Gene

KWMTBOMO09914  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013254

Annotation

PREDICTED:_aldo-keto_reductase_AKR2E4-like_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr16(-):11989904-12017093      View in EpiBrowser

Full name

Aldo-keto reductase AKR2E4      

Alternative Name

3-dehydroecdysone reductase
Aldo-keto reductase 2E

Location in the cell

Cytoplasmic   Reliability : 2.974

CDS

ATGGTTGTAGATGTACCCAGTATTAAACTGTCAAATGGGCAAGACATGCCAATTTTAGGGCTCGGAACTTATGCGAGGAAACCAGAGCCTGGTCAAGTTTTGAACTCGGTGAGATGGGCCATCGACGCTGGCTACAGGCACATAGACACCGCGACCGTCTACAAGAACGAGGCTGAAGTTGGTGAGGCCATCAGCGAGAAGATCGACCAGGGTGTCGTCAAGCGGGAACAGCTTTTCGTCACCACCAAATTATGGAACGATAAGCACGCGAGGTCTGATGTCCTGCCGACACTGAAGGAGTCCTTAGCAAAACTGCGTTTGGACTACGTCGATTTGTATCTGGTGCACTGGCCTGTGTCTGTCAACGACAAAGGTGAGGATCTGGCGATCGATCACCTCGACACGTGGAAGGGCATGGAGGAAGTCCTGGCACTGGGCCTCACGAAGGCCATAGGAGTCTCCAACTTCAACGAGGAGCAGCTCGAGAGGTTGCTCAAGGAAGCCACTGTTAAACCAGTCGTCAACCAAGTCGAAATCAACCCAACACTAACTCAGCACAAACTGGTGAGGTTCTGCCAGGAGAGGTCGGTGGTGCCGGTAGCGTATACTCCGCTCGGTCTGGTCTCGGACGCCCGGCCAGAGTTCGCGGGCCTCGACGTCATCAAAACCGACCCGAAGCTGGGCGGACTAGCCGACAAGTACGGAAAGACCAGGGCTCAAGTCGCCCTTAGGTATCTGACCCAACGCAACATTCCCGTTCTACCGAAATCGTTCACGAAGTCCCGGATCGAACAGAACATCGATATATTCGACTTCACGTTGACCGATGACGAGATGGCGCTTGTCGACGGCTACAACATCGACCACCGCTGCGTACCCTCGAAGGCGTTCGCCCATTTGAAGAATTATCCGTTTTAA

Protein

MVVDVPSIKLSNGQDMPILGLGTYARKPEPGQVLNSVRWAIDAGYRHIDTATVYKNEAEVGEAISEKIDQGVVKREQLFVTTKLWNDKHARSDVLPTLKESLAKLRLDYVDLYLVHWPVSVNDKGEDLAIDHLDTWKGMEEVLALGLTKAIGVSNFNEEQLERLLKEATVKPVVNQVEINPTLTQHKLVRFCQERSVVPVAYTPLGLVSDARPEFAGLDVIKTDPKLGGLADKYGKTRAQVALRYLTQRNIPVLPKSFTKSRIEQNIDIFDFTLTDDEMALVDGYNIDHRCVPSKAFAHLKNYPF

Description

NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. May play a role in the regulation of molting. Has lower activity with phenylglyoxal and isatin (in vitro). Has no activity with NADH as cosubstrate. Has no activity with nitrobenzaldehyde and 3-hydroxybenzaldehyde.

Biophysicochemical Properties

0.0044 mM for 3-dehydroecdysone

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

3D-structure   Complete proteome   Lipid metabolism   NADP   Oxidoreductase   Reference proteome   Steroid metabolism  

Feature

chain  Aldo-keto reductase AKR2E4

Uniprot

A0A291P0Y9   A0A291P0U2   A0A2A4IYA3   A0A0F6Q2W6   H9JUP1   A0A194PKB3   + More
U5KBY4   G9F9F4   S4PY90   A0A2H1V815   A0A212F244   A0A2W1BI87   D2A296   A0A2A4JMB2   A0A291P0T7   D6WCX8   A0A1D2MB39   F4WLB5   D6WBX9   A0A1L8D6L9   V5GT06   G9F9G0   A0A3S2LZY0   A0A154PH71   A0A088AGI5   A0A232EMX7   A0A212FML6   A0A0T6B8Q2   B2DBM2   A0A2H1VGR3   A0A151WRD3   A0A151J3M8   H9JTG9   A0A084WAD5   A0A195CRM5   A0A195FYJ2   R4WNM5   I4DP16   A0A182K591   I4DKQ3   A0A443RGQ3   A0A2W1BC51   F4WLB4   A0A2A4JM15   V9IEZ4   A0A0T6AZ90   A0A182QI37   A0A2H1VAA3   A0A2R7WWN4   A0A2R7WXG0   A0A1W4WL13   A0A1I9WLL7   A0A2A3EI70   A0A182RUK3   A0A158NZF8   A0A2H1VAB6   V5GQ24   A0A194Q090   A0A182LYX7   T1DFA3   E9J719   A0A182YBI3   A0A2M3ZFC7   A0A182N3T0   A0A182VI74   A0A182WUG5   A0A182KKP7   Q7PF06   A0A182HW13   V5GXH0   A0A310S4F9   A0A291P0U1   A0A195BMW2   A0A182YBI5   A0A1W4W9Z3   W5JBU8   F5BYH7   U5KC00   Q17DM5   A0A2M4BTH9   A0A2M4AF69   A0A182FVL2   Q17DM4   A0A195CTD6   A0A291P0X3   J3JZ92   A0A2M4BTI2   A0A182JHG0   A0A182WDU3   A0A182QZ12   A0A151IW05   A0A088AGI6   A0A2A4J3U1   A0A291P0W3   A0A067QJF4   A0A2J7QL56   A0A182SQ44   A0A2A3EJL9   E2AB23   A0A437BCA7  

EC Number

1.1.1.-

Pubmed

28986331    19121390    26354079    24053512    23622113    22118469    + More
28756777    18362917    19820115    27289101    21719571    28648823    18712529    24012638    24438588    23691247    22651552    27538518    21347285    21282665    25244985    20966253    12364791    14747013    17210077    20920257    23761445    21452889    17510324    22516182    24845553    20798317   

EMBL

MF687608    ATJ44534.1    MF687572    ATJ44498.1    NWSH01005088    PCG64446.1    + More
KP237872    AKD01725.1    BABH01022758    BABH01022759    BABH01022760    KQ459602    KPI93169.1    KC007350    AGQ45615.1    JN033699    JN033700    RSAL01000051    AEW46852.1    AEW46853.1    RVE50216.1    GAIX01003703    JAA88857.1    ODYU01001161    SOQ36985.1    AGBW02010783    OWR47810.1    KZ150106    PZC73415.1    KQ971338    EFA02158.1    NWSH01001060    PCG72858.1    MF687576    ATJ44502.1    KQ971311    EEZ99072.1    LJIJ01002106    ODM90218.1    GL888207    EGI65078.1    EEZ99009.1    GEYN01000020    JAV02109.1    GALX01003699    JAB64767.1    JN033705    AEW46858.1    RSAL01000093    RVE47941.1    KQ434902    KZC11162.1    NNAY01003257    OXU19723.1    AGBW02007651    OWR54929.1    LJIG01009120    KRT83716.1    AB264706    BAG30781.1    ODYU01002492    SOQ40039.1    KQ982807    KYQ50361.1    KQ980275    KYN17034.1    AB701383    ATLV01022099    KE525328    KFB47179.1    KQ977349    KYN03393.1    KQ981169    KYN45372.1    AK417251    BAN20466.1    AK403246    BAM19656.1    AK401871    BAM18493.1    NCKU01000718    RWS14444.1    KZ150230    PZC72001.1    EGI65077.1    PCG72859.1    JR040676    AEY59237.1    LJIG01022464    KRT80438.1    AXCN02001099    ODYU01001496    SOQ37780.1    KK855773    PTY23851.1    PTY23850.1    KU932401    APA34037.1    KZ288235    PBC31398.1    ADTU01004584    ADTU01004585    SOQ37779.1    GALX01004754    JAB63712.1    KQ459582    KPI98997.1    AXCM01001195    GAMD01003201    JAA98389.1    GL768421    EFZ11357.1    GGFM01006505    MBW27256.1    AAAB01008804    EAA45511.3    APCN01001457    GALX01003438    JAB65028.1    KQ777390    OAD52082.1    MF687570    ATJ44496.1    KQ976433    KYM87328.1    ADMH02001680    ETN61456.1    JF417982    AEB26313.1    KC007349    AGQ45614.1    CH477292    EAT44550.1    EAT44553.1    EAT44554.1    GGFJ01007171    MBW56312.1    GGFK01006115    MBW39436.1    EAT44551.1    EAT44552.1    KYN03394.1    MF687617    ATJ44543.1    BT128573    AEE63530.1    GGFJ01007172    MBW56313.1    KQ980881    KYN11974.1    NWSH01003180    PCG66817.1    MF687607    ATJ44533.1    KK853419    KDR07716.1    NEVH01013254    PNF29307.1    PBC31399.1    GL438234    EFN69299.1    RVE47938.1   

Proteomes

UP000218220    UP000005204    UP000053268    UP000283053    UP000007151    UP000007266    + More
UP000094527    UP000007755    UP000076502    UP000005203    UP000215335    UP000075809    UP000078492    UP000030765    UP000078542    UP000078541    UP000075881    UP000285301    UP000075886    UP000192223    UP000242457    UP000075900    UP000005205    UP000075883    UP000076408    UP000075884    UP000075903    UP000076407    UP000075882    UP000007062    UP000075840    UP000078540    UP000000673    UP000008820    UP000069272    UP000075880    UP000075920    UP000027135    UP000235965    UP000075901    UP000000311   

PRIDE

H9JUP1    H9JTG9   

Pfam

PF00248   Aldo_ket_red

Interpro

IPR023210   NADP_OxRdtase_dom        + More
IPR020471   Aldo/keto_reductase       
IPR018170   Aldo/ket_reductase_CS       
IPR036812   NADP_OxRdtase_dom_sf       
IPR036691   Endo/exonu/phosph_ase_sf       

SUPFAM

SSF51430   SSF51430       

Gene 3D

3.20.20.100     3.60.10.10    

CDD

cd06660  Aldo_ket_red

ProteinModelPortal

A0A291P0Y9   A0A291P0U2   A0A2A4IYA3   A0A0F6Q2W6   H9JUP1   A0A194PKB3   + More
U5KBY4   G9F9F4   S4PY90   A0A2H1V815   A0A212F244   A0A2W1BI87   D2A296   A0A2A4JMB2   A0A291P0T7   D6WCX8   A0A1D2MB39   F4WLB5   D6WBX9   A0A1L8D6L9   V5GT06   G9F9G0   A0A3S2LZY0   A0A154PH71   A0A088AGI5   A0A232EMX7   A0A212FML6   A0A0T6B8Q2   B2DBM2   A0A2H1VGR3   A0A151WRD3   A0A151J3M8   H9JTG9   A0A084WAD5   A0A195CRM5   A0A195FYJ2   R4WNM5   I4DP16   A0A182K591   I4DKQ3   A0A443RGQ3   A0A2W1BC51   F4WLB4   A0A2A4JM15   V9IEZ4   A0A0T6AZ90   A0A182QI37   A0A2H1VAA3   A0A2R7WWN4   A0A2R7WXG0   A0A1W4WL13   A0A1I9WLL7   A0A2A3EI70   A0A182RUK3   A0A158NZF8   A0A2H1VAB6   V5GQ24   A0A194Q090   A0A182LYX7   T1DFA3   E9J719   A0A182YBI3   A0A2M3ZFC7   A0A182N3T0   A0A182VI74   A0A182WUG5   A0A182KKP7   Q7PF06   A0A182HW13   V5GXH0   A0A310S4F9   A0A291P0U1   A0A195BMW2   A0A182YBI5   A0A1W4W9Z3   W5JBU8   F5BYH7   U5KC00   Q17DM5   A0A2M4BTH9   A0A2M4AF69   A0A182FVL2   Q17DM4   A0A195CTD6   A0A291P0X3   J3JZ92   A0A2M4BTI2   A0A182JHG0   A0A182WDU3   A0A182QZ12   A0A151IW05   A0A088AGI6   A0A2A4J3U1   A0A291P0W3   A0A067QJF4   A0A2J7QL56   A0A182SQ44   A0A2A3EJL9   E2AB23   A0A437BCA7  

PDB

3WCZ     E-value=3.58128e-79,     Score=749

KEGG

101744065    K00011 aldehyde reductase [EC:1.1.1.21] | (RefSeq) aldo-keto reductase AKR2E4-like

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00051    Fructose and mannose metabolism - Bombyx mori (domestic silkworm)
00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0008106   GO:0004032   GO:0005829   GO:0008202   GO:0046983   GO:0016020   GO:0015074   GO:0006414   GO:0004816   GO:0005737   GO:0006421   GO:0016155   GO:0003824   GO:0055114  

PANTHER

PTHR11732  

Length:

305

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01187

outside

1  -  305

 

 

Pi

192.090801

Theta

157.59792

Tajima's D

1.175737

CLR

0.390087

CSRT

0.705664716764162

Interpretation

Uncertain