Gene

KWMTBOMO10042

Pre Gene Modal

BGIBMGA005529

Annotation

PREDICTED:_N-sulphoglucosamine_sulphohydrolase_[Plutella_xylostella]

Location

Bomo_Chr17(+):798280-807094      View in EpiBrowser

Full name

N-sulphoglucosamine sulphohydrolase      

Alternative Name

Sulfoglucosamine sulfamidase
Sulphamidase

Location in the cell

Extracellular   Reliability : 0.917

CDS

ATGCGAGTTACCGGCATCAAACTTGCCCTTATCTTTTATTTTTTCATTACTGAAACTGTATTATCTGATAAGGTCCGCAATGTTCTTTTACTATTAGCGGACGATGGCGGTTTTGAGATAGGCGCGTATCGCAACAAAATATGTCAAACGCCGAATATAGATGAATTAGCGCGAAACGGCCTGTTGTTCAACAATGCATTCACATCAGTGAGCAGTTGCTCCCCAAGTCGGGCAGCACTCCTAACTGGGTCGCCGAGTCACCAGAATGGAATGTACGGGCTGCACCACGGCGTCCACCACTTCAACTCCTTCGACAACGTGACCAGTCTGCCGAACTTACTGCGCCAGAACGGAATTATGACGGGTATAATTGGTAAAAAGCACGTCGGGCCTTCGAGCGTGTATCAGTTTGATTATGAGCAGACGGAGGAGAACAACCACATTAATCAGGTCGGTCGCAACATCACCCACATGAAGCTGCTCGCCCGGGAGTTCATCGCGAGTGCAAACAAGGAAAACAAGCCCTTCTTCTTGTACGTGGCCTTCCATGACCCGCACCGCTGCGGACACAGCGACCCGCAGTACGGGCCCTTCTGCGAGAGGTTCGGCTCCGGCGAAGAAGGAATGGGCACCATTCCAGACTGGCAGCCGTGGTACTATCAGTGGGACGAGATTCAACTACCTTACTTCATACAGGACACTGAGGCGGCCAGGAGGGACATTGCCGCCCAGTACACAACGATGTCGCGACTCGACCAAGGGGTCGCCCTTATTCTGAAAGAACTGGAAAGCGCAGGGCACGCTGACGATACGTTAGTCATCTACACTTCAGACAACGGCATACCATTTCCATCGGGGAGAACTAATTTTTACGATCCGGGATTACGGGAGCCCCTCATCATTCGCTCACCTTCATCTTCAGCCAGAAAAAATGAGGCTTCAGGCGCCATGGTCAGCTTACTGGACATAATGCCAACCGTGCTAGACTGGTTTGGAATTGAGAAAGAAATGACAAATGACATTTGGGATGGAGATACACCAAAGAGTCTCTTACCTATACTGGAGAAAGAGCCGCCGCCCTCGGACTCGGACGCGGTGTTCGCCTCCCAGACGCACCACGAGATCACGATGTACTACCCGATGCGCGCCGTGCGCACGCGCCGCTACAAGCTGCTGCACAACCTCAACTACGGGATGCCGTTCCCGATCGACCAAGATCTATACGTCTCGCCCACATTTCAGGACCTATTAAACAGAACGCGCAGCAAGCAGCCTCTACCTTGGTACAAGACGCTGAAGCAATATTACTACCGGCCGCAGTGGGAGCTCTACGACCTTCGTAAGGATCCGGCAGAAACCAATAACTTACATGGTAAACCATCCCTGGAGGAGGTGGAGTCGAATCTCCGAGAACGATTGTCGCGATGGCAGCGCTCCACCCGCGACCCGTGGCTGTGTTCGCCCGACGCCGTCATGGAACGCGACTCTGACAACGCCGTGTGCCGCAGTCTAGACAACGGACTCCTAAACTATCATACACTATAG

Protein

MRVTGIKLALIFYFFITETVLSDKVRNVLLLLADDGGFEIGAYRNKICQTPNIDELARNGLLFNNAFTSVSSCSPSRAALLTGSPSHQNGMYGLHHGVHHFNSFDNVTSLPNLLRQNGIMTGIIGKKHVGPSSVYQFDYEQTEENNHINQVGRNITHMKLLAREFIASANKENKPFFLYVAFHDPHRCGHSDPQYGPFCERFGSGEEGMGTIPDWQPWYYQWDEIQLPYFIQDTEAARRDIAAQYTTMSRLDQGVALILKELESAGHADDTLVIYTSDNGIPFPSGRTNFYDPGLREPLIIRSPSSSARKNEASGAMVSLLDIMPTVLDWFGIEKEMTNDIWDGDTPKSLLPILEKEPPPSDSDAVFASQTHHEITMYYPMRAVRTRRYKLLHNLNYGMPFPIDQDLYVSPTFQDLLNRTRSKQPLPWYKTLKQYYYRPQWELYDLRKDPAETNNLHGKPSLEEVESNLRERLSRWQRSTRDPWLCSPDAVMERDSDNAVCRSLDNGLLNYHTL

Description

Catalyzes a step in lysosomal heparan sulfate degradation.

Catalytic Activity

H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate

Cofactor

Ca(2+)

Similarity

Belongs to the sulfatase family.

Keywords

3D-structure   Calcium   Complete proteome   Direct protein sequencing   Disease mutation   Disulfide bond   Glycoprotein   Hydrolase   Lysosome   Metal-binding   Mucopolysaccharidosis   Polymorphism   Reference proteome   Signal  

Feature

chain  N-sulphoglucosamine sulphohydrolase
sequence variant  In MPS3A; dbSNP:rs139850991.

Uniprot

A0A3S2NJ57   H9J7N7   A0A0N1PJL8   A0A2A4JJH2   A0A212FF84   A0A2W1BLH5   + More
A0A232FA88   K7J4V3   A0A336LBG8   A0A026WG24   A0A3L8DFF8   D6WXJ3   A0A0L7R4P9   A0A336KLZ7   A0A154P5W2   E2A6X9   A0A151X7X6   A0A088A242   A0A0M8ZZG7   A0A1B0D306   A0A1Y1LQD7   A0A067R9H1   A0A2J7RAV0   E2BZ75   F4W713   A0A151K0T4   A0A195C3R2   A0A182NSP7   A0A158NMB5   N6U038   A0A182XG83   A0A182W1E0   W5JQ78   A0A182PLV8   A0A1J1J0M6   A0A1S4FQA7   A0A182L776   A0A182IKU3   Q7PH12   A0A182GEZ8   A0A182IDC8   A0A2A3E146   A0A182KHP6   A0A182Q2U5   A0A084VNQ6   A0A0N8ES60   A0A1Q3FX62   A0A182U4Y7   A0A195DB10   A0A0J7K6A0   B4JGE7   A0A182RZJ1   A0A0K8W479   A0A034WT68   W8C7R9   Q16T02   A0A182G033   T1PDX4   A0A182Y5G7   A0A0A1WE65   A0A0L0CJH2   B3MSR6   A0A182SY23   A0A3B0KG69   Q298E8   A0A1B6EZN8   A0A182VGY4   B4G3P1   A0A182MJV8   F1NGI6   A0A293MCB0   B4K587   A0A226N1E7   A0A1S3HRU1   A0A1S3ILX1   A0A2K6FXZ7   B4PM30   A0A340XTI2   A0A3L8S0V7   A0A2K5HNE5   F6RC31   A0A1I8P9M3   A0A2R8ZKN1   A0A096NTB4   A0A218UL41   G3RBT8   A0A2Y9FM96   A0A2B4SGR8   Q8I1A5   P51688   A0A093GEM9   A0A2K5S515   A0A2K6SR45   A0A2K5C3H8   A0A1U7SZX2   H0V4W6   A0A2K6B4C9   F7DFZ7   A0A341CR07   U6CZ92  

EC Number

3.10.1.1

Pubmed

19121390    26354079    22118469    28756777    28648823    20075255    + More
24508170    30249741    18362917    19820115    20798317    28004739    24845553    21719571    21347285    23537049    20920257    23761445    20966253    12364791    14747013    17210077    26483478    24438588    26999592    17994087    25348373    24495485    17510324    25315136    25244985    25830018    26108605    15632085    15592404    17550304    30282656    19892987    22722832    22398555    18057021    7493035    14702039    15489334    12754519    19159218    24275569    24816101    9158154    9285796    9401012    9554748    9744479    11182930    12000360    11793481    12702166    15146460    15637719    15902564    17128482    16311287    18407553    21671382    28101780    21993624    17495919   

EMBL

RSAL01000075    RVE48897.1    BABH01020426    KQ460044    KPJ18297.1    NWSH01001312    + More
PCG71744.1    AGBW02008849    OWR52392.1    KZ150179    PZC72533.1    NNAY01000614    OXU27390.1    AAZX01007073    UFQS01001502    UFQT01001502    SSX11284.1    SSX30852.1    KK107231    EZA55070.1    QOIP01000009    RLU18932.1    KQ971361    EFA08854.1    KQ414657    KOC65833.1    UFQS01000253    UFQT01000253    SSX02060.1    SSX22437.1    KQ434823    KZC07309.1    GL437203    EFN70845.1    KQ982431    KYQ56472.1    KQ435812    KOX72773.1    AJVK01010815    GEZM01051103    JAV75171.1    KK852804    KDR16259.1    NEVH01006564    PNF37952.1    GL451577    EFN78981.1    GL887802    EGI70003.1    KQ981253    KYN44176.1    KQ978344    KYM94821.1    ADTU01002232    ADTU01002233    APGK01047787    KB741089    ENN73961.1    ADMH02000787    ETN65055.1    CVRI01000064    CRL04974.1    AAAB01008880    EAA44728.2    JXUM01058904    KQ562024    KXJ76879.1    APCN01005106    KZ288467    PBC25417.1    AXCN02000231    ATLV01014835    KE524991    KFB39600.1    GDUN01000370    JAN95549.1    GFDL01002878    JAV32167.1    KQ981042    KYN10073.1    LBMM01012961    KMQ85897.1    CH916369    EDV92616.1    GDHF01006634    JAI45680.1    GAKP01001567    JAC57385.1    GAMC01000367    JAC06189.1    CH477662    EAT37588.1    KA646138    AFP60767.1    GBXI01017311    JAC96980.1    JRES01000310    KNC32385.1    CH902623    EDV30306.1    OUUW01000007    SPP82638.1    CM000070    EAL28007.2    GECZ01026391    JAS43378.1    CH479179    EDW24362.1    AXCM01006741    AADN05000628    GFWV01013723    MAA38452.1    CH933806    EDW15087.1    MCFN01000295    OXB61069.1    CM000160    EDW95962.1    QUSF01000104    RLV92050.1    AJFE02110123    AJFE02110124    AHZZ02010799    MUZQ01000239    OWK54489.1    CABD030035768    CABD030035769    LSMT01000096    PFX27757.1    AY190951    CH964251    AAO01067.1    EDW83222.2    U30894    U60111    U60107    U60108    U60109    U60110    AK291257    BC047318    KL215558    KFV65337.1    AAKN02047339    HAAF01004165    CCP75990.1   

Proteomes

UP000283053    UP000005204    UP000053240    UP000218220    UP000007151    UP000215335    + More
UP000002358    UP000053097    UP000279307    UP000007266    UP000053825    UP000076502    UP000000311    UP000075809    UP000005203    UP000053105    UP000092462    UP000027135    UP000235965    UP000008237    UP000007755    UP000078541    UP000078542    UP000075884    UP000005205    UP000019118    UP000076407    UP000075920    UP000000673    UP000075885    UP000183832    UP000075882    UP000075880    UP000007062    UP000069940    UP000249989    UP000075840    UP000242457    UP000075881    UP000075886    UP000030765    UP000075902    UP000078492    UP000036403    UP000001070    UP000075900    UP000008820    UP000069272    UP000095301    UP000076408    UP000037069    UP000007801    UP000075901    UP000268350    UP000001819    UP000075903    UP000008744    UP000075883    UP000000539    UP000009192    UP000198323    UP000085678    UP000233160    UP000002282    UP000265300    UP000276834    UP000233080    UP000002281    UP000095300    UP000240080    UP000028761    UP000197619    UP000001519    UP000248484    UP000225706    UP000007798    UP000005640    UP000053875    UP000233040    UP000233220    UP000233020    UP000189704    UP000005447    UP000233120    UP000002280    UP000252040   

PRIDE

H9J7N7    P51688   

Pfam

PF00884   Sulfatase        + More
PF16347   DUF4976
PF10265   Miga
PF00640   PID
PF00017   SH2

Interpro

IPR017850   Alkaline_phosphatase_core_sf        + More
IPR032506   DUF4976       
IPR000917   Sulfatase_N       
IPR024607   Sulfatase_CS       
IPR006020   PTB/PI_dom       
IPR011993   PH-like_dom_sf       
IPR036860   SH2_dom_sf       
IPR006019   PID_Shc-like       
IPR000980   SH2       
IPR019392   Miga       

SUPFAM

SSF53649   SSF53649        + More
SSF55550   SSF55550       

Gene 3D

3.40.720.10     2.30.29.30     3.30.505.10    

CDD

cd01209  PTB_Shc

ProteinModelPortal

A0A3S2NJ57   H9J7N7   A0A0N1PJL8   A0A2A4JJH2   A0A212FF84   A0A2W1BLH5   + More
A0A232FA88   K7J4V3   A0A336LBG8   A0A026WG24   A0A3L8DFF8   D6WXJ3   A0A0L7R4P9   A0A336KLZ7   A0A154P5W2   E2A6X9   A0A151X7X6   A0A088A242   A0A0M8ZZG7   A0A1B0D306   A0A1Y1LQD7   A0A067R9H1   A0A2J7RAV0   E2BZ75   F4W713   A0A151K0T4   A0A195C3R2   A0A182NSP7   A0A158NMB5   N6U038   A0A182XG83   A0A182W1E0   W5JQ78   A0A182PLV8   A0A1J1J0M6   A0A1S4FQA7   A0A182L776   A0A182IKU3   Q7PH12   A0A182GEZ8   A0A182IDC8   A0A2A3E146   A0A182KHP6   A0A182Q2U5   A0A084VNQ6   A0A0N8ES60   A0A1Q3FX62   A0A182U4Y7   A0A195DB10   A0A0J7K6A0   B4JGE7   A0A182RZJ1   A0A0K8W479   A0A034WT68   W8C7R9   Q16T02   A0A182G033   T1PDX4   A0A182Y5G7   A0A0A1WE65   A0A0L0CJH2   B3MSR6   A0A182SY23   A0A3B0KG69   Q298E8   A0A1B6EZN8   A0A182VGY4   B4G3P1   A0A182MJV8   F1NGI6   A0A293MCB0   B4K587   A0A226N1E7   A0A1S3HRU1   A0A1S3ILX1   A0A2K6FXZ7   B4PM30   A0A340XTI2   A0A3L8S0V7   A0A2K5HNE5   F6RC31   A0A1I8P9M3   A0A2R8ZKN1   A0A096NTB4   A0A218UL41   G3RBT8   A0A2Y9FM96   A0A2B4SGR8   Q8I1A5   P51688   A0A093GEM9   A0A2K5S515   A0A2K6SR45   A0A2K5C3H8   A0A1U7SZX2   H0V4W6   A0A2K6B4C9   F7DFZ7   A0A341CR07   U6CZ92  

PDB

4MIV     E-value=2.20617e-165,     Score=1495

KEGG

101737423    K01565 N-sulfoglucosamine sulfohydrolase [EC:3.10.1.1] | (RefSeq) N-sulphoglucosamine sulphohydrolas

PATHWAY

00531    Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0008484   GO:0006027   GO:0030200   GO:0016250   GO:0016021   GO:0008053   GO:0035556   GO:0005764   GO:0046872   GO:0043202   GO:0070062   GO:0003824   GO:0008152   GO:0008270   GO:0005488   GO:0005634   GO:0004672   GO:0030677   GO:0016155  

Subcellular location

Lysosome  

SignalP

Position:   1 - 22,         Likelihood:  0.930554

 

 

Length:

514

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.83414

Exp number, first 60 AAs:

1.83087

Total prob of N-in:

0.10134

outside

1  -  514

 

 

Pi

199.054881

Theta

147.20731

Tajima's D

0.137092

CLR

0.289695

CSRT

0.410029498525074

Interpretation

Uncertain