Gene

KWMTBOMO10093  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005664

Annotation

trehalase_precursor_[Bombyx_mori]

Location

Bomo_Chr17(-):2175120-2190963      View in EpiBrowser

Full name

Trehalase      

Alternative Name

Alpha-trehalose glucohydrolase
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase

Location in the cell

Cytoplasmic   Reliability : 2.592

CDS

ATGAGGTTGTTTCTACTACTGGTGGGATTGACGACGGTAATCGCGGATGACCTACCGCCGACTTGCATCAGACCAGTTTACTGCAACAGTACGCTGCTTCATTACGTTCAAATGGCCAGACTCTACCCCGATTCTAAAACTTTCGTCGATTTTCAAATGCGTAAAGACGAGAACGCAACACTGTCCGCCTTCCAAGAGCTGTTGGACCGCACGAATCATAATCCAACGAAAGAAGACCTGCAGGAATTTGTCGTTGACTTTTTTGATGAAACCAGCGAACTTGAAGAATGGAAACCGGATGACCATAAAGAAAACCCGCCTTTCCTCGCCAAAATTCGTGATGAAGGTTTCCGGGAATTCGCTAAAGCTTTAAATGATATTTGGCCAACTTTAGCCAGACGCGTTAAGCCCTCGGTCCTTGAAAAACCCGAACAATCGAGTCTCGTGCCTATGACACATGGCTTCATCGTTCCTGGAGGTCGATTTAAAGAAATCTACTATTGGGACGCATATTGGATTATCGAAGGTCTTCTAATCACTGACATGACCGAAACTGCAAAAGGAATGATCGAAAACCTAATCGAGCTTCTGTATAAATTTGGCCACATTCCCAATGGAAGCAGATGGTATTACCAAGAACGTAGCCAGCCTCCTTTATTGGCGGCCATGATAAAGCTTTATTACGAAAAGACTAAGGACATCGAATTCATCAGAAAGTATATTAGTGCTTTAGAAAAGGAATTAGAATATTGGCTGGACACTCATCTTATCGCTTTCAACAAGAACGACAGAGTTTACACTCTCCTGAGGTATTATATTCCAAGCGCTGGTCCTCGACCGGAGTCCTATTACGAAGATTACGAATTGGCTCAGAAATTAAACAAGACTACTGATCCTAATGATATTTACGCCGATTTAAAAAGCGCCGCTGAGAGCGGGTGGGACTTTTCTACGCGCTGGTTTATTTCAGAAAGCGGCGACAACAGTGGTAATCTAACCAATTTAAACACAAAGAACGTTATCCCCGTAGACTTGAATGCTATTTTCGCCGGAGCGTTACAGATTACGGCGAACTTCCAAGCTATATTAAAGAATCCTCGGAGAGCGGCTCACTGGGGCTACATGGCCGAACAATGGAGAAGTTCTATAGAGCAAGCGTTATGGGATGAAGAAGACGGAGTCTGGCACGACTACGACATATTGAATAATAAGCCACGTAGATATTTTTACACTAGCAACCTAGCTCCCCTGTGGATGAACGCAGTCGAAAAACCATTTCTAGCTAAGCATGGCGCTAGAGTCCTGGAGTACCTTCACGAATCGCAAGCGCTCGAGTACCCCGGAGGTGTCCCGGTGTCTCTAGTCAACAGTGGAGAACAATGGGACTTCCCTAACGCTTGGCCTCCAGAAGTCAGCATTGTCGTTACGGCTATCCAAAACATTGGTTCCGAGGAGAGTAGTAAATTGGCAAAAGAACTCGCCCAGGTCTGGGTGAGAGCTTGTAAATCAGGATTTACCGAAAAGAAACAGATGTTTGAGAAGTACGATGCGTTGAACGCTGGTAAATACGGCGGCGGCGGTGAATACACGGTTCAAGATGGATTCGGATGGTCGAACGGCGTTGTCCTGGAGTTCTTAGATAGGTACGGAGCTGTACTGACTTCGGTGGACTCTGTAGATGCTAGTGCAAATAACGGTCAGTCAAACGAAGAATCTGAGACGGATTCTAAGGAAAAATAA

Protein

MRLFLLLVGLTTVIADDLPPTCIRPVYCNSTLLHYVQMARLYPDSKTFVDFQMRKDENATLSAFQELLDRTNHNPTKEDLQEFVVDFFDETSELEEWKPDDHKENPPFLAKIRDEGFREFAKALNDIWPTLARRVKPSVLEKPEQSSLVPMTHGFIVPGGRFKEIYYWDAYWIIEGLLITDMTETAKGMIENLIELLYKFGHIPNGSRWYYQERSQPPLLAAMIKLYYEKTKDIEFIRKYISALEKELEYWLDTHLIAFNKNDRVYTLLRYYIPSAGPRPESYYEDYELAQKLNKTTDPNDIYADLKSAAESGWDFSTRWFISESGDNSGNLTNLNTKNVIPVDLNAIFAGALQITANFQAILKNPRRAAHWGYMAEQWRSSIEQALWDEEDGVWHDYDILNNKPRRYFYTSNLAPLWMNAVEKPFLAKHGARVLEYLHESQALEYPGGVPVSLVNSGEQWDFPNAWPPEVSIVVTAIQNIGSEESSKLAKELAQVWVRACKSGFTEKKQMFEKYDALNAGKYGGGGEYTVQDGFGWSNGVVLEFLDRYGAVLTSVDSVDASANNGQSNEESETDSKEK

Catalytic Activity

alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose

Similarity

Belongs to the glycosyl hydrolase 37 family.

Keywords

Cell membrane   Complete proteome   Direct protein sequencing   Glycoprotein   Glycosidase   Hydrolase   Membrane   Reference proteome   Signal   Secreted  

Feature

chain  Trehalase

Uniprot

H9J822   P32358   A0A2D0WL58   A0A0L7LE05   C9S264   A0A1B2AQF5   + More
A0A194QTL1   A0A194QAN3   A0A0U2KM65   A0A2A4JN84   A0A3Q8VR24   A0A0F6PB63   A3RLQ5   D2KHJ0   E9MYJ9   Q0ZIF5   E9MYK0   E9MYK2   E9MYJ8   A0A2H1WGC5   E9MYK1   B0M0J3   A0A212FIA5   L7WW66   A0A194QS77   A0A194QAV1   H9J823   R9YXT2   A0A2H1WC95   A0A076JZN4   D6WYI7   Q8MMG9   A0A2D0WLR3   P32359   A0A1W4XR71   A0A1Y1LGB5   A0A1D8I2M4   A0A2A4JMD9   A0A1B6DB06   A0A1B6E3A9   Q3MV18   A0A385MK80   A0A1B6FTE3   A0A2L1TG97   A0A2S2PXE7   B5ATV4   A0A2J7Q3Z7   A0A1B6FGD8   H9J4Z6   A0A2D0WLR5   A0A067QSZ4   A7XZC0   A0A1B6EY79   A0A1S6Q350   A0A2J7REE6   A0A1B6CFS1   D6WYI8   A0A1B6DGL1   E0W4A8   A0A2H8TFR3   J9JU09   A0A195FE62   A0A0K8SR01   A0A224X931   A0A195BF82   A0A0K8SQP5   G9I465   A0A1B6KBM1   A0A1B6KL82   T1HKP0   A0A0F6PAZ3   A0A0K8TDD3   A0A067QGU4   E2BGR0   A0A2W1BGC4   A0A146LQW6   A0A0A9WUU0   R9YY06   A0A2H8TKV2   A0A2J7PTL5   D2KHI9   A0A1D8I2M1   S4UQ18   A0A2H1WN76   A0A2J7PTK0   A0A1B6F1K5   X2G4I4   A0A1Y1LN31   A0A1Y1LKH8   C3UWP1   E2BSG4   M1RYJ3   A0A1B2AQF4   A0A212FIB4   A0A0C9S2J2   A0A3G2SGP7   J9JVF6   A0A2P8YXZ4   A0A084WJ24   A3RLQ4  

EC Number

3.2.1.28

Pubmed

19121390    7916633    7519445    26227816    26354079    23613237    + More
21114846    19843188    18492231    22118469    23674305    23770497    18362917    19820115    12727301    1445264    28004739    16164606    24845553    20566863    26823975    22243654    20798317    28756777    25401762    23194342    29403074    24438588   

EMBL

BABH01020287    D13763    S73271    D86212    KU977455    ARD05073.1    + More
JTDY01001509    KOB73697.1    CT955980    CBH09244.1    KU640203    ANY30160.1    KQ461155    KPJ08340.1    KQ459232    KPJ02593.1    KR149447    ALF03966.1    NWSH01000985    PCG73246.1    MH050739    AZM68711.1    KJ652557    AJK29979.1    EF426724    ABO20846.1    GU211891    ADA63846.1    HQ328815    ADT64093.1    DQ447188    ABE27189.1    HQ328816    ADT64094.1    HQ328818    ADT64096.1    HQ328814    ADT64092.1    ODYU01008486    SOQ52128.1    HQ328817    ADT64095.1    EU427311    ABY86218.1    AGBW02008409    OWR53472.1    KC469893    AGC92667.2    KPJ08342.1    KPJ02592.1    KC818237    AGO32658.1    ODYU01007692    SOQ50705.1    KJ789159    AII81931.1    KQ971362    EFA08991.1    AJ459958    KU977456    ARD05074.1    D11338    GEZM01058095    JAV71911.1    KU756285    AOT99588.1    PCG73245.1    GEDC01021380    GEDC01014488    JAS15918.1    JAS22810.1    GEDC01014640    GEDC01004890    JAS22658.1    JAS32408.1    AB162717    BAE45249.1    MG460307    AYA60780.1    GECZ01016299    JAS53470.1    KY697913    AVF19696.1    GGMS01000994    MBY70197.1    EU872435    ACF94698.1    NEVH01018420    PNF23300.1    GECZ01020512    JAS49257.1    BABH01025716    KU977457    ARD05075.1    KK852980    KDR13013.1    EU106080    ABU95354.1    GECZ01026821    JAS42948.1    KX371565    AQV08187.1    NEVH01005277    PNF39211.1    GEDC01025075    JAS12223.1    EFA08992.1    GEDC01012469    JAS24829.1    DS235886    EEB20464.1    GFXV01001141    MBW12946.1    ABLF02022564    KQ981673    KYN38309.1    GBRD01010280    JAG55544.1    GFTR01007580    JAW08846.1    KQ976500    KYM83241.1    GBRD01010278    GDHC01021605    GDHC01004455    JAG55546.1    JAP97023.1    JAQ14174.1    JN565077    AEW67359.1    GEBQ01031162    JAT08815.1    GEBQ01027776    JAT12201.1    ACPB03020626    KJ652558    AJK29980.1    GBRD01002317    JAG63504.1    KK853443    KDR07599.1    GL448204    EFN85130.1    KZ150067    PZC74122.1    GDHC01009483    JAQ09146.1    GBHO01031362    JAG12242.1    KC853750    AGO32660.1    GFXV01002874    MBW14679.1    NEVH01021237    PNF19664.1    GU211890    ADA63845.1    KU756284    AOT99587.1    JX312193    AGL34007.2    ODYU01009835    SOQ54523.1    PNF19666.1    GECZ01025694    JAS44075.1    KJ025078    AHN15422.1    GEZM01054932    GEZM01054931    GEZM01054929    GEZM01054927    JAV73335.1    GEZM01054933    GEZM01054930    GEZM01054928    GEZM01054926    JAV73338.1    FJ795020    ACP28173.1    GL450233    EFN81352.1    JX134487    AGG35943.1    KU640202    ANY30159.1    OWR53471.1    GBYB01015126    JAG84893.1    MG787168    AYO46921.1    ABLF02022430    PYGN01000293    PSN49112.1    ATLV01023963    ATLV01023964    ATLV01023965    KE525347    KFB50218.1    EF426723    ABO20845.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000053268    UP000218220    UP000007151    + More
UP000007266    UP000192223    UP000235965    UP000027135    UP000009046    UP000007819    UP000078541    UP000078540    UP000015103    UP000008237    UP000245037    UP000030765   

PRIDE

H9J822    P32358    H9J823    P32359    Q3MV18    H9J4Z6    + More

Pfam

PF01204   Trehalase

Interpro

IPR001661   Glyco_hydro_37        + More
IPR012341   6hp_glycosidase-like_sf       
IPR008928   6-hairpin_glycosidase_sf       
IPR018232   Glyco_hydro_37_CS       

SUPFAM

SSF48208   SSF48208       

Gene 3D

1.50.10.10    

ProteinModelPortal

H9J822   P32358   A0A2D0WL58   A0A0L7LE05   C9S264   A0A1B2AQF5   + More
A0A194QTL1   A0A194QAN3   A0A0U2KM65   A0A2A4JN84   A0A3Q8VR24   A0A0F6PB63   A3RLQ5   D2KHJ0   E9MYJ9   Q0ZIF5   E9MYK0   E9MYK2   E9MYJ8   A0A2H1WGC5   E9MYK1   B0M0J3   A0A212FIA5   L7WW66   A0A194QS77   A0A194QAV1   H9J823   R9YXT2   A0A2H1WC95   A0A076JZN4   D6WYI7   Q8MMG9   A0A2D0WLR3   P32359   A0A1W4XR71   A0A1Y1LGB5   A0A1D8I2M4   A0A2A4JMD9   A0A1B6DB06   A0A1B6E3A9   Q3MV18   A0A385MK80   A0A1B6FTE3   A0A2L1TG97   A0A2S2PXE7   B5ATV4   A0A2J7Q3Z7   A0A1B6FGD8   H9J4Z6   A0A2D0WLR5   A0A067QSZ4   A7XZC0   A0A1B6EY79   A0A1S6Q350   A0A2J7REE6   A0A1B6CFS1   D6WYI8   A0A1B6DGL1   E0W4A8   A0A2H8TFR3   J9JU09   A0A195FE62   A0A0K8SR01   A0A224X931   A0A195BF82   A0A0K8SQP5   G9I465   A0A1B6KBM1   A0A1B6KL82   T1HKP0   A0A0F6PAZ3   A0A0K8TDD3   A0A067QGU4   E2BGR0   A0A2W1BGC4   A0A146LQW6   A0A0A9WUU0   R9YY06   A0A2H8TKV2   A0A2J7PTL5   D2KHI9   A0A1D8I2M1   S4UQ18   A0A2H1WN76   A0A2J7PTK0   A0A1B6F1K5   X2G4I4   A0A1Y1LN31   A0A1Y1LKH8   C3UWP1   E2BSG4   M1RYJ3   A0A1B2AQF4   A0A212FIB4   A0A0C9S2J2   A0A3G2SGP7   J9JVF6   A0A2P8YXZ4   A0A084WJ24   A3RLQ4  

PDB

5Z6H     E-value=4.87414e-75,     Score=717

KEGG

693027    K01194 alpha,alpha-trehalase [EC:3.2.1.28] | (RefSeq) trehalase

PATHWAY

00500    Starch and sucrose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004555   GO:0005991   GO:0016323   GO:0008152   GO:0005576   GO:0016021   GO:0003824   GO:0008026   GO:0005737   GO:0016301   GO:0016773   GO:0016155  

PANTHER

PTHR23403  

Subcellular location

Basolateral cell membrane  
Secreted  

SignalP

Position:   1 - 15,         Likelihood:  0.998917

 

 

Length:

579

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02588

Exp number, first 60 AAs:

0.0068

Total prob of N-in:

0.00038

outside

1  -  579

 

 

Pi

164.098744

Theta

163.345709

Tajima's D

0.685049

CLR

0.348433

CSRT

0.565121743912804

Interpretation

Uncertain