Gene

KWMTBOMO09762  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012910

Annotation

PREDICTED:_phospholipase_A2-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr16(+):8861290-8871787      View in EpiBrowser

Full name

Phospholipase A2       + More
Phospholipase A(2)      

Alternative Name

Phosphatidylcholine 2-acylhydrolase
Allergen Api m I

Location in the cell

Cytoplasmic   Reliability : 1.102 Extracellular   Reliability : 1.57 PlasmaMembrane   Reliability : 1.12

CDS

ATGTTTCGTCATTTATTCTGTCTCATTGTTCTGATCGCCGTTCACACTAACAAAGCGGCAGAGATCAGGATCGATCCGGATATTTTTGGTTTTCAAAGCGCCATATACGAAACTAACTTTGTGTTCCCTGGTACAATGTGGTGTGGTGCAGGACATGTGGCAGAGAGTTACGAGGATTTGGGTTCGGAGTGGGAGACCGACATGTGCTGTCGGGAGCACGACCACTGCACTGACCTCATACCCGCCGGGGAGACCAAGCACAGTCTCACCAATGACGGCTTCTATGCCAGATTAAGCTGTGAATGTGATGAAAAGTTTCGGCTATGTCTTAAAAATGCTAATACGGATATATCGCATACAGTTGGCATGACGTACTTCGATACTATTGGAACGAAGTGTTACAGAAAGGACTACCCGGTCGTAGGTTGCCAGATGTACGGAGGCATGTTCATGCCAATTTGTTTGGAGTACGAATTCGATAAGAAGAGCGAACAGATCTACCAGTGGTTCGACGTCAAAGGGTACTCTGAGTGA

Protein

MFRHLFCLIVLIAVHTNKAAEIRIDPDIFGFQSAIYETNFVFPGTMWCGAGHVAESYEDLGSEWETDMCCREHDHCTDLIPAGETKHSLTNDGFYARLSCECDEKFRLCLKNANTDISHTVGMTYFDTIGTKCYRKDYPVVGCQMYGGMFMPICLEYEFDKKSEQIYQWFDVKGYSE

Description

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

Cofactor

Ca(2+)

Miscellaneous

The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with melittin variation, i.e. their production increase in the same months.

Similarity

Belongs to the phospholipase A2 family.
Belongs to the phospholipase A2 family. Group III subfamily.

Keywords

Allergen   Calcium   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Lipid degradation   Lipid metabolism   Metal-binding   Secreted   Signal   3D-structure   Complete proteome   Reference proteome  

Feature

chain  Phospholipase A2
glycosylation site  N-linked (GlcNAc...) asparagine

Uniprot

H9JTP8   H9JTR6   H9JTR7   H9JTP9   H9JTQ0   H9JTR4   + More
A0A3Q8U958   A0A2H1VKV4   H9JTQ1   A0A212FMH8   A0A437BU79   A0A2A4ITF0   A0A2W1BZG9   D6WFW7   A0A1Y1LD35   A0A194PZT8   A0A154PF10   A0A151IY19   C0LTQ4   U4V016   A0A0L7R6K6   J3JUT4   A0A0C9QT97   A0A0T6B3S9   A0A2L2YPZ8   A0A0M8ZRJ1   A0A2L2XXA1   A0A139WH39   A0A0C9S3A5   C7B2L3   A0A087UYP2   U3N068   Q7M4I6   G3FP81   A0A218QXA5   A0A151X980   A0A218QXE2   A0A195CTK0   E2BDL0   A0A1W7RA22   I7GQA7   A0A2P6LH46   A0A2D0PCW5   A0A182HBX1   B0W2R2   Q7M4I5   Q16H86   A0A182WFX2   A0A084VSJ7   A0A170RBK2   A0A182QG10   A0A182SLS6   A0A182YKL8   A0A182NC88   A0A2P8YQI3   A0A182MAK3   A0A2A3EI01   W5JHV7   A0A087UYN9   Q7QGS9   A0A182FKB8   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   A0A1S4H571   A0A087UYP4   A0A2P6LAN4   A0A2L2YIA1   B7UUK1   P00630   A0A182PJB4   A0A1J1J4Y0   I1VC86   A0A182RYX2   Q9BMK4   A0A1J1HVT8   P82971   A0A0P4W3M7   A0A2J7Q6T9   I4DR12   A0A212F4F0   D6WLM2   A0A194QC58   A0A160G5A6   A0A139WH90   A0A224XGJ6   A0A2P6LH31   A0A224XFF0   A0A139WGU7   A0A182UJE0   T1E1S9   A0A437ATJ8   T1INX7   A0A170RBM5   A0A0U1TZ64  

EC Number

3.1.1.4

Pubmed

19121390    22118469    28756777    18362917    19820115    28004739    + More
26354079    19931277    23537049    22516182    26561354    25553591    19539776    20798317    28546807    26483478    17510324    24438588    25244985    29403074    20920257    23761445    12364791    20966253    12167627    17466468    2776767    4448181    20403370    4614976    8504812    2274788    11692115    22651552   

EMBL

BABH01003424    BABH01003425    BABH01003423    MH061374    AZL90156.1    ODYU01003111    + More
SOQ41453.1    AGBW02007651    OWR54900.1    RSAL01000008    RVE54007.1    NWSH01007341    PCG63001.1    KZ149898    PZC78657.1    KQ971328    EEZ99784.2    GEZM01059238    JAV71533.1    KQ459582    KPI98836.1    KQ434890    KZC10443.1    KQ980780    KYN13196.1    FJ768721    ACN42750.1    KI209013    KI210158    KI210159    ERL95965.1    ERL96175.1    ERL96180.1    KQ414646    KOC66459.1    BT126999    AEE61961.1    GBYB01003857    JAG73624.1    LJIG01009957    KRT82042.1    IAAA01047628    IAAA01047629    LAA10097.1    KQ435889    KOX69497.1    IAAA01000951    LAA00646.1    KQ971343    KYB27219.1    GBXR01000008    JAG85218.1    FJ768907    FJ768908    ACU12492.1    KK122319    KFM82481.1    KF214771    AGW23551.1    JF751030    AEO51763.1    GEUW01000062    JAW06983.1    KQ982398    KYQ56870.1    GEUW01000022    JAW07023.1    KQ977279    KYN04023.1    GL447678    EFN86172.1    GFAH01000398    JAV47991.1    AB731659    BAM25049.1    MWRG01000062    PRD37888.1    HAHE01000501    SNX36715.1    JXUM01032580    KQ560960    KXJ80209.1    DS231828    EDS29815.1    CH478192    EAT33614.1    ATLV01016045    KE525054    KFB40941.1    KU203673    ANB82417.1    AXCN02001761    PYGN01000431    PSN46508.1    AXCM01005795    KZ288249    PBC31104.1    ADMH02001144    ETN63942.1    KFM82478.1    AAAB01008823    EAA05503.4    APCN01003445    KFM82483.1    MWRG01000625    PRD35635.1    IAAA01020399    LAA07839.1    FM203121    CAR56722.1    AF438408    EF373554    X16709    CVRI01000072    CRL07447.1    JQ900380    AFI40558.1    AF321087    CVRI01000017    CRK90265.1    GDRN01087699    JAI61002.1    NEVH01017450    PNF24304.1    AK404884    BAM20352.1    AGBW02010376    OWR48611.1    EFA03430.2    KQ459193    KPJ03009.1    KU203672    ANB82416.1    KYB27221.1    GFBG01000075    JAW07092.1    PRD37887.1    GFBG01000076    JAW07091.1    KYB27220.1    GAKT01000015    JAA93047.1    RSAL01000502    RVE41521.1    JH431228    KU203674    ANB82418.1    EU252426    ACD11980.1   

Proteomes

UP000005204    UP000007151    UP000283053    UP000218220    UP000007266    UP000053268    + More
UP000076502    UP000078492    UP000030742    UP000053825    UP000053105    UP000054359    UP000075809    UP000078542    UP000008237    UP000069940    UP000249989    UP000002320    UP000008820    UP000075920    UP000030765    UP000075886    UP000075901    UP000076408    UP000075884    UP000245037    UP000075883    UP000242457    UP000000673    UP000007062    UP000069272    UP000076407    UP000075903    UP000075882    UP000075840    UP000005203    UP000075885    UP000183832    UP000075900    UP000235965    UP000075902   

PRIDE

H9JTP8    H9JTR6    H9JTR7    H9JTP9    H9JTQ0    H9JTR4    + More
H9JTQ1    P00630    P82971   

Pfam

PF05826   Phospholip_A2_2

Interpro

IPR033113   PLipase_A2_His_AS        + More
IPR016090   PLipase_A2_dom       
IPR036444   PLipase_A2_dom_sf       

SUPFAM

SSF48619   SSF48619       

Gene 3D

1.20.90.10    

ProteinModelPortal

H9JTP8   H9JTR6   H9JTR7   H9JTP9   H9JTQ0   H9JTR4   + More
A0A3Q8U958   A0A2H1VKV4   H9JTQ1   A0A212FMH8   A0A437BU79   A0A2A4ITF0   A0A2W1BZG9   D6WFW7   A0A1Y1LD35   A0A194PZT8   A0A154PF10   A0A151IY19   C0LTQ4   U4V016   A0A0L7R6K6   J3JUT4   A0A0C9QT97   A0A0T6B3S9   A0A2L2YPZ8   A0A0M8ZRJ1   A0A2L2XXA1   A0A139WH39   A0A0C9S3A5   C7B2L3   A0A087UYP2   U3N068   Q7M4I6   G3FP81   A0A218QXA5   A0A151X980   A0A218QXE2   A0A195CTK0   E2BDL0   A0A1W7RA22   I7GQA7   A0A2P6LH46   A0A2D0PCW5   A0A182HBX1   B0W2R2   Q7M4I5   Q16H86   A0A182WFX2   A0A084VSJ7   A0A170RBK2   A0A182QG10   A0A182SLS6   A0A182YKL8   A0A182NC88   A0A2P8YQI3   A0A182MAK3   A0A2A3EI01   W5JHV7   A0A087UYN9   Q7QGS9   A0A182FKB8   A0A182WYE6   A0A182UQ13   A0A182KVM6   A0A182I5H7   A0A1S4H571   A0A087UYP4   A0A2P6LAN4   A0A2L2YIA1   B7UUK1   P00630   A0A182PJB4   A0A1J1J4Y0   I1VC86   A0A182RYX2   Q9BMK4   A0A1J1HVT8   P82971   A0A0P4W3M7   A0A2J7Q6T9   I4DR12   A0A212F4F0   D6WLM2   A0A194QC58   A0A160G5A6   A0A139WH90   A0A224XGJ6   A0A2P6LH31   A0A224XFF0   A0A139WGU7   A0A182UJE0   T1E1S9   A0A437ATJ8   T1INX7   A0A170RBM5   A0A0U1TZ64  

PDB

1POC     E-value=2.61329e-31,     Score=333

KEGG

101746631    K01047 secretory phospholipase A2 [EC:3.1.1.4] | (RefSeq) phospholipase A2-like

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
00590    Arachidonic acid metabolism - Bombyx mori (domestic silkworm)
00591    Linoleic acid metabolism - Bombyx mori (domestic silkworm)
00592    alpha-Linolenic acid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006644   GO:0004623   GO:0050482   GO:0005576   GO:0016021   GO:0047498   GO:0046872   GO:0016042   GO:0102568   GO:0102567   GO:0005509   GO:0004222   GO:0016638   GO:0005488   GO:0005515   GO:0009258   GO:0016155   GO:0003824  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.995218

 

 

Length:

177

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.09966

Exp number, first 60 AAs:

0.04388

Total prob of N-in:

0.03137

outside

1  -  177

 

 

Pi

247.649095

Theta

184.685219

Tajima's D

1.491359

CLR

0.71153

CSRT

0.785210739463027

Interpretation

Uncertain