCTATTAAGCGCAAAATTGGTAAATACGGGGTTTTTATTGAAGAGTTTGAAAATATTGCATTGCCATGTTTAAACGAGACAACATCACAACCAAACTTACTAGTAATAGATGAAATTGGAAGCATGGAATTATCTAGTAAAAAGTTTAAAAATGTAATCGAAAATATTTTTAGTTCTGAGCAAAATTCTTACAATGTTGTGTTGGCAACCATACCTGTTAAAAACAGGTCTGCTCTTGTGGAGAACATTAGAAGTCATCCTAAAGCTAAAGTTTGGGTGATTACAAAAAAGAATAGAAATAAACTACATGAAGAAGTTATAAACGAAATGAAATCTGTTTTGAGTTTGATTTAA

Protein

MSKNPNTTIRFFILTGDPGIGKTTLTKKISSLLEAEGVKVNGFITEEVRNKGVREGFDVVTSAGVRGRLARDQDLITIPIKRKIGKYGVFIEEFENIALPCLNETTSQPNLLVIDEIGSMELSSKKFKNVIENIFSSEQNSYNVVLATIPVKNRSALVENIRSHPKAKVWVITKKNRNKLHEEVINEMKSVLSLI

Description

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity).
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

Catalytic Activity

a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate

Biophysicochemical Properties

5 uM for ATP
46 uM for ADP
4 uM for GTP
6 uM for CTP
7 uM for TTP

Subunit

Monomer.

Similarity

Belongs to the THEP1 NTPase family.

Keywords

Acetylation   ATP-binding   Complete proteome   Hydrolase   Nucleotide-binding   Reference proteome   3D-structure   Polymorphism  

Feature

chain  Cancer-related nucleoside-triphosphatase homolog
sequence variant  In dbSNP:rs12123482.

Uniprot

Q2F631   H9J7R5   A0A173FDM5   A0A2H1VHW6   A0A1E1W850   L7X3V9   + More
A0A194QC99   A0A212EI73   A0A1E1W9D0   A0A0L7L2L0   A0A194QS57   A0A2A4IUN2   B4QJM2   A0A1A9YTA1   B4IAJ2   A0A1A9VIS2   Q4V5T6   Q9VP84   B4PE79   B4J1L3   L7M6F5   K1Q1T3   A0A0P6K5D2   A0A1Z5L7L0   A0A0L0BWL5   B3NIV2   B4ITI0   A0A091DQ47   Q2M163   F1MM52   W5NZG4   H0VCP2   Q1LZ78   A0A1W4UXP8   A0A3B0J4U7   A0A2Y9DEX4   F6W380   A0A1I8M1G6   A0A131XH92   G3GWZ6   A0A2K5ND48   A0A2K6CY20   A0A2K5TSZ0   A0A2K5YE68   A0A0D9RCU8   A0A096MSK8   H9ZEC8   K9IYN6   A0A2D0QV73   I3MW13   B4LES7   A0A1Y1K683   G1T786   A0A340Y5P8   H2N3D9   A0A2U4BVF2   B3M6U6   A0A2C9LU97   A0A383ZFF4   A0A2R9AG00   K7CPD8   Q5TDE9   Q9BSD7   A0A1S3WBR3   G1Q846   A0A1U7QEM7   H0WQB7   G3S2M6   A0A3Q7VFU1   A0A2Y9LU58   A0A2I3HB03   A0A3Q2CBY7   A0A341AVD2   A0A3Q7TGB0   A0A2J7R6P6   A0A2K5R493   V3ZFT9   A0A3B4CS53   A0A3Q3GDA7   A0A1J1IQ59   A0A0M3QWA2   A0A2K5BV08   A0A023GF21   G1K8P1   A0A2K6T8C7   A0A2Y9FP34   L8IVF3   A0A023FIW2   A0A337S2Z4   H3D7D3   A0A0P4WBG2   A0A3Q1IGF5   A0A2U3WIR0   G3MLY6   B4KVY7   A0A1S3JTY1   A0A0K8RYF7   G3TP10   F1RGU8   C3KJN0  

EC Number

3.6.1.15

Pubmed

19121390    27251284    23674305    26354079    22118469    26227816    + More
17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    25576852    22992520    28528879    26108605    15632085    19393038    20809919    21993624    19892987    25315136    28049606    21804562    25319552    18057021    28004739    15562597    22722832    16136131    11181995    15489334    19413330    19608861    21269460    25944712    17291528    23254933    22751099    17975172    15496914    22216098    25727380    30723633   

EMBL

DQ311241    ABD36186.1    BABH01020258    BABH01020259    KT182637    ANG83454.1    + More
ODYU01002629    SOQ40386.1    GDQN01007929    JAT83125.1    KC469893    AGC92685.1    KQ459232    KPJ02610.1    AGBW02014684    OWR41186.1    GDQN01007478    JAT83576.1    JTDY01003352    KOB69687.1    KQ461155    KPJ08322.1    NWSH01007700    PCG62850.1    CM000363    CM002912    EDX11322.1    KMZ00919.1    CH480826    EDW44305.1    BT022570    AAY54986.1    AE014296    BT022513    AAF51671.2    AAY54929.1    CM000159    EDW95092.1    CH916366    EDV96933.1    GACK01006355    JAA58679.1    JH816081    EKC25319.1    GEBF01003302    JAO00331.1    GFJQ02003695    JAW03275.1    JRES01001238    KNC24423.1    CH954178    EDV52598.1    CH891700    EDW99693.1    KN122008    KFO34234.1    CH379069    EAL30712.3    AMGL01070647    AAKN02021646    AAKN02021647    BC116158    OUUW01000002    SPP76904.1    GEFH01002674    JAP65907.1    JH000057    EGW03340.1    AQIA01000466    AQIB01131522    AHZZ02017912    AHZZ02017913    JU336699    JU477490    AFE80452.1    AFH34294.1    GABZ01008101    JAA45424.1    AGTP01017295    AGTP01017296    CH940647    EDW70184.1    KRF84753.1    GEZM01091334    JAV56903.1    AAGW02026259    ABGA01149665    ABGA01149666    ABGA01149667    NDHI03003462    PNJ43528.1    CH902618    EDV39782.1    AJFE02086383    AACZ04026634    GABC01010870    GABF01010765    GABD01004916    GABE01002243    NBAG03000266    JAA00468.1    JAA11380.1    JAA28184.1    JAA42496.1    PNI55179.1    AK316591    CH471098    BAG38178.1    EAW69979.1    AF416713    BC005102    AAPE02053529    AAPE02053530    AAQR03135511    CABD030009447    ADFV01036771    ADFV01036772    NEVH01006756    PNF36508.1    KB203827    ESO82982.1    CVRI01000057    CRL01866.1    CP012525    ALC43793.1    GBBM01002727    JAC32691.1    JH880752    ELR59137.1    GBBK01003909    JAC20573.1    AANG04003799    GDRN01055236    JAI66001.1    JO842887    AEO34504.1    CH933809    EDW19538.1    GBKC01000580    JAG45490.1    AEMK02000096    DQIR01231014    HDB86491.1    BT083145    ACQ58852.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000037510    UP000053240    UP000218220    + More
UP000000304    UP000092443    UP000001292    UP000078200    UP000000803    UP000002282    UP000001070    UP000005408    UP000037069    UP000008711    UP000028990    UP000001819    UP000009136    UP000002356    UP000005447    UP000192221    UP000268350    UP000248480    UP000002281    UP000095301    UP000001075    UP000233060    UP000233120    UP000233100    UP000233140    UP000029965    UP000028761    UP000221080    UP000005215    UP000008792    UP000001811    UP000265300    UP000001595    UP000245320    UP000007801    UP000076420    UP000261681    UP000240080    UP000002277    UP000005640    UP000079721    UP000001074    UP000189706    UP000005225    UP000001519    UP000286642    UP000248483    UP000001073    UP000265020    UP000252040    UP000286640    UP000235965    UP000233040    UP000030746    UP000261440    UP000261660    UP000183832    UP000092553    UP000233020    UP000001646    UP000233220    UP000248484    UP000011712    UP000007303    UP000265040    UP000245340    UP000009192    UP000085678    UP000007646    UP000008227   

PRIDE

Q2F631    H9J7R5    Q4V5T6    Q9VP84    Q1LZ78    G3GWZ6    + More
Q9BSD7    F1RGU8   

Pfam

PF03266   NTPase_1

Interpro

IPR004948   Nuc-triphosphatase_THEP1        + More
IPR027417   P-loop_NTPase       
IPR003593   AAA+_ATPase       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

Q2F631   H9J7R5   A0A173FDM5   A0A2H1VHW6   A0A1E1W850   L7X3V9   + More
A0A194QC99   A0A212EI73   A0A1E1W9D0   A0A0L7L2L0   A0A194QS57   A0A2A4IUN2   B4QJM2   A0A1A9YTA1   B4IAJ2   A0A1A9VIS2   Q4V5T6   Q9VP84   B4PE79   B4J1L3   L7M6F5   K1Q1T3   A0A0P6K5D2   A0A1Z5L7L0   A0A0L0BWL5   B3NIV2   B4ITI0   A0A091DQ47   Q2M163   F1MM52   W5NZG4   H0VCP2   Q1LZ78   A0A1W4UXP8   A0A3B0J4U7   A0A2Y9DEX4   F6W380   A0A1I8M1G6   A0A131XH92   G3GWZ6   A0A2K5ND48   A0A2K6CY20   A0A2K5TSZ0   A0A2K5YE68   A0A0D9RCU8   A0A096MSK8   H9ZEC8   K9IYN6   A0A2D0QV73   I3MW13   B4LES7   A0A1Y1K683   G1T786   A0A340Y5P8   H2N3D9   A0A2U4BVF2   B3M6U6   A0A2C9LU97   A0A383ZFF4   A0A2R9AG00   K7CPD8   Q5TDE9   Q9BSD7   A0A1S3WBR3   G1Q846   A0A1U7QEM7   H0WQB7   G3S2M6   A0A3Q7VFU1   A0A2Y9LU58   A0A2I3HB03   A0A3Q2CBY7   A0A341AVD2   A0A3Q7TGB0   A0A2J7R6P6   A0A2K5R493   V3ZFT9   A0A3B4CS53   A0A3Q3GDA7   A0A1J1IQ59   A0A0M3QWA2   A0A2K5BV08   A0A023GF21   G1K8P1   A0A2K6T8C7   A0A2Y9FP34   L8IVF3   A0A023FIW2   A0A337S2Z4   H3D7D3   A0A0P4WBG2   A0A3Q1IGF5   A0A2U3WIR0   G3MLY6   B4KVY7   A0A1S3JTY1   A0A0K8RYF7   G3TP10   F1RGU8   C3KJN0  

PDB

2I3B     E-value=7.19376e-29,     Score=313

KEGG

693091    K06928 nucleoside-triphosphatase [EC:3.6.1.15] | (RefSeq) ATP binding protein

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0098519   GO:0016021   GO:0005524   GO:0017111   GO:0003723   GO:0016020   GO:0016301  

Length:

195

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00414

Exp number, first 60 AAs:

0.00357

Total prob of N-in:

0.32215

outside

1  -  195

 

 

Pi

128.581457

Theta

148.834265

Tajima's D

-0.295655

CLR

258.648726

CSRT

0.293035348232588

Interpretation

Uncertain