Gene

KWMTBOMO09830  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013134

Annotation

cell_division_cycle_2_[Bombyx_mori]

Location

Bomo_Chr16(-):9953789-9958322      View in EpiBrowser

Full name

Cyclin-dependent kinase 1      

Alternative Name

Cell division control protein 2 homolog
Cell division protein kinase 1
p34 protein kinase

Location in the cell

Cytoplasmic   Reliability : 2.477

CDS

ATGGATGATTTCTTAAAGATAGAAAAGATCGGCGAAGGTACTTACGGTGTCGTTTACAAAGGAAAAAACAAAATAACTGGTCAATTTGTAGCCATGAAAAAAATTCGCTTGGAGTCCGAAGACGAAGGCATACCATCCACGGCAATAAGAGAAATATCTCTACTTAAAGAACTGAACCACCCTAATATTGTCAAGTTGGAGGATGTCCTGATGGAAGAGTCGCGACTTTACTTAATCTTCGAATTCCTCTCTATGGACTTGAAGAAATATATGGACTCCCTTGGTTCTGGAAAGTTCATGGACCCATCTGTAGTTAAGAGCTATCTATATCAAATCAACAATGCCATCTTGTACTGTCACCAACGACGGATCCTGCATCGAGATCTCAAACCACAGAACCTACTCATCGACAAGACTGGAATCATTAAAGTTGCAGATTTTGGTCTTGGTCGAGCATTCGGTGTTCCAGTGCGGGTCTACACACATGAAGTTGTCACATTGTGGTACAGGGCTCCTGAGGTCTTACTAGGAAGTCAAAGATACTCTTGTCCAATTGATATATGGTCAGTTGGCTGTATATTCTCTGAGATGTCATCAAAGAAGCCACTGTTTCAAGGAGACTCTGAAATTGATCAACTCTTCCGCATTTTCAGAATGCTAAGAACGCCAACAGAAGAGATATGGCCTGGTGTTTCTCTCCTACCAGACTACAAGCCAACCTTCCCGAACTGGAACACGTACAATCTGCACAATCATGTACAAAACCTAGACGAAGTGGGCATGGATTTGTTACAAAAGATGTTAGTCTACGATCCGGTTAAAAGAATATCCGCGAAGGACGCGCGACGACACAAGTACTTTAGAGACGTGAAACTACCTCCCGGACTGACAGTGCACGACGCTTACATCAGAGTGACGCCAGAATACCCATACGACACGGATTCTGTTCAAAGTGTATAG

Protein

MDDFLKIEKIGEGTYGVVYKGKNKITGQFVAMKKIRLESEDEGIPSTAIREISLLKELNHPNIVKLEDVLMEESRLYLIFEFLSMDLKKYMDSLGSGKFMDPSVVKSYLYQINNAILYCHQRRILHRDLKPQNLLIDKTGIIKVADFGLGRAFGVPVRVYTHEVVTLWYRAPEVLLGSQRYSCPIDIWSVGCIFSEMSSKKPLFQGDSEIDQLFRIFRMLRTPTEEIWPGVSLLPDYKPTFPNWNTYNLHNHVQNLDEVGMDLLQKMLVYDPVKRISAKDARRHKYFRDVKLPPGLTVHDAYIRVTPEYPYDTDSVQSV

Description

Plays a key role in the control of the eukaryotic cell cycle (PubMed:2120044, PubMed:15581871). It is required in higher cells for entry into S-phase and mitosis (PubMed:2120044, PubMed:15581871, PubMed:29746464). In embryos, promotes the release of Rif1 from chromatin during mid-blastula transition (PubMed:29746464). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (PubMed:2120044).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]

Subunit

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Component of the Frs-CycA-Cdk1 complex composed of Cdk1, CycA and Z600 (PubMed:17431409).

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Keywords

ATP-binding   Cell cycle   Cell division   Complete proteome   Kinase   Mitosis   Nucleotide-binding   Nucleus   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Cyclin-dependent kinase 1

Uniprot

O17507   A0A2A4K9H0   A0A0N0PAS1   A0A437BIF8   B5U1S7   A0A212F219   + More
S4P3S9   A0A2A4K956   A0A067R2Y5   A0A2Z5TRS3   A0A1W4W9T3   A0A232F4F9   K7IS13   A0A2J7QZB0   A0A2J7QZB4   A0A310SIN9   A0A2A3EA15   A0A088A4R1   A0A1B6G3S9   A0A1B6INW1   A0A182JKT4   A0A1A9YD72   A0A1B0BUS5   A0A0K8UJ97   A0A034WGE1   A0A1B0GAL7   A0A1A9ZQV8   A0A0J7L7H9   A0A026WIZ1   A0A1A9VJA0   W8B9F6   A0A084VPR1   E9ISV0   A0A1J1HXL4   B0W261   A0A0L0CFH7   A0A0P6ILI8   A0A1Q3EWI8   D2A4I9   A0A1I8NYI8   A0A0P5LLB5   B4MG43   E2BR44   A0A182GLA7   E9H7Q1   Q16Y81   B3MJG3   B4JP29   A0A0P5GSM7   A0A1I8MNT0   A0A0P6GX11   A0A1B6EGF7   B3N9N4   A0A0M4E1F8   A0A0P6B4G7   A0A0J9TKI8   B4NZN0   B4HWM9   C0MJ66   P23572   A0A151WVD3   A0A158NZR9   A0ANU2   W5J5N0   A0A195BEF1   B4G798   A0A291S6U3   A0A182F595   A0A1W4UT73   G0YA72   F4WI76   A0A195F2S6   A0A023F3U5   T1HZ72   A0A151IXW2   B4KJH9   I6LPK8   A0A2J7QZA7   A0A154PNS2   A0A182M9V6   A0A182KCW2   A0A182P7F3   A0A182RGB2   A0A1U8YID4   A0A182Q1I3   A0A1A9ZKZ6   J3JUQ2   A0A0P4WIQ9   A0A182NEJ8   B6E5Q1   A0A182V9G5   A0A182UC56   A0A182L5G4   A0A182XIQ5   Q7QKF5   A0A182HG33   A0A195CM85   A0A182YG01   B5TVE0   A0A210QSV7  

Pubmed

9099577    19121390    26354079    22118469    23622113    24845553    + More
26760975    28648823    20075255    25348373    24508170    30249741    24495485    24438588    21282665    26108605    18362917    19820115    17994087    20798317    26483478    21292972    17510324    25315136    22936249    17550304    19126864    2120045    2120044    8223248    16951084    10731132    12537572    12537569    8405984    15581871    17431409    18327897    29746464    21347285    20920257    23761445    28992199    21719571    25474469    22516182    19118638    20966253    12364791    14747013    17210077    25244985    28812685   

EMBL

BABH01038541    D85134    BAA21483.1    NWSH01000035    PCG80443.1    KQ461178    + More
KPJ07774.1    RSAL01000051    RVE50217.1    FJ157364    ACH95804.1    AGBW02010783    OWR47795.1    GAIX01006309    JAA86251.1    PCG80444.1    KK853042    KDR12146.1    FX985780    BBA93667.1    NNAY01001030    OXU25419.1    NEVH01009070    PNF33917.1    PNF33916.1    KQ760801    OAD58957.1    KZ288315    PBC28324.1    GECZ01012673    JAS57096.1    GECU01019094    GECU01014922    JAS88612.1    JAS92784.1    JXJN01020906    GDHF01025580    JAI26734.1    GAKP01006114    JAC52838.1    CCAG010011279    LBMM01000393    KMQ98492.1    KK107182    QOIP01000003    EZA56012.1    RLU24703.1    GAMC01016742    GAMC01016739    JAB89816.1    ATLV01015028    KE524999    KFB39955.1    GL765434    EFZ16248.1    CVRI01000020    CRK90881.1    DS231825    EDS28189.1    JRES01000469    KNC30995.1    GDIP01025071    GDIQ01019885    GDIQ01006945    JAM78644.1    JAN74852.1    GFDL01015409    JAV19636.1    KQ971344    EFA05799.2    GDIQ01192866    JAK58859.1    CH940671    EDW58181.1    GL449898    EFN81850.1    JXUM01001773    KQ560128    KXJ84300.1    GL732601    EFX72219.1    CH477522    EAT39587.1    CH902620    EDV32331.1    CH916372    EDV99454.1    GDIQ01243660    JAK08065.1    GDIQ01028216    JAN66521.1    GEDC01000532    GEDC01000299    JAS36766.1    JAS36999.1    CH954177    EDV58529.1    CP012523    ALC39191.1    GDIP01022267    JAM81448.1    CM002910    KMY89515.1    CM000157    EDW88814.1    CH480818    EDW52424.1    FM245388    FM245389    FM245390    FM245391    FM245392    FM245393    FM245394    FM245395    FM245396    FM245397    FM245398    CAR93314.1    CAR93315.1    CAR93316.1    CAR93317.1    CAR93318.1    CAR93319.1    CAR93320.1    CAR93321.1    CAR93322.1    CAR93323.1    CAR93324.1    X57485    X57496    S66801    S66804    S66805    S66807    S66810    AM294319    AM294320    AM294321    AM294322    AM294323    AM294324    AM294325    AM294326    AM294327    AM294328    AM294329    AE014134    AY061450    KQ982717    KYQ51727.1    ADTU01004932    AM294330    CAL26260.1    ADMH02002093    ETN59296.1    KQ976511    KYM82589.1    CH479180    EDW28352.1    MF432981    ATL75332.1    HQ656803    AEJ91557.1    GL888175    EGI66007.1    KQ981856    KYN34686.1    GBBI01002612    JAC16100.1    ACPB03004679    KQ980791    KYN13117.1    CH933807    EDW13559.1    HQ457439    ADZ23998.1    PNF33918.1    KQ434999    KZC13377.1    AXCM01007160    KU866455    KY484157    AMP81926.1    AUZ97322.1    AXCN02000852    BT126967    AEE61929.1    GDRN01055977    GDRN01055976    JAI65892.1    FJ210468    ACI43009.1    AAAB01008797    EAA03621.4    APCN01004111    KQ977580    KYN01800.1    FJ015041    ACH88358.1    NEDP02002059    OWF51798.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000283053    UP000007151    UP000027135    + More
UP000192223    UP000215335    UP000002358    UP000235965    UP000242457    UP000005203    UP000075880    UP000092443    UP000092460    UP000092444    UP000092445    UP000036403    UP000053097    UP000279307    UP000078200    UP000030765    UP000183832    UP000002320    UP000037069    UP000007266    UP000095300    UP000008792    UP000008237    UP000069940    UP000249989    UP000000305    UP000008820    UP000007801    UP000001070    UP000095301    UP000008711    UP000092553    UP000002282    UP000001292    UP000000803    UP000075809    UP000005205    UP000000673    UP000078540    UP000008744    UP000069272    UP000192221    UP000007755    UP000078541    UP000015103    UP000078492    UP000009192    UP000076502    UP000075883    UP000075881    UP000075885    UP000075900    UP000075886    UP000075884    UP000075903    UP000075902    UP000075882    UP000076407    UP000007062    UP000075840    UP000078542    UP000076408    UP000242188   

PRIDE

O17507    C0MJ66    P23572   

Pfam

PF00069   Pkinase        + More
PF15477   SMAP

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR000719   Prot_kinase_dom       
IPR028124   SMAP_dom       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

O17507   A0A2A4K9H0   A0A0N0PAS1   A0A437BIF8   B5U1S7   A0A212F219   + More
S4P3S9   A0A2A4K956   A0A067R2Y5   A0A2Z5TRS3   A0A1W4W9T3   A0A232F4F9   K7IS13   A0A2J7QZB0   A0A2J7QZB4   A0A310SIN9   A0A2A3EA15   A0A088A4R1   A0A1B6G3S9   A0A1B6INW1   A0A182JKT4   A0A1A9YD72   A0A1B0BUS5   A0A0K8UJ97   A0A034WGE1   A0A1B0GAL7   A0A1A9ZQV8   A0A0J7L7H9   A0A026WIZ1   A0A1A9VJA0   W8B9F6   A0A084VPR1   E9ISV0   A0A1J1HXL4   B0W261   A0A0L0CFH7   A0A0P6ILI8   A0A1Q3EWI8   D2A4I9   A0A1I8NYI8   A0A0P5LLB5   B4MG43   E2BR44   A0A182GLA7   E9H7Q1   Q16Y81   B3MJG3   B4JP29   A0A0P5GSM7   A0A1I8MNT0   A0A0P6GX11   A0A1B6EGF7   B3N9N4   A0A0M4E1F8   A0A0P6B4G7   A0A0J9TKI8   B4NZN0   B4HWM9   C0MJ66   P23572   A0A151WVD3   A0A158NZR9   A0ANU2   W5J5N0   A0A195BEF1   B4G798   A0A291S6U3   A0A182F595   A0A1W4UT73   G0YA72   F4WI76   A0A195F2S6   A0A023F3U5   T1HZ72   A0A151IXW2   B4KJH9   I6LPK8   A0A2J7QZA7   A0A154PNS2   A0A182M9V6   A0A182KCW2   A0A182P7F3   A0A182RGB2   A0A1U8YID4   A0A182Q1I3   A0A1A9ZKZ6   J3JUQ2   A0A0P4WIQ9   A0A182NEJ8   B6E5Q1   A0A182V9G5   A0A182UC56   A0A182L5G4   A0A182XIQ5   Q7QKF5   A0A182HG33   A0A195CM85   A0A182YG01   B5TVE0   A0A210QSV7  

KEGG

693060    K02087 cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] | (RefSeq) Cdc2; cell division cycle 2

GO

GO:0005524   GO:0004674   GO:0004672   GO:0051301   GO:0003743   GO:0072686   GO:0044772   GO:0005737   GO:0005634   GO:0004693   GO:0006468   GO:0007284   GO:0032880   GO:0000082   GO:0030707   GO:0007095   GO:0000086   GO:0055059   GO:0030174   GO:0007140   GO:0001700   GO:0048142   GO:1901987   GO:0044818   GO:0008353   GO:0008270   GO:0005488   GO:0008565   GO:0015031   GO:0009258   GO:0016155   GO:0003824  

Subcellular location

Nucleus  

Length:

319

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00353

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01544

outside

1  -  319

 

 

Pi

241.660259

Theta

194.339088

Tajima's D

0.441669

CLR

1.030029

CSRT

0.499675016249188

Interpretation

Uncertain