Gene

KWMTBOMO10020

Pre Gene Modal

BGIBMGA005699

Annotation

PREDICTED:_7?8-dihydro-8-oxoguanine_triphosphatase-like_[Papilio_polytes]

Location

Bomo_Chr17(+):490790-491519      View in EpiBrowser

Full name

7,8-dihydro-8-oxoguanine triphosphatase      

Alternative Name

2-hydroxy-dATP diphosphatase
8-oxo-dGTPase
Nucleoside diphosphate-linked moiety X motif 1

Location in the cell

Cytoplasmic   Reliability : 2.469

CDS

ATGCTTCTAAAGAAAGTATACACTCTAGTCTTCATCTCGAAAGACCAACAAATACTTTTGGGTCTTAAAAAGCGCGGGTTTGGCGTCAACAAATGGAATGGTTTTGGCGGTAAATTGGAGCCGAACGAAACAATAGTTGAGGCCGCTTCAAGAGAATTACAAGAAGAATGCTGTATTAGGGTAAAAACGACAGATTTAAAGAACATCGGACATTTAGAATTTACTTTTGAAGGGGATAAAACTATGATGGAAGTCAGAGTATTTGGTTCGAAATTGTTTGAAGGAATTCCTAGAGAGACCGAAGAAATGTTACCGAAATGGTTTCCTTGCAATAACATCCCTTTTGATAACATGTGGCCTGATGATAGAATTTGGTTTCCCTATATGCTGAAGGGACAACTGTTTTATGGTAGATTTCATTACAAAGATCTTAATACAATATTGAATTATCATATTGAAGAGCTGAAGTCTATGGAAGAATTTTATAATAGAAATTTGTAA

Protein

MLLKKVYTLVFISKDQQILLGLKKRGFGVNKWNGFGGKLEPNETIVEAASRELQEECCIRVKTTDLKNIGHLEFTFEGDKTMMEVRVFGSKLFEGIPRETEEMLPKWFPCNNIPFDNMWPDDRIWFPYMLKGQLFYGRFHYKDLNTILNYHIEELKSMEEFYNRNL

Description

Antimutagenic (PubMed:11572992). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:29281266). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (By similarity). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968).
Antimutagenic. Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:7586133). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).

Catalytic Activity

8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)
2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate + H(+)

Cofactor

Mg(2+)

Subunit

Monomer.

Similarity

Belongs to the Nudix hydrolase family.

Keywords

3D-structure   Complete proteome   Cytoplasm   Cytoplasmic vesicle   Hydrolase   Magnesium   Membrane   Metal-binding   Nucleus   Reference proteome   RNA-binding   Signal  

Feature

chain  7,8-dihydro-8-oxoguanine triphosphatase

Uniprot

H9J857   A0A0N0PDS7   A0A2H1X285   A0A212FF71   A0A2W1B7M3   A0A2A4JT84   + More
A0A0L7LI40   A0A194QAQ3   S4PB70   C3ZJU9   W4Z1F4   A0A0P4WJF1   A0A2P2I8N0   A0A2B4SW84   A0A0B7B346   A0A232F278   A0A088A8N2   E9GZ80   A0A2G8JUD6   K7IZ70   G3WX39   S7QBG4   I3MPS7   A0A0M9A593   H9GEQ8   A0A2T7PZD0   F7FR03   A0A1W4Y9D1   A0A0P6AKK3   L5LRE6   A0A077WVB4   A0A210QSX7   A0A315V3X5   A0A0P5N7B8   G5BI84   H0VRB9   V9LD01   A0A1J4WNZ2   A0A2Y9GDT1   K9IQL2   A0A0L7R0U7   A0A091DB69   K1PBH8   A0A2L2Y921   A0A3B5MEY7   W5LZU0   A0A3B3SEY4   A0A0G0U9Y9   A0A0F8C880   L8Y3L9   A0A3B4X7C0   A0A2J7QAH4   P53368   A0A3L7HQ12   A0A3B4V3R6   A0A2Y9J9K4   A0A250YAK2   A0A226EFD6   A0A340Y2C8   A0A3B3B4G3   U6D127   A0A3Q4BXF9   A0A3Q7NCN7   A0A2U3VHB8   M3Z2J0   P53369   A0A2M7RHS1   T1J6Y5   A0A3Q1B3G7   A0A3P8THN9   A0A1S3JEB6   A0A2P4X9Z8   A0A2U9CT94   G1LAD2   F7IL36   A0A287AR30   A0A2U3XF28   H3CJ26   A0A1F7U7E9   A0A1D2MTM7   A0A3P8X2A5   W5P5K1   A0A2K6USY0   A0A067R9D0   A0A146XTG5   A0A1A6GSK5   A0A3B3YP22   A0A087UUR3   A0A146NAI6   A0A341CX57   A0A3P9JNP2   A0A024UP77   A0A2U4CBW9   A0A2Y9MQ33   A0A1U7T6Y9   A0A3B3I653   A0A384CNV9   A0A3Q3FRG5   A0A087YAZ4   A0A3B3VKL9  

EC Number

3.6.1.55

Pubmed

19121390    26354079    22118469    28756777    26227816    23622113    + More
18563158    28648823    21292972    29023486    20075255    21709235    21881562    17495919    28812685    29703783    21993625    21993624    24402279    27112493    22992520    26561354    29240929    25835551    23385571    7592783    9013634    16141072    15489334    11572992    21183079    21070968    29281266    29704459    28087693    29451363    7586133    11817101    28186564    20010809    15496914    27774985    27289101    24487278    20809919    24845553    17554307    24813606   

EMBL

BABH01039827    KQ460044    KPJ18318.1    ODYU01012895    SOQ59429.1    AGBW02008849    + More
OWR52370.1    KZ150306    PZC71498.1    NWSH01000621    PCG75247.1    JTDY01000984    KOB75198.1    KQ459232    KPJ02552.1    GAIX01006072    JAA86488.1    GG666633    EEN47234.1    AAGJ04013873    GDRN01010561    JAI67914.1    IACF01004779    LAB70368.1    LSMT01000020    PFX32675.1    HACG01039660    HACG01039661    CEK86525.1    CEK86526.1    NNAY01001222    OXU24692.1    GL732577    EFX75101.1    MRZV01001246    PIK39377.1    AEFK01076174    KE164528    EPQ18397.1    AGTP01110591    KQ435732    KOX77507.1    AAWZ02025450    PZQS01000001    PVD38768.1    GDIP01033361    LRGB01002060    JAM70354.1    KZS09539.1    KB108645    ELK28994.1    LK023346    CDS11240.1    NEDP02002059    OWF51812.1    NHOQ01002357    PWA17697.1    GDIQ01168236    JAK83489.1    JH170413    EHB08995.1    AAKN02032221    JW877372    AFP09889.1    MNWH01000042    OIO48961.1    GABZ01002805    JAA50720.1    KQ414669    KOC64474.1    KN124860    KFO20071.1    JH818586    EKC18833.1    IAAA01017335    LAA03830.1    AHAT01032352    LBYG01000005    KKR46962.1    KQ041428    KKF27055.1    KB366015    ELV11018.1    NEVH01016330    PNF25585.1    D49956    D88356    AK011695    AK088309    AK168312    CH466529    BC021940    BC098239    RAZU01000163    RLQ68027.1    GFFW01004194    JAV40594.1    LNIX01000004    OXA56262.1    HAAF01004835    CCP76660.1    AEYP01089007    D49977    D49980    PFME01000023    PIY96051.1    JH431897    NCKW01015590    POM62365.1    CP026261    AWP19180.1    ACTA01156832    AEMK02000013    MGEA01000052    OGL73657.1    LJIJ01000537    ODM96469.1    AMGL01069906    KK852804    KDR16209.1    GCES01040960    JAR45363.1    LZPO01073203    OBS69303.1    KK121735    KFM81102.1    GCES01158276    GCES01040959    JAQ28046.1    KI913953    ETW08261.1    AYCK01007272   

Proteomes

UP000005204    UP000053240    UP000007151    UP000218220    UP000037510    UP000053268    + More
UP000001554    UP000007110    UP000225706    UP000215335    UP000005203    UP000000305    UP000230750    UP000002358    UP000007648    UP000005215    UP000053105    UP000001646    UP000245119    UP000002280    UP000192224    UP000076858    UP000242188    UP000006813    UP000005447    UP000248481    UP000053825    UP000028990    UP000005408    UP000261380    UP000018468    UP000261540    UP000011518    UP000261360    UP000235965    UP000000589    UP000273346    UP000261420    UP000248482    UP000198287    UP000265300    UP000261560    UP000261620    UP000286641    UP000245340    UP000000715    UP000002494    UP000257160    UP000265080    UP000085678    UP000246464    UP000008912    UP000008225    UP000008227    UP000245341    UP000007303    UP000094527    UP000265120    UP000002356    UP000233220    UP000027135    UP000092124    UP000261480    UP000054359    UP000265000    UP000252040    UP000265200    UP000024375    UP000245320    UP000248483    UP000189704    UP000001038    UP000261680    UP000291021    UP000261660    UP000028760    UP000261500   

PRIDE

H9J857    P53368    P53369   

Pfam

PF00293   NUDIX        + More
PF00059   Lectin_C

Interpro

IPR015797   NUDIX_hydrolase-like_dom_sf        + More
IPR003563   OxG-triPHTase       
IPR000086   NUDIX_hydrolase_dom       
IPR016187   CTDL_fold       
IPR018378   C-type_lectin_CS       
IPR001304   C-type_lectin-like       
IPR016186   C-type_lectin-like/link_sf       
IPR020084   NUDIX_hydrolase_CS       
IPR020476   Nudix_hydrolase       

SUPFAM

SSF55811   SSF55811        + More
SSF56436   SSF56436       

Gene 3D

3.10.100.10    

ProteinModelPortal

H9J857   A0A0N0PDS7   A0A2H1X285   A0A212FF71   A0A2W1B7M3   A0A2A4JT84   + More
A0A0L7LI40   A0A194QAQ3   S4PB70   C3ZJU9   W4Z1F4   A0A0P4WJF1   A0A2P2I8N0   A0A2B4SW84   A0A0B7B346   A0A232F278   A0A088A8N2   E9GZ80   A0A2G8JUD6   K7IZ70   G3WX39   S7QBG4   I3MPS7   A0A0M9A593   H9GEQ8   A0A2T7PZD0   F7FR03   A0A1W4Y9D1   A0A0P6AKK3   L5LRE6   A0A077WVB4   A0A210QSX7   A0A315V3X5   A0A0P5N7B8   G5BI84   H0VRB9   V9LD01   A0A1J4WNZ2   A0A2Y9GDT1   K9IQL2   A0A0L7R0U7   A0A091DB69   K1PBH8   A0A2L2Y921   A0A3B5MEY7   W5LZU0   A0A3B3SEY4   A0A0G0U9Y9   A0A0F8C880   L8Y3L9   A0A3B4X7C0   A0A2J7QAH4   P53368   A0A3L7HQ12   A0A3B4V3R6   A0A2Y9J9K4   A0A250YAK2   A0A226EFD6   A0A340Y2C8   A0A3B3B4G3   U6D127   A0A3Q4BXF9   A0A3Q7NCN7   A0A2U3VHB8   M3Z2J0   P53369   A0A2M7RHS1   T1J6Y5   A0A3Q1B3G7   A0A3P8THN9   A0A1S3JEB6   A0A2P4X9Z8   A0A2U9CT94   G1LAD2   F7IL36   A0A287AR30   A0A2U3XF28   H3CJ26   A0A1F7U7E9   A0A1D2MTM7   A0A3P8X2A5   W5P5K1   A0A2K6USY0   A0A067R9D0   A0A146XTG5   A0A1A6GSK5   A0A3B3YP22   A0A087UUR3   A0A146NAI6   A0A341CX57   A0A3P9JNP2   A0A024UP77   A0A2U4CBW9   A0A2Y9MQ33   A0A1U7T6Y9   A0A3B3I653   A0A384CNV9   A0A3Q3FRG5   A0A087YAZ4   A0A3B3VKL9  

PDB

6EHH     E-value=6.68522e-40,     Score=407

KEGG

101739539    K17816 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] | (RefSeq) 7,8

GO

GO:0008413   GO:0006281   GO:0030246   GO:0046061   GO:0005829   GO:0042262   GO:0003924   GO:0005759   GO:0035539   GO:0005634   GO:0047693   GO:0006203   GO:0036219   GO:0030515   GO:0006195   GO:0005615   GO:0005886   GO:0001669   GO:0007568   GO:0031965   GO:0008584   GO:0005739   GO:0046686   GO:0005737   GO:0046872   GO:0016787   GO:0004553   GO:0006508   GO:0004672   GO:0030677   GO:0016155   GO:0003824  

Subcellular location

Cytoplasm  
Nucleus  
Nucleus membrane  
Cytoplasmic vesicle  
Secretory vesicle  
Acrosome  

Length:

166

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01175

Exp number, first 60 AAs:

0.00031

Total prob of N-in:

0.11240

outside

1  -  166

 

 

Pi

211.08525

Theta

183.920821

Tajima's D

0.536831

CLR

0.335894

CSRT

0.525923703814809

Interpretation

Uncertain