Gene

KWMTBOMO09901

Pre Gene Modal

BGIBMGA013166

Annotation

PREDICTED:_histone_deacetylase_3_[Bombyx_mori]

Location

Bomo_Chr16(+):11531494-11533549      View in EpiBrowser

Full name

Histone deacetylase      

Location in the cell

Cytoplasmic   Reliability : 1.12 Extracellular   Reliability : 1.26

CDS

ATGACTCAACAAAGGGTAGCGTATTTCTATAATCCGGACGTGGGTAATTTCCACTACGGTCCAGGGCATCCAATGAAACCACACAGGCTGGCTGTGACGCATTGTCTCGTGTTGAAGTATGGTCTTCATAAGAAAATGCAGATATATAAGCCGTATAGGGCCAGCGCTCACGATATGTGCCGTTTCCACAGCGAGGACTACATAGAGTTTCTGCAAAATGTAACTCCTCAAAATATACAGAGTTACTCAAAAGATCTTTTGCACTATAATGTTGGAGACGACTGTCCAGTATTCGAAGGTCTTTTCGATTTCTGCTCAATGTACACTGGAGCTTCATTGGAAGGTGCTATGAAGCTAAATAATAACACTTGTGACATTGCCATCAACTGGTCTGGGGGCTTGCATCATGCAAAGAAATTTGAACCTTCCGGATTTTGCTACGTCAATGATATAGTAATAGCAATTTTAGAGCTCCTAAAATATCATCCAAGGGTTCTGTACATAGATATTGATGTTCACCATGGAGATGGGGTTCAAGAAGCTTTTTACCTCACTGACCGAGTCATGACGGTTAGTTTCCACAAGTATGGGAACTATTTCTTCCCTGGAACGGGAGATATGTATGAAATTGGTGCAGAGAGTGGACGATATTATTCGGTAAATGTACCACTGAAAGAAGGCATAGATGATCAAAGCTACATACAGGTCAGTTTGGATGATTTATTATCTTAA

Protein

MTQQRVAYFYNPDVGNFHYGPGHPMKPHRLAVTHCLVLKYGLHKKMQIYKPYRASAHDMCRFHSEDYIEFLQNVTPQNIQSYSKDLLHYNVGDDCPVFEGLFDFCSMYTGASLEGAMKLNNNTCDIAINWSGGLHHAKKFEPSGFCYVNDIVIAILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYIQVSLDDLLS

Catalytic Activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Similarity

Belongs to the histone deacetylase family. HD Type 1 subfamily.
Belongs to the 14-3-3 family.

Uniprot

A0A437B1G7   S4PZV6   A0A212F234   A0A2H1X2Q6   A0A2A4JPL6   A0A0B5WYL7   + More
A0A194PIE2   A0A2J7R7Y7   A0A067R7R1   A0A2P8Y1E2   A0A2A3ESH4   A0A0M8ZVL7   A0A087ZYB8   A0A0L7R0K4   E0VKD4   A0A154PHT9   E2BDQ7   A0A0L8FHS1   F4WLJ6   A0A195EDT5   A0A195AV22   A0A195FWD1   A0A158NN93   A0A151XAF7   A0A195CR97   E9IVN9   V5GPE9   A0A232EXV9   A0A0J7KJK1   E1ZX52   K7ILW2   A0A1W4XTM3   A0A1B0D7S5   A0A131XHG3   A0A026WVG4   A0A0V0G9K2   D6WYS7   A0A131Z5C7   A0A1Y1K2Q7   L7MDR1   A0A224YUX6   A0A023G4L6   A0A0P4VL73   V5HVX6   A0A069DUM6   A0A023FUV4   A0A023F5P1   A0A2L2Y721   A0A182XNZ7   A0A1Z5LFZ1   A0A182HBL8   Q16QZ8   T1HNM1   A0A1L7N252   U5EVN6   A0A182VGB9   A0A182TF68   A0A182L8D0   Q7PX00   A0A182HK42   A0A087UPN1   A0A182YNC5   A0A182IW81   A0A293M5N3   A0A182RG01   A0A0A9WDV4   T1J752   A0A182PR77   A0A182JRG3   A0A182MEP8   A0A182QSK7   A0A182NQZ5   A0A1B0GIB0   A0A2M4BNS3   A0A2M3Z9Z7   A0A182FSA0   W5J5F1   J9KAR8   A0A1L8DWY8   A0A084W0K0   A0A2H8TMX3   A0A2M4ANK6   A0A336LLV5   B0X1P4   A0A1E1XAS3   A0A2R7VRL2   A0A1Q3F463   A0A1D2MJ42   A0A0P5B0K4   A0A0P6FEZ1   A0A1S3IYF3   A0A0P6EVN2   E9GEV8   A0A0P6GFG8   A0A1B6LRK8   A0A0P5V7Q1   A0A0P5WXA5   A0A0P5EVU3   A0A210QF79   A0A1A9XU26  

EC Number

3.5.1.98

Pubmed

23622113    22118469    28756777    26354079    24845553    29403074    + More
20566863    20798317    21719571    21347285    21282665    28648823    20075255    28049606    24508170    30249741    18362917    19820115    26830274    28004739    25576852    28797301    27129103    25765539    26334808    25474469    26561354    28528879    26483478    17510324    27956627    20966253    12364791    14747013    17210077    25244985    25401762    26823975    20920257    23761445    24438588    28503490    27289101    21292972    28812685   

EMBL

RSAL01000212    RVE44174.1    GAIX01000873    JAA91687.1    AGBW02010783    OWR47805.1    + More
ODYU01013000    SOQ59595.1    NWSH01000876    PCG73759.1    KM983338    KZ150072    AJH76982.1    PZC74020.1    KQ459602    KPI93181.1    NEVH01006723    PNF36945.1    KK852685    KDR18505.1    KDR18506.1    PYGN01001050    PSN38082.1    KZ288191    PBC34464.1    KQ435826    KOX72040.1    KQ414670    KOC64385.1    DS235242    EEB13840.1    KQ434912    KZC11393.1    GL447678    EFN86219.1    KQ431332    KOF63223.1    GL888208    EGI64932.1    KQ979039    KYN23368.1    KQ976738    KYM75875.1    KQ981208    KYN44753.1    ADTU01021179    KQ982351    KYQ57268.1    KQ977372    KYN03263.1    GL766328    EFZ15349.1    GALX01002482    JAB65984.1    NNAY01001656    OXU23306.1    LBMM01006632    KMQ90447.1    GL435014    EFN74242.1    AJVK01012514    GEFH01003505    JAP65076.1    KK107085    QOIP01000008    EZA60030.1    RLU19868.1    GECL01001493    JAP04631.1    KQ971357    EFA08457.1    GEDV01002911    JAP85646.1    GEZM01098405    GEZM01098404    JAV53895.1    GACK01002668    JAA62366.1    GFPF01008403    MAA19549.1    GBBM01006242    JAC29176.1    GDKW01000730    JAI55865.1    GANP01001704    JAB82764.1    GBGD01001517    JAC87372.1    GBBK01000029    JAC24453.1    GBBI01002228    JAC16484.1    IAAA01016117    LAA03969.1    GFJQ02000657    JAW06313.1    JXUM01125249    KQ566924    KXJ69730.1    CH477727    EAT36822.1    ACPB03012017    LC096258    BAW19562.1    GANO01001798    JAB58073.1    AAAB01008987    EAA01056.5    APCN01000816    KK120903    KFM79320.1    GFWV01009681    MAA34410.1    GBHO01037002    GDHC01018870    JAG06602.1    JAP99758.1    JH431912    AXCM01000085    AXCN02001485    AJWK01013622    AJWK01013623    GGFJ01005521    MBW54662.1    GGFM01004590    MBW25341.1    ADMH02002066    ETN59692.1    ABLF02027678    GFDF01003121    JAV10963.1    ATLV01019122    KE525262    KFB43744.1    GFXV01003670    MBW15475.1    GGFK01009055    MBW42376.1    UFQT01000046    SSX18880.1    DS232266    EDS38772.1    GFAC01002834    JAT96354.1    KK854012    PTY09310.1    GFDL01012701    JAV22344.1    LJIJ01001095    ODM93026.1    GDIP01191732    JAJ31670.1    GDIQ01060813    JAN33924.1    GDIQ01070157    JAN24580.1    GL732541    EFX81904.1    GDIQ01046326    JAN48411.1    GEBQ01013617    JAT26360.1    GDIP01104102    JAL99612.1    GDIP01080645    JAM23070.1    GDIP01233394    GDIP01233393    GDIP01154748    GDIP01154747    GDIP01148654    GDIP01148653    GDIQ01102898    GDIP01141854    GDIP01141853    GDIP01141852    GDIP01134453    GDIP01134452    GDIP01115204    GDIP01115203    GDIP01113758    GDIP01113757    GDIP01052264    GDIP01052263    GDIQ01062710    LRGB01002121    JAJ68654.1    JAL48828.1    KZS09068.1    NEDP02003918    OWF47395.1   

Proteomes

UP000283053    UP000007151    UP000218220    UP000053268    UP000235965    UP000027135    + More
UP000245037    UP000242457    UP000053105    UP000005203    UP000053825    UP000009046    UP000076502    UP000008237    UP000053454    UP000007755    UP000078492    UP000078540    UP000078541    UP000005205    UP000075809    UP000078542    UP000215335    UP000036403    UP000000311    UP000002358    UP000192223    UP000092462    UP000053097    UP000279307    UP000007266    UP000076407    UP000069940    UP000249989    UP000008820    UP000015103    UP000075903    UP000075902    UP000075882    UP000007062    UP000075840    UP000054359    UP000076408    UP000075880    UP000075900    UP000075885    UP000075881    UP000075883    UP000075886    UP000075884    UP000092461    UP000069272    UP000000673    UP000007819    UP000030765    UP000002320    UP000094527    UP000085678    UP000000305    UP000076858    UP000242188    UP000092443   

Pfam

PF00850   Hist_deacetyl        + More
PF00244   14-3-3

Interpro

IPR003084   His_deacetylse_1        + More
IPR037138   His_deacetylse_dom_sf       
IPR023696   Ureohydrolase_dom_sf       
IPR000286   His_deacetylse       
IPR023801   His_deacetylse_dom       
IPR036815   14-3-3_dom_sf       
IPR000308   14-3-3       
IPR023409   14-3-3_CS       
IPR023410   14-3-3_domain       

SUPFAM

SSF52768   SSF52768        + More
SSF48445   SSF48445       

Gene 3D

3.40.800.20     1.20.190.20    

ProteinModelPortal

A0A437B1G7   S4PZV6   A0A212F234   A0A2H1X2Q6   A0A2A4JPL6   A0A0B5WYL7   + More
A0A194PIE2   A0A2J7R7Y7   A0A067R7R1   A0A2P8Y1E2   A0A2A3ESH4   A0A0M8ZVL7   A0A087ZYB8   A0A0L7R0K4   E0VKD4   A0A154PHT9   E2BDQ7   A0A0L8FHS1   F4WLJ6   A0A195EDT5   A0A195AV22   A0A195FWD1   A0A158NN93   A0A151XAF7   A0A195CR97   E9IVN9   V5GPE9   A0A232EXV9   A0A0J7KJK1   E1ZX52   K7ILW2   A0A1W4XTM3   A0A1B0D7S5   A0A131XHG3   A0A026WVG4   A0A0V0G9K2   D6WYS7   A0A131Z5C7   A0A1Y1K2Q7   L7MDR1   A0A224YUX6   A0A023G4L6   A0A0P4VL73   V5HVX6   A0A069DUM6   A0A023FUV4   A0A023F5P1   A0A2L2Y721   A0A182XNZ7   A0A1Z5LFZ1   A0A182HBL8   Q16QZ8   T1HNM1   A0A1L7N252   U5EVN6   A0A182VGB9   A0A182TF68   A0A182L8D0   Q7PX00   A0A182HK42   A0A087UPN1   A0A182YNC5   A0A182IW81   A0A293M5N3   A0A182RG01   A0A0A9WDV4   T1J752   A0A182PR77   A0A182JRG3   A0A182MEP8   A0A182QSK7   A0A182NQZ5   A0A1B0GIB0   A0A2M4BNS3   A0A2M3Z9Z7   A0A182FSA0   W5J5F1   J9KAR8   A0A1L8DWY8   A0A084W0K0   A0A2H8TMX3   A0A2M4ANK6   A0A336LLV5   B0X1P4   A0A1E1XAS3   A0A2R7VRL2   A0A1Q3F463   A0A1D2MJ42   A0A0P5B0K4   A0A0P6FEZ1   A0A1S3IYF3   A0A0P6EVN2   E9GEV8   A0A0P6GFG8   A0A1B6LRK8   A0A0P5V7Q1   A0A0P5WXA5   A0A0P5EVU3   A0A210QF79   A0A1A9XU26  

PDB

4A69     E-value=2.68791e-114,     Score=1051

KEGG

101744884    K11404 histone deacetylase 3 [EC:3.5.1.98] | (RefSeq) histone deacetylase 3

GO

GO:0046872   GO:0004407   GO:0032041   GO:0005634   GO:0000118   GO:0070932   GO:0070933   GO:0045944   GO:0016787   GO:0019904   GO:0016575   GO:0006810   GO:0006412   GO:0006414   GO:0004816   GO:0005737   GO:0006421   GO:0016155   GO:0003824  

Subcellular location

Nucleus  

Length:

243

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02426

Exp number, first 60 AAs:

0.00492

Total prob of N-in:

0.16085

outside

1  -  243

 

 

Pi

14.499429

Theta

18.230547

Tajima's D

-0.72985

CLR

0.749271

CSRT

0.191190440477976

Interpretation

Uncertain