Gene

KWMTBOMO10085

Pre Gene Modal

BGIBMGA005670

Annotation

PREDICTED:_galactokinase-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr17(-):2070928-2090593      View in EpiBrowser

Full name

Galactokinase      

Alternative Name

Galactose kinase

Location in the cell

Cytoplasmic   Reliability : 2.213

CDS

ATGAATTGCGAAGCGATACCGAAAGGCGAGGGGGTGTTGTTGCGACAGGCCACTGACAGATTCATAGTCGCATACGGCAGACGACCGGAAGTCGCTGCAGCGGCGCCGGGACGCGTCAACCTCATCGGAGAACACGTTGACTATTGCGAAGGCTTCGTTCTACCAGTGGCAATACCGTTCCTTACCGTCGTCGTGGGATCGTACAACAACACAGATGTCTGTCGCGTGATCACAGTGTTGGCGTCCGGTGAGGAGTTGGAGGCCAGTTTCCCTGCTACCATCAAGGCAGAGTTACGACCAGGCCAACCGGAATGGGCTAATTATATCAAAGGAGTTATTGCTAATTTTCCTATAAAAGTGAACGGTTTCGATATTGTTGTCGTATCCGACGTGCCGATGGGTTCTGGTGTTTCCAGCAGCGCCGCCATTGAAGTGGCAGTATTCACGCTGCTAGAAGGACTCACGGGAAGGATGGTTAGTTTAGTGGAAAAAGCCAAGCTGTGTCAGAAGGCAGAGCACGACTTCCCTGGGATGCCGTGCGGCATCATGGATCAGTACATTGTTACTATGGGCAAAAAGGACCACGCATTACTTATTGACTGCAAGTCTTTGGAAGCAAAGCAGGTGCCGATTAAAATGGAGAATATATGTATACTAGTGATCAACTCCAACGTGAAGCATCGGTTGACGGGAAGCGAGTACCCTCAGAGGAGGGCTCAGTGTCAAGAAGCGGCCTGTCAACTGGGATTGACATCTTTGAGGGCGGCAAATATGCAGGATTTAGACAGTAAGTAA

Protein

MNCEAIPKGEGVLLRQATDRFIVAYGRRPEVAAAAPGRVNLIGEHVDYCEGFVLPVAIPFLTVVVGSYNNTDVCRVITVLASGEELEASFPATIKAELRPGQPEWANYIKGVIANFPIKVNGFDIVVVSDVPMGSGVSSSAAIEVAVFTLLEGLTGRMVSLVEKAKLCQKAEHDFPGMPCGIMDQYIVTMGKKDHALLIDCKSLEAKQVPIKMENICILVINSNVKHRLTGSEYPQRRAQCQEAACQLGLTSLRAANMQDLDSK

Catalytic Activity

alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)

Subunit

Homodimer.

Similarity

Belongs to the GHMP kinase family. GalK subfamily.

Keywords

3D-structure   Alternative splicing   ATP-binding   Carbohydrate metabolism   Cataract   Complete proteome   Direct protein sequencing   Disease mutation   Galactose metabolism   Kinase   Nucleotide-binding   Phosphoprotein   Polymorphism   Reference proteome   Transferase  

Feature

chain  Galactokinase
splice variant  In isoform 2.
sequence variant  In GALCT2; founder Romani mutation; dbSNP:rs104894572.

Uniprot

A0A2A4JN41   A0A194QS49   A0A194QC70   A0A212F634   A0A3S2NQJ0   L7X3T9   + More
A0A2H1WK86   C3XYY9   A0A210QGH3   A0A2T7PPI7   A0A3M6UW61   V4A9N7   A0A2C9JWW7   A0A1B6LEP5   A0A2B4SUG3   A0A3S3RYJ9   A0A2C9JWW3   A0A1D2NLM0   A0A1S3JZV3   A0A1B6IUY6   A0A1B6EPN4   K7FNQ1   A0A0N7ZAF3   A0A1J1ICY3   A0A2H8TKY3   A0A2L2Y4M5   K7JAZ0   A0A0B7BTK4   M7AVK1   A0A2J7RSL1   A0A369S5G7   B3RPU6   A0A2R5LFT5   Q71UH7   A0A069DTE4   A0A1V4KW43   A0A1L8E1T3   A0A1L8E211   A0A067RU16   V9KTD4   A0A1L8E1Q9   A0A1L8E1S8   A0A1W5AUB3   G1PSC3   A0A151WPH6   A0A0P4VXJ8   R4G3I8   A0A151JUX0   V9KSJ0   T1K5Q5   A0A1W5ANJ0   J9K0D5   A0A3B3TG07   A0A2D4LWP6   A0A158NFH1   F4WGT5   H3B0X3   A0A1U7RST3   A0A023F7V3   G3R272   A0A2G8KBI4   L9KZB3   A0A0P7ULY4   K7CVT8   V9HWE7   P51570   A0A232F4K3   A0A2R8ZVN8   A0A1W5AWA4   A0A1A6G300   A0A1U7QL83   A0A096NSY4   A0A2I2Z5K2   A0A2J8Y100   A0A2K6NWI5   A0A195DAT6   F7DF76   A0A2K6DBB2   A0A2K5UGN0   A0A2K6M6A9   F1R3T4   A0A226PNP2   K7DHK0   A0A2K5M7P1   A0A226N0U3   P51570-2   H2QDW0   A0A2R8ZR02   A0A182VP49   A0A195BCI9   A0A2U3VI60   A0A151N314   M3W4M6   A0A3Q7PIP6   A0A0Q3PAW1   Q5XJU9   F5HKF3   A0A2Y9HDU5   I2CVY3  

EC Number

2.7.1.6

Pubmed

26354079    22118469    23674305    18563158    28812685    30382153    + More
23254933    15562597    27289101    17381049    26561354    20075255    23624526    30042472    18719581    10570908    26334808    24845553    24402279    21993624    27129103    29240929    21347285    21719571    9215903    25474469    22398555    29023486    23385571    7670469    8908517    14702039    16625196    15489334    7542884    21269460    24275569    25944712    15590630    10521295    10790206    11231902    11139256    12694189    12942049    15024738    28648823    22722832    25362486    17431167    23594743    24621616    16136131    22293439    17975172    12364791    14747013    17210077    25319552   

EMBL

NWSH01000985    PCG73239.1    KQ461155    KPJ08348.1    KQ459232    KPJ02585.1    + More
AGBW02010097    OWR49169.1    RSAL01000145    RVE45937.1    KC469893    AGC92660.1    ODYU01009225    SOQ53493.1    GG666474    EEN66760.1    NEDP02003775    OWF47799.1    PZQS01000002    PVD35331.1    RCHS01000645    RMX57578.1    KB202518    ESO90001.1    GEBQ01017825    JAT22152.1    LSMT01000028    PFX32035.1    NCKU01005418    NCKU01004893    NCKU01003982    NCKU01003981    RWS04596.1    RWS05302.1    RWS06628.1    RWS06632.1    LJIJ01000010    ODN06164.1    GECU01016968    JAS90738.1    GECZ01029881    JAS39888.1    AGCU01174162    AGCU01174163    AGCU01174164    AGCU01174165    GDRN01099860    GDRN01099859    JAI58688.1    CVRI01000047    CRK97610.1    GFXV01002143    MBW13948.1    IAAA01004415    IAAA01004416    LAA03103.1    AAZX01004191    AAZX01015652    HACG01049664    CEK96529.1    KB608654    EMP23793.1    NEVH01000254    PNF43813.1    NOWV01000062    RDD42060.1    DS985242    EDV27702.1    GGLE01004071    MBY08197.1    AF084935    AAC35849.1    GBGD01001674    JAC87215.1    LSYS01001520    OPJ88588.1    GFDF01001416    JAV12668.1    GFDF01001415    JAV12669.1    KK852421    KDR24305.1    JW868936    AFP01454.1    GFDF01001414    JAV12670.1    GFDF01001413    JAV12671.1    AAPE02047513    KQ982877    KYQ49703.1    GDKW01002282    JAI54313.1    ACPB03022326    GAHY01001641    JAA75869.1    KQ981724    KYN37237.1    JW868836    AFP01354.1    CAEY01001590    ABLF02008254    ABLF02008255    IACM01049234    LAB25229.1    ADTU01014481    GL888147    EGI66554.1    AFYH01122898    GBBI01001387    JAC17325.1    CABD030036034    CABD030036035    MRZV01000717    PIK45366.1    KB320577    ELW68310.1    JARO02008297    KPP62899.1    GABC01008184    GABF01004202    GABD01004280    NBAG03000379    JAA03154.1    JAA17943.1    JAA28820.1    PNI32236.1    PNI32237.1    EU794610    ACJ13664.1    U26401    L76927    AK303832    AK314890    BT007005    AC087749    CH471099    BC001166    NNAY01001063    OXU25277.1    AJFE02042212    AJFE02042213    LZPO01107914    OBS60175.1    AHZZ02010709    AHZZ02010710    AHZZ02010711    ABGA01041253    NDHI03003284    PNJ87927.1    PNJ87929.1    KQ981063    KYN09962.1    JSUE03017446    AQIA01028664    AQIA01028665    FQ312018    AWGT02000039    OXB81120.1    GABE01010977    JAA33762.1    MCFN01000295    OXB61132.1    AACZ04070061    KQ976514    KYM82268.1    AKHW03004113    KYO31160.1    AANG04004184    LMAW01003207    KQK73396.1    BC083195    AAH83195.1    AAAB01008859    EAA07570.3    EGK96705.1    EGK96706.1    JV635778    AFJ71118.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000283053    UP000001554    + More
UP000242188    UP000245119    UP000275408    UP000030746    UP000076420    UP000225706    UP000285301    UP000094527    UP000085678    UP000007267    UP000183832    UP000002358    UP000031443    UP000235965    UP000253843    UP000009022    UP000190648    UP000027135    UP000192224    UP000001074    UP000075809    UP000015103    UP000078541    UP000015104    UP000007819    UP000261540    UP000005205    UP000007755    UP000008672    UP000189705    UP000001519    UP000230750    UP000011518    UP000034805    UP000005640    UP000215335    UP000240080    UP000092124    UP000189706    UP000028761    UP000001595    UP000233200    UP000078492    UP000006718    UP000233120    UP000233100    UP000233180    UP000000437    UP000198419    UP000233060    UP000198323    UP000002277    UP000075903    UP000078540    UP000245340    UP000050525    UP000011712    UP000286641    UP000051836    UP000007062    UP000248481   

PRIDE

Q71UH7    V9HWE7    P51570   

Pfam

PF08544   GHMP_kinases_C        + More
PF00288   GHMP_kinases_N
PF10509   GalKase_gal_bdg

Interpro

IPR019539   GalKase_gal-bd        + More
IPR000705   Galactokinase       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR013750   GHMP_kinase_C_dom       
IPR006206   Mevalonate/galactokinase       
IPR006203   GHMP_knse_ATP-bd_CS       
IPR036554   GHMP_kinase_C_sf       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR006204   GHMP_kinase_N_dom       
IPR019741   Galactokinase_CS       

SUPFAM

SSF54211   SSF54211        + More
SSF55060   SSF55060       

Gene 3D

3.30.230.10     3.30.70.890    

ProteinModelPortal

A0A2A4JN41   A0A194QS49   A0A194QC70   A0A212F634   A0A3S2NQJ0   L7X3T9   + More
A0A2H1WK86   C3XYY9   A0A210QGH3   A0A2T7PPI7   A0A3M6UW61   V4A9N7   A0A2C9JWW7   A0A1B6LEP5   A0A2B4SUG3   A0A3S3RYJ9   A0A2C9JWW3   A0A1D2NLM0   A0A1S3JZV3   A0A1B6IUY6   A0A1B6EPN4   K7FNQ1   A0A0N7ZAF3   A0A1J1ICY3   A0A2H8TKY3   A0A2L2Y4M5   K7JAZ0   A0A0B7BTK4   M7AVK1   A0A2J7RSL1   A0A369S5G7   B3RPU6   A0A2R5LFT5   Q71UH7   A0A069DTE4   A0A1V4KW43   A0A1L8E1T3   A0A1L8E211   A0A067RU16   V9KTD4   A0A1L8E1Q9   A0A1L8E1S8   A0A1W5AUB3   G1PSC3   A0A151WPH6   A0A0P4VXJ8   R4G3I8   A0A151JUX0   V9KSJ0   T1K5Q5   A0A1W5ANJ0   J9K0D5   A0A3B3TG07   A0A2D4LWP6   A0A158NFH1   F4WGT5   H3B0X3   A0A1U7RST3   A0A023F7V3   G3R272   A0A2G8KBI4   L9KZB3   A0A0P7ULY4   K7CVT8   V9HWE7   P51570   A0A232F4K3   A0A2R8ZVN8   A0A1W5AWA4   A0A1A6G300   A0A1U7QL83   A0A096NSY4   A0A2I2Z5K2   A0A2J8Y100   A0A2K6NWI5   A0A195DAT6   F7DF76   A0A2K6DBB2   A0A2K5UGN0   A0A2K6M6A9   F1R3T4   A0A226PNP2   K7DHK0   A0A2K5M7P1   A0A226N0U3   P51570-2   H2QDW0   A0A2R8ZR02   A0A182VP49   A0A195BCI9   A0A2U3VI60   A0A151N314   M3W4M6   A0A3Q7PIP6   A0A0Q3PAW1   Q5XJU9   F5HKF3   A0A2Y9HDU5   I2CVY3  

PDB

6QJE     E-value=7.08966e-61,     Score=591

KEGG

101735679    K00849 galactokinase [EC:2.7.1.6] | (RefSeq) galactokinase-like

PATHWAY

00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004335   GO:0005524   GO:0005534   GO:0005737   GO:0006012   GO:0005829   GO:0033499   GO:0061623   GO:0019402   GO:0019388   GO:0016020   GO:0070062   GO:0016301   GO:0046835   GO:0008152   GO:0016773   GO:0016155   GO:0003824  

PANTHER

PTHR10457:SF6  

Length:

264

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.19487

Exp number, first 60 AAs:

0.60048

Total prob of N-in:

0.05165

outside

1  -  264

 

 

Pi

145.874985

Theta

140.848112

Tajima's D

0.224721

CLR

0.146987

CSRT

0.43852807359632

Interpretation

Possibly Positive selection