Gene

KWMTBOMO09766

Pre Gene Modal

BGIBMGA012912

Annotation

PREDICTED:_phospholipase_A2-like_[Bombyx_mori]

Location

Bomo_Chr16(+):8884110-8886650      View in EpiBrowser

Full name

Phospholipase A2       + More
Phospholipase A(2)      

Alternative Name

Phosphatidylcholine 2-acylhydrolase
Allergen Api m I

Location in the cell

Extracellular   Reliability : 1.904

CDS

ATGATCATACCAAAATTTTATGGCCTAGGTACAAAATGGTGCGGTAAAGGGGACATAGCGAAGAACTACGATGACCTGGGCTCAGCGCGCGAGACTGACATGTGCTGTCGGGAGCACGACCACTGCACTGACCTTATACTCGCCGGGGAGACCAAGCACGGCCTCACCAACGACGCCTTCTACACCAGGTTGAACTGTAAATGTGACGAGGCATTCCGGCTGTGTCTGAACAAAGCTAACACGAAGACGTCGCGCAGAATCGGCAAGATATACTTCAACGCGCTCGGCACCAAGTGCTACAGACGAGACTACCCTGTCGTAGGCTGCAACACTTACGGAGGATTGTTCAGAAAGAAATGTTTGGAGTACGATTACGACACGAGGAGCGAACAGATCTACCAGTGGTTCGACGTCAGGAACTACGCCAACTGA

Protein

MIIPKFYGLGTKWCGKGDIAKNYDDLGSARETDMCCREHDHCTDLILAGETKHGLTNDAFYTRLNCKCDEAFRLCLNKANTKTSRRIGKIYFNALGTKCYRRDYPVVGCNTYGGLFRKKCLEYDYDTRSEQIYQWFDVRNYAN

Description

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

Cofactor

Ca(2+)

Miscellaneous

The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with melittin variation, i.e. their production increase in the same months.

Similarity

Belongs to the phospholipase A2 family.
Belongs to the phospholipase A2 family. Group III subfamily.

Keywords

Allergen   Calcium   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Lipid degradation   Lipid metabolism   Metal-binding   Secreted   Signal   3D-structure   Complete proteome   Reference proteome  

Feature

chain  Phospholipase A2
glycosylation site  N-linked (GlcNAc...) asparagine

Uniprot

H9JTQ0   H9JTR7   H9JTR6   H9JTR4   H9JTP9   H9JTQ1   + More
H9JTP8   A0A2H1VKV4   A0A3Q8U958   A0A437BU79   A0A212FMH8   A0A2A4ITF0   A0A2W1BZG9   D6WFW7   U4V016   A0A151IY19   J3JUT4   A0A1Y1LD35   A0A0M8ZRJ1   A0A0T6B3S9   A0A2P6LH46   A0A0C9QT97   A0A151X980   A0A154PF10   A0A2L2YPZ8   A0A194PZT8   A0A2L2XXA1   A0A0L7R6K6   Q7M4I6   E2BDL0   A0A195CTK0   C7B2L3   G3FP81   U3N068   T1E1S9   A0A2J7Q6Z2   A0A224XGJ6   A0A2P8YQI3   A0A087UYP4   A0A224XFF0   C0LTQ1   A0A087UYP2   Q7M4I5   A0A2L2YIA1   P82971   E1ZYJ2   A0A182WFX2   B0W2R2   I7GQA7   A0A182FKB8   A0A087UYN9   C0LTQ4   A0A0C9S3A5   A0A170RBK2   A0A218QXA5   A0A1W7RA22   A0A218QXE2   Q16H86   A0A182HBX1   A0A2A3EI01   W5JHV7   A0A182RYX2   A0A1J1J4Y0   A0A1J1HVT8   B7UUK1   P00630   A0A182UJE0   A0A182MAK3   A0A182NC88   A0A3L8DCJ6   A0A2P6LAN4   A0A084VSJ7   A0A026WKB6   I1VC86   Q9BMK4   A0A2D0PCW5   A0A182YKL8   A0A182SLS6   A0A182PJB4   A0A182QG10   A0A170RBM5   A0A139WH90   D6WLM2   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   A0A139WGU7   Q7QGS9   A0A1S4H571   A0A139WH39   T1INX7   A0A0P4W3M7   A0A160G5A6   A0A0U1TZ64   A0A151I0C4   A0A2P6LH31   A0A034VFP0  

EC Number

3.1.1.4

Pubmed

19121390    22118469    28756777    18362917    19820115    23537049    + More
22516182    28004739    26561354    26354079    20798317    19539776    29403074    19931277    11692115    28546807    25553591    17510324    26483478    20920257    23761445    12167627    17466468    2776767    4448181    20403370    4614976    8504812    2274788    30249741    24438588    24508170    25244985    20966253    12364791    25348373   

EMBL

BABH01003424    BABH01003423    BABH01003425    ODYU01003111    SOQ41453.1    MH061374    + More
AZL90156.1    RSAL01000008    RVE54007.1    AGBW02007651    OWR54900.1    NWSH01007341    PCG63001.1    KZ149898    PZC78657.1    KQ971328    EEZ99784.2    KI209013    KI210158    KI210159    ERL95965.1    ERL96175.1    ERL96180.1    KQ980780    KYN13196.1    BT126999    AEE61961.1    GEZM01059238    JAV71533.1    KQ435889    KOX69497.1    LJIG01009957    KRT82042.1    MWRG01000062    PRD37888.1    GBYB01003857    JAG73624.1    KQ982398    KYQ56870.1    KQ434890    KZC10443.1    IAAA01047628    IAAA01047629    LAA10097.1    KQ459582    KPI98836.1    IAAA01000951    LAA00646.1    KQ414646    KOC66459.1    GL447678    EFN86172.1    KQ977279    KYN04023.1    FJ768907    FJ768908    ACU12492.1    JF751030    AEO51763.1    KF214771    AGW23551.1    GAKT01000015    JAA93047.1    NEVH01017450    PNF24357.1    GFBG01000075    JAW07092.1    PYGN01000431    PSN46508.1    KK122319    KFM82483.1    GFBG01000076    JAW07091.1    FJ768718    ACN42747.1    KFM82481.1    IAAA01020399    LAA07839.1    GL435225    EFN73746.1    DS231828    EDS29815.1    AB731659    BAM25049.1    KFM82478.1    FJ768721    ACN42750.1    GBXR01000008    JAG85218.1    KU203673    ANB82417.1    GEUW01000062    JAW06983.1    GFAH01000398    JAV47991.1    GEUW01000022    JAW07023.1    CH478192    EAT33614.1    JXUM01032580    KQ560960    KXJ80209.1    KZ288249    PBC31104.1    ADMH02001144    ETN63942.1    CVRI01000072    CRL07447.1    CVRI01000017    CRK90265.1    FM203121    CAR56722.1    AF438408    EF373554    X16709    AXCM01005795    QOIP01000010    RLU17599.1    MWRG01000625    PRD35635.1    ATLV01016045    KE525054    KFB40941.1    KK107167    EZA56418.1    JQ900380    AFI40558.1    AF321087    HAHE01000501    SNX36715.1    AXCN02001761    KU203674    ANB82418.1    KQ971343    KYB27221.1    EFA03430.2    APCN01003445    KYB27220.1    AAAB01008823    EAA05503.4    KYB27219.1    JH431228    GDRN01087699    JAI61002.1    KU203672    ANB82416.1    EU252426    ACD11980.1    KQ976639    KYM78825.1    PRD37887.1    GAKP01018579    JAC40373.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000218220    UP000007266    UP000030742    + More
UP000078492    UP000053105    UP000075809    UP000076502    UP000053268    UP000053825    UP000008237    UP000078542    UP000235965    UP000245037    UP000054359    UP000000311    UP000075920    UP000002320    UP000069272    UP000008820    UP000069940    UP000249989    UP000242457    UP000000673    UP000075900    UP000183832    UP000005203    UP000075902    UP000075883    UP000075884    UP000279307    UP000030765    UP000053097    UP000076408    UP000075901    UP000075885    UP000075886    UP000076407    UP000075903    UP000075882    UP000075840    UP000007062    UP000078540   

PRIDE

H9JTQ0    H9JTR7    H9JTR6    H9JTR4    H9JTP9    H9JTQ1    + More
H9JTP8    P82971    P00630   

Pfam

PF05826   Phospholip_A2_2        + More
PF15706   TMEM132D_C
PF16070   TMEM132
PF15705   TMEM132D_N

Interpro

IPR033113   PLipase_A2_His_AS        + More
IPR016090   PLipase_A2_dom       
IPR036444   PLipase_A2_dom_sf       
IPR031436   TMEM132_C       
IPR026307   TMEM132       
IPR031435   TMEM132_N       
IPR031437   TMEM132_M       

SUPFAM

SSF48619   SSF48619       

Gene 3D

1.20.90.10    

ProteinModelPortal

H9JTQ0   H9JTR7   H9JTR6   H9JTR4   H9JTP9   H9JTQ1   + More
H9JTP8   A0A2H1VKV4   A0A3Q8U958   A0A437BU79   A0A212FMH8   A0A2A4ITF0   A0A2W1BZG9   D6WFW7   U4V016   A0A151IY19   J3JUT4   A0A1Y1LD35   A0A0M8ZRJ1   A0A0T6B3S9   A0A2P6LH46   A0A0C9QT97   A0A151X980   A0A154PF10   A0A2L2YPZ8   A0A194PZT8   A0A2L2XXA1   A0A0L7R6K6   Q7M4I6   E2BDL0   A0A195CTK0   C7B2L3   G3FP81   U3N068   T1E1S9   A0A2J7Q6Z2   A0A224XGJ6   A0A2P8YQI3   A0A087UYP4   A0A224XFF0   C0LTQ1   A0A087UYP2   Q7M4I5   A0A2L2YIA1   P82971   E1ZYJ2   A0A182WFX2   B0W2R2   I7GQA7   A0A182FKB8   A0A087UYN9   C0LTQ4   A0A0C9S3A5   A0A170RBK2   A0A218QXA5   A0A1W7RA22   A0A218QXE2   Q16H86   A0A182HBX1   A0A2A3EI01   W5JHV7   A0A182RYX2   A0A1J1J4Y0   A0A1J1HVT8   B7UUK1   P00630   A0A182UJE0   A0A182MAK3   A0A182NC88   A0A3L8DCJ6   A0A2P6LAN4   A0A084VSJ7   A0A026WKB6   I1VC86   Q9BMK4   A0A2D0PCW5   A0A182YKL8   A0A182SLS6   A0A182PJB4   A0A182QG10   A0A170RBM5   A0A139WH90   D6WLM2   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   A0A139WGU7   Q7QGS9   A0A1S4H571   A0A139WH39   T1INX7   A0A0P4W3M7   A0A160G5A6   A0A0U1TZ64   A0A151I0C4   A0A2P6LH31   A0A034VFP0  

PDB

1POC     E-value=3.00138e-30,     Score=322

KEGG

101746058    K01047 secretory phospholipase A2 [EC:3.1.1.4] | (RefSeq) phospholipase A2-like

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
00590    Arachidonic acid metabolism - Bombyx mori (domestic silkworm)
00591    Linoleic acid metabolism - Bombyx mori (domestic silkworm)
00592    alpha-Linolenic acid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0006644   GO:0004623   GO:0050482   GO:0005576   GO:0047498   GO:0046872   GO:0016042   GO:0102568   GO:0102567   GO:0005509   GO:0004222   GO:0016638   GO:0005488   GO:0005515   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR13388  

Subcellular location

Secreted  

Length:

143

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00018

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03904

outside

1  -  143

 

 

Pi

467.758132

Theta

228.694006

Tajima's D

3.504908

CLR

0.044429

CSRT

0.994250287485626

Interpretation

Uncertain