Silkworm Genome Informatics Database

Gene

KWMTBOMO09736

Pre Gene Modal

BGIBMGA012938

Annotation

PREDICTED:_adenosine_deaminase_CECR1-like_[Amyelois_transitella]

Location

Bomo_Chr16(-):8235120-8236811 View in EpiBrowser

Full name

Adenosine deaminase 2

Alternative Name

Cat eye syndrome critical region protein 1

Location in the cell

Cytoplasmic Reliability : 1.029 PlasmaMembrane Reliability : 1.386

CDS

ATGTGGGGCGTTATCTGTATATTATGTTCGTTTTGTTTAACCGCGATTTTAACAGAAGCAAAATTCGTCGATACCGACTACAAAAAGCAAAGGGAAGAACTCCTGCAAAAAGAATTCGAACGATCACTAGGAGGTAATTTGGTTCTGAGCGAAGATGAGAAAACGGTAAATGATATTCTAATGTACTGGAAGAATAAAGAATTAGATGAATGTTTTCGGAACCCTGATCGATTCAACTTGTCCAAGAGCTATTTCACGTACAGAGATTATATCAATATGTCTAATGTGTATAAGATAATCAGGCGAATGCCCAAAGGAGGCGCTCTACATATTCACAGTTCGTTAATGTTAGACGCGGATGGCCTAGTAAAGCTGACGTACGAAGACCACTTGTACTGTTGTTACGAAGGCGACGATTTAAAACTACAATTCTCCGAAGCCATTCCCGAACGACCTTGTACTGATAAATGGAGCCTGGTGAGTGACCTTAGAAACGCTTCCGATGACGTCATAGCCTTTGATAACGAATTGAGAAAGCACTTCATAATGTATGGCAAGGGCGACTACAATACGAGCGGTGCTAACGATTCGTGGAAAGAATTCAACAGGGTTTATAGAATCACAAAATCACTTAACAGCTACATACCGGCGAGAAAAAAGTACTTTTACGCGGGCCTTAAAAACTTTTATGAGGACAACGTGATGTATATGGAAATTAGAAGTACAGCTTTTGGTATTTTCGAATTCAACAGTACTTATCACAGCGGGATGTATTTACTGAATCTGTACCAAGAGATAACCGAAAATTTTAAAAAGGATCATCCCGACTTTTTTGGTATCAAATTTATACTGACTTCGCATAGAGACTTGGACACTGTCTTAGTAAGGCAGAACTTAAATCTAACTAGGCAGATTAAAAAGGAAATGCCAGAAATGTACGCTGGTTTCGACTTAGTCGGTCGAGAAGATTCCGGGAAAACACTGCTAGATCGTCTTCCCGAGCTGGCTGAAATGAAAAATGAGATAAACTACTATTTTCACGCCGGAGAAACTGCTCGGTACGGAACTTCGTCGGATGAAAATTTGATTGACGCCATACTTTTGGGCACACGGAGGATCGGCCATGGTTATGCCCTTTTAAAACATCCGAATCTTTTGAGTATCATTCAACAAAAAGACATAGCTATAGAAGTGAATGTGATATCGAATAATGTTCTATCGTTGGTGAACGATGTGAGGAATCATCCATTGGCAACATATTTAGCTCTCGGTCTTCCCGTGGTGTTGTCAAGCGACGATCCTGGCGTCTGGGGGGCTGATCCGTTGTCGCACGACTTCTACGTGACATTTGTCGGTGTCGCCAGTAAGCGCTCGGATTTAAGACTCTTAAAACAGCTGGCCATTAACTCTATAAAGTATAGCGCGTTAGACGACAAGGGCAAAACCAATTTGTTTCGGATATTCAATTCAAGATGGTCTGATTTTATCCAAGAGATTATTCAATTGAATGCACGCGGTGAATTTAATAGTGCGTAG

Protein

MWGVICILCSFCLTAILTEAKFVDTDYKKQREELLQKEFERSLGGNLVLSEDEKTVNDILMYWKNKELDECFRNPDRFNLSKSYFTYRDYINMSNVYKIIRRMPKGGALHIHSSLMLDADGLVKLTYEDHLYCCYEGDDLKLQFSEAIPERPCTDKWSLVSDLRNASDDVIAFDNELRKHFIMYGKGDYNTSGANDSWKEFNRVYRITKSLNSYIPARKKYFYAGLKNFYEDNVMYMEIRSTAFGIFEFNSTYHSGMYLLNLYQEITENFKKDHPDFFGIKFILTSHRDLDTVLVRQNLNLTRQIKKEMPEMYAGFDLVGREDSGKTLLDRLPELAEMKNEINYYFHAGETARYGTSSDENLIDAILLGTRRIGHGYALLKHPNLLSIIQQKDIAIEVNVISNNVLSLVNDVRNHPLATYLALGLPVVLSSDDPGVWGADPLSHDFYVTFVGVASKRSDLRLLKQLAINSIKYSALDDKGKTNLFRIFNSRWSDFIQEIIQLNARGEFNSA

Description

Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity).

Catalytic Activity

adenosine + H(+) + H2O = inosine + NH4(+)

Cofactor

Zn(2+)

Subunit

Homodimer. Interacts with adenosine receptors. Binds heparin (By similarity).

Similarity

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.

Keywords

Complete proteome Disulfide bond Glycoprotein Heparin-binding Hydrolase Metal-binding Reference proteome Secreted Signal Zinc

Feature

chain Adenosine deaminase 2

Uniprot

H9JTS6 A0A2W1BWC1 A0A2A4K563 A0A194R1C8 A0A194PZU2 A0A212FMK6 + More
A0A0L7LNV3 A0A2W1BU87 A0A2H1W0Y1 A0A2A4K5F4 A0A0L7LPB2 A0A194R6V8 A0A194Q1I1 A0A0L7LPB3 A0A2H1W0Z6 A0A194R1N1 I4DP17 A0A2A4JCS6 A0A194Q0L6 A0A2H1VBY9 A0A2H1VBV3 A0A212FMK2 H9JTN2 A0A2W1BUH1 A0A2A4JD81 H9JTS7 A7BEX8 A6M8U8 A0A2W1C0J8 A0A0L7K4B9 H9JTN3 A0A3G5BIM1 K7ILT7 A0A2H1VAK6 A0A212F3M6 A0A0L7LUI0 A0A1W6EVV3 A0A1I8MAS7 A0A0C9QAH8 H0XC51 T1P9Q7 B4PJJ8 A0A1Y1KT08 Q9VVK5 A0A2Y9DU83 W5JVM2 A0A182JEX0 A0A2K6FBY3 D6WEK0 B4QNZ1 A0A3B0KIU2 B4HKW2 Q2M0I1 A0A3B4ZKG7 A0A0S1LI92 A0A182MQK5 K7ILT4 A0A1Y1NF56 G3U108 G3TTH2 B3NHR7 A0A1W4WZ20 A0A232F1Z0 K7ILT8 A0A182GU01 Q179D4 A0A084WKR6 A0A0K8VRD8 A0A1A9WPY1 Q8T9T6 A0A1W4W4X4 A0A034VKN8 Q26642 W5PV50 A0A452EX87 V9KD01 A0A1A9V4I6 A0A452EXD4 A0A023ETL0 A7IZL5 A0A2U3WEE4 A0A2Y9H3U4 A0A0L0C082 A0A287BDN3 A0A1Y1MCA1 B3M4T9 A0A1A9XQJ8 A0A1I8PKD4 A0A0C9R445 A0A0C9RRA6 E9H0U5 A0A2U3YXX9 A0A3Q7MKZ4 A0A0P4VQR1 F7CUH1 A0A023EW36 A0A182Q0H3 Q06K61 A0A1Q3FNZ6 P58780

EC Number

3.5.4.4

Pubmed

19121390 28756777 26354079 22118469 26227816 22651552 + More
17439545 30400621 20075255 25315136 17994087 17550304 28004739 10731132 11738815 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 20920257 23761445 18362917 19820115 22936249 15632085 23185243 26493315 28648823 26483478 17510324 24438588 12213246 25348373 8662793 10756095 10967093 11562360 17011515 20809919 24402279 24945155 26108605 18057021 21292972 17495919 16952314

EMBL

BABH01003474 KZ149898 PZC78641.1 NWSH01000164 PCG78913.1 KQ460878 + More
KPJ11598.1 KQ459582 KPI98847.1 AGBW02007651 OWR54919.1 JTDY01000431 KOB77203.1 PZC78642.1 ODYU01005668 SOQ46760.1 PCG78912.1 KOB77204.1 KPJ11596.1 KPI98849.1 KOB77209.1 SOQ46761.1 KPJ11597.1 AK403248 BAM19657.1 NWSH01001926 PCG69649.1 KPI98848.1 ODYU01001720 SOQ38311.1 ODYU01001533 SOQ37882.1 OWR54920.1 BABH01003476 PZC78639.1 PCG69648.1 AB183871 BAF73622.1 DQ322663 ABC50165.1 PZC78640.1 JTDY01010697 KOB58090.1 BABH01003475 MK075218 AYV99621.1 SOQ37883.1 AGBW02010531 OWR48335.1 JTDY01000099 KOB78871.1 KY563447 ARK19856.1 GBYB01000214 JAG69981.1 AAQR03120202 AAQR03120203 AAQR03120204 AAQR03120205 AAQR03120206 KA644678 AFP59307.1 CM000159 EDW94686.1 GEZM01077315 JAV63330.1 AE014296 AY058655 AF337554 AAF49306.1 AAL13884.1 AAL40913.1 AAS64976.1 ADMH02000347 ETN66884.1 KQ971318 EFA00425.1 CM000363 CM002912 EDX10893.1 KMZ00301.1 OUUW01000009 SPP85001.1 CH480815 EDW41917.1 CH379069 EAL30951.3 KRT07791.1 KT160229 ALL27025.1 AXCM01005713 GEZM01008449 JAV94776.1 CH954178 EDV51932.1 NNAY01001294 OXU24457.1 JXUM01088455 KQ563703 KXJ73473.1 CH477354 EAT42834.1 ATLV01024134 KE525349 KFB50810.1 GDHF01010872 JAI41442.1 AF466610 AAL76033.1 GAKP01016292 GAKP01016291 GAKP01016290 JAC42662.1 D83125 BAA11812.1 AMGL01083860 LWLT01000005 JW863168 AFO95685.1 GAPW01000940 JAC12658.1 DQ835383 ABI20188.1 JRES01001077 KNC25705.1 AEMK02000037 GEZM01037063 JAV82220.1 CH902618 EDV40513.1 KPU78606.1 GBYB01011074 JAG80841.1 GBYB01011075 JAG80842.1 GL732582 EFX74640.1 GDRN01107117 JAI57470.1 GAPW01001034 JAC12564.1 AXCN02000560 DQ835357 ABI20162.1 GFDL01005842 JAV29203.1 AF384216

Proteomes

UP000005204 UP000218220 UP000053240 UP000053268 UP000007151 UP000037510 + More
UP000002358 UP000095301 UP000005225 UP000002282 UP000000803 UP000248480 UP000000673 UP000075880 UP000233160 UP000007266 UP000000304 UP000268350 UP000001292 UP000001819 UP000261400 UP000075883 UP000007646 UP000008711 UP000192223 UP000215335 UP000069940 UP000249989 UP000008820 UP000030765 UP000091820 UP000192221 UP000002356 UP000291000 UP000078200 UP000245340 UP000248481 UP000037069 UP000008227 UP000007801 UP000092443 UP000095300 UP000000305 UP000245341 UP000286641 UP000002280 UP000075886

PRIDE

H9JTS6 H9JTN2 H9JTS7 A7BEX8 H9JTN3 Q9VVK5 + More
P58780

Pfam

PF08451 A_deaminase_N + More
PF00962 A_deaminase

Interpro

IPR001365   A/AMP_deaminase_dom        + More
IPR032466   Metal_Hydrolase
IPR013659   A_deaminase_N
IPR006331   ADGF

SUPFAM

SSF51556 SSF51556

ProteinModelPortal

H9JTS6 A0A2W1BWC1 A0A2A4K563 A0A194R1C8 A0A194PZU2 A0A212FMK6 + More
A0A0L7LNV3 A0A2W1BU87 A0A2H1W0Y1 A0A2A4K5F4 A0A0L7LPB2 A0A194R6V8 A0A194Q1I1 A0A0L7LPB3 A0A2H1W0Z6 A0A194R1N1 I4DP17 A0A2A4JCS6 A0A194Q0L6 A0A2H1VBY9 A0A2H1VBV3 A0A212FMK2 H9JTN2 A0A2W1BUH1 A0A2A4JD81 H9JTS7 A7BEX8 A6M8U8 A0A2W1C0J8 A0A0L7K4B9 H9JTN3 A0A3G5BIM1 K7ILT7 A0A2H1VAK6 A0A212F3M6 A0A0L7LUI0 A0A1W6EVV3 A0A1I8MAS7 A0A0C9QAH8 H0XC51 T1P9Q7 B4PJJ8 A0A1Y1KT08 Q9VVK5 A0A2Y9DU83 W5JVM2 A0A182JEX0 A0A2K6FBY3 D6WEK0 B4QNZ1 A0A3B0KIU2 B4HKW2 Q2M0I1 A0A3B4ZKG7 A0A0S1LI92 A0A182MQK5 K7ILT4 A0A1Y1NF56 G3U108 G3TTH2 B3NHR7 A0A1W4WZ20 A0A232F1Z0 K7ILT8 A0A182GU01 Q179D4 A0A084WKR6 A0A0K8VRD8 A0A1A9WPY1 Q8T9T6 A0A1W4W4X4 A0A034VKN8 Q26642 W5PV50 A0A452EX87 V9KD01 A0A1A9V4I6 A0A452EXD4 A0A023ETL0 A7IZL5 A0A2U3WEE4 A0A2Y9H3U4 A0A0L0C082 A0A287BDN3 A0A1Y1MCA1 B3M4T9 A0A1A9XQJ8 A0A1I8PKD4 A0A0C9R445 A0A0C9RRA6 E9H0U5 A0A2U3YXX9 A0A3Q7MKZ4 A0A0P4VQR1 F7CUH1 A0A023EW36 A0A182Q0H3 Q06K61 A0A1Q3FNZ6 P58780

PDB

3LGG E-value=6.45876e-89, Score=836

KEGG

101742842 K19572 adenosine deaminase CECR1 [EC:3.5.4.4] | (RefSeq) adenosine deaminase AGSA-like

PATHWAY

00230 Purine metabolism - Bombyx mori (domestic silkworm)
01100 Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004000 GO:0005615 GO:0006154 GO:0031685 GO:0043394 GO:0042803 GO:0008270 GO:0006109 GO:0035167 GO:0043617 GO:0008284 GO:0042386 GO:0008083 GO:0046103 GO:0008201 GO:0019239 GO:0008289 GO:0016788 GO:0046872 GO:0003723 GO:0006730 GO:0009258 GO:0016155 GO:0003824

Subcellular location

Secreted

SignalP

Position: 1 - 20, Likelihood: 0.985309

Length:

511

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.54932

Exp number, first 60 AAs:

1.53257

Total prob of N-in:

0.07993

outside

1 - 511

Pi

279.450941

Theta

212.233358

Tajima's D

0.647412

CLR

30.252434

CSRT

0.55837208139593

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics