Gene

KWMTBOMO09822

Pre Gene Modal

BGIBMGA013123

Annotation

PREDICTED:_farnesol_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr16(+):9851769-9860433      View in EpiBrowser

Full name

Farnesol dehydrogenase      

Alternative Name

NADP+-dependent farnesol dehydrogenase 1

Location in the cell

Cytoplasmic   Reliability : 1.242 Mitochondrial   Reliability : 1.205

CDS

ATGCAACGTTGGCAAGGCAAGACTGCTGTGATCAGTGGAGCTAGTGCCGGCATTGGCGCCGCCATCTGCGTGGTGTTGGCGGACGCGGGAATGAGGGTCGTCGGCCTAGCGAGGAGACCACAGCTAGTTGACCAATTACAGTCTCAAGTGAGAGGCAACGGTTCGATACACTCGAGGCGATGCGACGTATCGAATTCCGATGATGTGGCAGCGACATTCAAATGGATCGATGAACAGTTTGGTAACATTCACGCTCTGGTCAACAACGCTGGGATATTTCCAAAGGGACATATCACTGAAATAGGTGATAACATTCTTTCTGAAGAAACGTTGATGTCAGTAGTGGATATTAATCTAAAAGGACCAGTGATGTGTGCGCGACATGCAGTCGCTTCTATGAAGAGGGCTAGCTTTGATGGACATATTATTAATATCAACAGTATCGCTGGTCACTATGTTCCGTTTGCAGACATGTTCAACGTATATCCGGGAACAAAGCACGCTATCACCGCTTTCACAGAGACCTTAGCCAATGAGCTAGCGTACTTCAATAGTAAAATCAAAATAACGAGTTTGTCGCCGGGCCTGGTGGATACAGATATGGCTCCTCGCGTGGATGGAGAGCTTTCTTTTGCAGCACTATCGCCTCAGGACGTTGCCGAAGCTGTTCTCTATGTATTGTCCACGCCCCCTCATGTTAATATCAAGGAATTAACGATAACACCGGTGTCGGAGAAACGACTTTAA

Protein

MQRWQGKTAVISGASAGIGAAICVVLADAGMRVVGLARRPQLVDQLQSQVRGNGSIHSRRCDVSNSDDVAATFKWIDEQFGNIHALVNNAGIFPKGHITEIGDNILSEETLMSVVDINLKGPVMCARHAVASMKRASFDGHIININSIAGHYVPFADMFNVYPGTKHAITAFTETLANELAYFNSKIKITSLSPGLVDTDMAPRVDGELSFAALSPQDVAEAVLYVLSTPPHVNIKELTITPVSEKRL

Description

Mediates oxidation of farnesol into farnesal, a precursor of juvenile hormone in the corpora allata (CA), the glands that synthesize juvenile hormone. Able to oxidize C(10) to C(15) isoprenoid and aliphatic alcohols.

Catalytic Activity

(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH

Biophysicochemical Properties

91 uM for (E,E) farnesol
97 uM for (Z,Z) farnesol
184 uM for 2-decanol
208 uM for geraniol (E)
109 uM for nerol (Z)
133 uM for citronellol
195 uM for octanol

Subunit

Homodimer.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Complete proteome   NAD   NADP   Oxidoreductase   Reference proteome  

Feature

chain  Farnesol dehydrogenase

Uniprot

A0A2A4K9G6   A0A2H1VLM0   A0A194RJ27   A0A212F297   A0A194PRR4   A0A182WQQ7   + More
A0A1W7R8Z8   D2WKE1   A0A1S4G628   A0A182H2F7   A0A182H2F8   A0A1Q3FRN8   Q171F3   B0WCC9   A0A2K7P6E4   D2WKD9   A0A182HF88   A0NEE2   A0A182V9I2   W5JEC7   B0XBQ7   A0A1Q3FR56   A0A182LJK3   A0A3F2YSU5   A0A1S4G5Z6   A0A023EKY6   A0A1Q3FQF5   B0XBQ6   D2WKE0   A0A182HF87   A0A182RF95   A0A182WQQ6   B0WCD3   Q7Q752   B0WCC8   A0A182U549   A0A084W2Y7   W5JRL0   B0XBQ5   A0A023EL01   B0WCD2   A0A182UZL4   A0A182J8G1   A0A1Q3FRV7   T1D4L4   E0VGI8   A0A182LJK2   T1DGH0   A0A182PN70   U5EW40   A0A182QH30   B0XBQ4   B0WES0   A0A2M4CZ18   A0A182T3W7   A0A084WK67   A0A182SUP5   Q16S89   D2A5K3   A0A1Q3FK82   T1PFF9   A0A182Y0X3   A0A182FF12   A0A023EK81   A0A182WQQ4   A0A2M4CZ68   A0A2J7QD21   A0A336MZB0   B0W657   A0A1B0DIX8   A0A1S4FRH3   A0A2M4BXZ0   W5JNI2   B0W2W1   A0A084WK66   A0A182QJQ7   A0A182MNA0   A0A182Q2S3   A0A182H418   A0A182Q801   B0WCD1   Q17L62   A0A1Q3FSD3   A0A182XIL9   A0A1L8E530   A0A182LJK0   A0NEE1   A0A1I8MPJ0   A0A1S4G5E5   A0A182KB61   W5JII6   A0A182J4V4   B0WCD0   W5JF43   A0A1Y1MM39   A0A182SKY5   A0A1Y1LVC5   A0A182VBR6   A0A1S4EYV0   A0A084W2Y8  

EC Number

1.1.1.216

Pubmed

26354079    22118469    17510324    19940247    26483478    12364791    + More
14747013    17210077    20920257    23761445    20966253    24945155    24438588    24330624    20566863    18362917    19820115    25315136    25244985    28004739   

EMBL

NWSH01000035    PCG80433.1    ODYU01003041    SOQ41322.1    KQ460323    KPJ15946.1    + More
AGBW02010783    OWR47844.1    KQ459595    KPI96002.1    GEHC01000038    JAV47607.1    GQ344799    CH477512    ADB03641.1    EJY57753.1    JXUM01105272    KQ564952    KXJ71515.1    JXUM01105273    KXJ71516.1    GFDL01004952    JAV30093.1    CH477457    EAT40616.1    DS231886    EDS43374.1    GQ344797    ADB03639.1    EJY57755.1    JXUM01133703    KQ568016    KXJ69194.1    AAAB01008960    EAU76461.2    ADMH02001376    ETN62712.1    DS232648    EDS44406.1    GFDL01004976    JAV30069.1    APCN01004328    GAPW01003735    JAC09863.1    GFDL01005220    JAV29825.1    EDS44405.1    GQ344798    ADB03640.1    EJY57754.1    KXJ69193.1    EDS43378.1    EAA11736.1    EDS43373.1    ATLV01019729    KE525278    KFB44581.1    ADMH02000550    ETN65913.1    EDS44404.1    GAPW01003736    JAC09862.1    EDS43377.1    GFDL01004823    JAV30222.1    GALA01000908    JAA93944.1    DS235145    EEB12494.1    GALA01000192    JAA94660.1    GANO01001602    JAB58269.1    AXCN02000941    EDS44403.1    DS231911    EDS45833.1    GGFL01006395    MBW70573.1    ATLV01024096    KE525349    KFB50611.1    CH477680    EAT37326.1    KQ971345    EFA05382.1    GFDL01007159    JAV27886.1    KA647522    AFP62151.1    GAPW01004068    JAC09530.1    GGFL01006445    MBW70623.1    NEVH01015829    PNF26476.1    UFQS01001628    UFQT01001628    SSX11673.1    SSX31238.1    DS231847    EDS36404.1    AJVK01034577    GGFJ01008805    MBW57946.1    ETN65912.1    DS231829    EDS30320.1    KFB50610.1    AXCM01001467    JXUM01108609    KQ565247    KXJ71182.1    AXCN02000361    EDS43376.1    CH477218    EAT47433.1    GFDL01004570    JAV30475.1    GFDF01000429    JAV13655.1    EAU76460.1    ETN62710.1    EDS43375.1    ETN62711.1    GEZM01031296    JAV84946.1    GEZM01048963    JAV76240.1    KFB44582.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000053268    UP000075920    UP000008820    + More
UP000069940    UP000249989    UP000002320    UP000007062    UP000075903    UP000000673    UP000075882    UP000075840    UP000075900    UP000075902    UP000030765    UP000075880    UP000009046    UP000075885    UP000075886    UP000075901    UP000007266    UP000095301    UP000076408    UP000069272    UP000235965    UP000092462    UP000075883    UP000076407    UP000075881   

Pfam

PF00106   adh_short        + More
PF01395   PBP_GOBP

Interpro

IPR002347   SDR_fam        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR006170   PBP/GOBP       
IPR036728   PBP_GOBP_sf       
IPR020904   Sc_DH/Rdtase_CS       

SUPFAM

SSF51735   SSF51735        + More
SSF47565   SSF47565       

Gene 3D

1.10.238.20    

ProteinModelPortal

A0A2A4K9G6   A0A2H1VLM0   A0A194RJ27   A0A212F297   A0A194PRR4   A0A182WQQ7   + More
A0A1W7R8Z8   D2WKE1   A0A1S4G628   A0A182H2F7   A0A182H2F8   A0A1Q3FRN8   Q171F3   B0WCC9   A0A2K7P6E4   D2WKD9   A0A182HF88   A0NEE2   A0A182V9I2   W5JEC7   B0XBQ7   A0A1Q3FR56   A0A182LJK3   A0A3F2YSU5   A0A1S4G5Z6   A0A023EKY6   A0A1Q3FQF5   B0XBQ6   D2WKE0   A0A182HF87   A0A182RF95   A0A182WQQ6   B0WCD3   Q7Q752   B0WCC8   A0A182U549   A0A084W2Y7   W5JRL0   B0XBQ5   A0A023EL01   B0WCD2   A0A182UZL4   A0A182J8G1   A0A1Q3FRV7   T1D4L4   E0VGI8   A0A182LJK2   T1DGH0   A0A182PN70   U5EW40   A0A182QH30   B0XBQ4   B0WES0   A0A2M4CZ18   A0A182T3W7   A0A084WK67   A0A182SUP5   Q16S89   D2A5K3   A0A1Q3FK82   T1PFF9   A0A182Y0X3   A0A182FF12   A0A023EK81   A0A182WQQ4   A0A2M4CZ68   A0A2J7QD21   A0A336MZB0   B0W657   A0A1B0DIX8   A0A1S4FRH3   A0A2M4BXZ0   W5JNI2   B0W2W1   A0A084WK66   A0A182QJQ7   A0A182MNA0   A0A182Q2S3   A0A182H418   A0A182Q801   B0WCD1   Q17L62   A0A1Q3FSD3   A0A182XIL9   A0A1L8E530   A0A182LJK0   A0NEE1   A0A1I8MPJ0   A0A1S4G5E5   A0A182KB61   W5JII6   A0A182J4V4   B0WCD0   W5JF43   A0A1Y1MM39   A0A182SKY5   A0A1Y1LVC5   A0A182VBR6   A0A1S4EYV0   A0A084W2Y8  

PDB

1XG5     E-value=2.98217e-32,     Score=344

KEGG

101741066    K15890 NADP+-dependent farnesol dehydrogenase [EC:1.1.1.216] | (RefSeq) farnesol dehydrogenase

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)
00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005549   GO:0016491   GO:0047886   GO:0006718   GO:0102132   GO:0102131   GO:0004316   GO:0016021   GO:0046872   GO:0006468   GO:0003995   GO:0005488   GO:0008565   GO:0015031   GO:0009258   GO:0016155   GO:0003824  

Length:

248

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.5435199999999

Exp number, first 60 AAs:

21.45631

Total prob of N-in:

0.94088

POSSIBLE N-term signal

sequence

inside

1  -  8

TMhelix

9  -  31

outside

32  -  248

 

 

Pi

325.082703

Theta

2.756877

Tajima's D

2.210368

CLR

0.283991

CSRT

0.930403479826009

Interpretation

Uncertain