Gene

KWMTBOMO09670

Annotation

PREDICTED:_dnaJ_(Hsp40)_homolog_11_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr16(-):6547847-6550156      View in EpiBrowser

Full name

S-adenosylmethionine sensor upstream of mTORC1      

Alternative Name

Probable methyltransferase BMT2 homolog

Location in the cell

Mitochondrial   Reliability : 1.397 Nuclear   Reliability : 1.401

CDS

ATGCTCCGTCAAAGAAACAATATTTTAGTGACAACTTTTTATAGACAATTTACTACCTCACCTCAATTTTGTGCCAGCCACTATGATGTGCTTGGAGTCACACCAAAAGCGACCCAGAACGATATAAAAACGGCTTACTATAAACTTTCCAAAGTACACCACCCGGACAAATCTAAGGATGAAGCATCTATCAAAAAGTTTCGAGCAATAACAGAAGCATATGAGGTACTTGGGAATATTCAACTTAAAAAAATGTATGATAGAGGTCTCTTAGTTGGTAGAGAGAATACTTCTCGTATGGAATACAAACCAGAACCAGAACCTACAGATCCTACCCTAAAGTTTTACAAGTCCCATGCAACTCGCAATATCACACCCACCATGGACGGGAAAGTTCCAATTTATGACTTTGATAGTTGGTCCAAACACCATTATTCAGATGTATTTGCAAAGCAGAAATATGATAAGGAAATGGTACGAAACTCACAAGAAAAACAACAGAAAATATTAGAATCTACTAAGCAAGAAGGAATTATTTGGCTTGTTATAATCATAGGTGGATTGTTTATTGCGGTGTTACTTAATGGACTCGATGATTATGATCAAAATCAGTTACAAAAGAATAATATAGAAAAAAAATGA

Protein

MLRQRNNILVTTFYRQFTTSPQFCASHYDVLGVTPKATQNDIKTAYYKLSKVHHPDKSKDEASIKKFRAITEAYEVLGNIQLKKMYDRGLLVGRENTSRMEYKPEPEPTDPTLKFYKSHATRNITPTMDGKVPIYDFDSWSKHHYSDVFAKQKYDKEMVRNSQEKQQKILESTKQEGIIWLVIIIGGLFIAVLLNGLDDYDQNQLQKNNIEKK

Description

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

Similarity

Belongs to the BMT2 family.

Uniprot

H6VTQ1   C7AQZ9   A0A194R200   A0A194Q1M8   S4PWU7   A0A437B8P7   + More
A0A212FBN5   A0A2H1W555   A0A2A4JE72   A0A2A4JD33   A0A0L7KL18   A0A0K8TN67   B0W3K6   A0A1Q3FH55   A0A182K4L5   A0A182QQW9   A0A182F942   A0A182PKG2   A0A084W4Y9   A0A2M4BYC0   A0A182T1S0   A0A1D6TIB9   A0A182UPK9   A0A182TSS3   A0A182LAY8   Q5TVD0   A0A182I908   A0A182YP33   A0A182WVC7   W5JB29   A0A067R0M0   T1DM52   A0A2M3ZJN0   A0A182N4K7   A0A182VY17   A0A182M7X9   A0A1I8MRF4   A0A1I8N2P0   A0A1I8MT85   J3JZ42   A0A1I8PFR0   A0A1Y1M290   A0A0T6B8C2   A0A423S9T9   A0A3R7LYD5   Q295I0   B4GDV0   D2A3L8   B4JUS2   A0A336K4I6   A0A2J7PRC0   A0A1A9W8C0   A0A0P4W746   A0A1A9VFM1   A0A0L0C784   A0A1A9XWB1   N6SUV0   A0A1B0FCP7   T1HR47   U4UQX3   A0A1B0A375   B4NJ37   A0A1L8DTW7   A0A1L8DTP6   A0A1L8DU93   A0A0P4VM14   A0A1B6HVP4   A0A1B6FYQ9   E9FYC9   A0A1S3CYK0  

Pubmed

26434795    26354079    23622113    22118469    26227816    26369729    + More
24438588    20966253    12364791    14747013    17210077    25244985    20920257    23761445    24845553    25315136    22516182    28004739    15632085    17994087    18362917    19820115    26108605    23537049    27129103    21292972   

EMBL

JN872886    AFC01225.1    FJ592084    ACT34045.1    KQ460878    KPJ11549.1    + More
KQ459582    KPI98899.1    GAIX01006168    JAA86392.1    RSAL01000115    RVE46882.1    AGBW02009293    OWR51154.1    ODYU01006408    SOQ48225.1    NWSH01001822    PCG70008.1    PCG70007.1    JTDY01009381    KOB63589.1    GDAI01002233    JAI15370.1    DS231832    EDS31792.1    GFDL01008183    JAV26862.1    AXCN02000044    ATLV01020424    KE525302    KFB45283.1    GGFJ01008871    MBW58012.1    AAAB01008844    EAA05983.3    APCN01003147    ADMH02001893    ETN60613.1    KK852802    KDR16290.1    GAMD01000086    JAB01505.1    GGFM01007934    MBW28685.1    AXCM01004998    BT128523    AEE63480.1    GEZM01042299    GEZM01042298    JAV79954.1    LJIG01009223    KRT83509.1    QCYY01004455    ROT60971.1    QCYY01003696    ROT62401.1    CM000070    EAL28732.3    CH479182    EDW34611.1    KQ971348    EFA05522.1    CH916374    EDV91242.1    UFQS01000022    UFQT01000022    SSW97613.1    SSX17999.1    NEVH01022362    PNF18883.1    GDRN01084928    JAI61421.1    JRES01000819    KNC28130.1    APGK01055728    KB741269    ENN71469.1    CCAG010010183    ACPB03009189    KB632330    ERL92556.1    CH964272    EDW83830.1    GFDF01004257    JAV09827.1    GFDF01004258    JAV09826.1    GFDF01004259    JAV09825.1    GDKW01003119    JAI53476.1    GECU01028958    JAS78748.1    GECZ01014457    JAS55312.1    GL732527    EFX87793.1   

Proteomes

UP000053240    UP000053268    UP000283053    UP000007151    UP000218220    UP000037510    + More
UP000002320    UP000075881    UP000075886    UP000069272    UP000075885    UP000030765    UP000075901    UP000076407    UP000075903    UP000075902    UP000075882    UP000007062    UP000075840    UP000076408    UP000000673    UP000027135    UP000075884    UP000075920    UP000075883    UP000095301    UP000095300    UP000283509    UP000001819    UP000008744    UP000007266    UP000001070    UP000235965    UP000091820    UP000078200    UP000037069    UP000092443    UP000019118    UP000092444    UP000015103    UP000030742    UP000092445    UP000007798    UP000000305    UP000079169   

PRIDE

H6VTQ1    C7AQZ9   

Pfam

PF00226   DnaJ        + More
PF11968   Bmt2

Interpro

IPR018253   DnaJ_domain_CS        + More
IPR036869   J_dom_sf       
IPR001623   DnaJ_domain       
IPR029063   SAM-dependent_MTases       
IPR021867   Bmt2/SAMTOR       

SUPFAM

SSF46565   SSF46565        + More
SSF53335   SSF53335       

Gene 3D

1.10.287.110    

CDD

cd06257  DnaJ

ProteinModelPortal

H6VTQ1   C7AQZ9   A0A194R200   A0A194Q1M8   S4PWU7   A0A437B8P7   + More
A0A212FBN5   A0A2H1W555   A0A2A4JE72   A0A2A4JD33   A0A0L7KL18   A0A0K8TN67   B0W3K6   A0A1Q3FH55   A0A182K4L5   A0A182QQW9   A0A182F942   A0A182PKG2   A0A084W4Y9   A0A2M4BYC0   A0A182T1S0   A0A1D6TIB9   A0A182UPK9   A0A182TSS3   A0A182LAY8   Q5TVD0   A0A182I908   A0A182YP33   A0A182WVC7   W5JB29   A0A067R0M0   T1DM52   A0A2M3ZJN0   A0A182N4K7   A0A182VY17   A0A182M7X9   A0A1I8MRF4   A0A1I8N2P0   A0A1I8MT85   J3JZ42   A0A1I8PFR0   A0A1Y1M290   A0A0T6B8C2   A0A423S9T9   A0A3R7LYD5   Q295I0   B4GDV0   D2A3L8   B4JUS2   A0A336K4I6   A0A2J7PRC0   A0A1A9W8C0   A0A0P4W746   A0A1A9VFM1   A0A0L0C784   A0A1A9XWB1   N6SUV0   A0A1B0FCP7   T1HR47   U4UQX3   A0A1B0A375   B4NJ37   A0A1L8DTW7   A0A1L8DTP6   A0A1L8DU93   A0A0P4VM14   A0A1B6HVP4   A0A1B6FYQ9   E9FYC9   A0A1S3CYK0  

PDB

2YUA     E-value=3.45695e-10,     Score=152

KEGG

100302623    K19374 DnaJ homolog subfamily C member 30 | (RefSeq) DnaJ-11; DnaJ (Hsp40) homolog 11

GO

GO:0016021   GO:0008168  

PANTHER

PTHR21008  

Length:

213

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.89436

Exp number, first 60 AAs:

0.00253

Total prob of N-in:

0.48813

outside

1  -  177

TMhelix

178  -  197

inside

198  -  213

 

 

Pi

231.266788

Theta

198.891173

Tajima's D

0.474817

CLR

0.05214

CSRT

0.512574371281436

Interpretation

Uncertain