Gene

KWMTBOMO10054

Pre Gene Modal

BGIBMGA005534

Annotation

glycosyltransferase_[Bombyx_mori]

Location

Bomo_Chr17(+):1146151-1150665      View in EpiBrowser

Full name

Hexosyltransferase       + More
Beta-1,3-galactosyltransferase brn      

Alternative Name

Brainiac protein
Neurogenic secreted-signaling protein brn

Location in the cell

Mitochondrial   Reliability : 1.163 Peroxisomal   Reliability : 1.26 PlasmaMembrane   Reliability : 1.005

CDS

ATGTTAGGGAAAGGTCCCAGAAAGCAGATTGTGAAATATCGCGAATCTCAGTGTACGTTAAAAAGACTGATAATGAGGAGAAACAGATATAAATTGATTGTATTCGCTTTGGTGCTTGTATATGTTTACCATTTTTTCGGTGTCGGCGATTACGTGCAGTCCAAGAACTTCGATAGCGATTTCAATTATCCTCTCAACGTAGACATTCGACCGATAGTCCAAGCAATACTAGACGGGCAAAAGCCGAATGTTAAACCTATAAATTACTACCCGTACAAGTTCTTGAGCAACTATCGTCAATGCAGTGTCGTCAACAAACCGGATTTAGTCATAATAGTCAAGTCGGCTATAGACCATTTCGGACACAGAGATGCAATTAGAAAGACTTATGGAAAACCACATGTCCAGGGCTACAACGTGAAGACATTCTTCTTTTTGGGCGTGGACAATGCCAGTTCAGATGTACAGAAGAATATTACGAAGGAAATGACAGAATTCAAAGATATCATACAGATGTCTTTCCGTGACAGTTATTTCAACAACACCATTAAAACGGTCATGTCCTTTCGCTGGATCTTTCAGCACTGCGCTGAAGCTCAACACTACTTATTCACCGACGACGACATGTACATATCGGTACAGAATTTACTAAAATACGTTAGCGACGTGACGACCGCGAGCGAAAGAGACGGAATACTGTTCGCCGGTTACGTCTTCAAGTCGGCGCCGCAACGGTTCCGGTCGAGCAAGTGGCGGGTGTCCTTGGAGGAGTATCCCTGGGACAAGTGGCCGCCTTACGTGACGGCCGGGGCGTACGTGGTGTCAAACAAAGCGATGAAGATGCTCTACGTCGGAAGCTTGTTCGTGAAGCATTTCAGATTCGATGACATTTACCTCGGCATAGTCGCGAAGAAGATGGGCATAGTGCCGACTCATTGTCCGCATTTCCACTTCTACAAGAAGCCGTACGAGCGAGAGGTTTATAGCGATGTGATCGCCTCGCACGGATATTCTAATCACGACGAATTGATTAGAGTGTGGAATGAACAAAACGCGTTGTGA

Protein

MLGKGPRKQIVKYRESQCTLKRLIMRRNRYKLIVFALVLVYVYHFFGVGDYVQSKNFDSDFNYPLNVDIRPIVQAILDGQKPNVKPINYYPYKFLSNYRQCSVVNKPDLVIIVKSAIDHFGHRDAIRKTYGKPHVQGYNVKTFFFLGVDNASSDVQKNITKEMTEFKDIIQMSFRDSYFNNTIKTVMSFRWIFQHCAEAQHYLFTDDDMYISVQNLLKYVSDVTTASERDGILFAGYVFKSAPQRFRSSKWRVSLEEYPWDKWPPYVTAGAYVVSNKAMKMLYVGSLFVKHFRFDDIYLGIVAKKMGIVPTHCPHFHFYKKPYEREVYSDVIASHGYSNHDELIRVWNEQNAL

Description

Neurogenic protein essential for the development and maintenance of epithelial structure. Required in the germline for establishing the follicular epithelium and for determining the dorsal-ventral polarity. Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Brn has a role in chorion formation.

Catalytic Activity

ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GM1 (d18:1(4E)) + H(+) + UDP

Similarity

Belongs to the glycosyltransferase 31 family.

Keywords

Complete proteome   Developmental protein   Glycoprotein   Glycosyltransferase   Golgi apparatus   Membrane   Notch signaling pathway   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Hexosyltransferase

Uniprot

G1UHW6   Q1HPJ8   E2D889   A0A0N1PFP1   A0A0L7L8F0   A0A1E1W1F1   + More
A0A194QAV8   A0A3S2M287   A0A212ETI5   Q5PXZ8   Q5PXZ7   D9ID41   D3JVR0   A0A2A4K9J6   A0A067QRS1   E9HV89   A0A154NZW8   E2BMU3   Q0IGE3   A0A0M8ZNQ2   A0A0L7QP54   A0A182HDD3   A0A2J7NKF6   A0A1S3D460   A0A1W4WGH9   A0A2P6KTZ4   Q7PYT4   A0A1B6K4H3   T1J2D0   A0A0N8D5E9   D6WJI2   B0XHE0   U5EYY4   A0A336LJU9   A0A0P5IBD9   A0A0P4WS61   A0A087TF44   A0A0P5QUX1   A0A0P5GTA3   A0A0P6IB83   A0A0P6DJB8   A0A1A9V177   E0VL04   A0A1Y1KV10   T1IBA4   T1JDR6   A0A182TSF4   A0A182HZW9   A0A182XGF7   A0A182LQZ7   A0A1A9X8X4   A0A1B0C6L7   J3JXL9   A0A2S2PJD7   A0A1I8PEV1   A0A1S4EVP1   J9JYX0   A0A1B0A854   A0A2R5LI61   A0A1E1XBY3   A0A2H8TEK6   A0A224YYJ4   A0A1I8ND63   A0A0P5PFP8   A0A1A9X293   A0A0P6BE03   L7LWW4   A0A131Z7J2   A0A1B0G146   A0A069DSB9   A0A0P4VUJ4   A0A023F211   G3MFC8   A0A0L0CJS7   A0A0T6B9A5   A0A224XR61   B4NPB3   A0A3B0JCB1   A0A1B6DFS7   A0A0K8TKI0   T1PA14   A0A131XUF2   B7PMS1   Q24157   N6TU70   A0A2M4BV23   B4R495   Q29I44   B4HA93   B4I125   B3MSL7   B4Q0F5   B4JNG9   A0A0P6DTJ0   B4L6M7   A0A1Z5L3C4   A0A2S2QMV1   B3NSU3   A0A1W4V3A8  

EC Number

2.4.1.-
2.4.1.62

Pubmed

22635270    19121390    26354079    26227816    22118469    17368198    + More
24845553    21292972    20798317    17510324    26483478    12364791    14747013    17210077    18362917    19820115    20566863    28004739    20966253    22516182    28503490    28797301    25315136    25576852    26830274    26334808    27129103    25474469    22216098    26108605    17994087    26369729    9012507    10731132    12537572    10731137    12537569    23537049    15632085    17550304    28528879   

EMBL

AB620073    BAK82125.1    BABH01020389    DQ443404    ABF51493.1    GQ904195    + More
ADK56127.1    KQ461156    KPJ08104.1    JTDY01002250    KOB71798.1    GDQN01010292    JAT80762.1    KQ459232    KPJ02564.1    RSAL01000062    RVE49555.1    AGBW02012580    OWR44789.1    AY821557    AAV74410.1    AY821558    AAV74411.1    HM135159    ADJ10636.1    GU321345    ADB79798.1    NWSH01000033    PCG80463.1    KK853038    KDR12199.1    GL732844    EFX64346.1    KQ434786    KZC05132.1    GL449347    EFN82978.1    CH477192    EAT48595.1    KQ435955    KOX68020.1    KQ414843    KOC60281.1    JXUM01001648    JXUM01001649    KQ560125    KXJ84347.1    NEVH01053892    PNE09454.1    MWRG01005281    PRD29796.1    AAAB01008987    EAA01002.5    GECU01001361    JAT06346.1    JH431799    GDIP01067055    JAM36660.1    KQ971342    EFA03672.1    DS233146    EDS28353.1    GANO01000028    JAB59843.1    UFQT01000030    SSX18216.1    GDIQ01215816    JAK35909.1    GDRN01066410    JAI64534.1    KK114937    KFM63733.1    GDIQ01109341    JAL42385.1    GDIQ01235950    JAK15775.1    GDIQ01014065    JAN80672.1    GDIQ01076651    JAN18086.1    DS235263    EEB14060.1    GEZM01077605    GEZM01077604    JAV63246.1    ACPB03006705    JH432108    APCN01002017    JXJN01026769    BT127988    AEE62950.1    GGMR01016953    MBY29572.1    ABLF02036596    GGLE01005094    MBY09220.1    GFAC01002592    JAT96596.1    GFXV01000709    MBW12514.1    GFPF01007898    MAA19044.1    GDIQ01150581    JAL01145.1    GDIP01016499    JAM87216.1    GACK01008734    JAA56300.1    GEDV01001755    JAP86802.1    CCAG010009992    GBGD01001931    JAC86958.1    GDKW01000232    JAI56363.1    GBBI01003324    JAC15388.1    JO840579    AEO32196.1    JRES01000305    KNC32500.1    LJIG01009076    KRT83803.1    GFTR01005384    JAW11042.1    CH964291    EDW86353.1    OUUW01000003    SPP78203.1    GEDC01020229    GEDC01019791    GEDC01012833    JAS17069.1    JAS17507.1    JAS24465.1    GDAI01002741    JAI14862.1    KA644788    AFP59417.1    GEFM01005509    JAP70287.1    ABJB010688608    DS749069    EEC07893.1    U41449    AE014298    AL033125    BT021250    AY070536    AAL48007.1    APGK01054226    KB741248    KB632305    ENN71941.1    ERL91861.1    GGFJ01007660    MBW56801.1    CM000366    EDX17037.1    CH379064    EAL31562.1    CH479239    EDW37487.1    CH480819    EDW53206.1    CH902622    EDV34772.1    CM000162    EDX01239.1    CH916371    EDV92262.1    GDIQ01073952    JAN20785.1    CH933812    EDW06023.1    GFJQ02005078    JAW01892.1    GGMS01009818    MBY79021.1    CH954180    EDV45773.2   

Proteomes

UP000005204    UP000053240    UP000037510    UP000053268    UP000283053    UP000007151    + More
UP000218220    UP000027135    UP000000305    UP000076502    UP000008237    UP000008820    UP000053105    UP000053825    UP000069940    UP000249989    UP000235965    UP000079169    UP000192223    UP000007062    UP000007266    UP000002320    UP000054359    UP000078200    UP000009046    UP000015103    UP000075902    UP000075840    UP000076407    UP000075882    UP000092443    UP000092460    UP000095300    UP000007819    UP000092445    UP000095301    UP000091820    UP000092444    UP000037069    UP000007798    UP000268350    UP000001555    UP000000803    UP000019118    UP000030742    UP000000304    UP000001819    UP000008744    UP000001292    UP000007801    UP000002282    UP000001070    UP000009192    UP000008711    UP000192221   

PRIDE

G1UHW6    Q1HPJ8    Q24157   

Pfam

PF01762   Galactosyl_T        + More
PF14974   P_C10

Interpro

IPR002659   Glyco_trans_31        + More
IPR026317   P_C10       
IPR029044   Nucleotide-diphossugar_trans       

SUPFAM

SSF53448   SSF53448       

Gene 3D

3.90.550.10    

ProteinModelPortal

G1UHW6   Q1HPJ8   E2D889   A0A0N1PFP1   A0A0L7L8F0   A0A1E1W1F1   + More
A0A194QAV8   A0A3S2M287   A0A212ETI5   Q5PXZ8   Q5PXZ7   D9ID41   D3JVR0   A0A2A4K9J6   A0A067QRS1   E9HV89   A0A154NZW8   E2BMU3   Q0IGE3   A0A0M8ZNQ2   A0A0L7QP54   A0A182HDD3   A0A2J7NKF6   A0A1S3D460   A0A1W4WGH9   A0A2P6KTZ4   Q7PYT4   A0A1B6K4H3   T1J2D0   A0A0N8D5E9   D6WJI2   B0XHE0   U5EYY4   A0A336LJU9   A0A0P5IBD9   A0A0P4WS61   A0A087TF44   A0A0P5QUX1   A0A0P5GTA3   A0A0P6IB83   A0A0P6DJB8   A0A1A9V177   E0VL04   A0A1Y1KV10   T1IBA4   T1JDR6   A0A182TSF4   A0A182HZW9   A0A182XGF7   A0A182LQZ7   A0A1A9X8X4   A0A1B0C6L7   J3JXL9   A0A2S2PJD7   A0A1I8PEV1   A0A1S4EVP1   J9JYX0   A0A1B0A854   A0A2R5LI61   A0A1E1XBY3   A0A2H8TEK6   A0A224YYJ4   A0A1I8ND63   A0A0P5PFP8   A0A1A9X293   A0A0P6BE03   L7LWW4   A0A131Z7J2   A0A1B0G146   A0A069DSB9   A0A0P4VUJ4   A0A023F211   G3MFC8   A0A0L0CJS7   A0A0T6B9A5   A0A224XR61   B4NPB3   A0A3B0JCB1   A0A1B6DFS7   A0A0K8TKI0   T1PA14   A0A131XUF2   B7PMS1   Q24157   N6TU70   A0A2M4BV23   B4R495   Q29I44   B4HA93   B4I125   B3MSL7   B4Q0F5   B4JNG9   A0A0P6DTJ0   B4L6M7   A0A1Z5L3C4   A0A2S2QMV1   B3NSU3   A0A1W4V3A8  

KEGG

733133    K02175 putative enzyme (brainiac) | (RefSeq) Bm_Bre5; beta-1,3-galactosyltransferase

PATHWAY

04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)

GO

GO:0008378   GO:0016021   GO:0000139   GO:0006486   GO:0016757   GO:0008532   GO:0005794   GO:0030311   GO:0005783   GO:0008376   GO:0001744   GO:0007293   GO:0007299   GO:0006688   GO:0042248   GO:0046981   GO:0007298   GO:0007275   GO:0047915   GO:0005576   GO:0048477   GO:0005795   GO:0007219   GO:0030707   GO:0008375   GO:0016333   GO:0016020   GO:0006412   GO:0043547   GO:0005634   GO:0004672   GO:0030677   GO:0016155   GO:0003824  

PANTHER

PTHR11214  

Subcellular location

Golgi apparatus membrane  

Length:

353

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.0762699999999

Exp number, first 60 AAs:

20.94732

Total prob of N-in:

0.99849

POSSIBLE N-term signal

sequence

inside

1  -  31

TMhelix

32  -  54

outside

55  -  353

 

 

Pi

195.534649

Theta

224.517079

Tajima's D

-0.600713

CLR

22.408487

CSRT

0.221338933053347

Interpretation

Uncertain