Gene

KWMTBOMO09707  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012948

Annotation

PREDICTED:_apyrase-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr16(-):7880640-7894172      View in EpiBrowser

Full name

Apyrase      

Alternative Name

ATP-diphosphatase
ATP-diphosphohydrolase
Adenosine diphosphatase

Location in the cell

Cytoplasmic   Reliability : 1.334 PlasmaMembrane   Reliability : 1.221

CDS

ATGACAAAAGGAAAATAATTTGAAGAGACCTCACTCCAGTTTCCGATGTGTCGCAATAATGACACCCAATGCTTGGGAGGATTCGCTCGTCTTTACCATGAGATAACGACGTTGGTCAAAGCTTATCCAGAAACGTTAGTATTGAACGCAGGAGACGTTTTCCAGGGCACCTACTGGTACACCCTATTGAAATGGAATGTAACCCAAAAATTCATCAACTTGCTACCAAATGATGTCCATGCAATAGGTAACCATGAATTCGATGATGGGGTAGCGGACTTATCGCGTTACATCGCGACCCTACGAGCGCCCGTCGTAGCTGCAAATATAGACATCAGCGATGTGCCCTCATTGCAGGGCATCATCAAGCCACATGTGGTTGTAACAAAGAACGGCCGTAATATCGGAGTCATCGGCCTGATAACTACAGAAACACCGATTGCATCAAAATCGGAGAACGTAAAATTTCTGGATTCAATTCCTGTTGTCGAAAGAGAAGCTAAGCTGCTAAAAGACAAAGGAGTCGATATCATAATTGTTCTGTCACATTGTGGCTTGGACGTTGACAAAGAAATAGCAAGGACCGTTGGGGAAAACATAGATGTAATAGTTGGTGGGCACACGCATAGTCTGCTTTGGAATGGTGAATCACCCTCAAAAGAAAAAGTAGCTGGCCCATACCCAATCTTGGTTGAGGCTACGCAAGGTTGTGATCATCAGGTAATAATTGTAACGGCATCATCTTTTACCAAATATTTGGGTAACATAACAGTGTTTTTCGACAAAAGTGGTGAAGTTGTGGATTTTGAGGGATCTCCGATATTTTTGAACAGATCGATTCCAGAAGATCCGGCCATTCTATCTTTACTGCAACCATACAAAAAAAAATTGCATTCATTAGTCGATGAAGAAATCGGATATTCCAATCAAATTCTATCGGATTACAATTGTAGTGCTCACGAATGTATCCTGGGTAATATAGTAGCCGATGGTTGTTGGAGAGCGACTGTTGCAAAGTATCCAACGAATTTGACAACCATAGCTTTTCTACTAAGAAATAACATAAGAAGTCCTCTACCGTCGGGAAAATTGACACGTGCTACGGCCCTCAATATATTCCCATTTTCTAATGAGTTGATTGCATTGGAAATTCAAGGGAGGTATATATTGGAAGCATTGAGAAAGTGCTTCAGCAAGTCTTATAACAGTGTTCCATTCTCTGGACCTTGGGTGCCACAGTTTTCTGGTATGAGAATCACAGTAAATACAACATTACCACGGAATGTAGCATCAGTACTTGTGAAGCGAGGTGATGTTTACCGACCTTTAGACCCGGATGAAGTCTATCAACTGGCCACGCTGGACTATTTCCTAATGGGAGGAGCTGGATTCACGATGCTAAAAGAAAATTCACGAAACCCTAAACATGTGGGGAAAATGCTAAAAGTTTTTGAAGATATAATAAAGGAAATATCTCCGATAGATGAGTCACAACATTCACTTGACGGTAGACTAAAACTTATAGAATAA

Protein

MTKGKXFEETSLQFPMCRNNDTQCLGGFARLYHEITTLVKAYPETLVLNAGDVFQGTYWYTLLKWNVTQKFINLLPNDVHAIGNHEFDDGVADLSRYIATLRAPVVAANIDISDVPSLQGIIKPHVVVTKNGRNIGVIGLITTETPIASKSENVKFLDSIPVVEREAKLLKDKGVDIIIVLSHCGLDVDKEIARTVGENIDVIVGGHTHSLLWNGESPSKEKVAGPYPILVEATQGCDHQVIIVTASSFTKYLGNITVFFDKSGEVVDFEGSPIFLNRSIPEDPAILSLLQPYKKKLHSLVDEEIGYSNQILSDYNCSAHECILGNIVADGCWRATVAKYPTNLTTIAFLLRNNIRSPLPSGKLTRATALNIFPFSNELIALEIQGRYILEALRKCFSKSYNSVPFSGPWVPQFSGMRITVNTTLPRNVASVLVKRGDVYRPLDPDEVYQLATLDYFLMGGAGFTMLKENSRNPKHVGKMLKVFEDIIKEISPIDESQHSLDGRLKLIE

Description

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host. Shows potential for antithrombotic activity. May reduce probing time by facilitating the speed of locating blood.

Catalytic Activity

a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate

Cofactor

a divalent metal cation

Similarity

Belongs to the 5'-nucleotidase family.

Keywords

Allergen   ATP-binding   Direct protein sequencing   Hydrolase   Metal-binding   Nucleotide-binding   Secreted   Signal  

Feature

chain  Apyrase

Uniprot

H9JTT6   A0A194R2W0   A0A194Q1J5   A0A2H1VGJ2   A0A2H1WL38   A0A2W1BHA1   + More
A0A437BB15   A0A212FN07   A0A437BAW0   A0A3G1T1Q5   A0A2A4JIV7   I4DS82   A0A2W1BJS8   E0A922   A0A212FN22   A0A2H1VCG8   S4PC70   A0A194Q631   A0A194R238   H9JXD3   A0A2A4JWR7   A0A2A4JW12   A0A1Y1N7H1   B0WJ00   Q17NS8   A0A067RQX4   A0A2M4AV02   A0A2J7RI11   A0A3S2M1V1   A0A182YAL5   A0A182VZA6   A0A026WZQ2   A0A182R636   A0A1Q3FIZ4   A0A3L8DU04   A0A182STK5   U5EW72   A0A182PGQ3   A0A2A4JX59   A0A182R637   E2A7Z8   A0A336KUY8   B4MAL8   A0A084VT66   V5G6C5   A0A182M997   B4NEB2   A0A182YAL6   A0A182HLB4   Q8T5H5   A0A336LSN5   W5J5F4   A0A182TN56   A0A336LWJ0   E9IPY5   A0A182L9P8   A0A151X5Z9   A0A182V0W0   A0A2A4JVW4   A0A182WSG4   A0A182FA78   A0A182VZA5   Q8MU74   A0A0Q9X374   A0A158NSU6   A0A212FMH9   A0A151I0J3   A0A1J1HLE0   Q9U9I6   A0A182M832   A0A182PGQ4   A0A3B0KAU5   A0A0R1EAP0   A0A0K8TQH7   A0A182Q352   F4WSK6   F1JZ10   B3A0N5   A0A0R3P4U5   A0A182JMY7   A0A1L8DPX0   A0A2H1WZX1   A0A182K4G0   B3MQ82   B3NVB0   A0A1L8DPP0   A0A1L8DPP4   A0A437B966   U5EQR9   H9JL90   A0A182NS58   B7S919   W5J3U7   A0A182V9Y4   B4L649   A0A1I8PB47   Q7PXU7  

EC Number

3.6.1.5

Pubmed

19121390    26354079    28756777    22118469    22651552    22848670    + More
23622113    28004739    17510324    24845553    25244985    24508170    30249741    20798317    17994087    24438588    12060762    12364791    14747013    17210077    20920257    23761445    21282665    20966253    21347285    10821849    17550304    26369729    21719571    21848516    15632085   

EMBL

BABH01003511    BABH01003512    KQ460878    KPJ11580.1    KQ459582    KPI98864.1    + More
ODYU01002180    SOQ39344.1    ODYU01009397    SOQ53793.1    KZ150128    PZC73085.1    RSAL01000100    RVE47543.1    AGBW02007648    OWR55136.1    RVE47544.1    MG770323    AXY94925.1    NWSH01001271    PCG71901.1    AK405462    BAM20772.1    PZC73086.1    HM569605    ADK90114.1    OWR55135.1    ODYU01001820    SOQ38540.1    GAIX01005602    JAA86958.1    KPI98865.1    KPJ11579.1    BABH01041952    NWSH01000463    PCG76226.1    PCG76227.1    GEZM01010744    JAV93862.1    DS231954    EDS28861.1    CH477196    EAT48396.1    KK852475    KDR23050.1    GGFK01011279    MBW44600.1    NEVH01003506    PNF40456.1    RSAL01000067    RVE49304.1    KK107054    EZA61540.1    GFDL01007465    JAV27580.1    QOIP01000004    RLU23851.1    GANO01000692    JAB59179.1    PCG76224.1    GL437468    EFN70435.1    UFQS01001030    UFQT01001030    SSX08629.1    SSX28545.1    CH940655    EDW66277.1    ATLV01016253    KE525074    KFB41160.1    GALX01002836    JAB65630.1    AXCM01013925    CH964239    EDW82081.2    APCN01000890    AJ439398    AAAB01008987    CAD28126.1    EAA00943.2    UFQT01000158    SSX21032.1    ADMH02002183    ETN57989.1    SSX21033.1    GL764659    EFZ17310.1    KQ982494    KYQ55710.1    NWSH01000580    PCG75530.1    AJ441131    CAD29633.1    KRF99569.1    ADTU01025187    ADTU01025188    AGBW02007651    OWR54937.1    KQ976619    KYM79119.1    CVRI01000003    CRK87057.1    AF169229    AAD49730.1    AXCM01013064    OUUW01000035    SPP89842.1    CM000162    KRK06524.1    GDAI01001190    JAI16413.1    AXCN02000266    GL888322    EGI62821.1    JF308210    ADX78255.1    CH379064    KRT06403.1    GFDF01005657    JAV08427.1    ODYU01012308    SOQ58557.1    CH902621    EDV44508.2    CH954180    EDV46098.2    GFDF01005651    JAV08433.1    GFDF01005652    JAV08432.1    RSAL01000115    RVE46873.1    GANO01003160    JAB56711.1    BABH01011796    EF710657    ACE75394.1    ETN57988.1    CH933812    EDW05845.1    EAA00979.2   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    UP000218220    + More
UP000002320    UP000008820    UP000027135    UP000235965    UP000076408    UP000075920    UP000053097    UP000075900    UP000279307    UP000075901    UP000075885    UP000000311    UP000008792    UP000030765    UP000075883    UP000007798    UP000075840    UP000007062    UP000000673    UP000075902    UP000075882    UP000075809    UP000075903    UP000076407    UP000069272    UP000005205    UP000078540    UP000183832    UP000268350    UP000002282    UP000075886    UP000007755    UP000001819    UP000075880    UP000075881    UP000007801    UP000008711    UP000075884    UP000009192    UP000095300   

PRIDE

H9JTT6    H9JXD3    H9JL90   

Pfam

PF02872   5_nucleotid_C        + More
PF00149   Metallophos

Interpro

IPR008334   5'-Nucleotdase_C        + More
IPR004843   Calcineurin-like_PHP_ApaH       
IPR036907   5'-Nucleotdase_C_sf       
IPR006179   5_nucleotidase/apyrase       
IPR029052   Metallo-depent_PP-like       
IPR006146   5'-Nucleotdase_CS       

SUPFAM

SSF55816   SSF55816       

Gene 3D

3.60.21.10     3.90.780.10    

ProteinModelPortal

H9JTT6   A0A194R2W0   A0A194Q1J5   A0A2H1VGJ2   A0A2H1WL38   A0A2W1BHA1   + More
A0A437BB15   A0A212FN07   A0A437BAW0   A0A3G1T1Q5   A0A2A4JIV7   I4DS82   A0A2W1BJS8   E0A922   A0A212FN22   A0A2H1VCG8   S4PC70   A0A194Q631   A0A194R238   H9JXD3   A0A2A4JWR7   A0A2A4JW12   A0A1Y1N7H1   B0WJ00   Q17NS8   A0A067RQX4   A0A2M4AV02   A0A2J7RI11   A0A3S2M1V1   A0A182YAL5   A0A182VZA6   A0A026WZQ2   A0A182R636   A0A1Q3FIZ4   A0A3L8DU04   A0A182STK5   U5EW72   A0A182PGQ3   A0A2A4JX59   A0A182R637   E2A7Z8   A0A336KUY8   B4MAL8   A0A084VT66   V5G6C5   A0A182M997   B4NEB2   A0A182YAL6   A0A182HLB4   Q8T5H5   A0A336LSN5   W5J5F4   A0A182TN56   A0A336LWJ0   E9IPY5   A0A182L9P8   A0A151X5Z9   A0A182V0W0   A0A2A4JVW4   A0A182WSG4   A0A182FA78   A0A182VZA5   Q8MU74   A0A0Q9X374   A0A158NSU6   A0A212FMH9   A0A151I0J3   A0A1J1HLE0   Q9U9I6   A0A182M832   A0A182PGQ4   A0A3B0KAU5   A0A0R1EAP0   A0A0K8TQH7   A0A182Q352   F4WSK6   F1JZ10   B3A0N5   A0A0R3P4U5   A0A182JMY7   A0A1L8DPX0   A0A2H1WZX1   A0A182K4G0   B3MQ82   B3NVB0   A0A1L8DPP0   A0A1L8DPP4   A0A437B966   U5EQR9   H9JL90   A0A182NS58   B7S919   W5J3U7   A0A182V9Y4   B4L649   A0A1I8PB47   Q7PXU7  

PDB

4H1S     E-value=9.05337e-58,     Score=567

KEGG

101744472    no KO assigned | (RefSeq) apyrase-like

GO

GO:0000166   GO:0016787   GO:0009166   GO:0016788   GO:0046872   GO:0016021   GO:0008253   GO:0005886   GO:0006196   GO:0017110   GO:0017111   GO:0102488   GO:0102490   GO:0102491   GO:0005576   GO:0102485   GO:0102486   GO:0102489   GO:0005524   GO:0102487   GO:0006810   GO:0008449   GO:0030203   GO:0003723   GO:0006730   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR11575  

Subcellular location

Secreted  

Length:

509

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10117

Exp number, first 60 AAs:

0.02392

Total prob of N-in:

0.00492

outside

1  -  509

 

 

Pi

317.895659

Theta

183.561647

Tajima's D

2.569666

CLR

0.227976

CSRT

0.951052447377631

Interpretation

Uncertain