Gene

KWMTBOMO09689  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012952

Annotation

N-acetylglucosamine-6-sulfatase_[Papilio_xuthus]

Location

Bomo_Chr16(-):7002373-7014831      View in EpiBrowser

Full name

N-acetylglucosamine-6-sulfatase      

Alternative Name

Glucosamine-6-sulfatase

Location in the cell

Extracellular   Reliability : 1.639

CDS

ATGTTACAATATTTATTTTTAATATTTTTCGTGAACAATGCTGTGGCTGAACTAAAACGACCAAACTTTGTTCTCATATTGACCGACGATCAAGATGTAGTTTTAGGTGGAATGGATCCGATGAAGAATGTTCAACGATTTATCGGGAAAGAAGGCATAACATTCACTAACTCCTACGTGACGTCACCGATATGCTGTCCAAGCAGAGCCAGTTTGCTGACAGGCATGTACGTTCACAACCACAAGACCGTGAACAATAGTCTTCACGGCGGATGCTATGGAGAGAACTGGAAAGATCACGAGAAACAGACGTTCGCTACTATACTTCAGGAAGCCGGATATGACACGTTCTATGCGGGGAAATATTTGAATCAGTATGGTACTAAAGAAGCCGGTGGCCCAGAGGTGGTACCCCCGGGCTGGACAGAATGGCGCGGCTTGGTCGGGAATTCAGTTTACTACAACTATACTTTGTCCAACAACGGCGTGCCGACGTTTTCGACTGATAGCTACTTAACCGATGTGATACGTGAACTGGGAGTCAGCTACATAGAGAATCAGACGGAATCGAAGCCCTTTCTGATGGTGCTCGCTCCCCCCGCCCCGCACCAGCCCTTCACCCCCGCCCCTCGACACAAAGACGCGTTCAGTAACGTGACAGTCGTAAAGAGCCCCAATTTCAATATCATCGCTGAGGATAAGCATTGGCTGCTCCGCATGCCTCCGTCGCCACTCCCTGACGTGATGCTTCCCGAACTCGACCAAGTGTACCGGTCCCGGTGGGAAACTCTGCTCTCGGTCGATGAGATGGTCGCCGACATTATAGGCGCTTTGGAAACTCAAGCGTTCCTGGATAACACATACGTAGTGTTCACTTCCGATAACGGTTACCATATCGGTCAAAACTCTCAAGTTTACGACAAACGTCAACCTTACGAAACTGACATCAAAGTTCCTTTACTAATAAAAGGGCCAGGACTGAAAAAGAACGTGGAAAACCGACAGCCGGTGTTAAATATTGATTTGGCGCCGACTATAATCAAACTGGCCGGCTTGGACATACCGAACAACGTGGACGGAAGGCCCATCGATGTTCACAACGAGGACATAGGCGAGAGGAACATGCTAATTGAATACTACGGCGAAGGCAAGGACGGATCTGTGGATAAAGAATGTCCTTGGAAGTATGATAGCGGTAATCTCGCTCAATGCTATCCTCAGTACAGTTGCAAGTGTCAAGACGCCAAAAACAATACATACGCCTGTATCAGACACATCGCGGAGCGAATCGACAAGAAATATTGCCTCTTCGCTGACAATGAGAACTTCAGTGAAATGTACAACATAGCAGACGATCCTTACGAATTGGAGAACATTGTGAACCACGTGTTTCCGGCGGTGAAGTACTGGTACAGAGAGATTCTAACGCGGATGCTGACCTGCTCCGGTGCTCATAATTGTGATCACCCATTGGAACCACTAATTAATATATTTTAG

Protein

MLQYLFLIFFVNNAVAELKRPNFVLILTDDQDVVLGGMDPMKNVQRFIGKEGITFTNSYVTSPICCPSRASLLTGMYVHNHKTVNNSLHGGCYGENWKDHEKQTFATILQEAGYDTFYAGKYLNQYGTKEAGGPEVVPPGWTEWRGLVGNSVYYNYTLSNNGVPTFSTDSYLTDVIRELGVSYIENQTESKPFLMVLAPPAPHQPFTPAPRHKDAFSNVTVVKSPNFNIIAEDKHWLLRMPPSPLPDVMLPELDQVYRSRWETLLSVDEMVADIIGALETQAFLDNTYVVFTSDNGYHIGQNSQVYDKRQPYETDIKVPLLIKGPGLKKNVENRQPVLNIDLAPTIIKLAGLDIPNNVDGRPIDVHNEDIGERNMLIEYYGEGKDGSVDKECPWKYDSGNLAQCYPQYSCKCQDAKNNTYACIRHIAERIDKKYCLFADNENFSEMYNIADDPYELENIVNHVFPAVKYWYREILTRMLTCSGAHNCDHPLEPLINIF

Catalytic Activity

Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.

Cofactor

Ca(2+)

Similarity

Belongs to the sulfatase family.

Feature

chain  N-acetylglucosamine-6-sulfatase

Uniprot

H9JTU0   A0A3S2L6R0   A0A194Q0P5   A0A194R227   S4PAQ9   A0A212FN11   + More
A0A2A4JY89   A0A2H1WZ35   A0A067R287   A0A2M4ATL5   A0A2M4ATQ1   A0A2M4BL80   A0A2M4BME1   Q17CP8   A0A182NN85   A0A2M3ZID9   A0A2M4BLJ4   A0A1W7R8K1   A0A023EVZ0   A0A182QZW2   A0A2M4DKR4   A0A2M4DKP3   A0A182R2T8   A0A1Q3FJH7   A0A034VMM1   A0A0K8VY72   A0A2J7R0V6   A0A182JMF2   A0A182K5F3   A0A2M3Z9R5   Q7Q2M5   A0A151JUB5   A0A0L0CP35   A0A232F1L4   W8B4N7   A0A1B6CPK4   A0A088A3D6   A0A1A9WMW8   R7TJ59   E9IVX7   E0VPN4   A0A336K4J7   T1PJN0   A0A1I8N5Y6   A0A2A3EDB1   A0A1A9XVG4   A0A3Q2Z177   A0A1B0AXE5   A0A154PS62   A0A1A9V2D5   A0A0A1WVI1   B3NRL5   A0A1B6KZS0   A0A0J9RCY8   A0A1A9ZYD8   Q5BIL9   B4GCV2   B4HQI3   E2ANB3   B4MIX0   A0A0C9QER4   B4JJV2   B5E066   Q95R73   A0A3B4VQF6   Q86NX7   A0A0P4WDR7   A0A1W4V529   B4P4I0   A0A3Q4M983   A0A3P8PYQ7   B4L7H5   A0A3P9C342   A0A2L2YGX1   H2YLW8   A0A3B4Y3C4   A0A182T8A8   A0A401PMW9   A0A3Q2WM37   A0A310SFM3   A0A1L8GYG5   A0A401RWF2   A0A3B4FRV1   A0A3Q3LPY1   A0A087YLI7   A0A3P8S7Z9   A0A3B3VQE4   V9K9M2   A0A401P548   A0A3Q1C3T3   A0A1Q3FJG5   A0A3N0Z2X4   A9JRM2   A0A3B0IZM1   B4MGI5   S4RF84   A0A3B3YC40   A0A3Q3GD06   A0A3P9PLX2   A0A401RY68  

EC Number

3.1.6.14

Pubmed

19121390    26354079    23622113    22118469    24845553    17510324    + More
24945155    25348373    12364791    14747013    17210077    26108605    28648823    24495485    23254933    21282665    20566863    25315136    25830018    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20798317    15632085    17550304    25186727    26561354    30297745    27762356    24402279    18057021   

EMBL

BABH01003609    BABH01003610    RSAL01000115    RVE46899.1    KQ459582    KPI98878.1    + More
KQ460878    KPJ11569.1    GAIX01004896    JAA87664.1    AGBW02007649    OWR55125.1    NWSH01000362    PCG76985.1    ODYU01012168    SOQ58339.1    KK852979    KDR13030.1    GGFK01010796    MBW44117.1    GGFK01010826    MBW44147.1    GGFJ01004685    MBW53826.1    GGFJ01004797    MBW53938.1    CH477305    EAT44148.1    GGFM01007528    MBW28279.1    GGFJ01004796    MBW53937.1    GEHC01000178    JAV47467.1    GAPW01001109    JAC12489.1    AXCN02001899    GGFL01013946    MBW78124.1    GGFL01013945    MBW78123.1    GFDL01007402    JAV27643.1    GAKP01015268    GAKP01015266    JAC43684.1    GDHF01008530    JAI43784.1    NEVH01008217    PNF34456.1    GGFM01004513    MBW25264.1    AAAB01008968    EAA13233.3    KQ981799    KYN35674.1    JRES01000104    KNC34095.1    NNAY01001304    OXU24419.1    GAMC01014527    JAB92028.1    GEDC01021892    JAS15406.1    AMQN01013733    KB310433    ELT91586.1    GL766449    EFZ15247.1    DS235366    EEB15340.1    UFQS01000022    UFQT01000022    SSW97623.1    SSX18009.1    KA648153    AFP62782.1    KZ288293    PBC29011.1    JXJN01005238    KQ435026    KZC13950.1    GBXI01011651    JAD02641.1    CH954179    EDV56167.1    GEBQ01023024    JAT16953.1    CM002911    KMY93479.1    AE013599    BT021205    AAG22274.2    AAX33353.1    CH479181    EDW32515.1    CH480816    EDW47718.1    GL441177    EFN65061.1    CH963719    EDW72059.2    GBYB01013013    JAG82780.1    CH916370    EDV99854.1    CM000071    EDY69300.2    AY061585    AAL29133.1    AAM68572.1    BT003587    AAO39590.1    GDRN01060069    JAI65436.1    CM000158    EDW90619.1    CH933813    EDW10969.1    IAAA01024018    LAA07394.1    BFAA01000980    GCB74459.1    KQ760495    OAD60118.1    CM004470    OCT88892.1    BEZZ01000011    GCC22476.1    AYCK01014435    AYCK01014436    JW861953    AFO94470.1    BFAA01005864    GCB68264.1    GFDL01007381    JAV27664.1    RJVU01015140    ROL52603.1    BC155714    AAI55715.1    OUUW01000001    SPP73874.1    CH940677    EDW58302.1    KRF78210.1    KRF78211.1    BEZZ01000022    GCC23049.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000007151    UP000218220    + More
UP000027135    UP000008820    UP000075884    UP000075886    UP000075900    UP000235965    UP000075880    UP000075881    UP000007062    UP000078541    UP000037069    UP000215335    UP000005203    UP000091820    UP000014760    UP000009046    UP000095301    UP000242457    UP000092443    UP000264820    UP000092460    UP000076502    UP000078200    UP000008711    UP000092445    UP000000803    UP000008744    UP000001292    UP000000311    UP000007798    UP000001070    UP000001819    UP000261420    UP000192221    UP000002282    UP000261580    UP000265100    UP000009192    UP000265160    UP000007875    UP000261360    UP000075901    UP000288216    UP000264840    UP000186698    UP000287033    UP000261460    UP000261640    UP000028760    UP000265080    UP000261500    UP000257160    UP000268350    UP000008792    UP000245300    UP000261480    UP000261660    UP000242638   

PRIDE

H9JTU0    Q5BIL9    Q95R73    Q86NX7   

Pfam

PF00884   Sulfatase

Interpro

IPR000917   Sulfatase_N        + More
IPR017850   Alkaline_phosphatase_core_sf       
IPR024607   Sulfatase_CS       
IPR012251   GlcNAc_6-SO4ase       
IPR015981   GlcNAc_6-SO4ase_met       

SUPFAM

SSF53649   SSF53649       

Gene 3D

3.40.720.10    

ProteinModelPortal

H9JTU0   A0A3S2L6R0   A0A194Q0P5   A0A194R227   S4PAQ9   A0A212FN11   + More
A0A2A4JY89   A0A2H1WZ35   A0A067R287   A0A2M4ATL5   A0A2M4ATQ1   A0A2M4BL80   A0A2M4BME1   Q17CP8   A0A182NN85   A0A2M3ZID9   A0A2M4BLJ4   A0A1W7R8K1   A0A023EVZ0   A0A182QZW2   A0A2M4DKR4   A0A2M4DKP3   A0A182R2T8   A0A1Q3FJH7   A0A034VMM1   A0A0K8VY72   A0A2J7R0V6   A0A182JMF2   A0A182K5F3   A0A2M3Z9R5   Q7Q2M5   A0A151JUB5   A0A0L0CP35   A0A232F1L4   W8B4N7   A0A1B6CPK4   A0A088A3D6   A0A1A9WMW8   R7TJ59   E9IVX7   E0VPN4   A0A336K4J7   T1PJN0   A0A1I8N5Y6   A0A2A3EDB1   A0A1A9XVG4   A0A3Q2Z177   A0A1B0AXE5   A0A154PS62   A0A1A9V2D5   A0A0A1WVI1   B3NRL5   A0A1B6KZS0   A0A0J9RCY8   A0A1A9ZYD8   Q5BIL9   B4GCV2   B4HQI3   E2ANB3   B4MIX0   A0A0C9QER4   B4JJV2   B5E066   Q95R73   A0A3B4VQF6   Q86NX7   A0A0P4WDR7   A0A1W4V529   B4P4I0   A0A3Q4M983   A0A3P8PYQ7   B4L7H5   A0A3P9C342   A0A2L2YGX1   H2YLW8   A0A3B4Y3C4   A0A182T8A8   A0A401PMW9   A0A3Q2WM37   A0A310SFM3   A0A1L8GYG5   A0A401RWF2   A0A3B4FRV1   A0A3Q3LPY1   A0A087YLI7   A0A3P8S7Z9   A0A3B3VQE4   V9K9M2   A0A401P548   A0A3Q1C3T3   A0A1Q3FJG5   A0A3N0Z2X4   A9JRM2   A0A3B0IZM1   B4MGI5   S4RF84   A0A3B3YC40   A0A3Q3GD06   A0A3P9PLX2   A0A401RY68  

PDB

3ED4     E-value=2.42707e-17,     Score=219

KEGG

101745680    K01137 N-acetylglucosamine-6-sulfatase [EC:3.1.6.14] | (RefSeq) N-acetylglucosamine-6-sulfatase-like

PATHWAY

00531    Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0008449   GO:0030203   GO:0005539   GO:0005764   GO:0016021   GO:0046872   GO:0003824   GO:0008152   GO:0008484   GO:0003723   GO:0006730   GO:0009258   GO:0016155  

PANTHER

PTHR43108:SF5  

Subcellular location

Lysosome  

SignalP

Position:   1 - 16,         Likelihood:  0.864498

 

 

Length:

498

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00227

Exp number, first 60 AAs:

0.00203

Total prob of N-in:

0.00023

outside

1  -  498

 

 

Pi

231.224388

Theta

159.311841

Tajima's D

1.521154

CLR

0.195791

CSRT

0.792410379481026

Interpretation

Uncertain