Gene

KWMTBOMO10088  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005667

Annotation

PREDICTED:_acylamino-acid-releasing_enzyme-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr17(-):2125825-2146813      View in EpiBrowser

Full name

Acylamino-acid-releasing enzyme      

Alternative Name

Acyl-peptide hydrolase
Acylaminoacyl-peptidase

Location in the cell

Cytoplasmic   Reliability : 1.365

CDS

ATGTCAAAAGAGTTCGAAAACGTGATAAGATTGTACAAGAATTTCTCGAAAGTTCCGTCGATCGTGGGCGCGCACTTGAGCAGGGACACTTCGAGGGTCACCGTCAAATGGACGGTGCGGAGCACGGACAGAGGCAAGAACACTAGATTCGTCTCAAGCTATATATTAAACGAGAGCTTAAAGGTCATAGCCGATTGCGGCTTTGGTACGGATATCAGTAATGAGCTCCTCTCGGCCGTTTCCCCCAATGAGACCTACCGAGCGGTCATCAGGGAGGAGAGGAATCAGAAGGACCTGAAGAAGCAGTACCTCGAAGTGTGGAGCAAGAACCATCTTGCGCACTGTATCGACCTCAATGCGCTGGATTTGCACGGGGACGTTTACGCTGATTCCGAATTTGGCTGCCTGAACTGGTCGCAGGATGAAAGCGCTATCGTTTACGTCGCGGAAAAGAAACTGGCCAAAGCAGAGCCTTACATCGTGAGGAAGCCCGCCGAAACACCCAAGTCCGACAGTAAAGAGACGCCGAGAAAGGGCGAGGAGTACATATACCGGCAGGACTGGGGCGAGCAGCTGGTCGGAAAGCACGCCTCAGTGATCGTCGTCTGTAAGATCGAGAGCGAGAGCTTCACCGTATTGGACGGCCTCCCCGAAGACTGGTGTCCCGGACAAGTACGTTTCACGTTGGACGGCAAAAGCGTTATCGGGATAGCGTGGAGCACGGAGCCGCGCCGACTGGGCCTCATCTTCTGCACGAACAGACCCGGACACGTGTTCACTTTATCCTTGGAAGACGATAAAGCGTTGAGCAGACTGTCGCCGGAGGGCATGTCGGTGCGGGCGGCGCGGCTGTCTCCCCGCGGTGCGCCCGTGTGGTTGCAGCGGGTCGCCCGCGGGCCGCACCACGCCGGACACCAACTGGTCACTGGTAACATCGCGGAGGCGCCGCTGACCGTCATAGTGGACCTGGTGCAGACGGTGACCAGGACGGACGACGGTCGGGACTTCCACGGCATCTACTCGCAGAGTCTGCCCGCGCGGTGCTTCAGCAAGGACGGGAAGAGAATCGTGTTTTCAACGCCCCAAAAGAACGAAATTAGGAGTTATGTTGTTGATATCGAGAGCGGCGGGATGGTGGACGTTTCAATCCGTCGAGCGGCGGGGTCGACGAGCGTGCTGGACGTGCACGATGACGTCATACTGGCCGCGCACTCCAGCCTCACCAGCCCCAGCCAGCTGTACGTAGCCAGACTGCCGGCGCGGGGCTCGGAGGCGGAGGTAGAGTGGATGCCGGTGACGTCACAGCCGGAGGTCCCCGCCGGCCTGGCCCGCTCCGAGGTCACCTACCTGCAGCTCGAGCACGCGGACTGCGCGGACCCCGTCAAGTCTTTCTCGGCGATATACCTCTCCCCGAGCGTGCAGGGCGGCTCCAAGCTGCCCCTGCTGGTGTGGCCCCACGGCGGACCTCACTCCAACTTTACGAACAGCTACTCTTTTGAAGCGGCCTTCTTCAATGACCTGGGTTTCGCCATACTGCACGTCAATTATCGAGGGTCCACCGGGGCAGGGGAGGCGTCTATGGCGTTCCTGCCGAAGCGCGTGGGTGACGCAGACGTGAAAGATTGTAAACTGGCCACGGAGACGGCCGTGGCCAGGTTCGGTCTGGACGAGAGTAAATTGTGTCTGATGGGCGGCTCCCACGGGGGCTTCCTGGTGGCGCACCTCAGCGGGCAGTACCCGGATCTGTTCAAGGTGGTCGTCAGCCGCAACCCGGTCATAGACGTCGCCAGCATGTTCAACTCCACGGACATCGCTGATTGGTGTGCGGTGGAAGCCGGTTTCCCGTTCACGGAGGAGGGTCCGCCTTCCGAGGAGCAGCTGCTGGCGATGCGCCGGTGCTCACCTCTGGTCCACGCTCACAAGGTCAAGGCTCCGACGGCCCTCATGCTGGGCTCTGCGGACAAGCGCGTCCCCCACTACCAGGGCCTGGAGTACGCGAGGAGGCTCAAGGCCAATGGTGTTGCGACCAGAGTCTACCTGTACGACGACAATCATTCGTTATCGTCGCCGCTTGTTGAGATGGACAATCTTATCAACGCCGCCCTTTGGTTCTTGAAGCATTTAGATCAGTAA

Protein

MSKEFENVIRLYKNFSKVPSIVGAHLSRDTSRVTVKWTVRSTDRGKNTRFVSSYILNESLKVIADCGFGTDISNELLSAVSPNETYRAVIREERNQKDLKKQYLEVWSKNHLAHCIDLNALDLHGDVYADSEFGCLNWSQDESAIVYVAEKKLAKAEPYIVRKPAETPKSDSKETPRKGEEYIYRQDWGEQLVGKHASVIVVCKIESESFTVLDGLPEDWCPGQVRFTLDGKSVIGIAWSTEPRRLGLIFCTNRPGHVFTLSLEDDKALSRLSPEGMSVRAARLSPRGAPVWLQRVARGPHHAGHQLVTGNIAEAPLTVIVDLVQTVTRTDDGRDFHGIYSQSLPARCFSKDGKRIVFSTPQKNEIRSYVVDIESGGMVDVSIRRAAGSTSVLDVHDDVILAAHSSLTSPSQLYVARLPARGSEAEVEWMPVTSQPEVPAGLARSEVTYLQLEHADCADPVKSFSAIYLSPSVQGGSKLPLLVWPHGGPHSNFTNSYSFEAAFFNDLGFAILHVNYRGSTGAGEASMAFLPKRVGDADVKDCKLATETAVARFGLDESKLCLMGGSHGGFLVAHLSGQYPDLFKVVVSRNPVIDVASMFNSTDIADWCAVEAGFPFTEEGPPSEEQLLAMRRCSPLVHAHKVKAPTALMLGSADKRVPHYQGLEYARRLKANGVATRVYLYDDNHSLSSPLVEMDNLINAALWFLKHLDQ

Description

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

Catalytic Activity

Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.

Subunit

Homotetramer.

Similarity

Belongs to the peptidase S9C family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Direct protein sequencing   Hydrolase   Phosphoprotein   Reference proteome  

Feature

chain  Acylamino-acid-releasing enzyme

Uniprot

A0A0X9PFK4   H9J825   A0A2A4JP98   A0A3S2PAG6   A0A2A4JP67   L7X3U3   + More
C9S261   A0A194QAY2   A0A2H1VYT8   L7X0N7   A0A212FIB6   D6X1Y3   A0A2J7RPZ1   A0A067R7F4   A0A1B6E573   J3JZL1   U4UB94   A0A1B6FVD6   A0A1B6KI34   A0A1Y1M7X3   E2AU18   A0A026WDI3   F4WIS2   A0A151JR70   A0A151WLI2   A0A158P480   A0A2A3E643   A0A1I9WLD0   A0A195BSH5   A0A195FPN7   A0A310S8V4   K7JV01   A0A088AHN3   A0A195CUC1   A0A0M9ABM8   K7JB55   H3AUX9   A0A1L8GP58   A0A224XKN0   F7EDX7   A0A0V0G8W1   A0A3B1KIC0   A0A3B1J1U2   E2B4E6   A0A098M0X3   N6T2C6   A0A1B6J6R1   A0A0A9XJL5   A0A2R7X5M7   G3WZ09   U3K2Y7   H2T3C9   A0A3B4BX73   A0A3B4WA29   A0A218UQS0   A0A3B4USR2   W5ULW3   A0A2D0R1Z5   G3SSI2   A0A2D0R1A6   G1KIG0   V9K946   A0A232F6H9   A0A3Q3BU54   A0A3Q2WJK2   A0A3Q2V6F2   A0A3P8P8K5   A0A3P9DNE3   M7BHW0   A0A1V4K8U9   G3H8F2   A0A1V4K937   A0A3B4GCJ9   H0VJ48   A0A3Q3LIN7   A0A3L7HP44   A0A3P8UTW4   A0A3B4BWY7   A0A2K5Z2S1   G1SMY7   F1SPS7   G3V9E4   A0A2K5LRR0   A0A096NQL6   Q6PFN2   F1QTY6   A0A2K5LRQ1   I3LFX8   A0A2K6DQ60   A0A2K5VH26   P19205   A0A0D9RR27   A0A2K6UHE9   B2GVB7   P13676   A0A2Y9D6D6   A0A3Q1BT80   A0A2K6DQ58   A0A2K5VH49  

EC Number

3.4.19.1

Pubmed

26778207    19121390    23674305    26354079    22118469    18362917    + More
19820115    24845553    22516182    23537049    28004739    20798317    24508170    21719571    21347285    27538518    20075255    9215903    27762356    20431018    25329095    25401762    21709235    21551351    23127152    24402279    28648823    25186727    23624526    21804562    21993624    29704459    24487278    30723633    15057822    15632090    22673903    23594743    2691504    8576092    15489334    2722805    2578023    3305492   

EMBL

KR094958    AMA07820.1    BABH01020294    NWSH01000985    PCG73242.1    RSAL01000145    + More
RVE45933.1    PCG73243.1    KC469893    AGC92665.2    CT955980    CBH09241.1    KQ459232    KPJ02589.1    ODYU01005286    SOQ45991.1    AGC92664.1    AGBW02008409    OWR53468.1    KQ971371    EFA09948.1    NEVH01001352    PNF42907.1    KK852687    KDR18399.1    GEDC01004223    JAS33075.1    BT128693    AEE63650.1    KB631924    ERL87235.1    GECZ01015603    JAS54166.1    GEBQ01028859    GEBQ01024592    JAT11118.1    JAT15385.1    GEZM01041416    JAV80425.1    GL442767    EFN63061.1    KK107260    EZA54140.1    GL888177    EGI65868.1    KQ978615    KYN29863.1    KQ982959    KYQ48718.1    ADTU01008701    ADTU01008702    KZ288371    PBC26742.1    KU932314    APA33950.1    KQ976417    KYM89970.1    KQ981382    KYN42272.1    KQ768478    OAD53128.1    AAZX01004297    KQ977279    KYN04122.1    KQ435689    KOX81227.1    AAZX01015192    AFYH01140805    AFYH01140806    AFYH01140807    AFYH01140808    AFYH01140809    AFYH01140810    CM004472    OCT85635.1    GFTR01007835    JAW08591.1    AAMC01058642    GECL01001654    JAP04470.1    GL445552    EFN89440.1    GBSI01000148    JAC96347.1    APGK01055044    APGK01055045    KB741259    ENN71683.1    GECU01012858    JAS94848.1    GBHO01022689    GBHO01022687    GBRD01015685    JAG20915.1    JAG20917.1    JAG50141.1    KK857235    PTY26971.1    AEFK01082837    AEFK01082838    AGTO01001625    MUZQ01000178    OWK55996.1    JT419048    AHH42931.1    JW861744    AFO94261.1    NNAY01000908    OXU25967.1    KB566894    EMP27807.1    LSYS01004144    OPJ80882.1    JH000209    EGW08934.1    OPJ80883.1    AAKN02012903    RAZU01000165    RLQ67707.1    AAGW02044088    AEMK02000086    DQIR01093527    HDA49003.1    AC128059    CH473954    EDL77191.1    AHZZ02020134    BC057485    AAH57485.1    CABZ01086615    CABZ01086616    CABZ01086617    CABZ01086618    CABZ01086619    AQIA01039641    AQIA01039642    D00524    AQIB01131867    BC166605    AAI66605.1    J04733    X14915   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000007266    + More
UP000235965    UP000027135    UP000030742    UP000000311    UP000053097    UP000007755    UP000078492    UP000075809    UP000005205    UP000242457    UP000078540    UP000078541    UP000002358    UP000005203    UP000078542    UP000053105    UP000008672    UP000186698    UP000008143    UP000018467    UP000008237    UP000019118    UP000007648    UP000016665    UP000005226    UP000261440    UP000261360    UP000197619    UP000261420    UP000221080    UP000007646    UP000001646    UP000215335    UP000264840    UP000265100    UP000265160    UP000031443    UP000190648    UP000001075    UP000261460    UP000005447    UP000261640    UP000273346    UP000265120    UP000233140    UP000001811    UP000008227    UP000002494    UP000233060    UP000028761    UP000000437    UP000233120    UP000233100    UP000029965    UP000233220    UP000248480    UP000257160   

PRIDE

H9J825    G3H8F2    F1SPS7    I3LFX8    P19205    B2GVB7    + More
P13676   

Pfam

PF00326   Peptidase_S9        + More
PF07676   PD40

Interpro

IPR001375   Peptidase_S9        + More
IPR029058   AB_hydrolase       
IPR002470   Peptidase_S9A       
IPR011042   6-blade_b-propeller_TolB-like       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR002471   Pept_S9_AS       
IPR011659   PD40       

SUPFAM

SSF53474   SSF53474       

Gene 3D

3.40.50.1820     2.120.10.30     2.130.10.10    

ProteinModelPortal

A0A0X9PFK4   H9J825   A0A2A4JP98   A0A3S2PAG6   A0A2A4JP67   L7X3U3   + More
C9S261   A0A194QAY2   A0A2H1VYT8   L7X0N7   A0A212FIB6   D6X1Y3   A0A2J7RPZ1   A0A067R7F4   A0A1B6E573   J3JZL1   U4UB94   A0A1B6FVD6   A0A1B6KI34   A0A1Y1M7X3   E2AU18   A0A026WDI3   F4WIS2   A0A151JR70   A0A151WLI2   A0A158P480   A0A2A3E643   A0A1I9WLD0   A0A195BSH5   A0A195FPN7   A0A310S8V4   K7JV01   A0A088AHN3   A0A195CUC1   A0A0M9ABM8   K7JB55   H3AUX9   A0A1L8GP58   A0A224XKN0   F7EDX7   A0A0V0G8W1   A0A3B1KIC0   A0A3B1J1U2   E2B4E6   A0A098M0X3   N6T2C6   A0A1B6J6R1   A0A0A9XJL5   A0A2R7X5M7   G3WZ09   U3K2Y7   H2T3C9   A0A3B4BX73   A0A3B4WA29   A0A218UQS0   A0A3B4USR2   W5ULW3   A0A2D0R1Z5   G3SSI2   A0A2D0R1A6   G1KIG0   V9K946   A0A232F6H9   A0A3Q3BU54   A0A3Q2WJK2   A0A3Q2V6F2   A0A3P8P8K5   A0A3P9DNE3   M7BHW0   A0A1V4K8U9   G3H8F2   A0A1V4K937   A0A3B4GCJ9   H0VJ48   A0A3Q3LIN7   A0A3L7HP44   A0A3P8UTW4   A0A3B4BWY7   A0A2K5Z2S1   G1SMY7   F1SPS7   G3V9E4   A0A2K5LRR0   A0A096NQL6   Q6PFN2   F1QTY6   A0A2K5LRQ1   I3LFX8   A0A2K6DQ60   A0A2K5VH26   P19205   A0A0D9RR27   A0A2K6UHE9   B2GVB7   P13676   A0A2Y9D6D6   A0A3Q1BT80   A0A2K6DQ58   A0A2K5VH49  

PDB

4HXF     E-value=5.46686e-15,     Score=200

KEGG

101747101    K01303 acylaminoacyl-peptidase [EC:3.4.19.1] | (RefSeq) acylamino-acid-releasing enzyme-like

GO

GO:0004252   GO:0008236   GO:0004177   GO:0008242   GO:0042802   GO:0050435   GO:0031965   GO:0005829   GO:0005737   GO:0006508   GO:0005515   GO:0008152   GO:0016301   GO:0016773   GO:0016155   GO:0003824  

Subcellular location

Cytoplasm  

Length:

710

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00593999999999998

Exp number, first 60 AAs:

0.00187

Total prob of N-in:

0.00040

outside

1  -  710

 

 

Pi

243.540468

Theta

183.324708

Tajima's D

0.627118

CLR

0.503587

CSRT

0.557722113894305

Interpretation

Uncertain