Gene
KWMTBOMO09633  
Validated by peptides from experiments
Pre Gene Modal
BGIBMGA012856
Annotation
hypothetical_protein_KGM_15471_[Danaus_plexippus]
Full name
Citron Rho-interacting kinase
+ More
Non-specific serine/threonine protein kinase
Alternative Name
Rho-interacting, serine/threonine-protein kinase 21
Serine/threonine-protein kinase 21
Location in the cell
Nuclear   Reliability : 2.47
Sequence
CDS
ATGGAACCTTCAAAGGAAGCAATAGCTGTGCGTATAGCACGATTAAATCGACAAATACTAGGCAAAGCAACAAGTGGTGTAAGTAGAAGCAAGAAAACAGTGGACCGAGAAGCATTGTTGGACGCACTTACAGTATTATACGATGAATGTAACGATGATCCTATCAAGAAAACTGATGAATTGGTTCGGGCTTTTGTGGATAAATACCGCAGCACTTTGGCAGAACTGCGAAGGACTAGAGTTTGTATTTCTGACTTTGAAGTAGTTCAAACCATTGGACGTGGATATTTTGGGGAAGTAAATATGGTGAGAGAAAAACAAAGTGGTGATGTATATGCCCTAAAAACATTACGCAAGGAACAATCACGGAAACGTGCCATTGCTTGCACTGAAGATGAGAGGGATGTGTTGGCATCAACGACTAGTCCTTGGATCCCACGTTTGCAGTATGCTTTTCAGGATAGCAACAATTTATACTTAGTAATGGAGCTATGTTCCGGTGGAGATCTTGCCGGGCTGATGTCTCGTCGAAACCATCCATTATCAGAACGAGATGCAGCATTCTACATTGCCGAAGTTGCACATGCTCTGAAAGCACTGCATGGGATGGGTTACATACATAGAGATGTCAAGCCCCACAACATATTTATTGATAGGTAA
Protein
MEPSKEAIAVRIARLNRQILGKATSGVSRSKKTVDREALLDALTVLYDECNDDPIKKTDELVRAFVDKYRSTLAELRRTRVCISDFEVVQTIGRGYFGEVNMVREKQSGDVYALKTLRKEQSRKRAIACTEDERDVLASTTSPWIPRLQYAFQDSNNLYLVMELCSGGDLAGLMSRRNHPLSERDAAFYIAEVAHALKALHGMGYIHRDVKPHNIFIDR
Summary
Description
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Subunit
Interacts with TTC3 (By similarity). Homodimer (Probable). Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form).
Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
Similarity
Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Keywords
Acetylation
Alternative splicing
ATP-binding
Cell cycle
Cell division
Coiled coil
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Kinase
Metal-binding
Mitosis
Neurogenesis
Nucleotide-binding
Phosphoprotein
Reference proteome
SH3-binding
Transferase
Zinc
Zinc-finger
Disease mutation
Polymorphism
Primary microcephaly
Feature
chain Citron Rho-interacting kinase
splice variant In isoform 3.
sequence variant In dbSNP:rs36054900.
PDB
4AW2
E-value=2.32345e-40,
Score=413
Ontologies
Topology
Subcellular location
Cytoplasm
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0441
Exp number, first 60 AAs:
0
Total prob of N-in:
0.05851
Population Genetic Test Statistics