Gene

KWMTBOMO09769

Pre Gene Modal

BGIBMGA012929

Annotation

PREDICTED:_phospholipase_A2-like_[Bombyx_mori]

Location

Bomo_Chr16(+):8894420-8895514      View in EpiBrowser

Full name

Phospholipase A2       + More
Phospholipase A(2)      

Alternative Name

Phosphatidylcholine 2-acylhydrolase
Allergen Api m I

Location in the cell

Extracellular   Reliability : 3.227

CDS

ATGGCCGCTTGTTTATATTGTTCCTTTCTAATGATCGTTTTATACATTAACGGAGTGACCGGCAGCTGGTTTGCGGACGACGCTGCTGTTAATATCGATGAAGACGTACTAGATATTCAAAGTGAAACAATAGCAAGGAAGAAGTTCGACTTCATATTTCCTGGTACAAAATGGTGCGGTAAGGGGGACATAGCGAAGAACTACGAGGACCTGGGCTCAGCGCGCGAGACTGACATGTGCTGTCGAGAGCACGACCACTGCACTGACCTCATACTCGCCGGGGAGACCAAGCACGGCCTCACCAACGACGCCTTCTACACCAGGTTGAACTGTAAATGTGACGAGGCATTCCGGCTGTGTCTGAACAAAGCTAACACGAAGACGTCGCGCAGAATCGGCAAGATATACTTCAACGCGCTCGGCACCAAGTGCTACAGACGAGACTACCCTGTCGTAGGCTGCAACACTTACGGAGGATTGTTCAGAAAGAAATGTTTGGAGTACGATTACGACACGAGGAGCGAACAGATCTACCAGTGGTTCGACGTCAGGAACTACGCCAACTGA

Protein

MAACLYCSFLMIVLYINGVTGSWFADDAAVNIDEDVLDIQSETIARKKFDFIFPGTKWCGKGDIAKNYEDLGSARETDMCCREHDHCTDLILAGETKHGLTNDAFYTRLNCKCDEAFRLCLNKANTKTSRRIGKIYFNALGTKCYRRDYPVVGCNTYGGLFRKKCLEYDYDTRSEQIYQWFDVRNYAN

Description

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

Cofactor

Ca(2+)

Miscellaneous

The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with melittin variation, i.e. their production increase in the same months.

Similarity

Belongs to the phospholipase A2 family.
Belongs to the phospholipase A2 family. Group III subfamily.

Keywords

Allergen   Calcium   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Lipid degradation   Lipid metabolism   Metal-binding   Secreted   Signal   3D-structure   Complete proteome   Reference proteome  

Feature

chain  Phospholipase A2
glycosylation site  N-linked (GlcNAc...) asparagine

Uniprot

H9JTR7   H9JTQ0   H9JTR6   H9JTP9   H9JTQ1   H9JTR4   + More
A0A2H1VKV4   A0A437BU79   A0A3Q8U958   A0A212FMH8   A0A2A4ITF0   A0A2W1BZG9   U4V016   J3JUT4   D6WFW7   A0A1Y1LD35   A0A151IY19   A0A0T6B3S9   A0A0C9QT97   A0A154PF10   A0A0L7R6K6   A0A2L2XXA1   A0A2L2YPZ8   A0A0M8ZRJ1   A0A151X980   A0A195CTK0   E2BDL0   C7B2L3   Q7M4I6   A0A2P6LH46   G3FP81   U3N068   C0LTQ1   T1E1S9   A0A087UYP2   A0A2P8YQI3   A0A1W7RA22   A0A087UYP4   C0LTQ4   B0W2R2   P82971   A0A087UYN9   Q7M4I5   A0A224XGJ6   A0A0C9S3A5   A0A218QXE2   A0A218QXA5   A0A224XFF0   A0A2P6LAN4   A0A182HBX1   A0A2L2YIA1   A0A1J1J4Y0   I7GQA7   Q16H86   A0A1J1HVT8   W5JHV7   A0A182WFX2   A0A139WH39   A0A336LWW5   A0A2A3EI01   B7UUK1   P00630   A0A182FKB8   A0A170RBK2   A0A182NC88   A0A084VSJ7   I1VC86   A0A182SLS6   A0A182YKL8   Q9BMK4   A0A182PJB4   A0A182RYX2   Q7QGS9   A0A1S4H571   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   A0A2D0PCW5   A0A182MAK3   T1INX7   A0A336LI29   A0A182QG10   A0A2P6LH31   A0A139WH90   D6WLM2   A0A139WGU7   A0A1W7RA16   A0A170RBM5   A0A2J7Q6T9   A0A1W4VE46   A0A0U1TZ64   B4P1P1  

EC Number

3.1.1.4

Pubmed

19121390    22118469    28756777    23537049    22516182    18362917    + More
19820115    28004739    26561354    20798317    19539776    19931277    29403074    11692115    25553591    26483478    28546807    17510324    20920257    23761445    12167627    17466468    2776767    4448181    20403370    4614976    8504812    2274788    24438588    25244985    12364791    20966253    17994087    17550304   

EMBL

BABH01003424    BABH01003423    ODYU01003111    SOQ41453.1    RSAL01000008    RVE54007.1    + More
MH061374    AZL90156.1    AGBW02007651    OWR54900.1    NWSH01007341    PCG63001.1    KZ149898    PZC78657.1    KI209013    KI210158    KI210159    ERL95965.1    ERL96175.1    ERL96180.1    BT126999    AEE61961.1    KQ971328    EEZ99784.2    GEZM01059238    JAV71533.1    KQ980780    KYN13196.1    LJIG01009957    KRT82042.1    GBYB01003857    JAG73624.1    KQ434890    KZC10443.1    KQ414646    KOC66459.1    IAAA01000951    LAA00646.1    IAAA01047628    IAAA01047629    LAA10097.1    KQ435889    KOX69497.1    KQ982398    KYQ56870.1    KQ977279    KYN04023.1    GL447678    EFN86172.1    FJ768907    FJ768908    ACU12492.1    MWRG01000062    PRD37888.1    JF751030    AEO51763.1    KF214771    AGW23551.1    FJ768718    ACN42747.1    GAKT01000015    JAA93047.1    KK122319    KFM82481.1    PYGN01000431    PSN46508.1    GFAH01000398    JAV47991.1    KFM82483.1    FJ768721    ACN42750.1    DS231828    EDS29815.1    KFM82478.1    GFBG01000075    JAW07092.1    GBXR01000008    JAG85218.1    GEUW01000022    JAW07023.1    GEUW01000062    JAW06983.1    GFBG01000076    JAW07091.1    MWRG01000625    PRD35635.1    JXUM01032580    KQ560960    KXJ80209.1    IAAA01020399    LAA07839.1    CVRI01000072    CRL07447.1    AB731659    BAM25049.1    CH478192    EAT33614.1    CVRI01000017    CRK90265.1    ADMH02001144    ETN63942.1    KQ971343    KYB27219.1    UFQS01000176    UFQT01000176    SSX00773.1    SSX21153.1    KZ288249    PBC31104.1    FM203121    CAR56722.1    AF438408    EF373554    X16709    KU203673    ANB82417.1    ATLV01016045    KE525054    KFB40941.1    JQ900380    AFI40558.1    AF321087    AAAB01008823    EAA05503.4    APCN01003445    HAHE01000501    SNX36715.1    AXCM01005795    JH431228    UFQS01004355    UFQT01004355    SSX16345.1    SSX35663.1    AXCN02001761    PRD37887.1    KYB27221.1    EFA03430.2    KYB27220.1    GFAH01000397    JAV47992.1    KU203674    ANB82418.1    NEVH01017450    PNF24304.1    EU252426    ACD11980.1    CM000157    EDW89177.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000218220    UP000030742    UP000007266    + More
UP000078492    UP000076502    UP000053825    UP000053105    UP000075809    UP000078542    UP000008237    UP000054359    UP000245037    UP000002320    UP000069940    UP000249989    UP000183832    UP000008820    UP000000673    UP000075920    UP000242457    UP000005203    UP000069272    UP000075884    UP000030765    UP000075901    UP000076408    UP000075885    UP000075900    UP000007062    UP000076407    UP000075903    UP000075882    UP000075840    UP000075883    UP000075886    UP000235965    UP000192221    UP000002282   

PRIDE

H9JTR7    H9JTQ0    H9JTR6    H9JTP9    H9JTQ1    H9JTR4    + More
P82971    P00630   

Pfam

PF05826   Phospholip_A2_2

Interpro

IPR016090   PLipase_A2_dom        + More
IPR036444   PLipase_A2_dom_sf       
IPR033113   PLipase_A2_His_AS       

SUPFAM

SSF48619   SSF48619       

Gene 3D

1.20.90.10    

ProteinModelPortal

H9JTR7   H9JTQ0   H9JTR6   H9JTP9   H9JTQ1   H9JTR4   + More
A0A2H1VKV4   A0A437BU79   A0A3Q8U958   A0A212FMH8   A0A2A4ITF0   A0A2W1BZG9   U4V016   J3JUT4   D6WFW7   A0A1Y1LD35   A0A151IY19   A0A0T6B3S9   A0A0C9QT97   A0A154PF10   A0A0L7R6K6   A0A2L2XXA1   A0A2L2YPZ8   A0A0M8ZRJ1   A0A151X980   A0A195CTK0   E2BDL0   C7B2L3   Q7M4I6   A0A2P6LH46   G3FP81   U3N068   C0LTQ1   T1E1S9   A0A087UYP2   A0A2P8YQI3   A0A1W7RA22   A0A087UYP4   C0LTQ4   B0W2R2   P82971   A0A087UYN9   Q7M4I5   A0A224XGJ6   A0A0C9S3A5   A0A218QXE2   A0A218QXA5   A0A224XFF0   A0A2P6LAN4   A0A182HBX1   A0A2L2YIA1   A0A1J1J4Y0   I7GQA7   Q16H86   A0A1J1HVT8   W5JHV7   A0A182WFX2   A0A139WH39   A0A336LWW5   A0A2A3EI01   B7UUK1   P00630   A0A182FKB8   A0A170RBK2   A0A182NC88   A0A084VSJ7   I1VC86   A0A182SLS6   A0A182YKL8   Q9BMK4   A0A182PJB4   A0A182RYX2   Q7QGS9   A0A1S4H571   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   A0A2D0PCW5   A0A182MAK3   T1INX7   A0A336LI29   A0A182QG10   A0A2P6LH31   A0A139WH90   D6WLM2   A0A139WGU7   A0A1W7RA16   A0A170RBM5   A0A2J7Q6T9   A0A1W4VE46   A0A0U1TZ64   B4P1P1  

PDB

1POC     E-value=1.21266e-32,     Score=345

KEGG

101745772    K01047 secretory phospholipase A2 [EC:3.1.1.4] | (RefSeq) phospholipase A2-like

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
00590    Arachidonic acid metabolism - Bombyx mori (domestic silkworm)
00591    Linoleic acid metabolism - Bombyx mori (domestic silkworm)
00592    alpha-Linolenic acid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004623   GO:0006644   GO:0050482   GO:0005576   GO:0016021   GO:0047498   GO:0046872   GO:0016042   GO:0102568   GO:0102567   GO:0005509   GO:0004222   GO:0016638   GO:0005488   GO:0005515   GO:0009258   GO:0016155   GO:0003824  

Subcellular location

Secreted  

SignalP

Position:   1 - 21,         Likelihood:  0.934144

 

 

Length:

188

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

14.9453

Exp number, first 60 AAs:

14.94404

Total prob of N-in:

0.69860

POSSIBLE N-term signal

sequence

outside

1  -  188

 

 

Pi

477.122387

Theta

213.097649

Tajima's D

3.839087

CLR

0.260155

CSRT

0.99830008499575

Interpretation

Uncertain