Gene

KWMTBOMO09833  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013129

Annotation

PREDICTED:_glucosylceramidase-like_isoform_X2_[Papilio_xuthus]

Location

Bomo_Chr16(+):9987143-10000037      View in EpiBrowser

Full name

Glucosylceramidase      

Location in the cell

PlasmaMembrane   Reliability : 2.324

CDS

ATGAAAATTTTAATTTGCATTTCTTTGTTAATATTCTACGTATCTTTGAAAGGAGCTCTTTCTGATACCGTATGCCAGGCGAGAGGATCGGATGCGATTGTTTGTGTTTGTAACGACACGTATTGCGATACTGTGACGAGGGAACCTCCGATTATAGGCGCATATAACACCTACACCACATCCGAGAGCGGCTTGCGATTCAGCAAAACTGGAGGAACATTAAACCCGTATAATAATTTAACGCAATGTGGGACGACATTAGTAATAGAACCAAGAGTGAGACATCAAATGATCGAGGGCTTCGGTGGGGCCGTCACTGACGCTGCCGGTATTCACTGGAAGAGCTTGTCGCAAAACTTGCAGAATCATCTTATCGAGTCATACTTCAGCCGCAACGGTCTTGAGTATAACATGATACGCGTTCCGATCGGTGGATCGGATTTCTCAACTCATCCGTACGCATACAACGAATTCCCGGAAAACGATGCAACGCTAAGTAACTTCACACTAGCTAAAGAAGACTACCAGTATAAGATTCCATTGATAAAATCGGCAATGAGTGCCACAAAGAGACAGATCCACATAGTCGCTACGACCTGGTCTCCGCCACCTTGGATGAAAACCAACAACCGGTATTCGGGTATCAGCAGGCTCAAACCTGAATATTTCCAGACCTACGCTGACTACCATCTGAAATTTATACAGAAGTACGCTGATGAAGGAATTCCGGTTTGGGCGATCACAACCACGAACGAACCCTTGTCAGGGATGCTTGGCTTGGACTCTTTTAATACTCTAGGATGGACACAAGATCAAATGGCAAAATGGATAATAAATAATTTAGGACCGACAATTAGGAATTCGACGCACAAAAATACAAAAATACTAGCTGTTGATGATCAGAGAATATCAATACCTTACTGGTTTAACTATATGGTCGCAAAGAACCCGAAGACCTTGGATTATATAGACGGTATAGCCGTGCATTACTACACAGATTTCATCACCCCTGCCTATATATTGACAGAGGTCTCCAAAGCGTTTCCTGATAAGTTTATTTTGGCTACCGAAGCATGTGAAGGAAGTTTCCCGTGGCAGAAGAATAAAGTGGAGCTCGGTTCCTGGACGAGGGCTGCAAACTATATAAACGACATTATAACAGATCTAAATCATAATGTGGTCGGCTGGATAGATTGGAATTTGTGTTTAGACGTCAATGGCGGGCCGAATTGGGCCAAGAACTTCGTTGATTCCCCGATCATAGTTTTCCCCGAAAATGGGGAGTTTGTGAAGCAGCCGATGTTCTATGCGATCGGTCACTTCTCAAAGTTCATACCAAGAGGTTCAGTGCGGATCAAGGTTCATGAAAGAAAAAGAATCTTCTCGAAATCAATAGAAAATGTAGCTTTCTTAACGCCATACGGTACCATTGTTGCTGTGCTTTATAACAGAGGCAACAGAGCTTCCGTGAAAATAAAAATACGAACGAAAGAGATTGTATTAGAATTATTAGCAAAATCGATCAGTACAGTGGAATTTCCCTATAAAACATAG

Protein

MKILICISLLIFYVSLKGALSDTVCQARGSDAIVCVCNDTYCDTVTREPPIIGAYNTYTTSESGLRFSKTGGTLNPYNNLTQCGTTLVIEPRVRHQMIEGFGGAVTDAAGIHWKSLSQNLQNHLIESYFSRNGLEYNMIRVPIGGSDFSTHPYAYNEFPENDATLSNFTLAKEDYQYKIPLIKSAMSATKRQIHIVATTWSPPPWMKTNNRYSGISRLKPEYFQTYADYHLKFIQKYADEGIPVWAITTTNEPLSGMLGLDSFNTLGWTQDQMAKWIINNLGPTIRNSTHKNTKILAVDDQRISIPYWFNYMVAKNPKTLDYIDGIAVHYYTDFITPAYILTEVSKAFPDKFILATEACEGSFPWQKNKVELGSWTRAANYINDIITDLNHNVVGWIDWNLCLDVNGGPNWAKNFVDSPIIVFPENGEFVKQPMFYAIGHFSKFIPRGSVRIKVHERKRIFSKSIENVAFLTPYGTIVAVLYNRGNRASVKIKIRTKEIVLELLAKSISTVEFPYKT

Catalytic Activity

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose

Similarity

Belongs to the glycosyl hydrolase 30 family.

Feature

chain  Glucosylceramidase

Uniprot

H9JUB6   A0A2H1VUS0   A0A194PPY1   A0A437BUD8   A0A1W1EGM7   A0A437B0B5   + More
A0A194Q614   A0A2A4K975   A0A2H1VG50   A0A212F248   A0A212F254   A0A2H1X380   A0A067QM95   A0A212F293   A0A0C9QXG4   A0A0N1IF15   A0A2H1VST3   A0A1B6FTD6   A0A2J7R6J1   A0A1B6IGC1   A0A1B6K1N7   H9JUB7   A0A194RBR5   A0A154P4F4   D6WRN0   A0A2A4K8P8   A0A1W2W3C7   A0A139WEE1   A0A0L7QMS7   A0A2H1WWW7   L7M0C6   H2YMC3   F7AA01   H2XQ11   A0A088APM4   A0A0P5V115   A0A0P5D4A0   T1JDD3   A0A0P6CTA3   A0A1B6CTI6   A0A182YB56   K7IX35   A0A182PGK5   A0A0P5V259   A0A0P5BE18   A0A0P6HWY3   A0A2A3EMA9   A0A182WSK9   A0A232EVH8   A0A182HLG2   A0A182SVA6   A0A182U728   Q7PXX9   A0A182L9U2   F6VKK2   A0A0P5VAG5   A0A212FNA8   A0A2D4IM94   U3DIF4   A0A210PEG6   U3DTR8   A0A131YKA6   A0A182US45   F7E7C1   A0A182MB91   A0A226EKU6   A0A2K5QV83   A0A250YJK2   A0A2K6SNW8   A0A3S2NLJ3   A0A162QRA1   V4B2P4   A0A2K5QVB6   A0A224YYV0   U3FUA9   A0A2K6ABH7   A0A158NXS0   A0A0N8C3M9   A0A0P5XL26   A0A2C9K3D4   A0A0N8A576   D6WRR5   A0A0P5WP50   A0A1Z5L9E9   K9J1N7   A0A0P5BMC7   A0A1D2MYE0   H3AB74   A0A0P5Z7Y2   H3AB73   A0A139WEN3   A0A034VZ93   A0A3Q7ULG3   A0A3Q7VSS4   L9KHN0   A0A182VZF3   A0A154P6S3   A0A0K8U5E6   A0A0P5X120  

EC Number

3.2.1.45

Pubmed

19121390    26354079    28680679    22118469    24845553    18362917    + More
19820115    25576852    12481130    15114417    25244985    20075255    28648823    12364791    14747013    17210077    20966253    17495919    25243066    28812685    26830274    28087693    23254933    28797301    21347285    15562597    28528879    27289101    9215903    25348373    23385571   

EMBL

BABH01038539    BABH01038540    BABH01038541    ODYU01004571    SOQ44585.1    KQ459602    + More
KPI93190.1    RSAL01000008    RVE53975.1    LT635665    SGZ49395.1    RSAL01000232    RVE43819.1    KQ459439    KPJ00977.1    NWSH01000035    PCG80448.1    ODYU01002190    SOQ39362.1    AGBW02010783    OWR47794.1    OWR47828.1    ODYU01013051    SOQ59702.1    KK853153    KDR10552.1    OWR47849.1    GBYB01005352    JAG75119.1    KQ461178    KPJ07773.1    ODYU01004232    SOQ43893.1    GECZ01016297    JAS53472.1    NEVH01006756    PNF36452.1    GECU01021735    JAS85971.1    GECU01002337    JAT05370.1    BABH01038531    BABH01038532    BABH01038533    BABH01038534    KQ460397    KPJ15278.1    KQ434814    KZC06829.1    KQ971354    EFA07058.2    PCG80449.1    KYB26348.1    KQ414868    KOC59952.1    ODYU01011672    SOQ57565.1    GACK01007712    JAA57322.1    EAAA01001913    GDIP01105548    JAL98166.1    GDIP01163230    LRGB01000311    JAJ60172.1    KZS19886.1    JH432104    GDIP01009481    JAM94234.1    GEDC01023766    GEDC01020570    GEDC01011572    GEDC01003214    JAS13532.1    JAS16728.1    JAS25726.1    JAS34084.1    AAZX01006377    AAZX01006727    GDIP01105549    JAL98165.1    GDIP01190080    JAJ33322.1    GDIQ01028607    JAN66130.1    KZ288219    PBC32336.1    NNAY01001997    OXU22351.1    APCN01000897    AAAB01008987    EAA00933.5    GDIP01102691    JAM01024.1    AGBW02006772    OWR55189.1    IACK01117848    LAA85338.1    GAMR01001910    JAB32022.1    NEDP02076748    OWF34883.1    GAMT01003193    GAMS01007908    GAMQ01006239    JAB08668.1    JAB15228.1    JAB35612.1    GEDV01009569    JAP78988.1    AXCM01012486    LNIX01000003    OXA58323.1    GFFW01001008    JAV43780.1    RVE53974.1    KZS19887.1    KB200701    ESP00722.1    GFPF01008008    MAA19154.1    GAMP01004625    JAB48130.1    ADTU01003452    ADTU01003453    ADTU01003454    ADTU01003455    GDIQ01118027    JAL33699.1    GDIP01070494    JAM33221.1    GDIP01181329    JAJ42073.1    EFA05962.2    GDIP01083544    JAM20171.1    GFJQ02003035    JAW03935.1    GABZ01005456    JAA48069.1    GDIP01182978    JAJ40424.1    LJIJ01000420    ODM97675.1    AFYH01203350    AFYH01203351    AFYH01203352    GDIP01060297    JAM43418.1    KYB26349.1    GAKP01011233    JAC47719.1    KB320819    ELW62425.1    KZC06830.1    GDHF01030553    JAI21761.1    GDIP01079198    JAM24517.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000218220    UP000007151    UP000027135    + More
UP000053240    UP000235965    UP000076502    UP000007266    UP000053825    UP000007875    UP000008144    UP000005203    UP000076858    UP000076408    UP000002358    UP000075885    UP000242457    UP000076407    UP000215335    UP000075840    UP000075901    UP000075902    UP000007062    UP000075882    UP000002280    UP000242188    UP000075903    UP000008225    UP000075883    UP000198287    UP000233040    UP000233220    UP000030746    UP000233140    UP000005205    UP000076420    UP000094527    UP000008672    UP000286642    UP000011518    UP000075920   

PRIDE

H9JUB6    H9JUB7   

Pfam

PF17189   Glyco_hydro_30C        + More
PF02055   Glyco_hydro_30

Interpro

IPR001139   Glyco_hydro_30        + More
IPR013780   Glyco_hydro_b       
IPR033453   Glyco_hydro_30_TIM-barrel       
IPR033452   GH30_C       
IPR017853   Glycoside_hydrolase_SF       

SUPFAM

SSF51445   SSF51445       

Gene 3D

2.60.40.1180    

ProteinModelPortal

H9JUB6   A0A2H1VUS0   A0A194PPY1   A0A437BUD8   A0A1W1EGM7   A0A437B0B5   + More
A0A194Q614   A0A2A4K975   A0A2H1VG50   A0A212F248   A0A212F254   A0A2H1X380   A0A067QM95   A0A212F293   A0A0C9QXG4   A0A0N1IF15   A0A2H1VST3   A0A1B6FTD6   A0A2J7R6J1   A0A1B6IGC1   A0A1B6K1N7   H9JUB7   A0A194RBR5   A0A154P4F4   D6WRN0   A0A2A4K8P8   A0A1W2W3C7   A0A139WEE1   A0A0L7QMS7   A0A2H1WWW7   L7M0C6   H2YMC3   F7AA01   H2XQ11   A0A088APM4   A0A0P5V115   A0A0P5D4A0   T1JDD3   A0A0P6CTA3   A0A1B6CTI6   A0A182YB56   K7IX35   A0A182PGK5   A0A0P5V259   A0A0P5BE18   A0A0P6HWY3   A0A2A3EMA9   A0A182WSK9   A0A232EVH8   A0A182HLG2   A0A182SVA6   A0A182U728   Q7PXX9   A0A182L9U2   F6VKK2   A0A0P5VAG5   A0A212FNA8   A0A2D4IM94   U3DIF4   A0A210PEG6   U3DTR8   A0A131YKA6   A0A182US45   F7E7C1   A0A182MB91   A0A226EKU6   A0A2K5QV83   A0A250YJK2   A0A2K6SNW8   A0A3S2NLJ3   A0A162QRA1   V4B2P4   A0A2K5QVB6   A0A224YYV0   U3FUA9   A0A2K6ABH7   A0A158NXS0   A0A0N8C3M9   A0A0P5XL26   A0A2C9K3D4   A0A0N8A576   D6WRR5   A0A0P5WP50   A0A1Z5L9E9   K9J1N7   A0A0P5BMC7   A0A1D2MYE0   H3AB74   A0A0P5Z7Y2   H3AB73   A0A139WEN3   A0A034VZ93   A0A3Q7ULG3   A0A3Q7VSS4   L9KHN0   A0A182VZF3   A0A154P6S3   A0A0K8U5E6   A0A0P5X120  

PDB

2XWE     E-value=1.21836e-109,     Score=1015

KEGG

101742640    K01201 glucosylceramidase [EC:3.2.1.45] | (RefSeq) glucosylceramidase-like

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0006665   GO:0004348   GO:0006680   GO:0016787   GO:0016021   GO:0032715   GO:0050295   GO:0032436   GO:0005783   GO:0005615   GO:0046512   GO:0009267   GO:0007040   GO:0032463   GO:0043202   GO:1905037   GO:0005765   GO:0043243   GO:1903061   GO:0023021   GO:0030259   GO:0071356   GO:0005124   GO:0005802   GO:0046527   GO:1904457   GO:0046513   GO:0035307   GO:1904925   GO:0032006   GO:0008203   GO:1901215   GO:0043407   GO:1903052   GO:0006914   GO:0005975   GO:0008270   GO:0005488   GO:0008565   GO:0015031   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR11069  

SignalP

Position:   1 - 21,         Likelihood:  0.998903

 

 

Length:

517

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.28765

Exp number, first 60 AAs:

0.18378

Total prob of N-in:

0.01012

outside

1  -  517

 

 

Pi

182.318393

Theta

166.879161

Tajima's D

0.37754

CLR

0.581239

CSRT

0.474176291185441

Interpretation

Uncertain