Gene

KWMTBOMO09685

Pre Gene Modal

BGIBMGA012878

Annotation

K3_protein_[Bombyx_mori]

Location

Bomo_Chr16(+):6949302-6958290      View in EpiBrowser

Full name

SH3 domain-containing protein Dlish      

Alternative Name

Dachs ligand with SH3 domains

Location in the cell

Nuclear   Reliability : 3.155

CDS

ATGGCATTTCTATGTCCAGTCAGGATCAGAAGGGGAAAGAAGAAGAAATCAAGTTCTGGAGACTCTGACAAAGACCTCTCCAGGCCCAGTTCAGGACTGAGTCCTGGGATGGGCCGCATCACAGGATCAGCAAGCATAGAAACATTAGTGAGAGTTGGCATTGAGAAGGAACATGGCCTCAGTCCTGATTCGAAGATGGTGGTGCTCCATGATTTCACACCATGTGTGGATGACGAGTTAGAGGTAAAACGTGGACAAATTGTTAATGTTCTATATAGAGAAAATGATTGGGTTTATGTCATAGTAGCAGAATCTCGAAGAGAAGGCTTCATACCGCATTCATATTGTGCACCATGTGAACATCATGATTTAAAGAAAAAACTCCCGAGAAGTAGATCCCCTGCCGATTTAGCCCATCGAGATGTTTCACAATTATCTGTATCTGATGGAGTAACAAATGATGGGCATTCAGAGCTTGGTAGTGAAGGTGAAGCATGTCCCTTTAGCAAAGATCCTTCAGGAAGATACGTAGTGCTATACACATTCACTGCAAGAGATGAAAATGATGTTGACGTAGAACGAGGAGAATTTGTTACAGTACTAAACAGAGAAGACCCAGATTGGTATTGGATAGTAAGGAGTGATGGTCAAGAAGGGTTTATACCATCTGGTTTTGTGTATCCTGCTGTCGTTCAAGCCACCACACAAGAGAACACACAGACCTTGCATCCTACGCCGCCAACAAATACAAATAACAGTATAATATCAACAAATAACAACAGTAGTATAAACAACACAACACAGCAGGACAACGACGGGAGGTATCACGGAACGGAACTAGTCATGCTTTATGATTACAAGGCTCAAGCACCTGACGATCTGACAGTGAAGCGAGGAGAGTGGGTTTATGCAGATCTGACCCAGCAAACTGTAGAGGGATGGTTGTGGGCACACGCACCCAAGTCACGACGATCCGGTTTCATACCTACAGCTTACGCTCGTGCACCTCACACTACATCACTTTGA

Protein

MAFLCPVRIRRGKKKKSSSGDSDKDLSRPSSGLSPGMGRITGSASIETLVRVGIEKEHGLSPDSKMVVLHDFTPCVDDELEVKRGQIVNVLYRENDWVYVIVAESRREGFIPHSYCAPCEHHDLKKKLPRSRSPADLAHRDVSQLSVSDGVTNDGHSELGSEGEACPFSKDPSGRYVVLYTFTARDENDVDVERGEFVTVLNREDPDWYWIVRSDGQEGFIPSGFVYPAVVQATTQENTQTLHPTPPTNTNNSIISTNNNSSINNTTQQDNDGRYHGTELVMLYDYKAQAPDDLTVKRGEWVYADLTQQTVEGWLWAHAPKSRRSGFIPTAYARAPHTTSL

Description

Required for the apical cell cortex localization, total cellular level and full activity of dachs.

Subunit

Interacts with dachs (via C-terminus); the interaction is direct. Interacts (via N-terminus including SH3 domain 1) with palmitoyltransferase app; this leads to palmitoylation of Dlish by app. Also interacts with dco, ft, ft-regulated E3 ubiquitin ligase Fbxl7, F-box protein slmb and SCF E3 ubiquitin-protein ligase complex component Cul1.

Keywords

Complete proteome   Cytoplasm   Lipoprotein   Palmitate   Reference proteome   Repeat   SH3 domain  

Feature

chain  SH3 domain-containing protein Dlish

Uniprot

B0I191   A0A194PZX7   A0A437B952   A0A2H1VRL2   S4P982   A0A2A4JZA6   + More
A0A212FBS2   H9JTL6   A0A194R2U4   A0A1Y1LW69   D6WMB9   A0A1Y1LW73   A0A1W4XET1   Q17LQ1   U4UN05   B0W5J6   A0A0N8ERZ4   A0A1L8DMH2   A0A2P8XSB3   A0A0J9RFI6   A1ZAY1   A0A182G0H6   Q8IGN9   B3NMM1   A0A1B0CSQ1   B4HMZ4   B4P551   A0A023F5F9   A0A2J7R2B5   A0A0A9XDR3   A0A1B6IIN7   A0A1W4V0T3   A0A067RIB4   A0A1S4G2Z6   B3MIE0   U5ETZ4   A0A1B6DKP4   B4GIA2   A0A1A9WK47   B5DZC0   A0A3S4R4W4   A0A3B0JQF8   A0A443SBK2   B4J5M3   B4K1U4   A0A2H8TZY2   J9JRL0   A0A0L0CK89   A0A224YZS3   A0A131YSH8   A0A1I8Q9Q2   L7M7S1   A0A2R5LL15   A0A1A9ZP91   B4NN52   B4LP50   T1JHQ5   A0A131XT93   A0A1J1J7X0   A0A131XI31   A0A1A9VX67   A0A1J1JAE9   A0A1B0GDL2   A0A2P2I2W9   A0A087TDS4   A0A1B0BR38   A0A1A9Y6C5   A0A182MM71   K7IZ02   A0A232FJ63   A0A444T7E9   A0A0T6B8U4   A0A0J7NM32   A0A310SA05   A0A195BP98   F4WL62   A0A026VST7   A0A151WLW5   A0A195CI93   A0A158P094   E9IKV0   E2BWK2   A0A088AFW4   A0A2A3EGM0   A0A154P8C3   E2AR06   A0A195FCU5   A0A1B0DHT7   A0A3L8D754   Q16FB7   A0A3Q0J412   T1H5W8   A0A0K8TSR1   Q7PNR5   A0A2M3ZBS8   A0A195EK69   A0A2S2NQ88   W5JFJ3   A0A2M4AF42   A0A182WB21  

Pubmed

26354079    23622113    22118469    19121390    28004739    18362917    + More
19820115    17510324    23537049    26999592    29403074    22936249    10731132    12537572    27692068    27824307    26483478    17994087    17550304    25474469    25401762    26823975    24845553    15632085    26108605    28797301    26830274    25576852    28049606    20075255    28648823    21719571    24508170    21347285    21282665    20798317    30249741    26369729    12364791    20920257    23761445   

EMBL

AB162719    BAG06921.1    KQ459582    KPI98882.1    RSAL01000115    RVE46895.1    + More
ODYU01004004    SOQ43438.1    GAIX01009190    JAA83370.1    NWSH01000362    PCG76974.1    AGBW02009293    OWR51168.1    BABH01003616    BABH01003617    KQ460878    KPJ11565.1    GEZM01045472    JAV77794.1    KQ971343    EFA04249.1    GEZM01045473    JAV77793.1    CH477213    EAT47651.1    KB632288    ERL91551.1    DS231843    EDS35479.1    GDUN01000898    JAN95021.1    GFDF01006425    JAV07659.1    PYGN01001431    PSN34887.1    CM002911    KMY94661.1    AE013599    BT099964    ACX47665.1    JXUM01001336    JXUM01001337    JXUM01001338    JXUM01001339    BT001682    AAN71437.1    CH954179    EDV54960.1    AJWK01026374    AJWK01026375    AJWK01026376    AJWK01026377    AJWK01026378    CH480816    EDW48344.1    CM000158    EDW91752.1    GBBI01002334    JAC16378.1    NEVH01007841    PNF34961.1    GBHO01028377    GBHO01028374    GBRD01010169    GDHC01011508    GDHC01008950    JAG15227.1    JAG15230.1    JAG55655.1    JAQ07121.1    JAQ09679.1    GECU01020917    JAS86789.1    KK852665    KDR19006.1    CH902619    EDV36988.1    GANO01001700    JAB58171.1    GEDC01011039    JAS26259.1    CH479183    EDW36222.1    CM000071    EDY69167.1    NCKU01001905    NCKU01001883    NCKU01001620    RWS10946.1    RWS11011.1    RWS11645.1    OUUW01000001    SPP74891.1    NCKV01004237    RWS24941.1    CH916367    EDW01799.1    CH917862    EDW04895.1    GFXV01007506    MBW19311.1    ABLF02035819    JRES01000265    KNC32818.1    GFPF01008166    MAA19312.1    GEDV01007009    JAP81548.1    GACK01005885    JAA59149.1    GGLE01006053    MBY10179.1    CH964282    EDW85791.1    CH940648    EDW62244.1    JH431388    GEFM01007005    JAP68791.1    CVRI01000075    CRL08533.1    GEFH01002821    JAP65760.1    CRL08534.1    CCAG010011939    IACF01002704    LAB68349.1    KK114767    KFM63263.1    JXJN01018905    AXCM01000549    NNAY01000120    OXU30784.1    SAUD01009372    RXG61563.1    LJIG01009135    KRT83685.1    LBMM01003433    KMQ93545.1    KQ767320    OAD53401.1    KQ976433    KYM87279.1    GL888207    EGI65025.1    KK108267    EZA46792.1    KQ982944    KYQ48882.1    KQ977720    KYN00460.1    ADTU01004650    ADTU01004651    GL764026    EFZ18861.1    GL451131    EFN79958.1    KZ288254    PBC30860.1    KQ434844    KZC08175.1    GL441846    EFN64152.1    KQ981685    KYN38022.1    AJVK01061554    QOIP01000012    RLU16104.1    CH478467    EAT32926.1    GDAI01000623    JAI16980.1    AAAB01008960    EAA11721.5    GGFM01005174    MBW25925.1    KQ978747    KYN28660.1    GGMR01006731    MBY19350.1    ADMH02001639    ETN61650.1    GGFK01006074    MBW39395.1   

Proteomes

UP000053268    UP000283053    UP000218220    UP000007151    UP000005204    UP000053240    + More
UP000007266    UP000192223    UP000008820    UP000030742    UP000002320    UP000245037    UP000000803    UP000069940    UP000008711    UP000092461    UP000001292    UP000002282    UP000235965    UP000192221    UP000027135    UP000007801    UP000008744    UP000091820    UP000001819    UP000285301    UP000268350    UP000288716    UP000001070    UP000007819    UP000037069    UP000095300    UP000092445    UP000007798    UP000008792    UP000183832    UP000078200    UP000092444    UP000054359    UP000092460    UP000092443    UP000075883    UP000002358    UP000215335    UP000288706    UP000036403    UP000078540    UP000007755    UP000053097    UP000075809    UP000078542    UP000005205    UP000008237    UP000005203    UP000242457    UP000076502    UP000000311    UP000078541    UP000092462    UP000279307    UP000079169    UP000015102    UP000007062    UP000078492    UP000000673    UP000075920   

PRIDE

B0I191    H9JTL6    A1ZAY1    Q8IGN9   

Pfam

PF00018   SH3_1        + More
PF00168   C2
PF14604   SH3_9
PF02437   Ski_Sno
PF08782   c-SKI_SMAD_bind

Interpro

IPR036028   SH3-like_dom_sf        + More
IPR001452   SH3_domain       
IPR000008   C2_dom       
IPR001565   Synaptotagmin       
IPR035892   C2_domain_sf       
IPR014890   c-SKI_SMAD4-bd_dom       
IPR023216   Tscrpt_reg_SKI_SnoN       
IPR037000   Ski_DNA-bd_sf       
IPR003380   SKI/SNO/DAC       
IPR010919   SAND-like_dom_sf       
IPR009061   DNA-bd_dom_put_sf       

SUPFAM

SSF50044   SSF50044        + More
SSF46955   SSF46955       
SSF63763   SSF63763       

Gene 3D

2.60.40.150     3.10.260.20     3.10.390.10    

ProteinModelPortal

B0I191   A0A194PZX7   A0A437B952   A0A2H1VRL2   S4P982   A0A2A4JZA6   + More
A0A212FBS2   H9JTL6   A0A194R2U4   A0A1Y1LW69   D6WMB9   A0A1Y1LW73   A0A1W4XET1   Q17LQ1   U4UN05   B0W5J6   A0A0N8ERZ4   A0A1L8DMH2   A0A2P8XSB3   A0A0J9RFI6   A1ZAY1   A0A182G0H6   Q8IGN9   B3NMM1   A0A1B0CSQ1   B4HMZ4   B4P551   A0A023F5F9   A0A2J7R2B5   A0A0A9XDR3   A0A1B6IIN7   A0A1W4V0T3   A0A067RIB4   A0A1S4G2Z6   B3MIE0   U5ETZ4   A0A1B6DKP4   B4GIA2   A0A1A9WK47   B5DZC0   A0A3S4R4W4   A0A3B0JQF8   A0A443SBK2   B4J5M3   B4K1U4   A0A2H8TZY2   J9JRL0   A0A0L0CK89   A0A224YZS3   A0A131YSH8   A0A1I8Q9Q2   L7M7S1   A0A2R5LL15   A0A1A9ZP91   B4NN52   B4LP50   T1JHQ5   A0A131XT93   A0A1J1J7X0   A0A131XI31   A0A1A9VX67   A0A1J1JAE9   A0A1B0GDL2   A0A2P2I2W9   A0A087TDS4   A0A1B0BR38   A0A1A9Y6C5   A0A182MM71   K7IZ02   A0A232FJ63   A0A444T7E9   A0A0T6B8U4   A0A0J7NM32   A0A310SA05   A0A195BP98   F4WL62   A0A026VST7   A0A151WLW5   A0A195CI93   A0A158P094   E9IKV0   E2BWK2   A0A088AFW4   A0A2A3EGM0   A0A154P8C3   E2AR06   A0A195FCU5   A0A1B0DHT7   A0A3L8D754   Q16FB7   A0A3Q0J412   T1H5W8   A0A0K8TSR1   Q7PNR5   A0A2M3ZBS8   A0A195EK69   A0A2S2NQ88   W5JFJ3   A0A2M4AF42   A0A182WB21  

PDB

1GRI     E-value=4.23967e-08,     Score=137

KEGG

100145898    no KO assigned | (RefSeq) K3, BmK3; K3 protein

GO

GO:0008021   GO:0017137   GO:0016020   GO:0006887   GO:0045296   GO:0045179   GO:0090251   GO:0016327   GO:0035331   GO:0090163   GO:0005737   GO:0001736   GO:0016301   GO:0035869   GO:0005515   GO:0006886   GO:0016787   GO:0003723   GO:0006730   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR10005  

Subcellular location

Cytoplasm   Low levels are found diffusely in the cytoplasm with high levels concentrated at the subapical cell cortex.   With evidence from 3 publications.
Cell cortex   Low levels are found diffusely in the cytoplasm with high levels concentrated at the subapical cell cortex.   With evidence from 3 publications.

Length:

341

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00013

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01162

outside

1  -  341

 

 

Pi

336.213716

Theta

228.844802

Tajima's D

1.546034

CLR

0.463797

CSRT

0.79846007699615

Interpretation

Uncertain