Gene

KWMTBOMO09790

Annotation

PREDICTED:_serine/threonine-protein_phosphatase_Pgam5?_mitochondrial_isoform_X4_[Bombyx_mori]

Location

Bomo_Chr16(-):9373797-9378494      View in EpiBrowser

Full name

Serine/threonine-protein phosphatase Pgam5, mitochondrial      

Alternative Name

Phosphoglycerate mutase family member 5 homolog

Location in the cell

Mitochondrial   Reliability : 2.599

CDS

ATGGGCTCACTTTCTAGATTTCATAAAATAGCCCTCATCAGCTTAGGTGCTGTAGGTGGTGGTTTAGCGTACTATCAGATAAACAGCGGGAAAAATGAGAAGAAATACGGTGCTTATAATTCATGGACTACAAATTTTACTCCAAGCGTGAAATGGGACAAGAACTGGGACCATAGAGAACCAGAGTCGATAGTTAGACCAAAAAGGTCAGATGAACCAGAAGAAGAGAACAAATACAATGAGAAATTGGAAAAAGCAAGAAGCAAAGCTGTCAGACATCTATTCCTGATCAGACATGGCCAGTACAATGTGCAGGGAGAAACAGACAAAGAAAGAACCCTCACGGACCTAGGTAGAATCCAAGCAGACCTAACAGGTCAGAGACTAGCATCCTTAGATATAAAATGGGATCTACTTGTTAAATCTACAATGACAAGAGCACAGGAAACTGCTGCCATTATAGCAAAGCACTTAGACAAAGATATTGAAGTTAAAGATTGTCAATTATTAGAAGAAGGTGCTCCGATACCCCCTGAACCTCCCGTGGGACACTGGAGGCCTGAACCAAGACAGTTCTTCCAGGACAGCGCAAGAATCGAAGCGGCGTTCCGGAGGTACTTCCACAGAGCTCCCCCGGAACAGACCAAGGACACCTACACGCTGCTCGTGTGCCATGCCAACGTCATACGCTTCTTTGTGTGCAAAGCCCTCCAGTTCCCGCCCGAAGGCTGGCTGAGGATCTCGCTGAACCACGCCTCGATAACGTGGATCTCGATAATGCCGAACGGGAACGTTGTGCTCCGCTCGCTCAGCGATACCGGCCACATGGAACCTAAATACATAACGAGCCGGTAA

Protein

MGSLSRFHKIALISLGAVGGGLAYYQINSGKNEKKYGAYNSWTTNFTPSVKWDKNWDHREPESIVRPKRSDEPEEENKYNEKLEKARSKAVRHLFLIRHGQYNVQGETDKERTLTDLGRIQADLTGQRLASLDIKWDLLVKSTMTRAQETAAIIAKHLDKDIEVKDCQLLEEGAPIPPEPPVGHWRPEPRQFFQDSARIEAAFRRYFHRAPPEQTKDTYTLLVCHANVIRFFVCKALQFPPEGWLRISLNHASITWISIMPNGNVVLRSLSDTGHMEPKYITSR

Description

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity).

Catalytic Activity

H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate

Subunit

Interacts with Pk92B/ASK1.

Similarity

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Keywords

Complete proteome   Hydrolase   Membrane   Mitochondrion   Mitochondrion outer membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Serine/threonine-protein phosphatase Pgam5, mitochondrial

Uniprot

A0A437BUF9   A0A2H1WV83   A0A2W1BYE3   A0A2A4J1E2   A0A2A4J0Q8   A0A194Q5X1   + More
A0A0N1PHP9   A0A212FN02   A0A0L7KYH2   A0A1B0CMK4   A0A1L8DKM7   A0A1B0D389   A0A336MRQ6   E2BG79   A0A1Y1N4C5   F4X478   A0A151I4A0   A0A158N9I5   A0A151XGP4   A0A1J1IA74   A0A026WDS1   A0A151I9T4   E2AE74   A0A151JUY6   A0A182VWU6   A0A182JUA4   A0A1B6EGW0   A0A1W4WDJ2   A0A182MRH9   A0A2M3ZKW3   A0A182FSP8   D2A3L7   A0A2M4BVZ7   W5J7G5   A0A182P039   A0A2M4BVX7   A0A182NRN6   A0A1W4W2Z8   Q174F3   A0A182LEV2   A0A182XAX1   Q7PRB9   A0A182HSS5   A0A182Q424   A0A182RS46   A0A182TWA7   A0A1W4W2Y8   A0A023ENK9   A0A182SD07   A0A1B6MRD5   B0WSH5   Q174F2   T1E8U4   A0A182YHP8   A0A182H689   A0A1B6EXN2   A0A182V4V6   A0A1B6J4Q5   A0A182JD79   A0A084VBL2   C3ZHT2   A0A1E1XGS7   A0A131Y9M1   A0A2R5LIP8   A0A1L8DKZ8   A0A023FW02   G3MR30   B4M7S0   A0A3B0JE35   B4GXS1   Q29HG0   A0A023GPC4   L7M5H5   A0A131YQ71   B4L6S9   B4NE96   A0A1E1XSU8   A0A224Z4G6   A0A1I8MN68   K1PV86   A0A1A9ZKT8   V9L720   A0A1S3J2P7   B3MR30   A0A1A9UW48   A0A0Q9W7J0   W8BXA8   A0A131YG98   V5I476   A0A0M3QYX5   A0A0R3NZV4   W4ZI62   A0A433TVK4   A0A1B0G8P5   B4PY69   A0A1A9YMG1   A0A0K8VL59   A0A1B0BDK0   V9L016   A0A1I8PC45  

EC Number

3.1.3.16

Pubmed

28756777    26354079    22118469    26227816    20798317    28004739    + More
21719571    21347285    24508170    30249741    18362917    19820115    20920257    23761445    17510324    20966253    12364791    14747013    17210077    24945155    25244985    26483478    24438588    18563158    28503490    22216098    17994087    15632085    25576852    26830274    29209593    28797301    25315136    22992520    24402279    24495485    25765539   

EMBL

RSAL01000008    RVE53996.1    ODYU01011315    SOQ56979.1    KZ149898    PZC78675.1    + More
NWSH01004296    PCG65260.1    PCG65258.1    KQ459582    KPI98805.1    KQ461183    KPJ07545.1    AGBW02007650    OWR55115.1    JTDY01004482    KOB68094.1    AJWK01018835    GFDF01007068    JAV07016.1    AJVK01023364    UFQS01000434    UFQT01000434    UFQT01002194    SSX03910.1    SSX32896.1    GL448116    EFN85287.1    GEZM01013127    JAV92733.1    GL888628    EGI58746.1    KQ976461    KYM84707.1    ADTU01009655    KQ982169    KYQ59468.1    CVRI01000044    CRK96468.1    KK107260    QOIP01000001    EZA54202.1    RLU27582.1    KQ978264    KYM95836.1    GL438827    EFN68307.1    KQ981713    KYN37343.1    GEDC01000184    JAS37114.1    AXCM01004545    GGFM01008418    MBW29169.1    KQ971348    EFA04909.1    GGFJ01008098    MBW57239.1    ADMH02002125    ETN58734.1    GGFJ01008099    MBW57240.1    CH477412    EAT41442.1    AAAB01008859    EAA07503.5    APCN01000336    AXCN02000007    GAPW01003093    JAC10505.1    GEBQ01001518    JAT38459.1    DS232071    EDS33833.1    EAT41441.1    GAMD01001892    JAA99698.1    JXUM01113639    KQ565709    KXJ70756.1    GECZ01027047    JAS42722.1    GECU01034278    GECU01013573    JAS73428.1    JAS94133.1    ATLV01008181    KE524456    KFB35356.1    GG666624    EEN47876.1    GFAC01000716    JAT98472.1    GEFM01000604    JAP75192.1    GGLE01005179    MBY09305.1    GFDF01006993    JAV07091.1    GBBL01001646    JAC25674.1    JO844331    AEO35948.1    CH940653    EDW62837.1    OUUW01000003    SPP78422.1    CH479196    EDW27548.1    CH379064    GBBM01000263    JAC35155.1    GACK01005734    JAA59300.1    GEDV01007937    JAP80620.1    CH933812    EDW06075.1    CH964239    EDW82065.1    GFAA01001059    JAU02376.1    GFPF01011723    MAA22869.1    JH816388    EKC25633.1    JW874911    AFP07428.1    CH902622    EDV34235.1    KRF80812.1    GAMC01000620    JAC05936.1    GEDV01011451    JAP77106.1    GANP01001505    JAB82963.1    CP012528    ALC48379.1    KRT06571.1    AAGJ04094608    RQTK01000164    RUS85620.1    CCAG010000299    CM000162    EDX00942.1    GDHF01014227    GDHF01012700    JAI38087.1    JAI39614.1    JXJN01012507    JW872408    AFP04926.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000092461    UP000092462    UP000008237    UP000007755    UP000078540    UP000005205    UP000075809    UP000183832    UP000053097    UP000279307    UP000078542    UP000000311    UP000078541    UP000075920    UP000075881    UP000192223    UP000075883    UP000069272    UP000007266    UP000000673    UP000075885    UP000075884    UP000008820    UP000075882    UP000076407    UP000007062    UP000075840    UP000075886    UP000075900    UP000075902    UP000075901    UP000002320    UP000076408    UP000069940    UP000249989    UP000075903    UP000075880    UP000030765    UP000001554    UP000008792    UP000268350    UP000008744    UP000001819    UP000009192    UP000007798    UP000095301    UP000005408    UP000092445    UP000085678    UP000007801    UP000078200    UP000092553    UP000007110    UP000271974    UP000092444    UP000002282    UP000092443    UP000092460    UP000095300   

PRIDE

B4L6S9   

Pfam

PF00300   His_Phos_1        + More
PF03896   TRAP_alpha

Interpro

IPR013078   His_Pase_superF_clade-1        + More
IPR029033   His_PPase_superfam       
IPR005595   TRAP_alpha       

SUPFAM

SSF53254   SSF53254       

Gene 3D

3.40.50.1240    

CDD

cd07067  HP_PGM_like

ProteinModelPortal

A0A437BUF9   A0A2H1WV83   A0A2W1BYE3   A0A2A4J1E2   A0A2A4J0Q8   A0A194Q5X1   + More
A0A0N1PHP9   A0A212FN02   A0A0L7KYH2   A0A1B0CMK4   A0A1L8DKM7   A0A1B0D389   A0A336MRQ6   E2BG79   A0A1Y1N4C5   F4X478   A0A151I4A0   A0A158N9I5   A0A151XGP4   A0A1J1IA74   A0A026WDS1   A0A151I9T4   E2AE74   A0A151JUY6   A0A182VWU6   A0A182JUA4   A0A1B6EGW0   A0A1W4WDJ2   A0A182MRH9   A0A2M3ZKW3   A0A182FSP8   D2A3L7   A0A2M4BVZ7   W5J7G5   A0A182P039   A0A2M4BVX7   A0A182NRN6   A0A1W4W2Z8   Q174F3   A0A182LEV2   A0A182XAX1   Q7PRB9   A0A182HSS5   A0A182Q424   A0A182RS46   A0A182TWA7   A0A1W4W2Y8   A0A023ENK9   A0A182SD07   A0A1B6MRD5   B0WSH5   Q174F2   T1E8U4   A0A182YHP8   A0A182H689   A0A1B6EXN2   A0A182V4V6   A0A1B6J4Q5   A0A182JD79   A0A084VBL2   C3ZHT2   A0A1E1XGS7   A0A131Y9M1   A0A2R5LIP8   A0A1L8DKZ8   A0A023FW02   G3MR30   B4M7S0   A0A3B0JE35   B4GXS1   Q29HG0   A0A023GPC4   L7M5H5   A0A131YQ71   B4L6S9   B4NE96   A0A1E1XSU8   A0A224Z4G6   A0A1I8MN68   K1PV86   A0A1A9ZKT8   V9L720   A0A1S3J2P7   B3MR30   A0A1A9UW48   A0A0Q9W7J0   W8BXA8   A0A131YG98   V5I476   A0A0M3QYX5   A0A0R3NZV4   W4ZI62   A0A433TVK4   A0A1B0G8P5   B4PY69   A0A1A9YMG1   A0A0K8VL59   A0A1B0BDK0   V9L016   A0A1I8PC45  

PDB

5MUF     E-value=3.59074e-70,     Score=671

KEGG

101741275    K15637 serine/threonine-protein phosphatase PGAM5 [EC:3.1.3.16] | (RefSeq) serine/threonine-protein

PATHWAY

04137    Mitophagy - animal - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005789   GO:0035970   GO:0006470   GO:0043539   GO:0004722   GO:0005741   GO:0019900   GO:0090141   GO:0072347   GO:0009408   GO:0004721  

Subcellular location

Mitochondrion outer membrane  

Length:

284

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

9.07047

Exp number, first 60 AAs:

8.9366

Total prob of N-in:

0.16940

outside

1  -  284

 

 

Pi

305.841948

Theta

200.665652

Tajima's D

1.661182

CLR

0

CSRT

0.822008899555022

Interpretation

Uncertain