Gene

KWMTBOMO10023  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005701

Annotation

PREDICTED:_protein_singed_[Plutella_xylostella]

Location

Bomo_Chr17(-):533189-588099      View in EpiBrowser

Full name

Fascin       + More
Protein singed      

Location in the cell

Cytoplasmic   Reliability : 1.441 Extracellular   Reliability : 1.058

CDS

ATGAACGGACACAGCAATGGCGACATCAACAGCGCTGGAGACATCCTCACCCAGAACCAGCAGAAAGGATGGTGGACCATCGGCCTGATAAACTCTCGGTACCGCTACCTCACCGCCGAGACCTTCGGCTTCAAGATCAACGCTAACGGCACCAGTCTAAAGAAGAAACAGATTTGGACCCTCGAGCCTGCTTCCGGGAATGCCAATGATAGCATGATCTACTTGAGGTCACACTTGGACAAGTACCTAGCAGTCGACAGCTTCGGTAACGTGACTTGCGAATCAGAGGAAAAGGAACCCGGCAGCAAGTTCCACATCAGTGTCTCCGACGACAACAGCGGCCGCTGGGCGCTGCGTAACGTCGAGCGTGGCTATTTCCTGGGCTCCAGCTCGGACAAACTGACCTGCACCGCCAAGGTCCCCGGAGACGCCGAACTTTGGCACGTCCATCTAGCCGCCAGACCTCAGATGAACCTCCGCTCGATCGGCCGCAAGCGTTTCGCTCACCTCTCGGAGTCGCTCGACGAGATCCACGTGGACGCTAACGTGCCGTGGGGCGAGGACACGCTGTTCACGCTGGAGTTCCGCGCTGACGAGGGCGGCAAGTACGCGCTCCACACCTGCAACAACAAGTACTTGAACGCAGGAGGGAAGCTCCAAGACACGTGCACCAGCGAGTGCCTGTTCAGCGCGGAGTACCACGCGGGCGCGCTGGCGCTGCGGGACGGCTCGGGCGCCTACCTCGCGCCCATCGGCTCCAAGGCGGTCCTCAAGACGCGCTCCACCGCCGTCACCAGGGACGAACTCTTCTCATTGGAAGACAGCCTCCCGCAAGCTGCCTTCGTGGCGGCTCTCAACGACAAATATGTTTCTGTAAAACAAGGAGTGGACGTCACAGCGAACCAAGATGAGATATCGTCTCATGAGACCTTCCAATTGGAGTTTGACTGGGCCACGAAGCGCTGGTACATCCGCACCATGCAGGACCGGTACTGGACCCTGGAGACTGGCGGCGGTATCCAAGCCAGCGGAGACAACAAGTCTTCTAACGCTCTGTTCGAGCTGGACTGGCAGGGAGACGGCTCCGTGGCCTTCCGCGCCAACAACGGCAAGTACTTGCTGACCAAGCGCTCCGGCCACCTCTACGCCAACGCGGACTCCATCGACGACAACTGCAAATACTACTTCTATCTCATCAACAGGCCGATCTTAGTGCTGAAGTGCGAACAAGGGTTCGTGGGCCCCAAGGGCGTGAAGCTGGAGTGCAACAAGGCCAACTACGAGACCATCCAGGTGGTGCGCGGGCCCAAGGGAGCCGTCTACTTCAAGGGTCAGAGCGGCAAGTACTGGCACGCGGACGGCGAGGCGGTGACGTGCGACTCGGACGCGGCGCAGGGCTTCCTGCTGGAGCTGCGCGAGCCCACGCGCCTCGCCATCCGCGCCGCCGCCGACCGACGCTACCTCGCCGCCGCCAAGAACGGGAACTTCCGCCTCGCTGATGCAGACCTCGCCTCCGCCACGCACTGGGAGTACTAG

Protein

MNGHSNGDINSAGDILTQNQQKGWWTIGLINSRYRYLTAETFGFKINANGTSLKKKQIWTLEPASGNANDSMIYLRSHLDKYLAVDSFGNVTCESEEKEPGSKFHISVSDDNSGRWALRNVERGYFLGSSSDKLTCTAKVPGDAELWHVHLAARPQMNLRSIGRKRFAHLSESLDEIHVDANVPWGEDTLFTLEFRADEGGKYALHTCNNKYLNAGGKLQDTCTSECLFSAEYHAGALALRDGSGAYLAPIGSKAVLKTRSTAVTRDELFSLEDSLPQAAFVAALNDKYVSVKQGVDVTANQDEISSHETFQLEFDWATKRWYIRTMQDRYWTLETGGGIQASGDNKSSNALFELDWQGDGSVAFRANNGKYLLTKRSGHLYANADSIDDNCKYYFYLINRPILVLKCEQGFVGPKGVKLECNKANYETIQVVRGPKGAVYFKGQSGKYWHADGEAVTCDSDAAQGFLLELREPTRLAIRAAADRRYLAAAKNGNFRLADADLASATHWEY

Description

Acts as an actin bundling protein (PubMed:1723709, PubMed:19729655). May have a role in the asymmetric organization and/or movement of cytoplasmic components (PubMed:1723709). It has a role in somatic cells during the formation of adult bristles and hairs, and in the female germline during oogenesis (PubMed:1723709, PubMed:19729655).

Subunit

Interacts with Rab35, with stronger binding to the Rab35-GTP form compared to the Rab35-GDP form.

Similarity

Belongs to the fascin family.

Keywords

Actin-binding   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Differentiation   Oogenesis   Reference proteome  

Feature

chain  Protein singed

Uniprot

H9J859   A0A2A4JT67   S4PG76   A0A1E1WFW1   A0A2W1BEA6   A0A212FF60   + More
A0A0N1PHI6   A0A194QGH1   D6WYE3   A0A1Y1M4E9   A0A0T6BFA3   A0A1W4WIZ5   A0A1W4WV15   A0A1W4WIY0   A0A067RT48   E0VCB6   A0A224XNI7   A0A146L7W0   A0A0P4VVV5   A0A0V0G7T2   A0A170YWZ7   A0A069DZ67   A0A0K8S4Q0   A0A1B6E103   A0A182IUX9   A0A182N0N4   A0A084WFF0   A0A182Q0K3   Q16I34   A0A182H019   A0A182WZ88   A0A182R248   A0A182VHW1   A0A182PVS2   W5J956   A0A182VVG5   F5HLZ2   A0A023ETG2   A0A182LRL9   A0A182K1B2   A0A182FM66   A0A182XYB7   A0A182SDZ3   A0A1Q3G2U7   A0A182HMQ8   B4H3U7   A0A1I8N5N0   A0A0L0CIE3   B4L534   A0A2H8U0C5   B4M708   B4NCJ3   A0A1W4VJ16   B4Q0P2   B3NY04   Q8SY66   A0A0K8WFZ6   A0A1A9WDB7   W8C7W9   A0A3B0J808   J9JR23   A4V441   Q24524   Q29JA2   A0A336LIU3   A0A0A1WEK7   A0A1I8NMD9   D3TMG6   B4JLX1   B3MRJ0   A0A0M4ESU5   A0A034VUT0   A0A1B0CA49   A0A2S2R2S4   A0A1L8E5U8   A0A1A9XY84   A0A1B0D4X9   B4IL65   A0A232F7T6   K7J2C3   A0A182UDW2   A0A0J7L0M2   A0A026WN89   E2AAI3   F4WFK5   E2BW15   A0A151HYG3   A0A195FT71   A0A158NSI5   A0A2A3E6L5   A0A154PBQ1   A0A195CSF6   A0A088AJI1   A0A151WID0   T1DP89   A0A1D2MJZ7   A0A0P6A9T9   A0A0P5J107   A0A0P6H540   A0A0P5Y7P1  

Pubmed

19121390    23622113    28756777    22118469    26354079    18362917    + More
19820115    28004739    24845553    20566863    26823975    27129103    26334808    24438588    17510324    26483478    20920257    23761445    12364791    14747013    17210077    24945155    25244985    17994087    25315136    26108605    18057021    17550304    24495485    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    1723709    19729655    15632085    25830018    20353571    25348373    28648823    20075255    24508170    30249741    20798317    21719571    21347285    27289101   

EMBL

BABH01039821    BABH01039822    BABH01039823    NWSH01000621    PCG75235.1    GAIX01003762    + More
JAA88798.1    GDQN01005195    JAT85859.1    KZ150288    PZC71597.1    AGBW02008849    OWR52374.1    KQ460044    KPJ18313.1    KQ459232    KPJ02546.1    KQ971362    EFA08966.1    GEZM01042351    JAV79918.1    LJIG01001006    KRT85934.1    KK852478    KDR22994.1    DS235051    EEB11002.1    GFTR01006877    JAW09549.1    GDHC01014148    GDHC01007766    GDHC01003036    JAQ04481.1    JAQ10863.1    JAQ15593.1    GDKW01000400    JAI56195.1    GECL01001937    JAP04187.1    GEMB01002855    JAS00345.1    GBGD01001170    JAC87719.1    GBRD01018112    JAG47715.1    GEDC01005707    JAS31591.1    ATLV01023340    KE525342    KFB48944.1    AXCN02002234    CH478114    EAT33922.1    JXUM01100585    KQ564581    KXJ72069.1    ADMH02001831    ETN60987.1    AAAB01008963    EGK97303.1    GAPW01001010    JAC12588.1    AXCM01001137    GFDL01000897    JAV34148.1    APCN01004858    APCN01004859    APCN01004860    CH479207    EDW31048.1    JRES01000336    KNC32178.1    CH933811    EDW06293.1    GFXV01007417    MBW19222.1    CH940653    EDW62575.1    KRF80722.1    CH964239    EDW82552.1    CM000162    EDX02313.1    CH954180    EDV47525.1    AY071759    AAL49381.1    GDHF01030623    GDHF01022611    GDHF01002345    JAI21691.1    JAI29703.1    JAI49969.1    GAMC01007791    GAMC01007790    JAB98764.1    OUUW01000003    SPP78277.1    ABLF02034554    ABLF02034556    AE014298    AAN09224.1    AAN09225.3    ACZ95232.1    X17549    X17550    CH379063    EAL32399.2    UFQT01000015    SSX17776.1    GBXI01017392    JAC96899.1    EZ422618    ADD18894.1    CH916371    EDV91732.1    CH902622    EDV34395.1    KPU75114.1    CP012528    ALC48488.1    GAKP01011861    JAC47091.1    AJWK01003273    GGMS01015093    MBY84296.1    GFDF01000001    JAV14083.1    AJVK01011651    AJVK01011652    CH480865    EDW53682.1    NNAY01000754    OXU26662.1    AAZX01001590    LBMM01001424    KMQ96347.1    KK107161    QOIP01000003    EZA56569.1    RLU24794.1    GL438128    EFN69530.1    GL888120    EGI66982.1    GL451091    EFN80047.1    KQ976719    KYM76743.1    KQ981276    KYN43502.1    ADTU01024941    KZ288349    PBC27403.1    KQ434869    KZC09292.1    KQ977329    KYN03575.1    KQ983089    KYQ47576.1    GAMD01002125    JAA99465.1    LJIJ01001029    ODM93290.1    GDIP01032843    JAM70872.1    GDIQ01204700    JAK47025.1    GDIQ01024367    JAN70370.1    GDIP01063388    LRGB01002384    JAM40327.1    KZS07891.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000007266    + More
UP000192223    UP000027135    UP000009046    UP000075880    UP000075884    UP000030765    UP000075886    UP000008820    UP000069940    UP000249989    UP000076407    UP000075900    UP000075903    UP000075885    UP000000673    UP000075920    UP000007062    UP000075883    UP000075881    UP000069272    UP000076408    UP000075901    UP000075840    UP000008744    UP000095301    UP000037069    UP000009192    UP000008792    UP000007798    UP000192221    UP000002282    UP000008711    UP000091820    UP000268350    UP000007819    UP000000803    UP000001819    UP000095300    UP000001070    UP000007801    UP000092553    UP000092461    UP000092443    UP000092462    UP000001292    UP000215335    UP000002358    UP000075902    UP000036403    UP000053097    UP000279307    UP000000311    UP000007755    UP000008237    UP000078540    UP000078541    UP000005205    UP000242457    UP000076502    UP000078542    UP000005203    UP000075809    UP000094527    UP000076858   

PRIDE

H9J859    Q8SY66    A4V441    Q24524   

Pfam

PF06268   Fascin

Interpro

IPR010431   Fascin        + More
IPR008999   Actin-crosslinking       
IPR024703   Fascin_metazoans       
IPR022768   Fascin-domain       
IPR030146   FSCN1       
IPR030144   FSCN2       
IPR039164   UBR1-like       

SUPFAM

SSF50405   SSF50405       

CDD

cd00257  Fascin

ProteinModelPortal

H9J859   A0A2A4JT67   S4PG76   A0A1E1WFW1   A0A2W1BEA6   A0A212FF60   + More
A0A0N1PHI6   A0A194QGH1   D6WYE3   A0A1Y1M4E9   A0A0T6BFA3   A0A1W4WIZ5   A0A1W4WV15   A0A1W4WIY0   A0A067RT48   E0VCB6   A0A224XNI7   A0A146L7W0   A0A0P4VVV5   A0A0V0G7T2   A0A170YWZ7   A0A069DZ67   A0A0K8S4Q0   A0A1B6E103   A0A182IUX9   A0A182N0N4   A0A084WFF0   A0A182Q0K3   Q16I34   A0A182H019   A0A182WZ88   A0A182R248   A0A182VHW1   A0A182PVS2   W5J956   A0A182VVG5   F5HLZ2   A0A023ETG2   A0A182LRL9   A0A182K1B2   A0A182FM66   A0A182XYB7   A0A182SDZ3   A0A1Q3G2U7   A0A182HMQ8   B4H3U7   A0A1I8N5N0   A0A0L0CIE3   B4L534   A0A2H8U0C5   B4M708   B4NCJ3   A0A1W4VJ16   B4Q0P2   B3NY04   Q8SY66   A0A0K8WFZ6   A0A1A9WDB7   W8C7W9   A0A3B0J808   J9JR23   A4V441   Q24524   Q29JA2   A0A336LIU3   A0A0A1WEK7   A0A1I8NMD9   D3TMG6   B4JLX1   B3MRJ0   A0A0M4ESU5   A0A034VUT0   A0A1B0CA49   A0A2S2R2S4   A0A1L8E5U8   A0A1A9XY84   A0A1B0D4X9   B4IL65   A0A232F7T6   K7J2C3   A0A182UDW2   A0A0J7L0M2   A0A026WN89   E2AAI3   F4WFK5   E2BW15   A0A151HYG3   A0A195FT71   A0A158NSI5   A0A2A3E6L5   A0A154PBQ1   A0A195CSF6   A0A088AJI1   A0A151WID0   T1DP89   A0A1D2MJZ7   A0A0P6A9T9   A0A0P5J107   A0A0P6H540   A0A0P5Y7P1  

PDB

6B0T     E-value=1.2055e-94,     Score=885

KEGG

101739127    K17455 fascin 1/2 | (RefSeq) protein singed

GO

GO:0030674   GO:0051015   GO:0005737   GO:0007015   GO:0005856   GO:0016477   GO:0007163   GO:0051017   GO:0003857   GO:0043025   GO:0035099   GO:0048812   GO:0016358   GO:0030034   GO:0035017   GO:0046847   GO:0034399   GO:0048800   GO:0043005   GO:0008407   GO:0042060   GO:0015629   GO:0035317   GO:0003779   GO:0030036   GO:0048477   GO:0009913   GO:0016021   GO:0008413   GO:0004553   GO:0006508   GO:0005634   GO:0004672   GO:0030677   GO:0016155   GO:0003824  

PANTHER

PTHR10551   PTHR10551:SF23   PTHR10551:SF24   PTHR21497  

Subcellular location

  

Length:

511

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000970000000000001

Exp number, first 60 AAs:

0.000770000000000001

Total prob of N-in:

0.00254

outside

1  -  511

 

 

Pi

26.329601

Theta

194.824598

Tajima's D

0.352877

CLR

0.543818

CSRT

0.469626518674066

Interpretation

Uncertain