Gene

KWMTBOMO09711  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014198

Annotation

PREDICTED:_apyrase-like_[Amyelois_transitella]

Location

Bomo_Chr16(-):7929073-7935322      View in EpiBrowser

Full name

Apyrase      

Alternative Name

ATP-diphosphatase
ATP-diphosphohydrolase
Adenosine diphosphatase

Location in the cell

Cytoplasmic   Reliability : 2.79

CDS

ATGATTGATTGGAACGGGGGCATGATCCGTTTGGACCGATCCATTCCTGAAGATCCAATGATGAAGGCAAAACTAAAACCATACATGAAACAAGTTCACGAAGGCGCAGCGGTGCCGATTGGTGAGACTCTAGTGGACATGCCGTTCAAGAATTGTCAAATTAAGGAGTGTGCGCTTGGAAATTTAGTAACAGACGCTTTTAATGAGAAAGCTATGAATACTGTCAAGACCGATTTGAGTTACATCGCATTCGCGCAATGTTCGTATCTTACTTCAAACATTCCAGAAGGAACTATCACCCACGGCCACATCGTCGAGCTGCTGCCTTACTACGATCAAATAGAAACATTCCAAATGAAAGGAAAATATATAATTGAGTTACTCGAGAGAAGCGCAAAGGATGTCCTACCATCAGAAATTCCGAATATGCTGCAAGTTTCTGGTTTGGAAATAGTTTATAATATGACTAAGCGGGAAGGAAAACGATTATACTCAGTGAAGGTCGGTCAAGAGAGCATGGACATCAACAAATTTTACCAGGTCACTGCCCCAGGATTTTTGGCTGACGGAGGTGATGGCTACACGATATTCAAAAAGCAGAAGAAAAACATGAAAGTTATCGGCTACGATCAAGACGTTTTAAAAGATTATATCAAGAAACATTCACCTATAGATTTAAATGTTGGTAACAGAATAAATATGGTCCGTTAG

Protein

MIDWNGGMIRLDRSIPEDPMMKAKLKPYMKQVHEGAAVPIGETLVDMPFKNCQIKECALGNLVTDAFNEKAMNTVKTDLSYIAFAQCSYLTSNIPEGTITHGHIVELLPYYDQIETFQMKGKYIIELLERSAKDVLPSEIPNMLQVSGLEIVYNMTKREGKRLYSVKVGQESMDINKFYQVTAPGFLADGGDGYTIFKKQKKNMKVIGYDQDVLKDYIKKHSPIDLNVGNRINMVR

Description

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host. Shows potential for antithrombotic activity. May reduce probing time by facilitating the speed of locating blood.

Catalytic Activity

a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate

Cofactor

a divalent metal cation

Similarity

Belongs to the 5'-nucleotidase family.

Keywords

Allergen   ATP-binding   Direct protein sequencing   Hydrolase   Metal-binding   Nucleotide-binding   Secreted   Signal  

Feature

chain  Apyrase

Uniprot

H9JXD3   A0A3G1T1Q5   A0A437BAW0   A0A2H1VFF9   A0A2H1VCG8   A0A194PZX0   + More
A0A2A4JIV7   A0A194R238   A0A212FN22   A0A194Q631   I4DS82   A0A2W1BJS8   E0A922   S4PC70   A0A212FN07   A0A2H1WL38   A0A2H1VGJ2   Q17NS8   A0A2W1BHA1   F1JZ10   B3A0N5   A0A0K8TQH7   A0A182GC77   Q9U9I6   A0A0L8HEY5   A0A1Q3FIZ4   A0A2G8JP94   A0A1L8DPP4   A0A1L8DPP0   A0A182JMY7   A0A1B0GP29   B0WJ00   A0A3S2M1V1   A0A182L9P8   Q8T5H5   A0A182HLB4   Q8MU74   A0A182WSG4   A0A194R6M3   A0A194Q1J5   A0A437BB15   A0A194R2W0   A0A182V0W0   A0A182TN56   A0A2G8LBN1   A0A0A1WD31   A0A1Y1N7H1   A0A182FA77   A0A1L8DPX0   H9JL89   A0A182K4G0   A0A084VT66   R7T630   A0A194PLJ4   A0A2A4JVW4   A0A151X5Z9   A0A336N6I4   W8BUB4   K1R448   A0A026WZQ2   A0A3L8DU04   W5J3U7   A0A336LDK1   A0A2M4AV02   D6WD64   A0A182PGQ3   W5J5F4   H9JL90   A0A1J1HLE0   A0A182FA78   A0A182NS57   Q95P65   A0A1B0ASU8   D3TRV7   W5J1N7   A0A182Q352   S6CVL9   E2A7Z8   A0A1I8NCS3   A0A194R505   A0A139WMA1   A0A182NMA1   J3JZ21   A0A1A9UUV1   H9JTT6   B7S919   A0A1A9XYG0   A0A2H1WZX1   A0A182STK5   A0A0N7ZAX7   K1R966   A0A336KUY8   A0A182J0X1   A0A336LSN5   A0A336LWJ0   A0A182Q7N3   A0A182R636   V5G6C5  

EC Number

3.6.1.5

Pubmed

19121390    26354079    22118469    22651552    28756777    22848670    + More
23622113    17510324    21848516    26369729    26483478    10821849    29023486    20966253    12060762    12364791    14747013    17210077    25830018    28004739    24438588    23254933    24495485    22992520    24508170    30249741    20920257    23761445    18362917    19820115    20353571    23938757    20798317    25315136    22516182   

EMBL

BABH01041952    MG770323    AXY94925.1    RSAL01000100    RVE47544.1    ODYU01002285    + More
SOQ39567.1    ODYU01001820    SOQ38540.1    KQ459582    KPI98866.1    NWSH01001271    PCG71901.1    KQ460878    KPJ11579.1    AGBW02007648    OWR55135.1    KPI98865.1    AK405462    BAM20772.1    KZ150128    PZC73086.1    HM569605    ADK90114.1    GAIX01005602    JAA86958.1    OWR55136.1    ODYU01009397    SOQ53793.1    ODYU01002180    SOQ39344.1    CH477196    EAT48396.1    PZC73085.1    JF308210    ADX78255.1    GDAI01001190    JAI16413.1    JXUM01054688    KQ561832    KXJ77401.1    AF169229    AAD49730.1    KQ418431    KOF87350.1    GFDL01007465    JAV27580.1    MRZV01001480    PIK37567.1    GFDF01005652    JAV08432.1    GFDF01005651    JAV08433.1    AJVK01033050    DS231954    EDS28861.1    RSAL01000067    RVE49304.1    AJ439398    AAAB01008987    CAD28126.1    EAA00943.2    APCN01000890    AJ441131    CAD29633.1    KQ460685    KPJ12890.1    KPI98864.1    RVE47543.1    KPJ11580.1    MRZV01000135    PIK57676.1    GBXI01017413    JAC96878.1    GEZM01010744    JAV93862.1    GFDF01005657    JAV08427.1    BABH01011794    BABH01011795    BABH01011796    ATLV01016253    KE525074    KFB41160.1    AMQN01015158    KB311668    ELT88815.1    KQ459600    KPI94306.1    NWSH01000580    PCG75530.1    KQ982494    KYQ55710.1    UFQT01002888    SSX34218.1    GAMC01013841    JAB92714.1    JH823220    EKC28636.1    KK107054    EZA61540.1    QOIP01000004    RLU23851.1    ADMH02002183    ETN57988.1    UFQS01002906    UFQT01002906    SSX14867.1    SSX34255.1    GGFK01011279    MBW44600.1    KQ971312    EEZ98343.1    ETN57989.1    CVRI01000003    CRK87057.1    AF384674    AAK63848.1    JXJN01003008    EZ424159    ADD20435.1    ADMH02002165    ETN58132.1    AXCN02000266    HF586473    CCQ71110.1    GL437468    EFN70435.1    KPJ12888.1    KYB29062.1    BT128502    AEE63459.1    BABH01003511    BABH01003512    EF710657    ACE75394.1    ODYU01012308    SOQ58557.1    GDRN01092605    JAI60080.1    JH818488    EKC30511.1    UFQS01001030    UFQT01001030    SSX08629.1    SSX28545.1    UFQT01000158    SSX21032.1    SSX21033.1    AXCN02000938    GALX01002836    JAB65630.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000218220    UP000053240    UP000007151    + More
UP000008820    UP000069940    UP000249989    UP000053454    UP000230750    UP000075880    UP000092462    UP000002320    UP000075882    UP000007062    UP000075840    UP000076407    UP000075903    UP000075902    UP000069272    UP000075881    UP000030765    UP000014760    UP000075809    UP000005408    UP000053097    UP000279307    UP000000673    UP000007266    UP000075885    UP000183832    UP000075884    UP000092460    UP000075886    UP000000311    UP000095301    UP000078200    UP000092443    UP000075901    UP000075900   

PRIDE

H9JXD3    H9JL89    H9JL90    H9JTT6   

Pfam

PF02872   5_nucleotid_C        + More
PF00149   Metallophos
PF07679   I-set

Interpro

IPR036907   5'-Nucleotdase_C_sf        + More
IPR008334   5'-Nucleotdase_C       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR006179   5_nucleotidase/apyrase       
IPR029052   Metallo-depent_PP-like       
IPR006146   5'-Nucleotdase_CS       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR013098   Ig_I-set       
IPR013106   Ig_V-set       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       

SUPFAM

SSF55816   SSF55816        + More
SSF48726   SSF48726       

Gene 3D

3.60.21.10     3.90.780.10     2.60.40.10    

ProteinModelPortal

H9JXD3   A0A3G1T1Q5   A0A437BAW0   A0A2H1VFF9   A0A2H1VCG8   A0A194PZX0   + More
A0A2A4JIV7   A0A194R238   A0A212FN22   A0A194Q631   I4DS82   A0A2W1BJS8   E0A922   S4PC70   A0A212FN07   A0A2H1WL38   A0A2H1VGJ2   Q17NS8   A0A2W1BHA1   F1JZ10   B3A0N5   A0A0K8TQH7   A0A182GC77   Q9U9I6   A0A0L8HEY5   A0A1Q3FIZ4   A0A2G8JP94   A0A1L8DPP4   A0A1L8DPP0   A0A182JMY7   A0A1B0GP29   B0WJ00   A0A3S2M1V1   A0A182L9P8   Q8T5H5   A0A182HLB4   Q8MU74   A0A182WSG4   A0A194R6M3   A0A194Q1J5   A0A437BB15   A0A194R2W0   A0A182V0W0   A0A182TN56   A0A2G8LBN1   A0A0A1WD31   A0A1Y1N7H1   A0A182FA77   A0A1L8DPX0   H9JL89   A0A182K4G0   A0A084VT66   R7T630   A0A194PLJ4   A0A2A4JVW4   A0A151X5Z9   A0A336N6I4   W8BUB4   K1R448   A0A026WZQ2   A0A3L8DU04   W5J3U7   A0A336LDK1   A0A2M4AV02   D6WD64   A0A182PGQ3   W5J5F4   H9JL90   A0A1J1HLE0   A0A182FA78   A0A182NS57   Q95P65   A0A1B0ASU8   D3TRV7   W5J1N7   A0A182Q352   S6CVL9   E2A7Z8   A0A1I8NCS3   A0A194R505   A0A139WMA1   A0A182NMA1   J3JZ21   A0A1A9UUV1   H9JTT6   B7S919   A0A1A9XYG0   A0A2H1WZX1   A0A182STK5   A0A0N7ZAX7   K1R966   A0A336KUY8   A0A182J0X1   A0A336LSN5   A0A336LWJ0   A0A182Q7N3   A0A182R636   V5G6C5  

PDB

4H2B     E-value=7.0771e-20,     Score=237

KEGG

101743541    no KO assigned | (RefSeq) apyrase-like

GO

GO:0009166   GO:0000166   GO:0016787   GO:0016788   GO:0046872   GO:0102488   GO:0102490   GO:0102491   GO:0005576   GO:0102485   GO:0102486   GO:0102489   GO:0005524   GO:0102487   GO:0008253   GO:0005886   GO:0006196   GO:0016021   GO:0015074   GO:0008449   GO:0030203   GO:0003723   GO:0006730   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR11575  

Subcellular location

Secreted  

Length:

236

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04055

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.10844

outside

1  -  236

 

 

Pi

428.859859

Theta

185.806312

Tajima's D

4.641006

CLR

0.579072

CSRT

0.99990000499975

Interpretation

Uncertain