Gene

KWMTBOMO09819

Pre Gene Modal

BGIBMGA013139

Annotation

AMP-activated_protein_kinase_[Bombyx_mori]

Location

Bomo_Chr16(-):9817287-9822738      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase      

Location in the cell

Cytoplasmic   Reliability : 2.947

CDS

ATGGCAGAGAAGCCTGATAAACCAGTTCCAGCAAGCGCGAACTGCCAGCCAATTGTAAAAATAGGGCACTACACACTCGGGACGACCCTAGGAGTAGGTACATTTGGAAAAGTTAAAATAGGAGAGCACCAACTAACCAAGCACAAAGTTGCTATTAAAATCCTCAACAGACAGAAGATTAAATCTCTAGATGTCGTGGGAAAGATAAGACGTGAGATCCAAAACCTCAAGTTGTTCAGACATCCGCATATCATCAAGCTATATCAGGTGATATCAACTCCAACTGATATATTTATGATTATGGAATATGTTTCTGGAGGAGAACTCTTTGATTACATTGTAAAGCGAGGAAAGCTCCAAGAACATGAAGCACGAAGGTTCTTTCAACAAATTATATCCGGTGTAGATTATTGTCACAGGCATATGATTGTACATAGAGACTTGAAGCCAGAGAATCTGTTGTTAGATCACAATATGCATGTGAAAATAGCAGACTTTGGACTGTCTAACATGATGATGGATGGAGAGTTTCTGAGGACTTCTTGTGGATCACCAAACTATGCAGCGCCTGAGGTAATATCAGGCAAATTGTATGCAGGTCCTGAAGTGGATGTATGGTCTTGTGGTGTTATTCTCTATGCACTCTTATGTGGTACTCTACCATTTGACGATGAACACGTCCCAACATTATTCAGAAAAATAAAGTCTGGAATATTCCCGATCCCCGAGTACTTAAACAAAAGTGTTGTTAGTTTATTGTGTATGATGCTCCAAGTGGACCCAATGAAGAGGGCCACTATAGAAGATGTAAAGAAACACGATTGGTTCCTGAAAGATCTGCCTGAGTATCTATTTCCGTCGCCTGTGGAACAGGATAGCAGTGTAATAGACACAGAAGCGATTGCCGAGGTGTGCGACAAGTTTGGTGTTAAAGAGCATGAGGTACACAACGCTCTGCTCAGCGGAGATCCGCACGACCAACTGGCGATAGCCTATCATCTCATCATAGACAACAAGAGGATCGCTGATGAAGCTGCTAAAGCTGAAATCAAAGACTTTTATGTGGCCAGCAACTCTCCGCCCGCTGTCACTGAGACTAACCGTCCTCACCCGGAACGTATCGCTCCGCTGCGCGACTCCACCGCGCCTCCGCCGCAAGACAAAGCAAGAGGCACCCCTGTCAAACGAGCGAAATGGCACTTGGGTATAAGGTCACAGAGCAAACCCAACGACATAATGCTGGAAGTGTTCCGCGCTATGAAAGCCCTTGACTACGAGTGGAAGGTCATCAACCCGTACCACGTAAGAGTACGAACCTTAAACAAAATGACCGAGAAATACGTAAAGATGTCGCTACAGCTGTACCAAGTGGACTACAAGTCGTACCTGCTGGACTTTAAGTCTTTGTCGGGCGAACGAGAGGAGTCCGACGAGGAGGGCGGGTCGGTGACCCCGGTGCCGCCGCCCCCGCCCCCACCGCCCTCCCCGCACCCCCACGGGCACCACACCATGGAGTTCTTCGAGATGTGCGCCGCGCTCATCATACAACTGGCCCGGTAA

Protein

MAEKPDKPVPASANCQPIVKIGHYTLGTTLGVGTFGKVKIGEHQLTKHKVAIKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPTDIFMIMEYVSGGELFDYIVKRGKLQEHEARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMMDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKSVVSLLCMMLQVDPMKRATIEDVKKHDWFLKDLPEYLFPSPVEQDSSVIDTEAIAEVCDKFGVKEHEVHNALLSGDPHDQLAIAYHLIIDNKRIADEAAKAEIKDFYVASNSPPAVTETNRPHPERIAPLRDSTAPPPQDKARGTPVKRAKWHLGIRSQSKPNDIMLEVFRAMKALDYEWKVINPYHVRVRTLNKMTEKYVKMSLQLYQVDYKSYLLDFKSLSGEREESDEEGGSVTPVPPPPPPPPSPHPHGHHTMEFFEMCAALIIQLAR

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.

Uniprot

A5YRY8   A0A437BIH2   H9JUC6   A0A2A4K8M9   H6WW18   A0A1W4X5X7   + More
A0A0K8TMT4   A0A1Y1MFU7   A0A1L8DX18   A0A1B6E922   A0A1B1PFX9   F4WKU5   A0A1B0D998   A0A2J7QRB5   J3JYE4   K7IWQ2   A0A2J7QRB3   A0A087ZXD9   A0A0L7R8Y5   A0A2A3EE85   E9J1P6   A0A1J1IT77   A0A151JVC6   A0A158P3X9   A0A151WVA7   E2AJ58   A0A0L0BW77   B0W6U5   A0A232EDP9   A0A195BKX3   A0A1B0GIV1   A0A084WR92   Q173G6   A0A0M9ACU2   A0A182VZW4   A0A182LTB9   A0A182Y427   A0A026WZ84   A0A2M4BII5   A0A182JNN3   A0A182V1L7   A0A182UL12   A0A182XAG2   Q7QCL4   A0A182HSA1   A0A182RTH5   A0A2M3ZGH8   A0A2M3ZGK8   A0A2M3ZGS3   A0A195CN83   A0A2M4BIG6   A0A0M4MEL0   A0A0N8AQC0   A0A0M4MP40   A0A0P5A8R2   D6WT75   A0A1A9WRE4   A0A182NR65   A0A1A9UUA4   A0A1B0ALR7   A0A1B0AK17   A0A0N8AAY3   D3TM05   A0A1A9X7W8   A0A182QB85   A0A0P6DAT0   A0A0K8UVJ3   A0A0P5WU44   A0A0P5RD70   A0A2M4A8R7   A0A2M4A932   A0A2M4AAR6   T1PMP7   A0A224XM52   A0A194QP12   A0A1I8NWT9   A0A0P6EI57   A0A069DVJ7   A0A182IP23   T1I9I6   A0A1B6H371   Q5BU47   A0A151J944   A0A0J7KJY2   A0A154PJ47   A0A226DLK2   A0A0N7Z974   A0A1Q3FF58   A0A226F6S5   A0A0A9Y017   A0A2S2R755   A0A0K8S3R1   J9JY44   A0A0P4WSL9   A0A0P5W4Q4   A0A1D2MKM9   A0A1B6GJ15   A0A023ETH9   A0A1B6L2Z6   A0A0P5IGP5  

EC Number

2.7.11.1

Pubmed

19121390    26369729    28004739    21719571    22516182    23537049    + More
20075255    21282665    21347285    20798317    26108605    28648823    24438588    17510324    25244985    24508170    30249741    12364791    14747013    17210077    18362917    19820115    20353571    25315136    26354079    26334808    27129103    25401762    26823975    27289101    24945155   

EMBL

EF583917    ABQ62953.1    RSAL01000051    RVE50226.1    BABH01038554    NWSH01000035    + More
PCG80429.1    JQ319811    AFA34910.1    GDAI01001949    JAI15654.1    GEZM01035437    JAV83215.1    GFDF01003142    JAV10942.1    GEDC01017711    GEDC01011215    GEDC01007500    GEDC01003994    GEDC01002944    GEDC01001273    JAS19587.1    JAS26083.1    JAS29798.1    JAS33304.1    JAS34354.1    JAS36025.1    KX121426    ANT47199.1    GL888206    EGI65187.1    AJVK01004284    NEVH01011919    PNF31113.1    APGK01058333    BT128270    KB741288    KB632322    AEE63230.1    ENN70683.1    ERL92327.1    AAZX01007094    PNF31110.1    KQ414631    KOC67236.1    KZ288288    PBC29321.1    GL767674    EFZ13258.1    CVRI01000057    CRL02310.1    KQ981701    KYN37488.1    ADTU01008610    KQ982708    KYQ51793.1    GL439967    EFN66498.1    JRES01001349    KNC23484.1    DS231849    EDS36926.1    NNAY01006053    OXU16477.1    KQ976453    KYM85332.1    AJWK01017665    ATLV01026002    KE525404    KFB52736.1    CH477425    EAT41169.1    KQ435689    KOX81246.1    AXCM01000275    KK107078    QOIP01000011    EZA60459.1    RLU16627.1    GGFJ01003706    MBW52847.1    AAAB01008859    EAA07706.4    APCN01000256    GGFM01006881    MBW27632.1    GGFM01006911    MBW27662.1    GGFM01006899    MBW27650.1    KQ977513    KYN02173.1    GGFJ01003705    MBW52846.1    KR075837    ALE20556.1    GDIP01251429    GDIP01200832    GDIQ01253299    GDIQ01186207    GDIP01099543    GDIQ01038118    LRGB01000930    JAI71972.1    JAJ98425.1    KZS14960.1    KR075832    ALE20551.1    GDIP01205980    JAJ17422.1    KQ971354    EFA07410.1    JXJN01000086    GDIP01165273    GDIQ01168815    JAJ58129.1    JAK82910.1    CCAG010001014    EZ422457    ADD18733.1    AXCN02001469    GDIQ01080650    JAN14087.1    GDHF01021766    JAI30548.1    GDIP01081754    JAM21961.1    GDIQ01121890    JAL29836.1    GGFK01003799    MBW37120.1    GGFK01003958    MBW37279.1    GGFK01004407    MBW37728.1    KA649370    AFP63999.1    GFTR01006906    JAW09520.1    KQ458756    KPJ05221.1    GDIQ01076255    JAN18482.1    GBGD01001157    JAC87732.1    ACPB03016988    GECZ01000646    JAS69123.1    AY870330    AAX20150.1    KQ979480    KYN21275.1    LBMM01006501    KMQ90562.1    KQ434931    KZC11833.1    LNIX01000017    OXA45724.1    GDKW01001339    JAI55256.1    GFDL01008855    JAV26190.1    LNIX01000001    OXA65154.1    GBHO01017192    JAG26412.1    GGMS01016550    MBY85753.1    GBRD01018043    GDHC01020273    GDHC01003623    JAG47784.1    JAP98355.1    JAQ15006.1    ABLF02028966    GDIP01251372    JAI72029.1    GDIP01091348    JAM12367.1    LJIJ01000979    ODM93461.1    GECZ01007358    JAS62411.1    GAPW01000985    JAC12613.1    GEBQ01021919    JAT18058.1    GDIQ01217209    JAK34516.1   

Proteomes

UP000283053    UP000005204    UP000218220    UP000192223    UP000007755    UP000092462    + More
UP000235965    UP000019118    UP000030742    UP000002358    UP000005203    UP000053825    UP000242457    UP000183832    UP000078541    UP000005205    UP000075809    UP000000311    UP000037069    UP000002320    UP000215335    UP000078540    UP000092461    UP000030765    UP000008820    UP000053105    UP000075920    UP000075883    UP000076408    UP000053097    UP000279307    UP000075881    UP000075903    UP000075902    UP000076407    UP000007062    UP000075840    UP000075900    UP000078542    UP000076858    UP000007266    UP000091820    UP000075884    UP000078200    UP000092460    UP000092445    UP000092444    UP000092443    UP000075886    UP000095301    UP000053268    UP000095300    UP000075880    UP000015103    UP000078492    UP000036403    UP000076502    UP000198287    UP000007819    UP000094527   

PRIDE

A5YRY8    H9JUC6   

Pfam

PF00069   Pkinase        + More
PF16579   AdenylateSensor
PF04869   Uso1_p115_head
PF18770   Arm_vescicular
PF06842   DUF1242
PF02135   zf-TAZ
PF16193   AAA_assoc_2
PF12002   MgsA_C
PF00004   AAA

Interpro

IPR028375   KA1/Ssp2_C        + More
IPR032270   AMPK_C       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR000719   Prot_kinase_dom       
IPR011989   ARM-like       
IPR006953   Vesicle_Uso1_P115_head       
IPR041209   P115_Arm_rpt       
IPR016024   ARM-type_fold       
IPR009653   Ksh1       
IPR029058   AB_hydrolase       
IPR008921   DNA_pol3_clamp-load_cplx_C       
IPR027417   P-loop_NTPase       
IPR035898   TAZ_dom_sf       
IPR003959   ATPase_AAA_core       
IPR021886   MgsA_C       
IPR000197   Znf_TAZ       
IPR032423   AAA_assoc_2       
IPR003593   AAA+_ATPase       

SUPFAM

SSF56112   SSF56112        + More
SSF103243   SSF103243       
SSF48371   SSF48371       
SSF48019   SSF48019       
SSF53474   SSF53474       
SSF52540   SSF52540       
SSF57933   SSF57933       

Gene 3D

1.25.10.10     1.20.1020.10     3.40.50.1820    

ProteinModelPortal

A5YRY8   A0A437BIH2   H9JUC6   A0A2A4K8M9   H6WW18   A0A1W4X5X7   + More
A0A0K8TMT4   A0A1Y1MFU7   A0A1L8DX18   A0A1B6E922   A0A1B1PFX9   F4WKU5   A0A1B0D998   A0A2J7QRB5   J3JYE4   K7IWQ2   A0A2J7QRB3   A0A087ZXD9   A0A0L7R8Y5   A0A2A3EE85   E9J1P6   A0A1J1IT77   A0A151JVC6   A0A158P3X9   A0A151WVA7   E2AJ58   A0A0L0BW77   B0W6U5   A0A232EDP9   A0A195BKX3   A0A1B0GIV1   A0A084WR92   Q173G6   A0A0M9ACU2   A0A182VZW4   A0A182LTB9   A0A182Y427   A0A026WZ84   A0A2M4BII5   A0A182JNN3   A0A182V1L7   A0A182UL12   A0A182XAG2   Q7QCL4   A0A182HSA1   A0A182RTH5   A0A2M3ZGH8   A0A2M3ZGK8   A0A2M3ZGS3   A0A195CN83   A0A2M4BIG6   A0A0M4MEL0   A0A0N8AQC0   A0A0M4MP40   A0A0P5A8R2   D6WT75   A0A1A9WRE4   A0A182NR65   A0A1A9UUA4   A0A1B0ALR7   A0A1B0AK17   A0A0N8AAY3   D3TM05   A0A1A9X7W8   A0A182QB85   A0A0P6DAT0   A0A0K8UVJ3   A0A0P5WU44   A0A0P5RD70   A0A2M4A8R7   A0A2M4A932   A0A2M4AAR6   T1PMP7   A0A224XM52   A0A194QP12   A0A1I8NWT9   A0A0P6EI57   A0A069DVJ7   A0A182IP23   T1I9I6   A0A1B6H371   Q5BU47   A0A151J944   A0A0J7KJY2   A0A154PJ47   A0A226DLK2   A0A0N7Z974   A0A1Q3FF58   A0A226F6S5   A0A0A9Y017   A0A2S2R755   A0A0K8S3R1   J9JY44   A0A0P4WSL9   A0A0P5W4Q4   A0A1D2MKM9   A0A1B6GJ15   A0A023ETH9   A0A1B6L2Z6   A0A0P5IGP5  

PDB

5EZV     E-value=0,     Score=1684

KEGG

100101222    K07198 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11] | (RefSeq) AMP-activa

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0004674   GO:0006886   GO:0048280   GO:0000139   GO:0016021   GO:0006355   GO:0003712   GO:0006260   GO:0003677   GO:0004402   GO:0005634   GO:0008270   GO:0031588   GO:0042149   GO:0035556   GO:0032007   GO:0005737   GO:0006468   GO:0004672   GO:0003995   GO:0005488   GO:0008565   GO:0015031   GO:0009258   GO:0016155   GO:0003824  

Length:

519

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10555

Exp number, first 60 AAs:

0.04268

Total prob of N-in:

0.00583

outside

1  -  519

 

 

Pi

303.858806

Theta

220.060086

Tajima's D

1.512024

CLR

0.67719

CSRT

0.788810559472026

Interpretation

Uncertain