Gene

KWMTBOMO09954  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013235

Annotation

PREDICTED:_proline_dehydrogenase_1?_mitochondrial_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr16(-):12702067-12732982      View in EpiBrowser

Full name

Proline dehydrogenase       + More
Proline dehydrogenase 1, mitochondrial      

Alternative Name

Proline oxidase
Protein sluggish-A

Location in the cell

Mitochondrial   Reliability : 2.57

CDS

ATGGCTCTGCTCAGACGACTCGTTGTGAACGCTCCCCGCAACGTGAGGGTGCTGTCGACGCCTTCGCCGGCATCGCGGGACGAACTCGACCTGACCTTTAACAGTCCGAAAGACGCGTTCAAGAGCAAGAAAACCAGCGAACTAGTCCGGGCCTACTTCGTCTATCAAATATGTTCGGTGAACTGGCTCGTAGAGAACAACGACATGTTGATGAAGAGGCTCCGCCAAGTGGTCGGCCAGAGGTTTTTCGAGGCCATCATGAAGGCAACCTTCTACGGGCAGTTCGTAGCCGGGGAAGACCAGAACAAAATCCGACCGACTATTGAAAGGCTCCGTTCTTTCGGCGTCAAGTCGATCTTGGATTACTCCGTTGAGGAAGACCTGTCCCAGGAGGAGGCAGAGAAACGTGAAGTCAGTGCTTCTATATCCGCGTGCGGCGACATGCAAGAAGAGGGTCAGCTGAAGCAGTACCACGTAGAGCAGAGGTTCGCCGACAGGCGCTACAAGGTGACCAGCGCCAGGACCTACTTCTACCTCAACGAAGCCTCCTGCGAGAAGAACATGGAAGCCTTCTTGAGGAGCATTGATGCTGTCGCCGGCATCACCAAGAGCACAGGGCTGATGGCCATCAAGTTGACAGCTCTCGGAAGGCCCCAACTACTTCTGCAACTCTCGGAGGTGATCATGCGCGCTCGTAACTACATGCAGCAGATAGCTGGTGGGACAGGCAACGTCTTGACTCACCACAAGACCATCGAGGACTTCCAGAGGTACTTCGGTGATCACAGCACCAAGCCTGAGGTCCAGCAGTTCATGAAGAAGATCACGTCTGACAAAGAGGGGATCGTCCATTTATTCCCGTGGTCGAATATTCTCGACGAGGACATGAACTTGTCGGAGTCGTTTAGGGTGCCCGATCCTAAAACGGGTCAGATGAGGAGACTCATATCACAGATATCGACGAAAGAGGAAGAGATGTTCAGGAATATGCTCCGCCGTCTCAACCACATCATCCAGGTGGCGAACGAGGCTGACGTGAGAGTCATGATCGACGCTGAGCAGACTTACTTCCAGCCCGCCATCTCGAGGATCTGTCTCGAAATGATGAGGAGATACAATAAGGACAAGTTCCTGGTCTTCAACACTTACCAGACGTACTTGAAGAATACGTACAATGAGATCGTGACTGATCTAGAACAGGCCCACAGGCAGAACTTCTTCTGGGGGGCGAAGCTTGTGCGTGGCGCTTATATCGAGCAGGAGCGAGCACGCGCTGCCGCCATGGGATACGAGGATCCCACGTGCGAGAACGTGGACGCCACCACCGCATCCTTCCACAAGTGCCTCAAGGAAATTCTCAGCAGGGTTAAAGCAAACGTATTGGTGCGCGGTTTGTTTGGTATTGCCGAAGCGATCCACTTAATGGCTTTTGTGCATTGTGGCTCGAGTGGTCGATTCTCGTCAGTCCATAACTCGGAAGAAGTAGGACGCCTAGGAGGAGCGGTCGTGGTCATAACAGCAACGAGACGCACTGGTCGACAGTGGTCAGCTACGTGGATAAGTGGTGCCGCTGGTATTCCGGTACACCTTACTGAACCAGAACCGGGTCGCCATGTCGGAGTGCGATACACCGTCAACCGCTCCCTCTTTGACATCAACTCCGCGGCTGGAGGGTTGACCCCCGAACCGTCACCGAGGGAGCCCTGTGGAGGGCGGCCTCCTGTACAGGGCTGTCACCTCATATACGTTAACTTTAATAAAGATCAGGTTATAAAAAGTCAAGCTGGTTATTCGGTCTACAAGTACGTGCCATATGGACCGGTAGTTGAAGTGCTACCGTATCTATCGCGGAGGGCGAACGAAAACCGGGGCTTCCTCAAGAAAATCAAGAAGGAGAAGAAGCTACTCCTCAAAGAAATCGTCCGCAGGGTCGTTTCTGGTCAAATGTTTTACAAGCCCATCGGGAATTACACGCCTGTCTAA

Protein

MALLRRLVVNAPRNVRVLSTPSPASRDELDLTFNSPKDAFKSKKTSELVRAYFVYQICSVNWLVENNDMLMKRLRQVVGQRFFEAIMKATFYGQFVAGEDQNKIRPTIERLRSFGVKSILDYSVEEDLSQEEAEKREVSASISACGDMQEEGQLKQYHVEQRFADRRYKVTSARTYFYLNEASCEKNMEAFLRSIDAVAGITKSTGLMAIKLTALGRPQLLLQLSEVIMRARNYMQQIAGGTGNVLTHHKTIEDFQRYFGDHSTKPEVQQFMKKITSDKEGIVHLFPWSNILDEDMNLSESFRVPDPKTGQMRRLISQISTKEEEMFRNMLRRLNHIIQVANEADVRVMIDAEQTYFQPAISRICLEMMRRYNKDKFLVFNTYQTYLKNTYNEIVTDLEQAHRQNFFWGAKLVRGAYIEQERARAAAMGYEDPTCENVDATTASFHKCLKEILSRVKANVLVRGLFGIAEAIHLMAFVHCGSSGRFSSVHNSEEVGRLGGAVVVITATRRTGRQWSATWISGAAGIPVHLTEPEPGRHVGVRYTVNRSLFDINSAAGGLTPEPSPREPCGGRPPVQGCHLIYVNFNKDQVIKSQAGYSVYKYVPYGPVVEVLPYLSRRANENRGFLKKIKKEKKLLLKEIVRRVVSGQMFYKPIGNYTPV

Description

Converts proline to delta-1-pyrroline-5-carboxylate.

Catalytic Activity

a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

Cofactor

FAD

Similarity

Belongs to the proline oxidase family.

Keywords

Alternative splicing   Complete proteome   FAD   Flavoprotein   Mitochondrion   Oxidoreductase   Proline metabolism   Reference proteome   Transit peptide  

Feature

chain  Proline dehydrogenase 1, mitochondrial
splice variant  In isoform C.

Uniprot

A0A3S2NVE4   A0A0R3P2Q9   A0A1S4FZI4   B4NCH3   A0A0A1WYU4   B3NYE0   + More
A0A0R1ECN7   A0A1Y9IZV4   A0A0M3QZA6   A0A1J1INZ5   A0A0K8UDS2   A0A034VNJ3   A0A1W4V8Z5   Q04499-2   A0A023EVI0   A4V4U5   Q29JE6   A0A453Z3A0   A0A182LAI2   B4L5D4   A0A182VIP8   A0A2M4A294   A0A2M4BGF1   A0A2M4BH17   A0A2M4BGE1   T1PCL5   A0A0R3P3I8   A0A2M3Z2S6   A0A1I8NGA1   A0A0K8W3R4   A0A2M4CSL8   B4PZ36   A0A3B0J6M0   A0A2M4CJU1   A0A0A1X0X8   A0A0Q9X282   A0A0K8VBG7   B4JNG2   A0A1W4UV99   A0A0Q5TKD1   Q04499-5   A0A1Q3FX38   M9NHG9   A0A0Q9XMF7   A0A1Q3FXD9   A0A1Q3FX24   A0A1I8NGB7   Q04499-3   A0A1W4V7L3   M9NFJ2   A0A1W4UVA5   A0A0Q9XGT3   A0A0R3NXT5   A0A0K8WCY6   A0A182M7K8   A0A1Q3FX60   A0A0R1ECL0   Q04499   A0A0Q9XEB9   A0A1W4UVN8   A0A1I8PJW6   A0A1I8PK49   B3MRV8   A0A1W4X1K2   A0A1B0CSB1   D6WUI6   A0A1I8PJZ5   A0A1I8PK44   A0A1L8E2Z3   A0A1L8E2J3   A0A1W4XC56   A0A087ZJR8   A0A1Q3FWY3   A0A1Y1M7E3   A0A1L8E2Q6   E2AQ70   A0A067QZG1   E0VMP1  

EC Number

1.5.5.2

Pubmed

15632085    17994087    25830018    18057021    17550304    25348373    + More
8096642    9520435    10731132    12537572    12537569    24945155    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    23185243    20966253    25315136    18362917    19820115    20920257    28004739    20798317    24845553    20566863   

EMBL

RSAL01000158    RVE45544.1    CH379063    KRT05901.1    CH964239    EDW82532.2    + More
GBXI01010275    JAD04017.1    CH954180    EDV47619.2    CM000162    KRK07117.1    CP012528    ALC49039.1    CVRI01000057    CRL01955.1    GDHF01032925    GDHF01027502    JAI19389.1    JAI24812.1    GAKP01015834    GAKP01015833    GAKP01015831    GAKP01015829    GAKP01015828    GAKP01015827    JAC43118.1    L07330    AF017777    AE014298    AY069407    GAPW01000445    JAC13153.1    AAS65413.1    EAL32355.3    CH933811    EDW06393.1    GGFK01001623    MBW34944.1    GGFJ01002956    MBW52097.1    GGFJ01002957    MBW52098.1    GGFJ01002946    MBW52087.1    KA646502    AFP61131.1    KRT05904.1    GGFM01002070    MBW22821.1    GDHF01006491    JAI45823.1    GGFL01004142    MBW68320.1    EDX03097.1    OUUW01000003    SPP77814.1    GGFL01001263    MBW65441.1    GBXI01009540    JAD04752.1    KRF99635.1    GDHF01016020    JAI36294.1    CH916371    EDV92255.1    KQS30580.1    GFDL01002937    JAV32108.1    AFH07508.1    KRG06890.1    GFDL01002889    JAV32156.1    GFDL01002940    JAV32105.1    AFH07507.1    KRG06889.1    KRT05902.1    GDHF01003609    JAI48705.1    AXCM01000394    GFDL01002876    JAV32169.1    KRK07113.1    KRG06891.1    CH902622    EDV34513.2    AJWK01025870    AJWK01025871    KQ971357    EFA08381.1    GFDF01001219    JAV12865.1    GFDF01001218    JAV12866.1    GFDL01002925    JAV32120.1    GEZM01042453    JAV79846.1    GFDF01001232    JAV12852.1    GL441701    EFN64404.1    KK853156    KDR10499.1    DS235321    EEB14647.1   

Proteomes

UP000283053    UP000001819    UP000007798    UP000008711    UP000002282    UP000076407    + More
UP000092553    UP000183832    UP000192221    UP000000803    UP000075882    UP000009192    UP000075903    UP000095301    UP000268350    UP000001070    UP000075883    UP000095300    UP000007801    UP000192223    UP000092461    UP000007266    UP000000311    UP000027135    UP000009046   

PRIDE

Q04499    A4V4U5    M9NHG9    M9NFJ2   

Pfam

PF01619   Pro_dh

Interpro

IPR015659   Proline_oxidase        + More
IPR002872   Proline_DH_dom       
IPR029041   FAD-linked_oxidoreductase-like       

SUPFAM

SSF51730   SSF51730       

ProteinModelPortal

A0A3S2NVE4   A0A0R3P2Q9   A0A1S4FZI4   B4NCH3   A0A0A1WYU4   B3NYE0   + More
A0A0R1ECN7   A0A1Y9IZV4   A0A0M3QZA6   A0A1J1INZ5   A0A0K8UDS2   A0A034VNJ3   A0A1W4V8Z5   Q04499-2   A0A023EVI0   A4V4U5   Q29JE6   A0A453Z3A0   A0A182LAI2   B4L5D4   A0A182VIP8   A0A2M4A294   A0A2M4BGF1   A0A2M4BH17   A0A2M4BGE1   T1PCL5   A0A0R3P3I8   A0A2M3Z2S6   A0A1I8NGA1   A0A0K8W3R4   A0A2M4CSL8   B4PZ36   A0A3B0J6M0   A0A2M4CJU1   A0A0A1X0X8   A0A0Q9X282   A0A0K8VBG7   B4JNG2   A0A1W4UV99   A0A0Q5TKD1   Q04499-5   A0A1Q3FX38   M9NHG9   A0A0Q9XMF7   A0A1Q3FXD9   A0A1Q3FX24   A0A1I8NGB7   Q04499-3   A0A1W4V7L3   M9NFJ2   A0A1W4UVA5   A0A0Q9XGT3   A0A0R3NXT5   A0A0K8WCY6   A0A182M7K8   A0A1Q3FX60   A0A0R1ECL0   Q04499   A0A0Q9XEB9   A0A1W4UVN8   A0A1I8PJW6   A0A1I8PK49   B3MRV8   A0A1W4X1K2   A0A1B0CSB1   D6WUI6   A0A1I8PJZ5   A0A1I8PK44   A0A1L8E2Z3   A0A1L8E2J3   A0A1W4XC56   A0A087ZJR8   A0A1Q3FWY3   A0A1Y1M7E3   A0A1L8E2Q6   E2AQ70   A0A067QZG1   E0VMP1  

PDB

5UR2     E-value=2.47097e-05,     Score=116

KEGG

101742434    K00318 proline dehydrogenase [EC:1.5.5.2] | (RefSeq) proline dehydrogenase 1, mitochondrial

PATHWAY

00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006560   GO:0016491   GO:0006562   GO:0004657   GO:0010133   GO:0005739   GO:0007626   GO:0006537   GO:0005759   GO:0071949   GO:0042331  

PANTHER

PTHR13914  

Subcellular location

Mitochondrion matrix  

Length:

660

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.27226

Exp number, first 60 AAs:

0.13593

Total prob of N-in:

0.01233

outside

1  -  660

 

 

Pi

201.708167

Theta

142.166412

Tajima's D

1.401625

CLR

0.209018

CSRT

0.765611719414029

Interpretation

Uncertain