Gene

KWMTBOMO09712  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012947

Annotation

PREDICTED:_apyrase-like_[Bombyx_mori]

Location

Bomo_Chr16(-):7959739-7968942      View in EpiBrowser

Full name

Apyrase      

Alternative Name

ATP-diphosphatase
ATP-diphosphohydrolase
Adenosine diphosphatase

Location in the cell

Cytoplasmic   Reliability : 3.913

CDS

ATGGGCAGTTGTTTTGGCTTTTGGGTCTATAAAAAACAGGTATTGATCGTGCAGGCTTCGGCTTTTACAAAATACATGGGCAATTTATCAGTTTATTTTGATTACAAAGGTGACTACGTTCAATGGGAAGGGGGCCCGGTGTTTTTGAACAGATCTATTCCGGAAGATGAAAATATAAAGGCCAAACTAGAACCATACGCTAAAATCGTGCACGATGCTGAAAACGTGCCGATAGGGAGTAGCAACAAAACATATCACTTCGAAGACTGCGTGTACGGTGAATGCACTGTTGGAGATTTGCTAGTCGATGGATTTGTGGAGTGGGGCAAAACTAAATCGGGCACCGACAAGGAGTTCTTGTCGCTTATGCAGCGTGGCAATATAAGGGCTTCGATAATGGAAGGCGATATAACCCAAGGGGCTGTCTTCGAATTGTTACCTTTCAATGACAAAATGAAGACTTTTGAGTTACAAGGGAAGTACATATTAGAGGCTCTGGAGAGAGGCGTCAGCGAGGCTTGGGGATACAAGCCCTTCAAAGGTCCATGGCTCTTGCAAGTCTCAGGTCTCCGTGTCACATACAATATTACGCTACCAGTAGGTAACAGGGTGACCTCAGTTGTCGTCGGAAAAAACCAGACACCGTTGGATGTTGAGAAGATGTATAATATGATTACTACGTCATTCCTGTGTGATGGCGGAGATGGATTCACGATGATCAAAGACCATAAGAAGAATGAAGTCGTGGTGGGCCGTGACCAGCAGGTTTTCCGAGCCTACGTCGAGAAGCACTCACCACTCAGCGTTGAAACTGACGGTCGGATAGTGATCAATGAATAA

Protein

MGSCFGFWVYKKQVLIVQASAFTKYMGNLSVYFDYKGDYVQWEGGPVFLNRSIPEDENIKAKLEPYAKIVHDAENVPIGSSNKTYHFEDCVYGECTVGDLLVDGFVEWGKTKSGTDKEFLSLMQRGNIRASIMEGDITQGAVFELLPFNDKMKTFELQGKYILEALERGVSEAWGYKPFKGPWLLQVSGLRVTYNITLPVGNRVTSVVVGKNQTPLDVEKMYNMITTSFLCDGGDGFTMIKDHKKNEVVVGRDQQVFRAYVEKHSPLSVETDGRIVINE

Description

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host. Shows potential for antithrombotic activity. May reduce probing time by facilitating the speed of locating blood.

Catalytic Activity

a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate

Cofactor

a divalent metal cation

Similarity

Belongs to the 5'-nucleotidase family.

Keywords

Allergen   ATP-binding   Direct protein sequencing   Hydrolase   Metal-binding   Nucleotide-binding   Secreted   Signal  

Feature

chain  Apyrase

Uniprot

A0A2W1BJS8   A0A2A4JIV7   E0A922   A0A437BAW0   A0A3G1T1Q5   A0A2H1VFF9   + More
A0A2H1VCG8   A0A194PZX0   S4PC70   A0A212FN22   I4DS82   A0A194Q631   A0A194R238   H9JXD3   A0A212FN07   A0A2H1WL38   A0A2H1VGJ2   A0A437BB15   H9JTT6   A0A2W1BHA1   A0A194Q1J5   A0A0K8TQH7   A0A194R2W0   Q9U9I6   A0A182GC77   F1JZ10   B3A0N5   A0A1L8DPX0   W5JVI8   Q17NS8   W4Z243   A0A3S2M1V1   B0WJ00   W5J5F4   H9JL89   J3JZ21   A0A1L8DPP4   A0A1L8DPP0   A0A1B0GP29   A0A182MGY7   A0A1B0GJ04   K1R448   A0A182ISY8   A0A194R6M3   A0A2C9GRQ1   Q7QIZ1   A0A182R637   A0A1Q3FIZ4   A0A182VC59   A0A1C7CZG9   A0A182FA78   A0A067RQX4   A0A182IVB6   A0A336LSN5   A0A336LWJ0   A0A182QET4   A0A182K4F9   A0A182SCB1   A0A182PCT2   A0A437B966   A0A084WEL8   A0A336KUY8   A0A182WX10   A0A1C7CZH0   A0A182VZA6   A0A182HLB4   A0A182L9P8   Q8T5H5   A0A182WSG4   Q8MU74   A0A182TN56   A0A182JMY7   A0A182V0W0   A0A182U110   A0A182GQ46   A0A2A4JW25   A0A182VA04   H9JL90   A0A2A4JVW4   Q5TWQ4   A0A182STK5   A0A182R636   A0A182TQC9   A0A182FA77   A0A194PLJ4   N6UFA8   A0A182FH63   A0A084VT66   N6UCC2   A0A182YAL6   Q16QA5   A0A2C9GRQ0   A0A182YKS6   W5J3U7   A0A182NS58   W5JSD1   A0A182TJY0  

EC Number

3.6.1.5

Pubmed

28756777    22848670    26354079    23622113    22118469    22651552    + More
19121390    26369729    10821849    26483478    21848516    20920257    23761445    17510324    22516182    22992520    12364791    14747013    17210077    20966253    24845553    24438588    12060762    23537049    25244985   

EMBL

KZ150128    PZC73086.1    NWSH01001271    PCG71901.1    HM569605    ADK90114.1    + More
RSAL01000100    RVE47544.1    MG770323    AXY94925.1    ODYU01002285    SOQ39567.1    ODYU01001820    SOQ38540.1    KQ459582    KPI98866.1    GAIX01005602    JAA86958.1    AGBW02007648    OWR55135.1    AK405462    BAM20772.1    KPI98865.1    KQ460878    KPJ11579.1    BABH01041952    OWR55136.1    ODYU01009397    SOQ53793.1    ODYU01002180    SOQ39344.1    RVE47543.1    BABH01003511    BABH01003512    PZC73085.1    KPI98864.1    GDAI01001190    JAI16413.1    KPJ11580.1    AF169229    AAD49730.1    JXUM01054688    KQ561832    KXJ77401.1    JF308210    ADX78255.1    GFDF01005657    JAV08427.1    ADMH02000310    ETN67025.1    CH477196    EAT48396.1    AAGJ04106048    AAGJ04106049    AAGJ04106050    RSAL01000067    RVE49304.1    DS231954    EDS28861.1    ADMH02002183    ETN57989.1    BABH01011794    BABH01011795    BABH01011796    BT128502    AEE63459.1    GFDF01005652    JAV08432.1    GFDF01005651    JAV08433.1    AJVK01033050    AXCM01018154    AJWK01017966    AJWK01017967    JH823220    EKC28636.1    KQ460685    KPJ12890.1    APCN01000169    AAAB01008807    EAA04249.4    GFDL01007465    JAV27580.1    KK852475    KDR23050.1    UFQT01000158    SSX21032.1    SSX21033.1    AXCN02000433    RSAL01000115    RVE46873.1    ATLV01023228    KE525341    KFB48662.1    UFQS01001030    UFQT01001030    SSX08629.1    SSX28545.1    APCN01000890    AJ439398    AAAB01008987    CAD28126.1    EAA00943.2    AJ441131    CAD29633.1    JXUM01079657    JXUM01079658    JXUM01079659    KQ563139    KXJ74403.1    NWSH01000463    PCG76225.1    NWSH01000580    PCG75530.1    EAL41866.3    KQ459600    KPI94306.1    APGK01029191    APGK01029192    KB740727    KB631815    ENN79311.1    ERL86398.1    ATLV01016253    KE525074    KFB41160.1    ENN79310.1    ERL86397.1    CH477755    EAT36583.1    ETN57988.1    ETN67026.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000007151    UP000053240    UP000005204    + More
UP000069940    UP000249989    UP000000673    UP000008820    UP000007110    UP000002320    UP000092462    UP000075883    UP000092461    UP000005408    UP000075880    UP000075840    UP000007062    UP000075900    UP000075903    UP000075882    UP000069272    UP000027135    UP000075886    UP000075881    UP000075901    UP000075885    UP000030765    UP000076407    UP000075920    UP000075902    UP000019118    UP000030742    UP000076408    UP000075884   

PRIDE

H9JXD3    H9JTT6    H9JL89    H9JL90   

Pfam

PF00149   Metallophos        + More
PF02872   5_nucleotid_C
PF00089   Trypsin
PF05154   TM2
PF00226   DnaJ
PF07679   I-set

Interpro

IPR036907   5'-Nucleotdase_C_sf        + More
IPR006146   5'-Nucleotdase_CS       
IPR008334   5'-Nucleotdase_C       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR006179   5_nucleotidase/apyrase       
IPR029052   Metallo-depent_PP-like       
IPR033116   TRYPSIN_SER       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR009003   Peptidase_S1_PA       
IPR036869   J_dom_sf       
IPR001623   DnaJ_domain       
IPR007829   TM2       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR013098   Ig_I-set       
IPR013106   Ig_V-set       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       

SUPFAM

SSF55816   SSF55816        + More
SSF50494   SSF50494       
SSF46565   SSF46565       
SSF48726   SSF48726       

Gene 3D

3.60.21.10     3.90.780.10     1.10.287.110     2.60.40.10    

CDD

cd00190  Tryp_SPc
cd06257  DnaJ

ProteinModelPortal

A0A2W1BJS8   A0A2A4JIV7   E0A922   A0A437BAW0   A0A3G1T1Q5   A0A2H1VFF9   + More
A0A2H1VCG8   A0A194PZX0   S4PC70   A0A212FN22   I4DS82   A0A194Q631   A0A194R238   H9JXD3   A0A212FN07   A0A2H1WL38   A0A2H1VGJ2   A0A437BB15   H9JTT6   A0A2W1BHA1   A0A194Q1J5   A0A0K8TQH7   A0A194R2W0   Q9U9I6   A0A182GC77   F1JZ10   B3A0N5   A0A1L8DPX0   W5JVI8   Q17NS8   W4Z243   A0A3S2M1V1   B0WJ00   W5J5F4   H9JL89   J3JZ21   A0A1L8DPP4   A0A1L8DPP0   A0A1B0GP29   A0A182MGY7   A0A1B0GJ04   K1R448   A0A182ISY8   A0A194R6M3   A0A2C9GRQ1   Q7QIZ1   A0A182R637   A0A1Q3FIZ4   A0A182VC59   A0A1C7CZG9   A0A182FA78   A0A067RQX4   A0A182IVB6   A0A336LSN5   A0A336LWJ0   A0A182QET4   A0A182K4F9   A0A182SCB1   A0A182PCT2   A0A437B966   A0A084WEL8   A0A336KUY8   A0A182WX10   A0A1C7CZH0   A0A182VZA6   A0A182HLB4   A0A182L9P8   Q8T5H5   A0A182WSG4   Q8MU74   A0A182TN56   A0A182JMY7   A0A182V0W0   A0A182U110   A0A182GQ46   A0A2A4JW25   A0A182VA04   H9JL90   A0A2A4JVW4   Q5TWQ4   A0A182STK5   A0A182R636   A0A182TQC9   A0A182FA77   A0A194PLJ4   N6UFA8   A0A182FH63   A0A084VT66   N6UCC2   A0A182YAL6   Q16QA5   A0A2C9GRQ0   A0A182YKS6   W5J3U7   A0A182NS58   W5JSD1   A0A182TJY0  

PDB

2Z1A     E-value=1.54404e-33,     Score=355

KEGG

101736450    no KO assigned | (RefSeq) apyrase-like

GO

GO:0009166   GO:0016788   GO:0000166   GO:0046872   GO:0016787   GO:0102488   GO:0102490   GO:0102491   GO:0005576   GO:0102485   GO:0102486   GO:0102489   GO:0005524   GO:0102487   GO:0008253   GO:0005886   GO:0006196   GO:0004252   GO:0016021   GO:0015074   GO:0008449   GO:0030203   GO:0003723   GO:0006730   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR11575  

Subcellular location

Secreted  

Length:

279

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13745

Exp number, first 60 AAs:

0.13414

Total prob of N-in:

0.01146

outside

1  -  279

 

 

Pi

195.686297

Theta

139.510695

Tajima's D

1.032479

CLR

0.428454

CSRT

0.67791610419479

Interpretation

Uncertain