Pre Gene Modal
BGIBMGA012853
Annotation
PREDICTED:_histone-lysine_N-methyltransferase_pr-set7_[Amyelois_transitella]
Full name
Histone-lysine N-methyltransferase
+ More
Histone-lysine N-methyltransferase PR-Set7
Alternative Name
PR/SET domain-containing protein 07
Location in the cell
Cytoplasmic Reliability : 1.79 Mitochondrial Reliability : 1.37 Nuclear Reliability : 1.568
Sequence
CDS
ATGGCAGTTCAAGAAGGGGTAAAGACTCCACATCGCATTGAATTGTGTGAAGACAAGCCTGCTAGGCCCACACGGAATTATAGGAAACGAAGGATTATCACTGCAATACAGCCAAAGACTGAAAATGAAGAACTGAGTTCTGAGCCTCCATTCAAGAAAACTGAACAAAAATCGAAACCATTGAAGACTAGCAACGGTATTTCCAATATGACAAATGGACACTCACTGAGGACACGTGCTGCAAGGGCAGAGATACGTGCAGCGGAAAGCCACAAATTAACAGAGTATTTCAAAGAGGAAATAAAAGTTCCTAAAGTAGAACCTGCTGTATCTCCTTCACCCATAGAAAAGACTGTTAAAGTTGAGAAAGTTTCAAATGGAAATGCAAACCACAAATTAACTGAATTTTTTCCTGTAAGAAGAAGTGTAAGGAAAACATCAAAATGTGTCATGGCTGAGAAAATGAGAGATTTAGAAAGAGCTGTTAGAGAACAAAGAGAAGATGGATTACAAGTTGCCTATTTCGAAGCCAAAGGTCGCGGAGTGATCGCAACCCGTCCGTTTAGTCGCGGTCAGTACGTGGTGGAATATGCCGGTGAACTGATCGGCGTGGCAGAAGCTCGTGAACGAGAACGTTTGTACGCCCTGGATCCTGAGGCCGGATGTTACATGTATTACTTCAGACATGGAGATCAACAGTATTGTATTGATGCAACTGCTGAGTCGGGACGGCTGGGTCGATTGGTGAACCACTCTCGCAACGGTAATCTTCACACAAAGGCGTTGTGGGTGGACGGGCCGCGACTCGTGCTGATCGCTGCACAGGATATCTCCCCGGGGGATGAACTCACTTATGATTATGGAGACCGCTCTAAGGAATCCCTGCAACATCATCCCTGGCTCGCTTTCTGA
Protein
MAVQEGVKTPHRIELCEDKPARPTRNYRKRRIITAIQPKTENEELSSEPPFKKTEQKSKPLKTSNGISNMTNGHSLRTRAARAEIRAAESHKLTEYFKEEIKVPKVEPAVSPSPIEKTVKVEKVSNGNANHKLTEFFPVRRSVRKTSKCVMAEKMRDLERAVREQREDGLQVAYFEAKGRGVIATRPFSRGQYVVEYAGELIGVAEARERERLYALDPEAGCYMYYFRHGDQQYCIDATAESGRLGRLVNHSRNGNLHTKALWVDGPRLVLIAAQDISPGDELTYDYGDRSKESLQHHPWLAF
Summary
Description
Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis (By similarity).
Catalytic Activity
L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
Keywords
Cell cycle
Cell division
Chromatin regulator
Chromosome
Complete proteome
Methyltransferase
Mitosis
Nucleus
Reference proteome
Repressor
S-adenosyl-L-methionine
Transcription
Transcription regulation
Transferase
Feature
chain Histone-lysine N-methyltransferase PR-Set7
PDB
5HQ2
E-value=1.3817e-48,
Score=486
Ontologies
Topology
Subcellular location
Nucleus
Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions (By similarity). With evidence from 1 publications.
Chromosome
Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions (By similarity). With evidence from 1 publications.
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0
Exp number, first 60 AAs:
0
Total prob of N-in:
0.02741
Population Genetic Test Statistics