SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO09763
Pre Gene Modal
BGIBMGA012929
Annotation
PREDICTED:_phospholipase_A2-like_[Bombyx_mori]
Full name
Phospholipase A2       + More
Phospholipase A(2)      
Alternative Name
Phosphatidylcholine 2-acylhydrolase
Allergen Api m I
Location in the cell
Extracellular   Reliability : 2.994
 

Sequence

CDS
ATGGCCGCTTGTTTATATTGTTTCTTTCTAATGATCGTTTTATACATTAACGGAGTGACCGGCAGCTGGTTCGCGAACGACGCTGCTGTTAATATCGATGAAGACGTACTAGATATTCAAAGTGAAACAATAGCAAGGAAGAAGTTCGACTTCATATTTCCTGGTACAAAATGGTGCGGTAAAGGGGACATAGCGAAGAACTACGAGGACCTGGGCTCAGCGCGCGAGACTGACATGTGCTGTCGGGAGCACGACCACTGCACTGACCTCATACTCGCCGGGGAGACCAAGCACGGCCTCACCAACGATGCCTTCTACACCAGGTTGAACTGTAAATGTGACGAGACATTCCGGCTGTGTCTGAACAAAGCTAACACGAAGACGTCGCGCAGAATCGGCAAGATATACTTCAACGCGCTCGGCACTAAGTGCTACAGACGAGACTACCCTGTCGTAGGCTGCAACACTTACGGAGGATTGTTCAGAAAGAAATGTTTGGAGTACGATTACGATACGAGGAGCGAACAGATCTACCAGTGGTTCGACGTCAGGAACTACGCCAACTGA
Protein
MAACLYCFFLMIVLYINGVTGSWFANDAAVNIDEDVLDIQSETIARKKFDFIFPGTKWCGKGDIAKNYEDLGSARETDMCCREHDHCTDLILAGETKHGLTNDAFYTRLNCKCDETFRLCLNKANTKTSRRIGKIYFNALGTKCYRRDYPVVGCNTYGGLFRKKCLEYDYDTRSEQIYQWFDVRNYAN

Summary

Description
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Catalytic Activity
a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
Cofactor
Ca(2+)
Miscellaneous
The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with melittin variation, i.e. their production increase in the same months.
Similarity
Belongs to the phospholipase A2 family.
Belongs to the phospholipase A2 family. Group III subfamily.
Keywords
Allergen   Calcium   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Lipid degradation   Lipid metabolism   Metal-binding   Secreted   Signal   3D-structure   Complete proteome   Reference proteome  
Feature
chain  Phospholipase A2
glycosylation site  N-linked (GlcNAc...) asparagine
EC Number
3.1.1.4
EMBL
BABH01003424    BABH01003423    ODYU01003111    SOQ41453.1    RSAL01000008    RVE54007.1    + More
MH061374    AZL90156.1    AGBW02007651    OWR54900.1    NWSH01007341    PCG63001.1    KZ149898    PZC78657.1    KI209013    KI210158    KI210159    ERL95965.1    ERL96175.1    ERL96180.1    KQ971328    EEZ99784.2    BT126999    AEE61961.1    GEZM01059238    JAV71533.1    KQ980780    KYN13196.1    GBYB01003857    JAG73624.1    LJIG01009957    KRT82042.1    KQ434890    KZC10443.1    IAAA01000951    LAA00646.1    IAAA01047628    IAAA01047629    LAA10097.1    KQ414646    KOC66459.1    KQ982398    KYQ56870.1    KQ435889    KOX69497.1    FJ768907    FJ768908    ACU12492.1    KQ977279    KYN04023.1    KF214771    AGW23551.1    JF751030    AEO51763.1    GL447678    EFN86172.1    MWRG01000062    PRD37888.1    FJ768718    ACN42747.1    KK122319    KFM82481.1    GFAH01000398    JAV47991.1    PYGN01000431    PSN46508.1    GAKT01000015    JAA93047.1    KFM82483.1    FJ768721    ACN42750.1    KFM82478.1    DS231828    EDS29815.1    JXUM01032580    KQ560960    KXJ80209.1    CH478192    EAT33614.1    GFBG01000075    JAW07092.1    GBXR01000008    JAG85218.1    GEUW01000062    JAW06983.1    GEUW01000022    JAW07023.1    KZ288249    PBC31104.1    GFBG01000076    JAW07091.1    ADMH02001144    ETN63942.1    IAAA01020399    LAA07839.1    CVRI01000072    CRL07447.1    KQ971343    KYB27219.1    CVRI01000017    CRK90265.1    AB731659    BAM25049.1    MWRG01000625    PRD35635.1    FM203121    CAR56722.1    AF438408    EF373554    X16709    AF321087    ATLV01016045    KE525054    KFB40941.1    KU203673    ANB82417.1    JQ900380    AFI40558.1    UFQS01000176    UFQT01000176    SSX00773.1    SSX21153.1    AAAB01008823    EAA05503.4    QOIP01000010    RLU17599.1    APCN01003445    JH431228    AXCM01005795    HAHE01000501    SNX36715.1    KU203674    ANB82418.1    GFAH01000397    JAV47992.1    AXCN02001761    KQ976639    KYM78825.1    PRD37887.1    KYB27221.1    EFA03430.2    KYB27220.1    NEVH01017450    PNF24304.1    UFQS01004355    UFQT01004355    SSX16345.1    SSX35663.1    EU252426    ACD11980.1   
Pfam
PF05826   Phospholip_A2_2        + More
PF16070   TMEM132
PF15705   TMEM132D_N
PF15706   TMEM132D_C
Interpro
IPR016090   PLipase_A2_dom        + More
IPR036444   PLipase_A2_dom_sf       
IPR033113   PLipase_A2_His_AS       
IPR031436   TMEM132_C       
IPR026307   TMEM132       
IPR031435   TMEM132_N       
IPR031437   TMEM132_M       
SUPFAM
SSF48619   SSF48619       
Gene 3D
PDB
1POC     E-value=1.07e-32,     Score=346

Ontologies

Topology

Subcellular location
Secreted  
SignalP
Position:   1 - 21,         Likelihood:  0.969767
 
 
Length:
188
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
19.30389
Exp number, first 60 AAs:
19.30276
Total prob of N-in:
0.85853
POSSIBLE N-term signal
sequence
inside
1  -  1
TMhelix
2  -  24
outside
25  -  188
 
 

Population Genetic Test Statistics

Pi
386.863414
Theta
212.654768
Tajima's D
2.647558
CLR
0
CSRT
0.955102244887756
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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