SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO09624
Pre Gene Modal
BGIBMGA012853
Annotation
PREDICTED:_histone-lysine_N-methyltransferase_pr-set7_[Amyelois_transitella]
Full name
Histone-lysine N-methyltransferase       + More
Histone-lysine N-methyltransferase PR-Set7      
Alternative Name
PR/SET domain-containing protein 07
Location in the cell
Cytoplasmic   Reliability : 1.79 Mitochondrial   Reliability : 1.37 Nuclear   Reliability : 1.568
 

Sequence

CDS
ATGGCAGTTCAAGAAGGGGTAAAGACTCCACATCGCATTGAATTGTGTGAAGACAAGCCTGCTAGGCCCACACGGAATTATAGGAAACGAAGGATTATCACTGCAATACAGCCAAAGACTGAAAATGAAGAACTGAGTTCTGAGCCTCCATTCAAGAAAACTGAACAAAAATCGAAACCATTGAAGACTAGCAACGGTATTTCCAATATGACAAATGGACACTCACTGAGGACACGTGCTGCAAGGGCAGAGATACGTGCAGCGGAAAGCCACAAATTAACAGAGTATTTCAAAGAGGAAATAAAAGTTCCTAAAGTAGAACCTGCTGTATCTCCTTCACCCATAGAAAAGACTGTTAAAGTTGAGAAAGTTTCAAATGGAAATGCAAACCACAAATTAACTGAATTTTTTCCTGTAAGAAGAAGTGTAAGGAAAACATCAAAATGTGTCATGGCTGAGAAAATGAGAGATTTAGAAAGAGCTGTTAGAGAACAAAGAGAAGATGGATTACAAGTTGCCTATTTCGAAGCCAAAGGTCGCGGAGTGATCGCAACCCGTCCGTTTAGTCGCGGTCAGTACGTGGTGGAATATGCCGGTGAACTGATCGGCGTGGCAGAAGCTCGTGAACGAGAACGTTTGTACGCCCTGGATCCTGAGGCCGGATGTTACATGTATTACTTCAGACATGGAGATCAACAGTATTGTATTGATGCAACTGCTGAGTCGGGACGGCTGGGTCGATTGGTGAACCACTCTCGCAACGGTAATCTTCACACAAAGGCGTTGTGGGTGGACGGGCCGCGACTCGTGCTGATCGCTGCACAGGATATCTCCCCGGGGGATGAACTCACTTATGATTATGGAGACCGCTCTAAGGAATCCCTGCAACATCATCCCTGGCTCGCTTTCTGA
Protein
MAVQEGVKTPHRIELCEDKPARPTRNYRKRRIITAIQPKTENEELSSEPPFKKTEQKSKPLKTSNGISNMTNGHSLRTRAARAEIRAAESHKLTEYFKEEIKVPKVEPAVSPSPIEKTVKVEKVSNGNANHKLTEFFPVRRSVRKTSKCVMAEKMRDLERAVREQREDGLQVAYFEAKGRGVIATRPFSRGQYVVEYAGELIGVAEARERERLYALDPEAGCYMYYFRHGDQQYCIDATAESGRLGRLVNHSRNGNLHTKALWVDGPRLVLIAAQDISPGDELTYDYGDRSKESLQHHPWLAF

Summary

Description
Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis (By similarity).
Catalytic Activity
L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
Keywords
Cell cycle   Cell division   Chromatin regulator   Chromosome   Complete proteome   Methyltransferase   Mitosis   Nucleus   Reference proteome   Repressor   S-adenosyl-L-methionine   Transcription   Transcription regulation   Transferase  
Feature
chain  Histone-lysine N-methyltransferase PR-Set7
EC Number
2.1.1.43
Pfam
PF00856   SET
Interpro
IPR016858   Hist_H4-K20_MeTrfase        + More
IPR001214   SET_dom       
PDB
5HQ2     E-value=1.3817e-48,     Score=486

Ontologies

Topology

Subcellular location
Nucleus   Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions (By similarity).   With evidence from 1 publications.
Chromosome   Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions (By similarity).   With evidence from 1 publications.
Length:
303
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0
Exp number, first 60 AAs:
0
Total prob of N-in:
0.02741
outside
1  -  303
 
 

Population Genetic Test Statistics

Pi
173.353584
Theta
170.423143
Tajima's D
0.140835
CLR
0.409033
CSRT
0.408829558522074
Interpretation
Uncertain
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