SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO09633  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA012856
Annotation
hypothetical_protein_KGM_15471_[Danaus_plexippus]
Full name
Citron Rho-interacting kinase       + More
Non-specific serine/threonine protein kinase      
Alternative Name
Rho-interacting, serine/threonine-protein kinase 21
Serine/threonine-protein kinase 21
Location in the cell
Nuclear   Reliability : 2.47
 

Sequence

CDS
ATGGAACCTTCAAAGGAAGCAATAGCTGTGCGTATAGCACGATTAAATCGACAAATACTAGGCAAAGCAACAAGTGGTGTAAGTAGAAGCAAGAAAACAGTGGACCGAGAAGCATTGTTGGACGCACTTACAGTATTATACGATGAATGTAACGATGATCCTATCAAGAAAACTGATGAATTGGTTCGGGCTTTTGTGGATAAATACCGCAGCACTTTGGCAGAACTGCGAAGGACTAGAGTTTGTATTTCTGACTTTGAAGTAGTTCAAACCATTGGACGTGGATATTTTGGGGAAGTAAATATGGTGAGAGAAAAACAAAGTGGTGATGTATATGCCCTAAAAACATTACGCAAGGAACAATCACGGAAACGTGCCATTGCTTGCACTGAAGATGAGAGGGATGTGTTGGCATCAACGACTAGTCCTTGGATCCCACGTTTGCAGTATGCTTTTCAGGATAGCAACAATTTATACTTAGTAATGGAGCTATGTTCCGGTGGAGATCTTGCCGGGCTGATGTCTCGTCGAAACCATCCATTATCAGAACGAGATGCAGCATTCTACATTGCCGAAGTTGCACATGCTCTGAAAGCACTGCATGGGATGGGTTACATACATAGAGATGTCAAGCCCCACAACATATTTATTGATAGGTAA
Protein
MEPSKEAIAVRIARLNRQILGKATSGVSRSKKTVDREALLDALTVLYDECNDDPIKKTDELVRAFVDKYRSTLAELRRTRVCISDFEVVQTIGRGYFGEVNMVREKQSGDVYALKTLRKEQSRKRAIACTEDERDVLASTTSPWIPRLQYAFQDSNNLYLVMELCSGGDLAGLMSRRNHPLSERDAAFYIAEVAHALKALHGMGYIHRDVKPHNIFIDR

Summary

Description
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Subunit
Interacts with TTC3 (By similarity). Homodimer (Probable). Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form).
Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
Similarity
Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Keywords
Acetylation   Alternative splicing   ATP-binding   Cell cycle   Cell division   Coiled coil   Complete proteome   Cytoplasm   Developmental protein   Differentiation   Direct protein sequencing   Kinase   Metal-binding   Mitosis   Neurogenesis   Nucleotide-binding   Phosphoprotein   Reference proteome   SH3-binding   Transferase   Zinc   Zinc-finger   Disease mutation   Polymorphism   Primary microcephaly  
Feature
chain  Citron Rho-interacting kinase
splice variant  In isoform 3.
sequence variant  In dbSNP:rs36054900.
EC Number
2.7.11.1
EMBL
ODYU01003294    SOQ41863.1    NWSH01002014    PCG69429.1    KQ459582    KPI98802.1    + More
AGBW02007651    OWR54966.1    PCG69428.1    KQ460208    KPJ16621.1    BABH01003698    BABH01003699    BABH01003700    BABH01003701    BABH01003702    RSAL01000051    RVE50300.1    KK117600    KFM70916.1    KK853478    KDR07314.1    KB632003    ERL87819.1    GFPF01006788    MAA17934.1    DS469641    EDO37677.1    GEFM01004314    JAP71482.1    KQ971347    KYB26957.1    GBIH01002004    JAC92706.1    GFAA01002693    JAU00742.1    QCYY01001877    ROT74596.1    JH816753    EKC34043.1    IACF01006400    LAB71983.1    AF070065    AAC27932.1    AMQN01000719    KB295062    ELU13656.1    GGLE01004480    MBY08606.1    APGK01044205    KB741021    ENN75042.1    CP012525    ALC44339.1    U39904    AF086823    AF086824    AK145037    AF070066    BC023775    BC051165    GAMC01014414    JAB92141.1    ATLV01019208    KE525264    KFB43925.1    CH933809    EDW18138.1    KE676001    ERE74492.1    ERE74494.1    ERE74495.1    MNPL01018732    OQR70024.1    ERE74493.1    GDIP01030393    JAM73322.1    CH379069    EAL30910.1    JH000026    EGV93151.1    GDIP01064879    JAM38836.1    GDIP01053130    JAM50585.1    GDRN01100663    GDRN01100662    JAI58523.1    LRGB01000930    KZS15038.1    KK674753    KFQ07934.1    GDIQ01013295    JAN81442.1    NBAG03000260    PNI57719.1    AABR07036527    AABR07036528    AABR07036529    AABR07036530    AABR07036531    JRES01000577    KNC30067.1    DS233256    EDS28986.1    AY257469    AY209000    AY681966    AB023166    AC002563    AC079317    AC004813    CH479188    EDW40345.1    AMGL01039306    AMGL01039307    AMGL01039308    AEFK01072816    AEFK01072817    AEFK01072818    AEFK01072819    AEFK01072820    AEFK01072821    AEFK01072822    AJWK01006467    LWLT01000018    PPHD01027952    POI26580.1    KK735113    KFR12457.1    GL732664    EFX67999.1    NDHI03003364    PNJ82444.1    CH902618    EDV40286.1    JH881290    ELR55202.1    OUUW01000012    SPP87439.1    HAAD01005910    CDG72142.1    AC115795    AC162461    CH964062    EDW78776.2    AXCM01008027    AANG04002472    NEDP02004827    OWF44281.1    KL872580    KGL96209.1    GL192692    EFB19632.1    ACTA01027909    ACTA01035909    ACTA01043908    ACTA01051908    ACTA01059908    GDIP01088224    JAM15491.1    CH480815    EDW41273.1    AKCR02000059    PKK22678.1    KB375996    EMC78645.1    CM002912    KMY99247.1   
Pfam
PF00069   Pkinase        + More
PF00780   CNH
PF00433   Pkinase_C
PF00169   PH
PF08395   7tm_7
PF00130   C1_1
PF04916   Phospholip_B
PF09532   FDF
PF12701   LSM14
Interpro
IPR008271   Ser/Thr_kinase_AS        + More
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR017405   Citron_Rho-interacting_kinase       
IPR000719   Prot_kinase_dom       
IPR000961   AGC-kinase_C       
IPR029875   LET-502       
IPR001180   CNH_dom       
IPR017892   Pkinase_C       
IPR037708   CRIK_dom       
IPR001849   PH_domain       
IPR002219   PE/DAG-bd       
IPR011993   PH-like_dom_sf       
IPR013604   7TM_chemorcpt       
IPR007000   PLipase_B-like       
IPR025768   TFG_box       
IPR025761   FFD_box       
IPR010920   LSM_dom_sf       
IPR019050   FDF_dom       
IPR025762   DFDF       
IPR025609   Lsm14-like_N       
IPR004152   GAT_dom       
SUPFAM
SSF56112   SSF56112        + More
SSF50182   SSF50182       
Gene 3D
PDB
4AW2     E-value=2.32345e-40,     Score=413

Ontologies

Topology

Subcellular location
Cytoplasm  
Length:
219
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0441
Exp number, first 60 AAs:
0
Total prob of N-in:
0.05851
outside
1  -  219
 
 

Population Genetic Test Statistics

Pi
186.952941
Theta
177.955701
Tajima's D
0.339012
CLR
0.907844
CSRT
0.465576721163942
Interpretation
Uncertain
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