Gene

KWMTBOMO10086  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005544

Annotation

PREDICTED:_geranylgeranyl_transferase_type-2_subunit_beta_[Amyelois_transitella]

Location

Bomo_Chr17(+):2100344-2105442      View in EpiBrowser

Full name

Geranylgeranyl transferase type-2 subunit beta      

Alternative Name

Geranylgeranyl transferase type II subunit beta
Rab geranyl-geranyltransferase subunit beta
Rab geranylgeranyltransferase subunit beta
Type II protein geranyl-geranyltransferase subunit beta

Location in the cell

Nuclear   Reliability : 1.46 PlasmaMembrane   Reliability : 1.189

CDS

ATGTCTTTTACAACGAAAGATGTTGTCTTAAAAGAAGATCGACCTAAAACTTTACTCTTACAAAAGCACTCCGACTATTTAGCCAGTTACGGCTTAAATAAAGATGACTACGAGTATTGTATGACCGAATATCTAAGAATGTCCGGTATTTACTGGAGTTTAACTGCTATGGAACTCATGGGACAATCATCAAGGATGCCTAAAGAAGATATAATAGAATTCATTACACAATGCCAAGATAGTGAAAGTGGAGGTATCTCGGCTAGCATCGGACATGATCCACACATACTATACACATTAAGTGCTGTACAGGTACTGGCGATGTATGATAGATTAGATGCTGTTGATATTGAAGGAATTGTCAGATACATAGTTTCCTTACAGCAAGAAGATGGTAGTTTTTATGGAGACAAATGGGGTGAAATAGACACTAGGTTCTCTTTCTGTGCGGTAATGTGTCTATCACTCTTACAACGATTGGATGCCATCGACATCAACAAGACTGTGGAGTTTGTGCTCAGTTGCATGAACTTTGATGGTGGATTCGGTTCCAAACCTGGATCGGAAAGCCATGCTGGTCTAATTTACTGCTGTGTGGGTACACTGTCGATATGCAAGCGCATGGATGCCCTACACGCAGACGAGCTGGCGTGGTGGCTATGTGAACGACAGCTGCCCAGTGGTGGTCTGAATGGTCGACCGGAAAAGCTGCCAGATTTGTGCTACTCTTGGTGGGTCATGTCTTCACTTTCAATGCTGAATAGAATTCACTGGGTAGACAAGAAAAGCTTAGAAGAATTTATCTTAGCATGTCAAGATAATGAAACTGGTGGCTTTAGTGACAGGCCCGGAGACATCACAGACCCATTCCATACATTGTTTGGTCTGGCAGGCCTTTCATTACTAGGCAACACCAGTATAAAACCTGTTAACCCCACATACTGCATGCCACAGGAAACAATAGACAGGCTGAAACTAAAACCACAGATACTGCAAATTTAA

Protein

MSFTTKDVVLKEDRPKTLLLQKHSDYLASYGLNKDDYEYCMTEYLRMSGIYWSLTAMELMGQSSRMPKEDIIEFITQCQDSESGGISASIGHDPHILYTLSAVQVLAMYDRLDAVDIEGIVRYIVSLQQEDGSFYGDKWGEIDTRFSFCAVMCLSLLQRLDAIDINKTVEFVLSCMNFDGGFGSKPGSESHAGLIYCCVGTLSICKRMDALHADELAWWLCERQLPSGGLNGRPEKLPDLCYSWWVMSSLSMLNRIHWVDKKSLEEFILACQDNETGGFSDRPGDITDPFHTLFGLAGLSLLGNTSIKPVNPTYCMPQETIDRLKLKPQILQI

Description

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

Catalytic Activity

geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]

Cofactor

Zn(2+)
FAD

Subunit

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity. Interacts with CHODL.

Similarity

Belongs to the protein prenyltransferase subunit beta family.
Belongs to the acyl-CoA dehydrogenase family.

Keywords

Acetylation   Complete proteome   Metal-binding   Phosphoprotein   Prenyltransferase   Reference proteome   Repeat   Transferase   Zinc  

Feature

chain  Geranylgeranyl transferase type-2 subunit beta

Uniprot

H9J7Q2   A0A3S2LX13   S4NU03   A0A194QGL3   A0A2A4JPA2   A0A194QS82   + More
L7X1D3   A0A2H1VBC7   A0A2J7R3C0   A0A067QVU7   A0A1W4YF36   A0A1B6KNI4   A0A210QV44   A0A1B6GAS2   A0A1B6DJX0   W5M713   A0A1U7RPK9   J3SEF7   H3AJC0   H9GH71   T1E6G1   K1QIP5   Q4V946   A0A1W7RH66   A0A0S7HD41   W5KFT0   F7H322   A0A3B3WB06   A0A087X723   A0A098LYI2   A0A0A0AHE9   A0A2D4KJJ7   A9JTX7   G1NTI6   K7FVG3   A0A3B4C3Z4   A0A099ZA23   A0A2U3WP41   A0A2K6CHX8   A0A2K5WEG7   G1REP9   A0A2K5ZF01   A0A0D9S6Y8   A0A2R9AUI7   A0A096P020   A0A2K6RE21   A0A2K5MNF4   A0A2K5HJX6   H2N708   H2PZ92   F6TFB0   Q6IB63   P53611   F7CEP1   A0A1B6EFJ0   G1TB66   G3SRQ0   K9IZX7   A0A287BJ15   A0A287BFL8   A0A0Q3UTA5   A0A2K6U876   A0A091HMJ4   A0A2K5HJZ7   F7H489   A0A1W4XJS5   F1P4E5   A0A3B3WB59   Q5E9B3   G1NHW3   A0A3Q7P2J9   A0A3Q0D8E9   M3YHJ8   A0A091GGL3   A0A091QI78   A0A091RCC9   A0A3B5PT83   A0A250XYN8   A0A2Y9J3L3   F6TFA1   G8JKY6   A0A1L1RQG8   G3QPT1   A0A1S3GR13   I3N1M9   F1P6X0   A0A3L8RWH8   A0A093JPF3   A0A3Q3LNC0   A0A091WN32   W5PSV6   R0L7L0   H0ZJM1   I3KPS0   A0A1A8VJN5   A0A1A8SJ23   A0A1A8KLR5   A0A1A8BY93   D7EK21   A0A2I2UUA5  

EC Number

2.5.1.60

Pubmed

19121390    23622113    26354079    23674305    24845553    28812685    + More
23025625    9215903    21881562    23758969    25727380    22992520    23594743    26358130    25329095    25243066    20431018    21993624    17381049    22722832    25362486    16136131    17431167    25319552    11181995    8706741    8954794    15489334    11447212    7991565    18532927    18691976    18669648    19413330    20068231    21269460    23186163    30723633    15592404    16305752    20838655    26319212    23542700    28087693    19393038    22398555    16341006    30282656    20809919    20360741    25186727    18362917    19820115    17975172   

EMBL

BABH01020294    BABH01020295    BABH01020296    RSAL01000145    RVE45936.1    GAIX01012011    + More
JAA80549.1    KQ459232    KPJ02586.1    NWSH01000985    PCG73240.1    KQ461155    KPJ08347.1    KC469893    AGC92661.2    ODYU01001641    SOQ38150.1    NEVH01007821    PNF35337.1    KK852897    KDR14173.1    GEBQ01026977    JAT13000.1    NEDP02001728    OWF52601.1    GECZ01010231    JAS59538.1    GEDC01028572    GEDC01018203    GEDC01015854    GEDC01015695    GEDC01011317    GEDC01009501    GEDC01002158    JAS08726.1    JAS19095.1    JAS21444.1    JAS21603.1    JAS25981.1    JAS27797.1    JAS35140.1    AHAT01018239    JU174640    GBEX01001356    AFJ50166.1    JAI13204.1    AFYH01155084    AFYH01155085    AFYH01155086    AFYH01155087    AFYH01155088    AFYH01155089    AAWZ02004349    GAAZ01000961    GBKC01001428    GBKD01000864    JAA96982.1    JAG44642.1    JAG46754.1    JH817502    EKC28770.1    CT027702    BC097066    BC164578    AAH97066.1    AAI64578.1    GDAY02000939    JAV50488.1    GBYX01442571    JAO38821.1    GAMT01009533    GAMS01006925    GAMR01000747    GAMQ01003891    GAMP01009303    JAB02328.1    JAB16211.1    JAB33185.1    JAB37960.1    JAB43452.1    AYCK01011917    GBSI01000959    JAC95537.1    KL871554    KGL92420.1    IACL01069754    LAB08854.1    AAMC01053522    AAMC01053523    AAMC01053524    BC155527    AAI55528.1    AAPE02012132    AGCU01135394    AGCU01135395    KL891373    KGL78611.1    AQIA01003692    ADFV01189075    AQIB01085525    AJFE02107703    AHZZ02016192    ABGA01367960    NDHI03003382    PNJ71905.1    AACZ04058133    GABC01007448    GABF01004113    GABD01010940    GABE01000418    NBAG03000287    JAA03890.1    JAA18032.1    JAA22160.1    JAA44321.1    PNI47812.1    JSUE03001697    JU335736    JU473413    AFE79489.1    AFH30217.1    CR456941    CH471059    CAG33222.1    EAX06397.1    U49245    X98001    Y08201    BC020790    GEDC01000664    JAS36634.1    AAGW02002003    GABZ01006961    JAA46564.1    AEMK02000047    DQIR01030293    HCZ85768.1    LMAW01001570    KQK83170.1    KL217539    KFO96337.1    AADN05000647    BT021007    BC147953    AEYP01045772    KL448248    KFO81525.1    KK676384    KFQ09194.1    KK812913    KFQ36877.1    GFFV01003469    JAV36476.1    DAAA02008284    CABD030004015    AGTP01063383    AAEX03004896    QUSF01000183    RLV88627.1    KL206247    KFV80594.1    KK736080    KFR17097.1    AMGL01002554    KB743069    EOB01614.1    ABQF01054680    AERX01019662    HAEJ01018871    SBS59328.1    HAEH01015903    HAEI01015454    SBS17923.1    HAED01022293    HAEE01013158    SBR33208.1    HADZ01007524    HAEA01014993    SBP71465.1    DS497725    EFA12967.1    AANG04003279   

Proteomes

UP000005204    UP000283053    UP000053268    UP000218220    UP000053240    UP000235965    + More
UP000027135    UP000192224    UP000242188    UP000018468    UP000189705    UP000008672    UP000001646    UP000005408    UP000000437    UP000018467    UP000008225    UP000261480    UP000028760    UP000053858    UP000008143    UP000001074    UP000007267    UP000261440    UP000053641    UP000245340    UP000233120    UP000233100    UP000001073    UP000233140    UP000029965    UP000240080    UP000028761    UP000233200    UP000233060    UP000233080    UP000001595    UP000002277    UP000006718    UP000005640    UP000001811    UP000007646    UP000008227    UP000051836    UP000233220    UP000054308    UP000192223    UP000000539    UP000009136    UP000001645    UP000286641    UP000189706    UP000000715    UP000053760    UP000002852    UP000248482    UP000001519    UP000081671    UP000005215    UP000002254    UP000276834    UP000053584    UP000261640    UP000053605    UP000002356    UP000007754    UP000005207    UP000007266    UP000011712   

PRIDE

H9J7Q2    P53611    Q5E9B3   

Pfam

PF00432   Prenyltrans        + More
PF00732   GMC_oxred_N
PF05199   GMC_oxred_C
PF02770   Acyl-CoA_dh_M
PF00441   Acyl-CoA_dh_1

Interpro

IPR001330   PFTB_repeat        + More
IPR026873   Ptb1       
IPR008930   Terpenoid_cyclase/PrenylTrfase       
IPR036188   FAD/NAD-bd_sf       
IPR000172   GMC_OxRdtase_N       
IPR007867   GMC_OxRtase_C       
IPR027424   Glucose_Oxidase_domain_2       
IPR006091   Acyl-CoA_Oxase/DH_cen-dom       
IPR009100   AcylCoA_DH/oxidase_NM_dom       
IPR009075   AcylCo_DH/oxidase_C       
IPR006089   Acyl-CoA_DH_CS       
IPR037069   AcylCoA_DH/ox_N_sf       
IPR036250   AcylCo_DH-like_C       

SUPFAM

SSF48239   SSF48239        + More
SSF51905   SSF51905       
SSF56645   SSF56645       
SSF47203   SSF47203       

Gene 3D

3.50.50.60     4.10.450.10     1.10.540.10    

CDD

cd02894  GGTase-II

ProteinModelPortal

H9J7Q2   A0A3S2LX13   S4NU03   A0A194QGL3   A0A2A4JPA2   A0A194QS82   + More
L7X1D3   A0A2H1VBC7   A0A2J7R3C0   A0A067QVU7   A0A1W4YF36   A0A1B6KNI4   A0A210QV44   A0A1B6GAS2   A0A1B6DJX0   W5M713   A0A1U7RPK9   J3SEF7   H3AJC0   H9GH71   T1E6G1   K1QIP5   Q4V946   A0A1W7RH66   A0A0S7HD41   W5KFT0   F7H322   A0A3B3WB06   A0A087X723   A0A098LYI2   A0A0A0AHE9   A0A2D4KJJ7   A9JTX7   G1NTI6   K7FVG3   A0A3B4C3Z4   A0A099ZA23   A0A2U3WP41   A0A2K6CHX8   A0A2K5WEG7   G1REP9   A0A2K5ZF01   A0A0D9S6Y8   A0A2R9AUI7   A0A096P020   A0A2K6RE21   A0A2K5MNF4   A0A2K5HJX6   H2N708   H2PZ92   F6TFB0   Q6IB63   P53611   F7CEP1   A0A1B6EFJ0   G1TB66   G3SRQ0   K9IZX7   A0A287BJ15   A0A287BFL8   A0A0Q3UTA5   A0A2K6U876   A0A091HMJ4   A0A2K5HJZ7   F7H489   A0A1W4XJS5   F1P4E5   A0A3B3WB59   Q5E9B3   G1NHW3   A0A3Q7P2J9   A0A3Q0D8E9   M3YHJ8   A0A091GGL3   A0A091QI78   A0A091RCC9   A0A3B5PT83   A0A250XYN8   A0A2Y9J3L3   F6TFA1   G8JKY6   A0A1L1RQG8   G3QPT1   A0A1S3GR13   I3N1M9   F1P6X0   A0A3L8RWH8   A0A093JPF3   A0A3Q3LNC0   A0A091WN32   W5PSV6   R0L7L0   H0ZJM1   I3KPS0   A0A1A8VJN5   A0A1A8SJ23   A0A1A8KLR5   A0A1A8BY93   D7EK21   A0A2I2UUA5  

PDB

3HXF     E-value=3.90592e-141,     Score=1284

KEGG

101735538    K05956 geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60] | (RefSeq) geranylgeranyl transf

GO

GO:0018344   GO:0004663   GO:0046872   GO:0005968   GO:0050660   GO:0016614   GO:0018342   GO:0008270   GO:0005886   GO:0006464   GO:0042981   GO:0007601   GO:0017137   GO:0043687   GO:0005829   GO:0003995   GO:0003824   GO:0046835   GO:0005737   GO:0008152   GO:0016301   GO:0016773   GO:0016155  

Length:

333

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.09339

Exp number, first 60 AAs:

0.02724

Total prob of N-in:

0.01807

outside

1  -  333

 

 

Pi

179.418974

Theta

156.265587

Tajima's D

0.884568

CLR

0.077341

CSRT

0.629468526573671

Interpretation

Uncertain