Gene

KWMTBOMO09805  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013148

Annotation

diphthamide_synthesis_protein_[Bombyx_mori]

Location

Bomo_Chr16(-):9609810-9611348      View in EpiBrowser

Full name

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1      

Location in the cell

Cytoplasmic   Reliability : 1.228

CDS

ATGGAAGATTTTACCAATAATCCTGGTATAGTTGTTATACGTGCGAAACCGGAAGGACAAAGAAAAACTTTTAAACCCAAAGTTAGATCTTTAAATAAAATACCTGATGATTTGTTGAATGATCCCCTGCTAAACAGGGCTTGCGCGGCTTTACCAGAAAATTATAATTTCGAAATACACAAGACGATATGGAGAATACGGTCTACAGCGGCAAAACGCGTGGCCCTACAGATGCCTGAAGGTCTAACTATGTTTGCAACGACCCTCTGTGACATAATAGAAACATTCACCGAAGCCGATACTGTGATAATGGGAGATGTGACATACGGAGCCTGCTGTATAGATGACTTCACTGCTGTGGCACTCGGTGTAGACCTCCTTGTGCACTATGGACACTCTTGCCTAATTCCCATAGATCAAACTAGTAGTATTAAGGTTCTGTACATATTTGTGGATATAAAAATTGATCCGTCACATTTCATAGAAACAATAAAAGTAAACTTTCCATCTAAAACTCATTTAGCATTAGTTAGCACAATTCAATTCGTAACCACTCTACATTCTGTAGCTAAGAATCTTCGTATTGAAGAATACATGGTTACAGTGCCACAAACTAAACCCCTTTCACCAGGAGAGATACTAGGATGCACTGCTCCTAAATTACAAGCAGATGCAATTGTTTATTTAGGAGATGGAAGATTTCATTTAGAATCTATAATGATAGCGAATCCTACAATAAGTGCCTACAAATATGATCCATATGATAAAAAATTTACAAAAGAAGAATATGATCATGTTCTCATGAAGGCCAACAGACAGAAGCAAGTGAAGACTGCGGAGTCTGCAAGTAATTTTGGCCTTATTCTTGGCACTCTTGGAAGACAGGGCAGCACAAAAGTGTTAGCAAATTTAGAAAAGCAATTATCAAACTCTGATAAACATTATGTAAAGATATTGCTATCAGAGATTTTTCCTAGCAAACTTGCCTTATTTGGACTGGATGCATTTGTTCAGTGA

Protein

MEDFTNNPGIVVIRAKPEGQRKTFKPKVRSLNKIPDDLLNDPLLNRACAALPENYNFEIHKTIWRIRSTAAKRVALQMPEGLTMFATTLCDIIETFTEADTVIMGDVTYGACCIDDFTAVALGVDLLVHYGHSCLIPIDQTSSIKVLYIFVDIKIDPSHFIETIKVNFPSKTHLALVSTIQFVTTLHSVAKNLRIEEYMVTVPQTKPLSPGEILGCTAPKLQADAIVYLGDGRFHLESIMIANPTISAYKYDPYDKKFTKEEYDHVLMKANRQKQVKTAESASNFGLILGTLGRQGSTKVLANLEKQLSNSDKHYVKILLSEIFPSKLALFGLDAFVQ

Description

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Catalytic Activity

L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine

Similarity

Belongs to the DPH1/DPH2 family. DPH1 subfamily.
Belongs to the DPH1/DPH2 family.

Feature

chain  2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Uniprot

H9JUD5   Q2F5S3   A0A0L7LAW6   S4PV65   A0A2H1VL98   A0A212FJ23   + More
A0A1B0D580   A0A1L8DRK0   A0A1L8DRV4   A0A1J1J1X5   A0A182JIQ6   A0A1B0C9D6   A0A023ESE3   A0A182QRW7   A0A067QWF0   A0A182Y5X8   A0A182U1I3   A0A182SX18   A0A182N9L6   A0A182LUX9   A0A2J7QGS8   A0A182KDX2   A0A2M4ANX9   A0A182LP79   A0A2M4AP09   A0A182WEV6   A0A182RD29   A0A1B6I3C7   A0A2S2R5G8   A0A182FC28   A0A2M3Z7Q1   A0A182VG11   A0A2M3ZI03   A0A2M4BM58   A0A2M4CSS7   A0A2M4CSJ5   A0A182HNC2   A0A1B6FQL0   A0A2M4BM35   A0A182XC23   A0A336K702   A0A2R7VZ90   A0A034VQ42   A0A0K8UBF9   A0A182PL67   A0A0A1WEP6   A0A1Q3F6G1   D6WDC5   J9JPJ3   W8C3A4   A0A069DSX3   A0A0V0GCI1   A0A023FAB1   B0WLD0   B4IZC0   A0A0P4VV67   R4FKY8   A0A1B6D814   E9H287   K7IMS9   A0A0P5ZG97   A0A1A9WH61   B4N4M0   A0A162CC92   A0A0P6A778   A0A0P4YDQ0   A0A1I8P1D5   A0A0P4XZ24   A0A0P5U319   A0A0M3QWZ7   A0A0C9R5G0   B4LCR0   B4HAH3   A0A0P6J0J1   A0A0Q9WKC7   Q2LZ76   A0A0Q9WSH7   A0A0L0CEC1   A0A146LEQ0   B4QQ98   T1PK69   A0A0A9Y073   A0A1I8MLV5   A0A0A9XYR1   B4HEX3   Q9VTM2   B3NGZ2   A0A1W4W6K0   B4PFM8   A0A0P5DLK9   B4KUS5   E0VAN8   A0A3B0J8Y3   A0A3Q3G744   A0A0P5DFU1   A0A0P5D7I4   A0A2D0SW18   A0A0P5ZRK5   A0A1A8DR56   A0A3B0J9X1  

EC Number

2.5.1.108

Pubmed

19121390    26227816    23622113    22118469    24945155    24845553    + More
25244985    20966253    25348373    25830018    18362917    19820115    24495485    26334808    25474469    17994087    27129103    21292972    20075255    18057021    15632085    23185243    26108605    26823975    22936249    25401762    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    20566863   

EMBL

BABH01038580    DQ311350    ABD36294.1    JTDY01001999    KOB72361.1    GAIX01009078    + More
JAA83482.1    ODYU01002923    SOQ41024.1    AGBW02008320    OWR53743.1    AJVK01003397    AJVK01003398    AJVK01003399    AJVK01003400    GFDF01004976    JAV09108.1    GFDF01004977    JAV09107.1    CVRI01000063    CRL04857.1    AJWK01002233    GAPW01001431    JAC12167.1    AXCN02002036    KK852879    KDR14464.1    AXCM01003863    NEVH01014359    PNF27788.1    GGFK01009169    MBW42490.1    GGFK01009203    MBW42524.1    GECU01026258    JAS81448.1    GGMS01016032    MBY85235.1    GGFM01003805    MBW24556.1    GGFM01007344    MBW28095.1    GGFJ01004994    MBW54135.1    GGFL01004137    MBW68315.1    GGFL01004136    MBW68314.1    APCN01001904    GECZ01017340    JAS52429.1    GGFJ01004996    MBW54137.1    UFQS01000131    UFQT01000131    SSX00237.1    SSX20617.1    KK854186    PTY12782.1    GAKP01015284    JAC43668.1    GDHF01028335    JAI23979.1    GBXI01017126    JAC97165.1    GFDL01011890    JAV23155.1    KQ971321    EEZ99477.1    ABLF02027856    GAMC01010247    GAMC01010246    JAB96309.1    GBGD01001696    JAC87193.1    GECL01000515    JAP05609.1    GBBI01000849    JAC17863.1    DS231984    EDS30423.1    CH916366    EDV96675.1    GDKW01001897    JAI54698.1    ACPB03004220    GAHY01001643    JAA75867.1    GEDC01015470    JAS21828.1    GL732585    EFX74125.1    GDIP01045770    JAM57945.1    CH964095    EDW79094.1    LRGB01001005    KZS14052.1    GDIP01034195    JAM69520.1    GDIP01238643    JAI84758.1    GDIP01238642    JAI84759.1    GDIP01120701    JAL83013.1    CP012525    ALC45053.1    GBYB01002066    JAG71833.1    CH940647    EDW70952.1    KRF85206.1    CH479240    EDW37571.1    GDIQ01024761    JAN69976.1    KRF85209.1    CH379069    EAL29632.1    KRF85207.1    JRES01000502    KNC30600.1    GDHC01013629    JAQ05000.1    CM000363    CM002912    EDX10116.1    KMY99046.1    KA648358    AFP62987.1    GBHO01019096    GBHO01019095    GBHO01019094    GBHO01004433    GBRD01002551    GDHC01019971    GDHC01018994    GDHC01014745    JAG24508.1    JAG24509.1    JAG24510.1    JAG39171.1    JAG63270.1    JAP98657.1    JAP99634.1    JAQ03884.1    GBHO01019097    GBHO01019093    JAG24507.1    JAG24511.1    CH480815    EDW41142.1    AE014296    AY069411    AAF50025.1    AAL39556.1    CH954178    EDV51449.1    CM000159    EDW94177.1    GDIP01154550    JAJ68852.1    CH933809    EDW19331.1    DS235012    EEB10444.1    OUUW01000002    SPP76773.1    GDIP01156899    JAJ66503.1    GDIP01161950    JAJ61452.1    GDIP01041061    JAM62654.1    HAEA01007573    SBQ36053.1    SPP76772.1   

Proteomes

UP000005204    UP000037510    UP000007151    UP000092462    UP000183832    UP000075880    + More
UP000092461    UP000075886    UP000027135    UP000076408    UP000075902    UP000075901    UP000075884    UP000075883    UP000235965    UP000075881    UP000075882    UP000075920    UP000075900    UP000069272    UP000075903    UP000075840    UP000076407    UP000075885    UP000007266    UP000007819    UP000002320    UP000001070    UP000015103    UP000000305    UP000002358    UP000091820    UP000007798    UP000076858    UP000095300    UP000092553    UP000008792    UP000008744    UP000001819    UP000037069    UP000000304    UP000095301    UP000001292    UP000000803    UP000008711    UP000192221    UP000002282    UP000009192    UP000009046    UP000268350    UP000261660    UP000221080   

PRIDE

H9JUD5    Q2F5S3    Q9VTM2   

Pfam

PF01866   Diphthamide_syn

Interpro

IPR042265   DPH1/DPH2_3        + More
IPR035435   DPH1/DPH2_euk_archaea       
IPR042263   DPH1/DPH2_1       
IPR016435   DPH1/DPH2       
IPR042264   DPH1/DPH2_2       
IPR022428   Dph2_arc       

Gene 3D

3.40.50.11840     3.40.50.11850     3.40.50.11860    

ProteinModelPortal

H9JUD5   Q2F5S3   A0A0L7LAW6   S4PV65   A0A2H1VL98   A0A212FJ23   + More
A0A1B0D580   A0A1L8DRK0   A0A1L8DRV4   A0A1J1J1X5   A0A182JIQ6   A0A1B0C9D6   A0A023ESE3   A0A182QRW7   A0A067QWF0   A0A182Y5X8   A0A182U1I3   A0A182SX18   A0A182N9L6   A0A182LUX9   A0A2J7QGS8   A0A182KDX2   A0A2M4ANX9   A0A182LP79   A0A2M4AP09   A0A182WEV6   A0A182RD29   A0A1B6I3C7   A0A2S2R5G8   A0A182FC28   A0A2M3Z7Q1   A0A182VG11   A0A2M3ZI03   A0A2M4BM58   A0A2M4CSS7   A0A2M4CSJ5   A0A182HNC2   A0A1B6FQL0   A0A2M4BM35   A0A182XC23   A0A336K702   A0A2R7VZ90   A0A034VQ42   A0A0K8UBF9   A0A182PL67   A0A0A1WEP6   A0A1Q3F6G1   D6WDC5   J9JPJ3   W8C3A4   A0A069DSX3   A0A0V0GCI1   A0A023FAB1   B0WLD0   B4IZC0   A0A0P4VV67   R4FKY8   A0A1B6D814   E9H287   K7IMS9   A0A0P5ZG97   A0A1A9WH61   B4N4M0   A0A162CC92   A0A0P6A778   A0A0P4YDQ0   A0A1I8P1D5   A0A0P4XZ24   A0A0P5U319   A0A0M3QWZ7   A0A0C9R5G0   B4LCR0   B4HAH3   A0A0P6J0J1   A0A0Q9WKC7   Q2LZ76   A0A0Q9WSH7   A0A0L0CEC1   A0A146LEQ0   B4QQ98   T1PK69   A0A0A9Y073   A0A1I8MLV5   A0A0A9XYR1   B4HEX3   Q9VTM2   B3NGZ2   A0A1W4W6K0   B4PFM8   A0A0P5DLK9   B4KUS5   E0VAN8   A0A3B0J8Y3   A0A3Q3G744   A0A0P5DFU1   A0A0P5D7I4   A0A2D0SW18   A0A0P5ZRK5   A0A1A8DR56   A0A3B0J9X1  

PDB

6BXO     E-value=5.62656e-23,     Score=265

KEGG

692933    K07561 2-(3-amino-3-carboxypropyl)histidine synthase [EC:2.5.1.108] | (RefSeq) diphthamide synthesis

GO

GO:0016740   GO:0017183   GO:0005737  

PANTHER

PTHR10762  

Length:

338

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03749

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01017

outside

1  -  338

 

 

Pi

333.192769

Theta

236.784723

Tajima's D

1.258885

CLR

0

CSRT

0.727713614319284

Interpretation

Uncertain