Gene

KWMTBOMO09763

Pre Gene Modal

BGIBMGA012929

Annotation

PREDICTED:_phospholipase_A2-like_[Bombyx_mori]

Location

Bomo_Chr16(-):8872801-8874029      View in EpiBrowser

Full name

Phospholipase A2       + More
Phospholipase A(2)      

Alternative Name

Phosphatidylcholine 2-acylhydrolase
Allergen Api m I

Location in the cell

Extracellular   Reliability : 2.994

CDS

ATGGCCGCTTGTTTATATTGTTTCTTTCTAATGATCGTTTTATACATTAACGGAGTGACCGGCAGCTGGTTCGCGAACGACGCTGCTGTTAATATCGATGAAGACGTACTAGATATTCAAAGTGAAACAATAGCAAGGAAGAAGTTCGACTTCATATTTCCTGGTACAAAATGGTGCGGTAAAGGGGACATAGCGAAGAACTACGAGGACCTGGGCTCAGCGCGCGAGACTGACATGTGCTGTCGGGAGCACGACCACTGCACTGACCTCATACTCGCCGGGGAGACCAAGCACGGCCTCACCAACGATGCCTTCTACACCAGGTTGAACTGTAAATGTGACGAGACATTCCGGCTGTGTCTGAACAAAGCTAACACGAAGACGTCGCGCAGAATCGGCAAGATATACTTCAACGCGCTCGGCACTAAGTGCTACAGACGAGACTACCCTGTCGTAGGCTGCAACACTTACGGAGGATTGTTCAGAAAGAAATGTTTGGAGTACGATTACGATACGAGGAGCGAACAGATCTACCAGTGGTTCGACGTCAGGAACTACGCCAACTGA

Protein

MAACLYCFFLMIVLYINGVTGSWFANDAAVNIDEDVLDIQSETIARKKFDFIFPGTKWCGKGDIAKNYEDLGSARETDMCCREHDHCTDLILAGETKHGLTNDAFYTRLNCKCDETFRLCLNKANTKTSRRIGKIYFNALGTKCYRRDYPVVGCNTYGGLFRKKCLEYDYDTRSEQIYQWFDVRNYAN

Description

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

Cofactor

Ca(2+)

Miscellaneous

The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with melittin variation, i.e. their production increase in the same months.

Similarity

Belongs to the phospholipase A2 family.
Belongs to the phospholipase A2 family. Group III subfamily.

Keywords

Allergen   Calcium   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Lipid degradation   Lipid metabolism   Metal-binding   Secreted   Signal   3D-structure   Complete proteome   Reference proteome  

Feature

chain  Phospholipase A2
glycosylation site  N-linked (GlcNAc...) asparagine

Uniprot

H9JTR7   H9JTR6   H9JTQ0   H9JTP9   H9JTQ1   H9JTR4   + More
A0A2H1VKV4   A0A437BU79   A0A3Q8U958   A0A212FMH8   A0A2A4ITF0   A0A2W1BZG9   U4V016   D6WFW7   J3JUT4   A0A1Y1LD35   A0A151IY19   A0A0C9QT97   A0A0T6B3S9   A0A154PF10   A0A2L2XXA1   A0A2L2YPZ8   A0A0L7R6K6   A0A151X980   A0A0M8ZRJ1   C7B2L3   A0A195CTK0   U3N068   G3FP81   E2BDL0   Q7M4I6   A0A2P6LH46   C0LTQ1   A0A087UYP2   A0A1W7RA22   A0A2P8YQI3   T1E1S9   A0A087UYP4   C0LTQ4   P82971   A0A087UYN9   B0W2R2   A0A182HBX1   Q7M4I5   Q16H86   A0A224XGJ6   A0A0C9S3A5   A0A218QXA5   A0A218QXE2   A0A2A3EI01   A0A224XFF0   W5JHV7   A0A2L2YIA1   A0A1J1J4Y0   A0A139WH39   A0A1J1HVT8   I7GQA7   A0A182WFX2   A0A2P6LAN4   A0A182SLS6   B7UUK1   P00630   A0A182FKB8   Q9BMK4   A0A182NC88   A0A084VSJ7   A0A170RBK2   A0A182PJB4   I1VC86   A0A182YKL8   A0A182RYX2   A0A336LWW5   Q7QGS9   A0A3L8DCJ6   A0A1S4H571   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   T1INX7   A0A182MAK3   A0A2D0PCW5   A0A170RBM5   A0A1W7RA16   A0A182QG10   A0A151I0C4   A0A2P6LH31   A0A139WH90   D6WLM2   A0A139WGU7   A0A1W4VE46   A0A2J7Q6T9   A0A336LI29   A0A0U1TZ64  

EC Number

3.1.1.4

Pubmed

19121390    22118469    28756777    23537049    18362917    19820115    + More
22516182    28004739    26561354    19539776    20798317    19931277    29403074    11692115    26483478    17510324    25553591    20920257    23761445    28546807    12167627    17466468    2776767    4448181    20403370    4614976    8504812    2274788    24438588    25244985    12364791    30249741    20966253   

EMBL

BABH01003424    BABH01003423    ODYU01003111    SOQ41453.1    RSAL01000008    RVE54007.1    + More
MH061374    AZL90156.1    AGBW02007651    OWR54900.1    NWSH01007341    PCG63001.1    KZ149898    PZC78657.1    KI209013    KI210158    KI210159    ERL95965.1    ERL96175.1    ERL96180.1    KQ971328    EEZ99784.2    BT126999    AEE61961.1    GEZM01059238    JAV71533.1    KQ980780    KYN13196.1    GBYB01003857    JAG73624.1    LJIG01009957    KRT82042.1    KQ434890    KZC10443.1    IAAA01000951    LAA00646.1    IAAA01047628    IAAA01047629    LAA10097.1    KQ414646    KOC66459.1    KQ982398    KYQ56870.1    KQ435889    KOX69497.1    FJ768907    FJ768908    ACU12492.1    KQ977279    KYN04023.1    KF214771    AGW23551.1    JF751030    AEO51763.1    GL447678    EFN86172.1    MWRG01000062    PRD37888.1    FJ768718    ACN42747.1    KK122319    KFM82481.1    GFAH01000398    JAV47991.1    PYGN01000431    PSN46508.1    GAKT01000015    JAA93047.1    KFM82483.1    FJ768721    ACN42750.1    KFM82478.1    DS231828    EDS29815.1    JXUM01032580    KQ560960    KXJ80209.1    CH478192    EAT33614.1    GFBG01000075    JAW07092.1    GBXR01000008    JAG85218.1    GEUW01000062    JAW06983.1    GEUW01000022    JAW07023.1    KZ288249    PBC31104.1    GFBG01000076    JAW07091.1    ADMH02001144    ETN63942.1    IAAA01020399    LAA07839.1    CVRI01000072    CRL07447.1    KQ971343    KYB27219.1    CVRI01000017    CRK90265.1    AB731659    BAM25049.1    MWRG01000625    PRD35635.1    FM203121    CAR56722.1    AF438408    EF373554    X16709    AF321087    ATLV01016045    KE525054    KFB40941.1    KU203673    ANB82417.1    JQ900380    AFI40558.1    UFQS01000176    UFQT01000176    SSX00773.1    SSX21153.1    AAAB01008823    EAA05503.4    QOIP01000010    RLU17599.1    APCN01003445    JH431228    AXCM01005795    HAHE01000501    SNX36715.1    KU203674    ANB82418.1    GFAH01000397    JAV47992.1    AXCN02001761    KQ976639    KYM78825.1    PRD37887.1    KYB27221.1    EFA03430.2    KYB27220.1    NEVH01017450    PNF24304.1    UFQS01004355    UFQT01004355    SSX16345.1    SSX35663.1    EU252426    ACD11980.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000218220    UP000030742    UP000007266    + More
UP000078492    UP000076502    UP000053825    UP000075809    UP000053105    UP000078542    UP000008237    UP000054359    UP000245037    UP000002320    UP000069940    UP000249989    UP000008820    UP000242457    UP000000673    UP000183832    UP000075920    UP000075901    UP000005203    UP000069272    UP000075884    UP000030765    UP000075885    UP000076408    UP000075900    UP000007062    UP000279307    UP000076407    UP000075903    UP000075882    UP000075840    UP000075883    UP000075886    UP000078540    UP000192221    UP000235965   

PRIDE

H9JTR7    H9JTR6    H9JTQ0    H9JTP9    H9JTQ1    H9JTR4    + More
P82971    P00630   

Pfam

PF05826   Phospholip_A2_2        + More
PF16070   TMEM132
PF15705   TMEM132D_N
PF15706   TMEM132D_C

Interpro

IPR016090   PLipase_A2_dom        + More
IPR036444   PLipase_A2_dom_sf       
IPR033113   PLipase_A2_His_AS       
IPR031436   TMEM132_C       
IPR026307   TMEM132       
IPR031435   TMEM132_N       
IPR031437   TMEM132_M       

SUPFAM

SSF48619   SSF48619       

Gene 3D

1.20.90.10    

ProteinModelPortal

H9JTR7   H9JTR6   H9JTQ0   H9JTP9   H9JTQ1   H9JTR4   + More
A0A2H1VKV4   A0A437BU79   A0A3Q8U958   A0A212FMH8   A0A2A4ITF0   A0A2W1BZG9   U4V016   D6WFW7   J3JUT4   A0A1Y1LD35   A0A151IY19   A0A0C9QT97   A0A0T6B3S9   A0A154PF10   A0A2L2XXA1   A0A2L2YPZ8   A0A0L7R6K6   A0A151X980   A0A0M8ZRJ1   C7B2L3   A0A195CTK0   U3N068   G3FP81   E2BDL0   Q7M4I6   A0A2P6LH46   C0LTQ1   A0A087UYP2   A0A1W7RA22   A0A2P8YQI3   T1E1S9   A0A087UYP4   C0LTQ4   P82971   A0A087UYN9   B0W2R2   A0A182HBX1   Q7M4I5   Q16H86   A0A224XGJ6   A0A0C9S3A5   A0A218QXA5   A0A218QXE2   A0A2A3EI01   A0A224XFF0   W5JHV7   A0A2L2YIA1   A0A1J1J4Y0   A0A139WH39   A0A1J1HVT8   I7GQA7   A0A182WFX2   A0A2P6LAN4   A0A182SLS6   B7UUK1   P00630   A0A182FKB8   Q9BMK4   A0A182NC88   A0A084VSJ7   A0A170RBK2   A0A182PJB4   I1VC86   A0A182YKL8   A0A182RYX2   A0A336LWW5   Q7QGS9   A0A3L8DCJ6   A0A1S4H571   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   T1INX7   A0A182MAK3   A0A2D0PCW5   A0A170RBM5   A0A1W7RA16   A0A182QG10   A0A151I0C4   A0A2P6LH31   A0A139WH90   D6WLM2   A0A139WGU7   A0A1W4VE46   A0A2J7Q6T9   A0A336LI29   A0A0U1TZ64  

PDB

1POC     E-value=1.07e-32,     Score=346

KEGG

101746486    K01047 secretory phospholipase A2 [EC:3.1.1.4] | (RefSeq) phospholipase A2-like

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
00590    Arachidonic acid metabolism - Bombyx mori (domestic silkworm)
00591    Linoleic acid metabolism - Bombyx mori (domestic silkworm)
00592    alpha-Linolenic acid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004623   GO:0006644   GO:0050482   GO:0005576   GO:0016021   GO:0047498   GO:0046872   GO:0016042   GO:0102568   GO:0102567   GO:0005509   GO:0004222   GO:0016638   GO:0005488   GO:0005515   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR13388  

Subcellular location

Secreted  

SignalP

Position:   1 - 21,         Likelihood:  0.969767

 

 

Length:

188

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.30389

Exp number, first 60 AAs:

19.30276

Total prob of N-in:

0.85853

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  24

outside

25  -  188

 

 

Pi

386.863414

Theta

212.654768

Tajima's D

2.647558

CLR

0

CSRT

0.955102244887756

Interpretation

Uncertain