Gene

KWMTBOMO09791

Annotation

PREDICTED:_uncharacterized_protein_LOC101741325_isoform_X1?_partial_[Bombyx_mori]

Location

Bomo_Chr16(-):9379011-9389784      View in EpiBrowser

Full name

Cytochrome P450 4C1      

Alternative Name

CYPIVC1

Location in the cell

Nuclear   Reliability : 1.362 PlasmaMembrane   Reliability : 1.381

CDS

ATGATCTCGTACATGATCCTCATTGTTATCGTGTTTGCCTTGATGTGGTCGGGATGGAAGCAAAAAAACAAAAAGTTTATGGAAATGGCTAATCAATTTCCTGGACCGCAAGCTCTCCCATTTATTGGAAATGCTTTGCGCTTCATGTGTGAACCTGAAGAATTAATTTCGGTAATCAAAGAGCTGCTGCAAGTCTACGGGGAAGCATCCAGATTCTGGCTGGGACCCAATTTAAACGTCATAATTAACAACCCTGATGATTTGAAGATTTTACTGTCAAGCTCCAAAACGAGTACCAAGGGTCCTCAATACAAATATATGGCTCATGTACTCGGGGGTGGAATTCTAAGCGGTTCCGGTGTGACTTGGCGGAAACATAGAAAAATAGCAACACCAAATTACGGGAAAAAAGTTGTAGATAGCTACGAAAAAATCTTTAATGAAGAAGTGCATCTCCTATTGAAGAAATTGCGGAATATTCCAAGCGAACAAGAGTTTGATATTTATAATAAAATCGTACAGACGACGAGCTATTGTGTTTGCCAAACCTTGTTAAACTTGAGTAAGGAACAAGTTACTGAAATACCTCATCTCCAAGAAATCATTGATTGCACACCAAGAAACTACGATATAGTTTTCGACAGAATGATAAAATGGTACCTACAAATCGACCCCGTGTTTTGGATGACTAAATCTTATCAAGATCAAAAGCATTTCGTCGCGTTAATAACAGAATTCAGTAAAGCGATCATTGAAAATAGAAAAAGGGAAATTAATAAAATATACCTTAATAACGAAGAATCAATAAACAGACAGTTAGGTGTGATAGATAGATTCATATTGTCTGAAGAGTTAACACAAGAGGAACTTATCAAGGAAACTTTTACGATATTTACTTCTAGTCAAGAAGCAACAGCAAAGATTTGTTCTTTCGTTTTGTTGATGATGGCTTATCATCCTAAATCTCAGGAAAAGCTTTACGAAGAAATTACTAAAATAATCGGTGATAAAGACAGATGTGTTACGAACGAAGATTTCAAACAAATGCCCTACTTGGATATGGTCTTCAAGGAAGTTTTACGTCTTTTTCCAATTGGTAGCATGCTGCAAAGGACTATTAATGAAAATATTCGGATAAGTTCTGGGACACTACCAGCAGGGTGTTCCTTGGTAGCACCGATATATCATTTGCATCGCGACTCTCGTTTCTGGACTAGGCCCGACGATTTCGATCCCGAGAGATTCAATCCAGTTAATACGAAGTTGAGACAACCGAACTGCTATATTCCTTTTAGTTTAGGACCCATGGACTGTTTGGGAAGATACTTCGGTACTAGGTTAGTAAAAATGATTTGCGTTCGAGTACTAAGAGAGTTCGAAGTGACAACATCTAGAACATACAAGGATCTCAAACTATCGATAGCTATATCTGTGTCTCCATTGGATGGGTTCCCAGTTAAATTACATCCCAGGAAAATTAAAGAGAAACAGTAA

Protein

MISYMILIVIVFALMWSGWKQKNKKFMEMANQFPGPQALPFIGNALRFMCEPEELISVIKELLQVYGEASRFWLGPNLNVIINNPDDLKILLSSSKTSTKGPQYKYMAHVLGGGILSGSGVTWRKHRKIATPNYGKKVVDSYEKIFNEEVHLLLKKLRNIPSEQEFDIYNKIVQTTSYCVCQTLLNLSKEQVTEIPHLQEIIDCTPRNYDIVFDRMIKWYLQIDPVFWMTKSYQDQKHFVALITEFSKAIIENRKREINKIYLNNEESINRQLGVIDRFILSEELTQEELIKETFTIFTSSQEATAKICSFVLLMMAYHPKSQEKLYEEITKIIGDKDRCVTNEDFKQMPYLDMVFKEVLRLFPIGSMLQRTINENIRISSGTLPAGCSLVAPIYHLHRDSRFWTRPDDFDPERFNPVNTKLRQPNCYIPFSLGPMDCLGRYFGTRLVKMICVRVLREFEVTTSRTYKDLKLSIAISVSPLDGFPVKLHPRKIKEKQ

Catalytic Activity

an alkane + O2 + reduced [NADPH--hemoprotein reductase] = a primary alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]

Cofactor

heme

Similarity

Belongs to the cytochrome P450 family.

Keywords

Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase  

Feature

chain  Cytochrome P450 4C1

Uniprot

A0A248QG88   A0A2H1WV90   A0A2W1C397   A0A068ETT0   A0A411E5J7   J7FKN6   + More
A0A0C5C1K7   A0A2A4IZA0   A0A1V0D9I7   A0A437B147   A0A3S2KZU1   A0A212FMZ1   A0A0K8TUH1   A0A0K8TV51   X5D4I7   J7FJY4   A0A437AW77   A0A068EWN3   A0A2A4JUY6   A0A2W1BU78   A0A248QHM1   A0A0K8TVP0   A0A1V0D9J2   H9LJ80   A0A2H1WX44   A0A212FN17   A0A346IHX0   A0A411E587   A0A346IHX3   A0A346IHX1   K7IVR3   A0A232FLR9   A0A1W6L1R4   A0A0C9RFM1   K7IZM3   A0A2J7RF67   A0A1Y1KCR3   A0A1W6L1D9   A0A2P8YHB5   A0A2J7QZQ8   A0A067RD05   A0A1Q1NKY5   A0A1Y1KEU4   A0A1U8YID0   A0A067QZ59   A0A0K0LBC0   A0A386RVW0   A0A0C9RC41   W5JA69   B3GVW4   A0A182FP14   A0A182QJY3   A0A288ZBI1   A0A0C9Q9T8   K4JQ86   A0A0K0LBB9   A0A2J7QZP4   A0A0K8WFU3   A0A034VJL6   A0A0P4W8L7   J9K6X1   A0A0P4W0N6   R9UE02   A0A2H4W6J8   A0A0P4W5K9   K4FC60   A0A0A1X896   B0X9M4   A0A182TID1   A0A0K1YWG5   P29981   A0A1Q3FR82   A0A067RPH3   J9JPA0   B0XD07   Q7QK81   A0A182P4H5   Q6VT81   A0A182NMT9   A0A0U3YU82   A0A182WZG4   A0A182HZK9   B0XI56   A0A0C9QY76   A0A182LQM0   T1J576   Q16ZZ2   I1VJ30   A0A182LYM2   A0A0C9QJ49   A0A2S2Q7M2   A0A2H8U0V3   A0A1I8M0L8   A0A2P8ZA66   A0A0M3RSL3   D2A4W1   A0A1B6GWX7   K4JRV5  

EC Number

1.14.14.1

Pubmed

28881445    28756777    22984814    22118469    26017144    24361403    + More
20075255    28648823    28004739    29403074    24845553    28092127    29136191    20920257    23761445    24324548    25348373    25830018    2034694    12364791    14747013    17210077    14521903    20966253    17510324    22516182    25315136    26319543    18362917    19820115   

EMBL

KX443473    ASO98048.1    ODYU01011315    SOQ56980.1    KZ149898    PZC78633.1    + More
KM016720    AID54872.1    MH236448    QBA57453.1    JX310092    AFP20603.1    KP001146    AJN91191.1    NWSH01004296    PCG65257.1    KY212093    ARA91657.1    RSAL01000212    RVE44177.1    RSAL01000342    RVE42385.1    AGBW02007650    OWR55114.1    GCVX01000091    JAI18139.1    GCVX01000089    JAI18141.1    KF701176    AHW57346.1    JX310090    AFP20601.1    RVE42386.1    KM016719    AID54871.1    NWSH01000564    PCG75619.1    PZC78632.1    KX443472    ASO98047.1    GCVX01000095    JAI18135.1    KY212092    ARA91656.1    JF751066    AEF13244.1    SOQ56984.1    AGBW02007649    OWR55127.1    MH138184    AXP17125.1    MH236447    QBA57452.1    MH138187    AXP17128.1    MH138185    AXP17126.1    NNAY01000046    OXU31595.1    KX609529    ARN17936.1    GBYB01007184    GBYB01007185    JAG76951.1    JAG76952.1    NEVH01004413    PNF39482.1    GEZM01088761    JAV57970.1    KX609528    ARN17935.1    PYGN01000596    PSN43623.1    NEVH01009068    PNF34044.1    KK852542    KDR21746.1    KX660697    AQM57036.1    GEZM01088778    GEZM01088777    GEZM01088771    JAV57936.1    KR057738    AMP19274.1    KK853084    KDR11600.1    KM217039    AIW80002.1    MG566044    QKKF02003370    AYE67168.1    RZF47741.1    GBYB01014154    JAG83921.1    ADMH02001706    ETN61352.1    FM163385    CAQ57675.1    AXCN02001559    KX812713    ASU43935.1    GBYB01011138    JAG80905.1    JX876495    QKKF02010319    AFU86425.1    RZF44819.1    KM217035    AIW79998.1    PNF34047.1    GDHF01025726    GDHF01017970    GDHF01010867    GDHF01010630    GDHF01004503    GDHF01002276    JAI26588.1    JAI34344.1    JAI41447.1    JAI41684.1    JAI47811.1    JAI50038.1    GAKP01017244    JAC41708.1    GDRN01081741    JAI61951.1    ABLF02015202    GDRN01081744    JAI61950.1    JX463004    AGN52797.1    KP234017    AUB85739.1    GDRN01081739    JAI61953.1    JN835470    AFH35031.1    GBXI01007404    JAD06888.1    DS232542    EDS43226.1    KP859404    AKZ17714.1    M63798    GFDL01005043    JAV30002.1    KK852503    KDR22530.1    ABLF02015245    DS232733    EDS45242.1    AAAB01008799    EAA03812.4    AY328467    AAQ93010.1    KT071008    ALX81393.1    APCN01001985    DS233259    EDS28996.1    GBYB01000650    JAG70417.1    JH431852    CH477480    EAT40232.1    JQ855651    AFI45014.1    AXCM01001767    GBYB01003574    JAG73341.1    GGMS01004545    MBY73748.1    GFXV01008004    MBW19809.1    PYGN01000129    PSN53387.1    KR012840    ALD15915.1    KQ971344    EFA05711.1    GECZ01002831    JAS66938.1    JX876513    AFU86443.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000002358    UP000215335    UP000235965    + More
UP000245037    UP000027135    UP000291343    UP000000673    UP000069272    UP000075886    UP000007819    UP000002320    UP000075902    UP000007062    UP000075885    UP000075884    UP000076407    UP000075840    UP000075882    UP000008820    UP000075883    UP000095301    UP000007266   

PRIDE

H9LJ80    P29981   

Pfam

PF00067   p450

Interpro

IPR001128   Cyt_P450        + More
IPR002401   Cyt_P450_E_grp-I       
IPR036396   Cyt_P450_sf       
IPR017972   Cyt_P450_CS       
IPR002403   Cyt_P450_E_grp-IV       

SUPFAM

SSF48264   SSF48264       

Gene 3D

1.10.630.10    

ProteinModelPortal

A0A248QG88   A0A2H1WV90   A0A2W1C397   A0A068ETT0   A0A411E5J7   J7FKN6   + More
A0A0C5C1K7   A0A2A4IZA0   A0A1V0D9I7   A0A437B147   A0A3S2KZU1   A0A212FMZ1   A0A0K8TUH1   A0A0K8TV51   X5D4I7   J7FJY4   A0A437AW77   A0A068EWN3   A0A2A4JUY6   A0A2W1BU78   A0A248QHM1   A0A0K8TVP0   A0A1V0D9J2   H9LJ80   A0A2H1WX44   A0A212FN17   A0A346IHX0   A0A411E587   A0A346IHX3   A0A346IHX1   K7IVR3   A0A232FLR9   A0A1W6L1R4   A0A0C9RFM1   K7IZM3   A0A2J7RF67   A0A1Y1KCR3   A0A1W6L1D9   A0A2P8YHB5   A0A2J7QZQ8   A0A067RD05   A0A1Q1NKY5   A0A1Y1KEU4   A0A1U8YID0   A0A067QZ59   A0A0K0LBC0   A0A386RVW0   A0A0C9RC41   W5JA69   B3GVW4   A0A182FP14   A0A182QJY3   A0A288ZBI1   A0A0C9Q9T8   K4JQ86   A0A0K0LBB9   A0A2J7QZP4   A0A0K8WFU3   A0A034VJL6   A0A0P4W8L7   J9K6X1   A0A0P4W0N6   R9UE02   A0A2H4W6J8   A0A0P4W5K9   K4FC60   A0A0A1X896   B0X9M4   A0A182TID1   A0A0K1YWG5   P29981   A0A1Q3FR82   A0A067RPH3   J9JPA0   B0XD07   Q7QK81   A0A182P4H5   Q6VT81   A0A182NMT9   A0A0U3YU82   A0A182WZG4   A0A182HZK9   B0XI56   A0A0C9QY76   A0A182LQM0   T1J576   Q16ZZ2   I1VJ30   A0A182LYM2   A0A0C9QJ49   A0A2S2Q7M2   A0A2H8U0V3   A0A1I8M0L8   A0A2P8ZA66   A0A0M3RSL3   D2A4W1   A0A1B6GWX7   K4JRV5  

PDB

5VCG     E-value=3.62661e-33,     Score=355

KEGG

101741606    no KO assigned | (RefSeq) cytochrome P450 4C1

GO

GO:0005506   GO:0016705   GO:0016021   GO:0020037   GO:0004497   GO:0070330   GO:0005789   GO:0030131   GO:0005488   GO:0008565   GO:0015031   GO:0009258   GO:0016155   GO:0003824   GO:0055114  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

SignalP

Position:   1 - 20,         Likelihood:  0.632601

 

 

Length:

497

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

17.75148

Exp number, first 60 AAs:

17.21679

Total prob of N-in:

0.93935

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  19

outside

20  -  497

 

 

Pi

267.079615

Theta

187.457281

Tajima's D

1.417844

CLR

0

CSRT

0.768011599420029

Interpretation

Uncertain