Gene

KWMTBOMO09957  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013232

Annotation

PREDICTED:_peptidyl-tRNA_hydrolase_2?_mitochondrial-like_[Papilio_xuthus]

Location

Bomo_Chr16(-):12779156-12780032      View in EpiBrowser

Full name

Peptidyl-tRNA hydrolase 2, mitochondrial      

Alternative Name

Bcl-2 inhibitor of transcription
Bcl-2 inhibitor of transcription 1

Location in the cell

Cytoplasmic   Reliability : 1.778 Mitochondrial   Reliability : 1.327

CDS

ATGACGTTCGATATGTCTTTTTACACTGGCCTAAGCTGCGGTATTTGTATCGGCCTATCAATATTTGCGATTCGAAAGTACATGAAGATGTTTTCTAATGCCAGTGAAACTGTTAAAAAGTTTGTATCGAATGAAGAGTACAAATTGGTTCTAGTTGTCCGAACAGACCTAAGTATGGGTAAAGGCAAAATAGCAGCTCAATGCTGTCATGCAGCAGTTGGAGCTTTTGAGAAAGCACTAAAAAAAGACCCTGAAGGTTTGAAAGCCTGGCAAATGACAGGACAGGCTAAAGTGGCCCTTAAAATTGACTCTTTAGAGGAAATAAAAAAAATTGCAGACAATGCAAAGAAAATGGGCTTAATCACATCTTTAATACGTGATGCGGGCCGTACCCAGATTGCACCAAATTCAATAACAGTTTTGGGTGTAGGACCAGCACCGAAAGACATTATAGACAAAGTCACCGGTCACCTTAAGTTGCTGTGA

Protein

MTFDMSFYTGLSCGICIGLSIFAIRKYMKMFSNASETVKKFVSNEEYKLVLVVRTDLSMGKGKIAAQCCHAAVGAFEKALKKDPEGLKAWQMTGQAKVALKIDSLEEIKKIADNAKKMGLITSLIRDAGRTQIAPNSITVLGVGPAPKDIIDKVTGHLKLL

Description

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.

Catalytic Activity

H2O + N-acyl-L-alpha-aminoacyl-tRNA = an N-acyl-L-amino acid + H(+) + tRNA

Subunit

Monomer.

Similarity

Belongs to the PTH2 family.

Keywords

Complete proteome   Hydrolase   Isopeptide bond   Mitochondrion   Reference proteome   Transit peptide   Ubl conjugation   3D-structure   Apoptosis   Disease mutation  

Feature

chain  Peptidyl-tRNA hydrolase 2, mitochondrial
sequence variant  In IMNEPD; dbSNP:rs730882234.

Uniprot

H9JUL9   A0A2A4JPI5   A0A437B4X6   A0A2H1V2R5   A0A0N0PC43   A0A212FJ33   + More
A0A1E1WPF4   A0A0L7K3A7   A4IGX7   A0A2K6SMI2   A0A1B0C8E5   A0A091PCS3   A0A2T7PD38   A0A2K5CE31   A0A1L8HFU3   A0A3Q0EI15   A0A1U7UK08   F7HZT2   U3EMU8   A0A091VSR0   F6PQA8   A0A2R5L7F2   A0A2K6ETW0   A0A1S4FCF4   A0A2D4BRB5   A0A2K5PJ50   E1BWS4   A0A023EHQ7   A0A0D9S9B4   E2RND8   H0XIT5   A0A452E2A9   W5P154   K3WU49   A0A2Y9I750   A0A3Q7S7E7   Q177N9   F1S227   A0A2U3VR79   G1NR67   M7BPU4   A0A226PG38   A0A2U3Y9I0   A0A3Q7X793   A0A384CGZ8   A0A3Q7MK85   A0A091IUC8   A0A226NBN1   W5LT50   A0A091SX53   A0A452R180   A0A452R182   A0A3Q7XFP4   A0A384CFX6   A0A286XAG6   Q3ZBL5   L8IR93   A0A094KE74   G3UA53   E9H345   A0A067R5D2   A0A093R4V7   A0A2P4XPH0   A0A2K6L8S4   A0A2K6QIN2   A0A2K5JGL3   A0A1Z5LD88   A0A2Y9JWZ1   M3WNP1   Q9NAZ7   G7PUH4   F7GV88   A0A2K5TM78   A0A2K5XY13   A0A2K5NV60   A0A2K6CUM5   A0A096P4W9   A0A1D5QQ67   A0A340WQ00   A0A091PL18   Q96ME4   A0A091NBE6   G1QJ28   A0A2J8W7L2   A0A093NGX2   A0A2J8W7J7   D2HLU6   G9L1D3   A0A091FV65   Q7QK06   A0A3P4NL33   M3Z7D7   U6CTF4   A0A293LIY7   K7DQ09   Q9Y3E5   A0A2R9AL47   H2QDK5   J3KQ48  

EC Number

3.1.1.29

Pubmed

19121390    26354079    22118469    26227816    27762356    25243066    + More
20431018    15592404    24945155    26483478    16341006    20809919    17510324    30723633    20838655    23624526    24621616    24813606    25329095    21993624    16305752    22751099    21292972    24845553    28186564    25362486    28528879    17975172    11762196    22002653    17431167    25319552    14702039    20010809    23236062    12364791    14747013    17210077    10810093    15489334    17974005    15006356    18669648    21269460    23186163    25574476    25558065    25621951    25944712    14660562    22722832    16136131    16625196   

EMBL

BABH01022680    NWSH01000975    PCG73320.1    RSAL01000158    RVE45541.1    ODYU01000380    + More
SOQ35066.1    KQ460655    KPJ12954.1    AGBW02008320    OWR53720.1    GDQN01002182    JAT88872.1    JTDY01013301    KOB52159.1    BC135286    AAI35287.1    AJWK01000518    KL384128    KFP89320.1    PZQS01000004    PVD31332.1    CM004468    OCT94962.1    GAMS01006065    GAMR01010587    GAMQ01000451    GAMP01006873    JAB17071.1    JAB23345.1    JAB41400.1    JAB45882.1    KK734272    KFR05518.1    AAMC01027133    GGLE01001266    MBY05392.1    BBXB01000050    GAX96580.1    AADN05000057    JXUM01127242    JXUM01132779    GAPW01005021    KQ567891    KQ567165    JAC08577.1    KXJ69236.1    KXJ69585.1    AQIB01117261    AAEX03006586    AAQR03121548    LWLT01000022    AMGL01017392    GL376613    CH477373    EAT42379.1    AEMK02000080    DQIR01116625    DQIR01254069    HDA72101.1    HDC09547.1    KB521250    EMP37730.1    AWGT02000074    OXB79045.1    KK501002    KFP11912.1    MCFN01000109    OXB64898.1    KK936918    KFQ47675.1    AAKN02033032    AB238942    BT021191    BC103230    JH880797    ELR58836.1    KL344832    KFZ55168.1    GL732587    EFX73896.1    KK852685    KDR18489.1    KL438923    KFW93645.1    NCKW01009159    POM67434.1    GFJQ02002059    JAW04911.1    AANG04003358    AF275673    AAF87580.1    CM001291    EHH58023.1    JSUE03017039    JU475959    JV047344    CM001268    AFH32763.1    AFI37415.1    EHH24869.1    AQIA01027655    AHZZ02010224    KK674812    KFQ07978.1    AK057033    BAB71351.2    KK828104    KFP74329.1    ADFV01107753    NDHI03003397    PNJ65731.1    KL224565    KFW61245.1    ABGA01152269    PNJ65732.1    PNJ65733.1    GL193022    EFB14817.1    JP022364    AES10962.1    KL447514    KFO74405.1    AAAB01008805    EAA03889.5    CYRY02026482    VCW98752.1    AEYP01021737    HAAF01001945    CCP73771.1    GFWV01003953    MAA28683.1    GABC01009269    GABF01006306    GABD01006927    GABE01006322    NBAG03000258    JAA02069.1    JAA15839.1    JAA26173.1    JAA38417.1    PNI58065.1    PNI58066.1    AF151905    AK098219    CH471109    BC006807    AL137322    AJFE02058761    AACZ04026964    PNI58064.1    AC091271   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000007151    UP000037510    + More
UP000233220    UP000092461    UP000245119    UP000233020    UP000186698    UP000189704    UP000008225    UP000053605    UP000008143    UP000233160    UP000054177    UP000233040    UP000000539    UP000069940    UP000249989    UP000029965    UP000002254    UP000005225    UP000291000    UP000002356    UP000248481    UP000286640    UP000008820    UP000008227    UP000245340    UP000001645    UP000031443    UP000198419    UP000245341    UP000286642    UP000261680    UP000291021    UP000286641    UP000053119    UP000198323    UP000018467    UP000291022    UP000005447    UP000009136    UP000007646    UP000000305    UP000027135    UP000233180    UP000233200    UP000233080    UP000248482    UP000011712    UP000009130    UP000006718    UP000233100    UP000233140    UP000233060    UP000233120    UP000028761    UP000265300    UP000001073    UP000054081    UP000001595    UP000053760    UP000007062    UP000000715    UP000005640    UP000240080    UP000002277   

PRIDE

H9JUL9    E2RND8    W5P154    F1S227    Q3ZBL5    Q96ME4    + More
Q9Y3E5    J3KQ48   

Pfam

PF01981   PTH2

Interpro

IPR002833   PTH2        + More
IPR023476   Pep_tRNA_hydro_II_dom_sf       

SUPFAM

SSF102462   SSF102462       

Gene 3D

3.40.1490.10    

CDD

cd02430  PTH2

ProteinModelPortal

H9JUL9   A0A2A4JPI5   A0A437B4X6   A0A2H1V2R5   A0A0N0PC43   A0A212FJ33   + More
A0A1E1WPF4   A0A0L7K3A7   A4IGX7   A0A2K6SMI2   A0A1B0C8E5   A0A091PCS3   A0A2T7PD38   A0A2K5CE31   A0A1L8HFU3   A0A3Q0EI15   A0A1U7UK08   F7HZT2   U3EMU8   A0A091VSR0   F6PQA8   A0A2R5L7F2   A0A2K6ETW0   A0A1S4FCF4   A0A2D4BRB5   A0A2K5PJ50   E1BWS4   A0A023EHQ7   A0A0D9S9B4   E2RND8   H0XIT5   A0A452E2A9   W5P154   K3WU49   A0A2Y9I750   A0A3Q7S7E7   Q177N9   F1S227   A0A2U3VR79   G1NR67   M7BPU4   A0A226PG38   A0A2U3Y9I0   A0A3Q7X793   A0A384CGZ8   A0A3Q7MK85   A0A091IUC8   A0A226NBN1   W5LT50   A0A091SX53   A0A452R180   A0A452R182   A0A3Q7XFP4   A0A384CFX6   A0A286XAG6   Q3ZBL5   L8IR93   A0A094KE74   G3UA53   E9H345   A0A067R5D2   A0A093R4V7   A0A2P4XPH0   A0A2K6L8S4   A0A2K6QIN2   A0A2K5JGL3   A0A1Z5LD88   A0A2Y9JWZ1   M3WNP1   Q9NAZ7   G7PUH4   F7GV88   A0A2K5TM78   A0A2K5XY13   A0A2K5NV60   A0A2K6CUM5   A0A096P4W9   A0A1D5QQ67   A0A340WQ00   A0A091PL18   Q96ME4   A0A091NBE6   G1QJ28   A0A2J8W7L2   A0A093NGX2   A0A2J8W7J7   D2HLU6   G9L1D3   A0A091FV65   Q7QK06   A0A3P4NL33   M3Z7D7   U6CTF4   A0A293LIY7   K7DQ09   Q9Y3E5   A0A2R9AL47   H2QDK5   J3KQ48  

PDB

1Q7S     E-value=3.22859e-34,     Score=357

KEGG

101742288    K04794 peptidyl-tRNA hydrolase, PTH2 family [EC:3.1.1.29] | (RefSeq) peptidyl-tRNA hydrolase 2, mito

GO

GO:0004045   GO:0016021   GO:0005739   GO:0016787   GO:0005829   GO:2000210   GO:2000811   GO:0016020   GO:0010629   GO:0006915   GO:0003700   GO:0005634   GO:0006355   GO:0006468   GO:0004672   GO:0030677   GO:0016155   GO:0003824  

PANTHER

PTHR12649  

Subcellular location

Mitochondrion  

Length:

161

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.31256

Exp number, first 60 AAs:

19.30447

Total prob of N-in:

0.27538

POSSIBLE N-term signal

sequence

outside

1  -  4

TMhelix

5  -  24

inside

25  -  161

 

 

Pi

157.617782

Theta

53.705453

Tajima's D

1.395659

CLR

1.309748

CSRT

0.76301184940753

Interpretation

Uncertain