Gene

KWMTBOMO09660

Pre Gene Modal

BGIBMGA012871

Annotation

PREDICTED:_apyrase_[Amyelois_transitella]

Location

Bomo_Chr16(+):6425097-6436701      View in EpiBrowser

Full name

Apyrase      

Alternative Name

ATP-diphosphatase
ATP-diphosphohydrolase
Adenosine diphosphatase

Location in the cell

PlasmaMembrane   Reliability : 1.682

CDS

ATGTGGAAACTAGTTTTGTATCTTGTAGTTCTCGGCACAGTTTTGGGACAATCTGACAATGGGCTTTTCGAATTAAACATCATTCACTATAACGATTTCCACGCACACTTCGACGAGATTAGTCCACGAGGAACGATCTGTAATCCCACCGAAGACCCATGCATCGGTGGTTTTGCTAGGCTGTATACAGCCATTATGGAGATTTTTGAAGCCGAACCAGATTCGCTACTTCTTAACGGAGGGGACACGTTCCAAGGAACAATCTGGTACAACTTCTTGAGATGGAATGTCACTCAACATTTTATGAACATGCTGCCACATGATGCACACGTACTCGGAAACCACGAGTTCGATCATGGAGTGGAAGGTCTATTGCCGTATTTGGAACGTTTAAATTCCCCAATGCTAGGTGCTAATGTTAATACAACTTTTGAACCATCTTTGACGCCATTCGTGAAAAATCACGTAATTGTAGAACGAAATGGTAGGAAGATTGGTATCATAGGTGTTTTGTTGCGAGTGTTTTCAGCGCCAATTGGTCAAGTCATCATGGAAGATGAACTTGAGGCTGTAAATCGAGAAGCGGCCATACTAACCGAAGCCGGAGTTGATATTATAATTGTACTCTCTCATATTGGATACACCAGTGATTTAAATCTAGCGGCCCGCGTTGTTCCGGAAGTGGATATCATAGTTGGCGCGCATTCCCATACACTGTTGTTCAACGGAGAAACTCCTAATGGTGACACGGCATTAGGGGAATACCCGACTGTTGTCACACAAGATAATGGACACAGGGTACTGGTGGTTCAAGCGTCTTGTTACACGCGATATTTGGGCGACATAAAACTGTATATCAACGATAGAGGCATTATTGAAAGCTGGGAAGGGCTGCCTGTTTTCTTAGGATCATCTATTGTACAAGATCCTAGGATCCTGGATGAATTAGAGCCGTGGCGTCAGGAGGTGGATGCGATTGGTAAAGAGGTGCTCGGCACTACACTGACGAGTCTCAGCCGAGGATGTACGCGCCGTGAGTGTAACCTTGGCAGCTGGGCGTGTGATGGATTTCTAGAAGAGATGTTGTCACAAGCTACGGGTACAGCGTGGAATGGAGCTCATCTCTGCTTAATAAATTCGGGCGGATTGCGCGTGCAAATAGCACCTGGCGAGGTAACAACTGAGGGACTGCTAATGGCTATACCGTTTGAGAATTACATCCAAGTGTACGACCTAAAGGGTGAATACCTACTCGAGGCGTTAGAGTTTTCTGTGGGTGTGGCACAGACAACACCGGGAGACTTCTCTAGTTCACGAATGTTACAAATAGGAGGGATGCGCAATGTATACAATGCGTCAGCTCCGATCGGTTCCCGTGTGATTTCCGCGACGGTCCGGTGCATAGAGTGCGACGTACCGCAGTATGAGCCCCTCGACGTCACCGCCACCTACAGAGTGGTGACGCAAAACTATATCGGAGATGGAGGCGGCGGTTACACGATGCTGTCGAACAACAGAGAAAACCTCGAGAATTTGGATGTCGACTACGTAGTGTTACAACGTTACATGCGTAGACAACAAACAGTACTGCAAGACCTGGACGGACGCATACAGATTGTGTATTAA

Protein

MWKLVLYLVVLGTVLGQSDNGLFELNIIHYNDFHAHFDEISPRGTICNPTEDPCIGGFARLYTAIMEIFEAEPDSLLLNGGDTFQGTIWYNFLRWNVTQHFMNMLPHDAHVLGNHEFDHGVEGLLPYLERLNSPMLGANVNTTFEPSLTPFVKNHVIVERNGRKIGIIGVLLRVFSAPIGQVIMEDELEAVNREAAILTEAGVDIIIVLSHIGYTSDLNLAARVVPEVDIIVGAHSHTLLFNGETPNGDTALGEYPTVVTQDNGHRVLVVQASCYTRYLGDIKLYINDRGIIESWEGLPVFLGSSIVQDPRILDELEPWRQEVDAIGKEVLGTTLTSLSRGCTRRECNLGSWACDGFLEEMLSQATGTAWNGAHLCLINSGGLRVQIAPGEVTTEGLLMAIPFENYIQVYDLKGEYLLEALEFSVGVAQTTPGDFSSSRMLQIGGMRNVYNASAPIGSRVISATVRCIECDVPQYEPLDVTATYRVVTQNYIGDGGGGYTMLSNNRENLENLDVDYVVLQRYMRRQQTVLQDLDGRIQIVY

Description

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host. Shows potential for antithrombotic activity. May reduce probing time by facilitating the speed of locating blood.

Catalytic Activity

a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate

Cofactor

a divalent metal cation

Similarity

Belongs to the 5'-nucleotidase family.

Keywords

Allergen   ATP-binding   Direct protein sequencing   Hydrolase   Metal-binding   Nucleotide-binding   Secreted   Signal  

Feature

chain  Apyrase

Uniprot

H9JTK9   A0A2A4JWR7   A0A2A4JW12   A0A437B966   A0A212FMH9   A0A194Q670   + More
A0A2A4JX59   A0A194R1G7   A0A2A4JW25   A0A3S2M1V1   A0A2A4JVW4   A0A194R505   H9JL90   A0A2H1WZX1   A0A194R6M3   B0WJ00   A0A194PLJ4   A0A194PMT9   A0A1Q3FIZ4   A0A182U110   A0A2C9GRQ1   A0A182GQ46   A0A1Q3FN26   A0A1C7CZG9   A0A067RQX4   A0A182VC59   A0A1S4KDB8   Q7QIZ1   Q16QA5   A0A182HLB4   Q8T5H5   Q17NS8   A0A182L9P8   A0A182SCB1   Q8MU74   A0A182WSG4   A0A182V0W0   A0A182R636   A0A182VZA6   A0A182MGY7   A0A2J7RI11   A0A182TN56   A0A336LSN5   A0A1L8ECN7   A0A1I8PB47   A0A336LWJ0   A0A1Y1N7H1   A0A182IVB6   A0A084VT67   A0A182YKS7   A0A1I8NGR4   A0A182R0R0   A0A182K4G0   A0A182YAL5   V5G6C5   B4NEB2   U5EW72   A0A182GQ47   T1PD85   A0A336KUY8   Q16UA0   W5JVI8   A0A182M997   Q16QA4   A0A084VT66   A0A034WIT9   Q9U9I6   A0A034WFB4   B0XGC2   A0A2M4AV02   A0A0K8WAX8   A0A0K8VPE5   A0A182GQ45   W5JSD1   B4MAL8   W8BUB4   A0A182NS57   A0A1L8DPP0   A0A1L8DPP4   A0A182J0X1   A0A182JMY7   A0A182PGQ3   A0A0Q9X374   B4L649   A0A0R3P4U5   A0A182WX10   A0A0A1WD31   A0A1I8NCS8   B3NVB0   A0A182Q352   A0A1L8DPX0   F1JZ10   B3A0N5   A0A182QET4   A0A182PGQ4   A0A182PCT2   J3JZ21   A0A3G1T1Q5   W5J3U7  

EC Number

3.6.1.5

Pubmed

19121390    22118469    26354079    26483478    20966253    24845553    + More
12364791    14747013    17210077    17510324    12060762    28004739    24438588    25244985    25315136    17994087    20920257    23761445    25348373    10821849    24495485    15632085    25830018    21848516    22516182   

EMBL

BABH01003658    BABH01003659    NWSH01000463    PCG76226.1    PCG76227.1    RSAL01000115    + More
RVE46873.1    AGBW02007651    OWR54937.1    KQ459582    KPI98905.1    PCG76224.1    KQ460878    KPJ11542.1    PCG76225.1    RSAL01000067    RVE49304.1    NWSH01000580    PCG75530.1    KQ460685    KPJ12888.1    BABH01011796    ODYU01012308    SOQ58557.1    KPJ12890.1    DS231954    EDS28861.1    KQ459600    KPI94306.1    KPI94308.1    GFDL01007465    JAV27580.1    APCN01000169    JXUM01079657    JXUM01079658    JXUM01079659    KQ563139    KXJ74403.1    GFDL01006108    JAV28937.1    KK852475    KDR23050.1    AAAB01008807    EAA04249.4    CH477755    EAT36583.1    APCN01000890    AJ439398    AAAB01008987    CAD28126.1    EAA00943.2    CH477196    EAT48396.1    AJ441131    CAD29633.1    AXCM01018154    NEVH01003506    PNF40456.1    UFQT01000158    SSX21032.1    GFDG01002404    JAV16395.1    SSX21033.1    GEZM01010744    JAV93862.1    ATLV01016253    KE525074    KFB41161.1    AXCN02000433    GALX01002836    JAB65630.1    CH964239    EDW82081.2    GANO01000692    JAB59179.1    JXUM01079660    KXJ74404.1    KA646644    AFP61273.1    UFQS01001030    UFQT01001030    SSX08629.1    SSX28545.1    CH477627    EAT38116.1    ADMH02000310    ETN67025.1    AXCM01013925    EAT36584.1    KFB41160.1    GAKP01004725    JAC54227.1    AF169229    AAD49730.1    GAKP01004726    JAC54226.1    DS233012    EDS27504.1    GGFK01011279    MBW44600.1    GDHF01004097    JAI48217.1    GDHF01011563    JAI40751.1    JXUM01079656    KXJ74402.1    ETN67026.1    CH940655    EDW66277.1    GAMC01013841    JAB92714.1    GFDF01005651    JAV08433.1    GFDF01005652    JAV08432.1    KRF99569.1    CH933812    EDW05845.1    CH379064    KRT06403.1    GBXI01017413    JAC96878.1    CH954180    EDV46098.2    AXCN02000266    GFDF01005657    JAV08427.1    JF308210    ADX78255.1    BT128502    AEE63459.1    MG770323    AXY94925.1    ADMH02002183    ETN57988.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000053240    + More
UP000002320    UP000075902    UP000075840    UP000069940    UP000249989    UP000075882    UP000027135    UP000075903    UP000007062    UP000008820    UP000075901    UP000076407    UP000075900    UP000075920    UP000075883    UP000235965    UP000095300    UP000075880    UP000030765    UP000076408    UP000095301    UP000075886    UP000075881    UP000007798    UP000000673    UP000008792    UP000075884    UP000075885    UP000009192    UP000001819    UP000008711   

PRIDE

H9JTK9    H9JL90   

Pfam

PF00149   Metallophos        + More
PF02872   5_nucleotid_C
PF03381   CDC50
PF07679   I-set
PF00089   Trypsin
PF05154   TM2
PF00226   DnaJ

Interpro

IPR029052   Metallo-depent_PP-like        + More
IPR006179   5_nucleotidase/apyrase       
IPR006146   5'-Nucleotdase_CS       
IPR036907   5'-Nucleotdase_C_sf       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR008334   5'-Nucleotdase_C       
IPR005045   CDC50/LEM3_fam       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR013098   Ig_I-set       
IPR013106   Ig_V-set       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR033116   TRYPSIN_SER       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR036869   J_dom_sf       
IPR001623   DnaJ_domain       
IPR018114   TRYPSIN_HIS       
IPR007829   TM2       

SUPFAM

SSF55816   SSF55816        + More
SSF48726   SSF48726       
SSF50494   SSF50494       
SSF46565   SSF46565       

Gene 3D

3.60.21.10     3.90.780.10     2.60.40.10     1.10.287.110    

CDD

cd00190  Tryp_SPc
cd06257  DnaJ

ProteinModelPortal

H9JTK9   A0A2A4JWR7   A0A2A4JW12   A0A437B966   A0A212FMH9   A0A194Q670   + More
A0A2A4JX59   A0A194R1G7   A0A2A4JW25   A0A3S2M1V1   A0A2A4JVW4   A0A194R505   H9JL90   A0A2H1WZX1   A0A194R6M3   B0WJ00   A0A194PLJ4   A0A194PMT9   A0A1Q3FIZ4   A0A182U110   A0A2C9GRQ1   A0A182GQ46   A0A1Q3FN26   A0A1C7CZG9   A0A067RQX4   A0A182VC59   A0A1S4KDB8   Q7QIZ1   Q16QA5   A0A182HLB4   Q8T5H5   Q17NS8   A0A182L9P8   A0A182SCB1   Q8MU74   A0A182WSG4   A0A182V0W0   A0A182R636   A0A182VZA6   A0A182MGY7   A0A2J7RI11   A0A182TN56   A0A336LSN5   A0A1L8ECN7   A0A1I8PB47   A0A336LWJ0   A0A1Y1N7H1   A0A182IVB6   A0A084VT67   A0A182YKS7   A0A1I8NGR4   A0A182R0R0   A0A182K4G0   A0A182YAL5   V5G6C5   B4NEB2   U5EW72   A0A182GQ47   T1PD85   A0A336KUY8   Q16UA0   W5JVI8   A0A182M997   Q16QA4   A0A084VT66   A0A034WIT9   Q9U9I6   A0A034WFB4   B0XGC2   A0A2M4AV02   A0A0K8WAX8   A0A0K8VPE5   A0A182GQ45   W5JSD1   B4MAL8   W8BUB4   A0A182NS57   A0A1L8DPP0   A0A1L8DPP4   A0A182J0X1   A0A182JMY7   A0A182PGQ3   A0A0Q9X374   B4L649   A0A0R3P4U5   A0A182WX10   A0A0A1WD31   A0A1I8NCS8   B3NVB0   A0A182Q352   A0A1L8DPX0   F1JZ10   B3A0N5   A0A182QET4   A0A182PGQ4   A0A182PCT2   J3JZ21   A0A3G1T1Q5   W5J3U7  

PDB

4H2I     E-value=4.38944e-89,     Score=838

KEGG

101735389    no KO assigned | (RefSeq) apyrase-like

GO

GO:0000166   GO:0046872   GO:0009166   GO:0016788   GO:0016021   GO:0016787   GO:0008253   GO:0005886   GO:0006196   GO:0004252   GO:0017110   GO:0017111   GO:0102488   GO:0102490   GO:0102491   GO:0005576   GO:0102485   GO:0102486   GO:0102489   GO:0005524   GO:0102487   GO:0003723   GO:0006730   GO:0009258   GO:0016155   GO:0003824  

PANTHER

PTHR11575  

Subcellular location

Secreted  

SignalP

Position:   1 - 16,         Likelihood:  0.995809

 

 

Length:

541

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.346300000000001

Exp number, first 60 AAs:

0.30384

Total prob of N-in:

0.01602

outside

1  -  541

 

 

Pi

202.585045

Theta

150.376191

Tajima's D

1.032896

CLR

0.242947

CSRT

0.668066596670167

Interpretation

Uncertain