Gene

KWMTBOMO09821

Annotation

PREDICTED:_farnesol_dehydrogenase-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr16(+):9842769-9850812      View in EpiBrowser

Full name

Farnesol dehydrogenase      

Alternative Name

NADP+-dependent farnesol dehydrogenase 1

Location in the cell

Cytoplasmic   Reliability : 1.653

CDS

ATGGATCGTTGGGGTGGTAAACTTGCAGTGGTTACGGGTGCCGCTTCAGGTATTGGCGCTGCCGTAGCCCAGGCTCTGGATCGAGCTGGACTCCAGGTGGTAGGATTGGACGTAAAAACGCACGTGGAGGCCAAGGAATCCGAAATAGAATGCAAAGGAAACATTACATCCAAATATTGCGACATCTCTAAGCTTGAAGATATTGAAAGGGTTTTCAAATGGATCGAAGATAATTTCGGATCTGTTTATGTTTTAGTAAACTGTGCCGGCATTCTTTACCAAGGACAAATAACAGGCGTTGGAGACAATCCTTTAAGTGTGAATCAGCTTGTCGAAACTTTGGACGTGAACTTGAAAGGGTCTATTTTATGTGCACGGACTGCTGTTGAATGCATGAAGAAATACGACATCAGCGGACACATAATTAACATTAACAGTCTGGCAGGCCATTATGTGCCGTTTTCTTCGTCAATGAACCTCTACGCCAGTACAAAGTACGCGATAACCGCCTTCACGGAGACCCTTTCGCAGGAGTTGGCTCATTTCTCCAACAGGATTAAAGTTACGAGCTTATCGCCAGGGTTGACAAAAACTGAGATGGCAGCGCATATGGATGATGGCCTACCAGGCCTCGCGCAAAGCGAAGTCGCAGATGCGGTCCTGTATGTTTTGTCTACACCACCACATATTAATATAAGCGAATTAACAATAACATCAGTGTTGGAGAAGAGAATCTAG

Protein

MDRWGGKLAVVTGAASGIGAAVAQALDRAGLQVVGLDVKTHVEAKESEIECKGNITSKYCDISKLEDIERVFKWIEDNFGSVYVLVNCAGILYQGQITGVGDNPLSVNQLVETLDVNLKGSILCARTAVECMKKYDISGHIININSLAGHYVPFSSSMNLYASTKYAITAFTETLSQELAHFSNRIKVTSLSPGLTKTEMAAHMDDGLPGLAQSEVADAVLYVLSTPPHINISELTITSVLEKRI

Description

Mediates oxidation of farnesol into farnesal, a precursor of juvenile hormone in the corpora allata (CA), the glands that synthesize juvenile hormone. Able to oxidize C(10) to C(15) isoprenoid and aliphatic alcohols.

Catalytic Activity

(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH

Biophysicochemical Properties

91 uM for (E,E) farnesol
97 uM for (Z,Z) farnesol
184 uM for 2-decanol
208 uM for geraniol (E)
109 uM for nerol (Z)
133 uM for citronellol
195 uM for octanol

Subunit

Homodimer.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Complete proteome   NAD   NADP   Oxidoreductase   Reference proteome  

Feature

chain  Farnesol dehydrogenase

Uniprot

A0A2A4K9G6   A0A2H1VLM0   A0A194RJ27   A0A212F297   A0A194PRR4   A0A2K7P6E4   + More
D2WKD9   A0A182HF88   A0A1Q3FQF5   B0WCC8   A0A1W7R8Z8   B0XBQ7   B0XBQ5   A0A182HF87   A0A023EKY6   A0A023EL01   A0A182H2F8   B0XBQ6   A0A1Q3FR56   A0A1Q3FRN8   B0WCC9   T1D4L4   B0WCD2   B0XBQ4   A0A1Y1L931   Q171F3   A0A1Q3FRV7   A0A182WQQ7   A0A1S4G5Z6   A0A182H2F7   A0A1S4G628   B0WCD3   T1DGH0   D2A5K3   D2WKE1   D2WKE0   A0A1Q3FK82   A0A1S4EYV0   B0WCD1   B0WES0   B0W2W1   A0A084W2Y7   Q17L62   A0A023EK81   A0A182RF95   E0VGI8   A0A0T6B5E6   A0A1J1IUT8   Q16S89   A0A182LJK3   A0A3F2YSU5   U5EW40   A0A182J8G1   B0WCD0   A0A182UZL4   A0A182MNA0   D7ELE5   T1PFF9   A0A1S4FRH3   D2A5V8   A0A182U549   Q7Q752   A0A182SUP5   A0A182GZK3   A0A182FF11   U5EYB8   A0A182WQQ5   A0A2J7QD21   A0A2M4BYU7   A0A2M4BXV1   W5JRL0   A0A1S4G5E5   V5H636   A0A1Y1N9P5   A0A084WK68   W5JNI2   B4L3Z8   A0A182H418   A0A182PHM3   W5JEC7   A0A2M4BXX5   A0A182XMX0   A0A023F997   A0A2J7QD10   A0A067QZX5   D2A464   A0A182Y1A2   A0A182Y0X3   A0A1J1HNS8   W5JT61   A0A0K8TT65   J9HGI5   A0A182H368   A0A182Q801   A0A182K244   J9HTI9   A0A0C9REG3   A0A1I8MB96   A0A2J7QD23   A0A2M4CZ68  

EC Number

1.1.1.216

Pubmed

26354079    22118469    19940247    17510324    26483478    24945155    + More
24330624    28004739    18362917    19820115    24438588    20566863    20966253    25315136    12364791    14747013    17210077    20920257    23761445    17994087    25474469    24845553    25244985    26369729   

EMBL

NWSH01000035    PCG80433.1    ODYU01003041    SOQ41322.1    KQ460323    KPJ15946.1    + More
AGBW02010783    OWR47844.1    KQ459595    KPI96002.1    GQ344797    CH477512    ADB03639.1    EJY57755.1    JXUM01133703    KQ568016    KXJ69194.1    GFDL01005220    JAV29825.1    DS231886    EDS43373.1    GEHC01000038    JAV47607.1    DS232648    EDS44406.1    EDS44404.1    KXJ69193.1    GAPW01003735    JAC09863.1    GAPW01003736    JAC09862.1    JXUM01105273    KQ564952    KXJ71516.1    EDS44405.1    GFDL01004976    JAV30069.1    GFDL01004952    JAV30093.1    EDS43374.1    GALA01000908    JAA93944.1    EDS43377.1    EDS44403.1    GEZM01062037    GEZM01062036    GEZM01062035    JAV70104.1    CH477457    EAT40616.1    GFDL01004823    JAV30222.1    JXUM01105272    KXJ71515.1    EDS43378.1    GALA01000192    JAA94660.1    KQ971345    EFA05382.1    GQ344799    ADB03641.1    EJY57753.1    GQ344798    ADB03640.1    EJY57754.1    GFDL01007159    JAV27886.1    EDS43376.1    DS231911    EDS45833.1    DS231829    EDS30320.1    ATLV01019729    KE525278    KFB44581.1    CH477218    EAT47433.1    GAPW01004068    JAC09530.1    DS235145    EEB12494.1    LJIG01009674    KRT82607.1    CVRI01000057    CRL02305.1    CH477680    EAT37326.1    APCN01004328    GANO01001602    JAB58269.1    EDS43375.1    AXCM01001467    DS497842    EFA12017.1    KA647522    AFP62151.1    EFA05017.1    AAAB01008960    EAA11736.1    JXUM01099676    KQ564510    KXJ72157.1    GANO01002098    JAB57773.1    NEVH01015829    PNF26476.1    GGFJ01008767    MBW57908.1    GGFJ01008766    MBW57907.1    ADMH02000550    ETN65913.1    GALX01000208    JAB68258.1    GEZM01009462    JAV94573.1    ATLV01024096    KE525349    KFB50612.1    ETN65912.1    CH933810    EDW07276.1    JXUM01108609    KQ565247    KXJ71182.1    ADMH02001376    ETN62712.1    GGFJ01008768    MBW57909.1    GBBI01001224    JAC17488.1    PNF26478.1    KK852809    KDR16000.1    KQ971348    EFA04837.1    CVRI01000014    CRK89701.1    ETN65914.1    GDAI01000044    JAI17559.1    CH477816    EJY57947.1    JXUM01106763    KQ565082    KXJ71362.1    AXCN02000361    EJY57948.1    GBYB01014999    JAG84766.1    PNF26475.1    GGFL01006445    MBW70623.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000053268    UP000008820    UP000069940    + More
UP000249989    UP000002320    UP000075920    UP000007266    UP000030765    UP000075900    UP000009046    UP000183832    UP000075882    UP000075840    UP000075880    UP000075903    UP000075883    UP000095301    UP000075902    UP000007062    UP000075901    UP000069272    UP000235965    UP000000673    UP000009192    UP000075885    UP000076407    UP000027135    UP000076408    UP000075886    UP000075881   

Pfam

PF00106   adh_short        + More
PF01395   PBP_GOBP

Interpro

IPR002347   SDR_fam        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR006170   PBP/GOBP       
IPR036728   PBP_GOBP_sf       
IPR020904   Sc_DH/Rdtase_CS       

SUPFAM

SSF51735   SSF51735        + More
SSF47565   SSF47565       

Gene 3D

1.10.238.20    

ProteinModelPortal

A0A2A4K9G6   A0A2H1VLM0   A0A194RJ27   A0A212F297   A0A194PRR4   A0A2K7P6E4   + More
D2WKD9   A0A182HF88   A0A1Q3FQF5   B0WCC8   A0A1W7R8Z8   B0XBQ7   B0XBQ5   A0A182HF87   A0A023EKY6   A0A023EL01   A0A182H2F8   B0XBQ6   A0A1Q3FR56   A0A1Q3FRN8   B0WCC9   T1D4L4   B0WCD2   B0XBQ4   A0A1Y1L931   Q171F3   A0A1Q3FRV7   A0A182WQQ7   A0A1S4G5Z6   A0A182H2F7   A0A1S4G628   B0WCD3   T1DGH0   D2A5K3   D2WKE1   D2WKE0   A0A1Q3FK82   A0A1S4EYV0   B0WCD1   B0WES0   B0W2W1   A0A084W2Y7   Q17L62   A0A023EK81   A0A182RF95   E0VGI8   A0A0T6B5E6   A0A1J1IUT8   Q16S89   A0A182LJK3   A0A3F2YSU5   U5EW40   A0A182J8G1   B0WCD0   A0A182UZL4   A0A182MNA0   D7ELE5   T1PFF9   A0A1S4FRH3   D2A5V8   A0A182U549   Q7Q752   A0A182SUP5   A0A182GZK3   A0A182FF11   U5EYB8   A0A182WQQ5   A0A2J7QD21   A0A2M4BYU7   A0A2M4BXV1   W5JRL0   A0A1S4G5E5   V5H636   A0A1Y1N9P5   A0A084WK68   W5JNI2   B4L3Z8   A0A182H418   A0A182PHM3   W5JEC7   A0A2M4BXX5   A0A182XMX0   A0A023F997   A0A2J7QD10   A0A067QZX5   D2A464   A0A182Y1A2   A0A182Y0X3   A0A1J1HNS8   W5JT61   A0A0K8TT65   J9HGI5   A0A182H368   A0A182Q801   A0A182K244   J9HTI9   A0A0C9REG3   A0A1I8MB96   A0A2J7QD23   A0A2M4CZ68  

PDB

1XG5     E-value=7.73481e-29,     Score=314

KEGG

101743359    K15890 NADP+-dependent farnesol dehydrogenase [EC:1.1.1.216] | (RefSeq) farnesol dehydrogenase-like

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)
00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005549   GO:0016491   GO:0047886   GO:0006718   GO:0102132   GO:0102131   GO:0004316   GO:0016021   GO:0046872   GO:0006468   GO:0003995   GO:0005488   GO:0008565   GO:0015031   GO:0009258   GO:0016155   GO:0003824  

Length:

245

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.0619

Exp number, first 60 AAs:

2.33486

Total prob of N-in:

0.18103

outside

1  -  245

 

 

Pi

23.329182

Theta

23.300215

Tajima's D

1.597337

CLR

0.381535

CSRT

0.816259187040648

Interpretation

Uncertain