Gene

KWMTBOMO09597  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014201

Annotation

PREDICTED:_cytosolic_10-formyltetrahydrofolate_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr16(+):5033119-5058605      View in EpiBrowser

Full name

10-formyltetrahydrofolate dehydrogenase       + More
Cytosolic 10-formyltetrahydrofolate dehydrogenase      

Alternative Name

Aldehyde dehydrogenase family 1 member L1

Location in the cell

Cytoplasmic   Reliability : 3.407

CDS

ATGCCGCCAGTATCATTGACTGATCATGCACCAAAAAAAAGCCTAAGAGTTGCCATTATTGGCCAAAGTACATTTGCAGCTGAAGTTTTCAAACTCATCCAAAGAGACGGTCATGAAGTTGTGGGTGTCTTCACAATTCCTGACAAAGGCAACAGGGAGGACCCTTTAGCTACTATTGCCGCACAGAATGGCAAACCAGTTTACAAATACAAGTCTTGGCGTATTAAAGGACAAGTCATCCCTGAAGTACTTGAGCAGTACAAATCGGTGAACGCCGACCTCAATGTTCTACCGTTCTGCACTCAATTCATACCCATGGAGGTGATCACGGCTCCTAAATACGAGAGCATCTGTTACCATCCGAGCATTTTACCCAGACATCGGGGAGCTTCATCAGTTAATTGGACCTTGATCGAGGGTGACACTACATGCGGCTTCTCCATATTTTGGGCGGACGACGGCTTAGACACCGGCCCCATATTACTGCAAAAGAGCTATCCCACAACCATCGATGACACCGTAGACACGATCTACAACAAATTCTTATATCCTGAAGGTATCAAAGCCTTAGCTGAAGCCGTCAACATGGTTGCGAATGGTGTGGCTCCTAAAATCAAGCAGTCTGAAGAAGGCGCCACATACGACCCAGCTCTTTTCAAACCTGAAACTCATCTGATCGATTGGAGCAAAGGAGGGCTGGCTCTGCACAACTTCGTGCGAGGACTGGACTCATCACCGGGAGCCACCTCCTTCATCGAACCTCAGACCAAAGAGGGGATAATCGGAGACGGTGAAAAAATTGAGATAAAATTCTTCGGATCCTCCCTCTGGCAATCTGAATATGAGACCGAAGGAGATAAACTGTATATAACAGGCCTTAATAAACCAGCCGTGGTCCACGAAGCCGGCTTACTTGTTACTGCCAATGATGGAGTTAGGCTCAACATACAGAGGCTAAAAGTTAACGGGAAGATGATCAACGCTCAAAACTTCTTCAAAGCTAGCGAAGAGAAGATCTCTATAGAACTGAATTCGGATGAGTTAAAGTTCGTGGAGAGCTGCCGCGAGGTGTGGAGGGCGATTCTTCGCATTGAAATCGAAAACCACACCGACTTCTTCGCATCCGGAGCCGGCTCTATGGACGTCGTGAGGCTGGTCGAAGAAGTCAAGGACTTGGCGAACGTGGAGCTCCAGAATGAGGATGTATACATGAACACCACGTTTGAAGAGTTCTATAGTGTGGCCGTGTTGAAGGCGAGAGGCGGCTCGGATACAAAAGAGGTTGTTTATGAGGGACTCGAAATGGAGGTCAATAAAATGAAGATTAAATTCCCGACACAGCTGTTTATTAATGGCGAGTTCGTGAACGCTGACAGTGGTAAAACCTTGACCCTGATCAATCCAACGGACGAGAGCGTGATCTGTAAAGTGCAAAGCGCCTCGCCCAACGACGTTGACAAGGCAGTGCGGGCCGCTAAGAAGGCGTTCGATGAAGGGGAATGGTCCAAGATCAGTGCCCGTGAGAGAGCACAAATCTTATTTAAGTTGGCAGATTTGATGGAACAACACAAAGAGGAGCTGGCCACAATCGAATCCATAGACTCGGGAGCTGTCTACACGTTAGCACTCAAAACCCACGTGGGCATGTCCATAGACACGTGGCGCTACTTCGCTGGCTGGTGCGACAAGATCCAAGGCGCCACCGTGCCCATAAACCACGCCAGGCCAAACAGAAATCTGTGCATCACGAGAAAAGAGCCGATCGGCGTTTGCGCGATAATAACGCCCTGGAATTATCCGCTGATGATGCTGTCGTGGAAGATGGCGGCCTGTCTCGCTGCTGGCAATACTGTCGTCATGAAACCCGCTGCGGTGTGCCCCCTGACAGCGTTGAAGTTCGCCGAGCTGTGCGTCCGAGCGGGGGTTCCCCCCGGCGTCGTGAACATCCTCCCCGGGAGCGGCGCGGCGTGCGGGCAGGCGCTCGCCGACCATCCGCTCGTCCGGAAGCTGGGCTTCACAGGCAGCACTCCCATCGGTCAAACCATAATGAAGTCGTGTGCAGCATCGAATATGAAGAAGGTGTCGTTGGAGCTAGGAGGCAAGTCGCCTCTCGTTATATTCGAAGACTGCGATCTGGACAAAGCCGTCAGAAACGGTATGGCAGCTGTGTTCTTCAATAAAGGCGAGAATTGCATAGCAGCAGGTCGGTTGTTCGTTGAAGAGACGATACACGACGAGTTCGTACGTCGCGTTATAGAGGAGACCGAGAAGATCCGTATCGGCGACCCACTGCACCGGGGCACTTCACACGGACCCCAGAACCATAAGGCGCATATGGATAAACTGATAGAGTACTGCGAGCGTGGCGTCAAAGAAGGTGCCAAGCTAGTGTACGGAGGCAAGAGGGTGGATAGAAAAGGCTATTTCTTCCAGCCGACTGTCTTTACCGACGTCACAGACGAGATGTACATCGCCAAGGAGGAATCGTTTGGACCCATCATGATCATCAGCAAGTTCAGCAGCAAGAATTTGGAGGACGTGATCCGTCGCGCGAACAACACGGAGTATGGGCTCGCGAGCGGCGTGTTCACGCGGGACGTGTCGCGGGCGCTGCAGTTCGCCGAGCGCATCGACGCGGGCACGGTGTTCGTCAACACGTACAACAAGACCGACGTGGCGGCGCCCTTCGGAGGCTTCAAGCAGTCCGGCTTCGGAAAGGACTTGGGCCAAGACGCTCTCAACGAATATCTGAAAACGAAATGCGTGACAATAGAATATTAA

Protein

MPPVSLTDHAPKKSLRVAIIGQSTFAAEVFKLIQRDGHEVVGVFTIPDKGNREDPLATIAAQNGKPVYKYKSWRIKGQVIPEVLEQYKSVNADLNVLPFCTQFIPMEVITAPKYESICYHPSILPRHRGASSVNWTLIEGDTTCGFSIFWADDGLDTGPILLQKSYPTTIDDTVDTIYNKFLYPEGIKALAEAVNMVANGVAPKIKQSEEGATYDPALFKPETHLIDWSKGGLALHNFVRGLDSSPGATSFIEPQTKEGIIGDGEKIEIKFFGSSLWQSEYETEGDKLYITGLNKPAVVHEAGLLVTANDGVRLNIQRLKVNGKMINAQNFFKASEEKISIELNSDELKFVESCREVWRAILRIEIENHTDFFASGAGSMDVVRLVEEVKDLANVELQNEDVYMNTTFEEFYSVAVLKARGGSDTKEVVYEGLEMEVNKMKIKFPTQLFINGEFVNADSGKTLTLINPTDESVICKVQSASPNDVDKAVRAAKKAFDEGEWSKISARERAQILFKLADLMEQHKEELATIESIDSGAVYTLALKTHVGMSIDTWRYFAGWCDKIQGATVPINHARPNRNLCITRKEPIGVCAIITPWNYPLMMLSWKMAACLAAGNTVVMKPAAVCPLTALKFAELCVRAGVPPGVVNILPGSGAACGQALADHPLVRKLGFTGSTPIGQTIMKSCAASNMKKVSLELGGKSPLVIFEDCDLDKAVRNGMAAVFFNKGENCIAAGRLFVEETIHDEFVRRVIEETEKIRIGDPLHRGTSHGPQNHKAHMDKLIEYCERGVKEGAKLVYGGKRVDRKGYFFQPTVFTDVTDEMYIAKEESFGPIMIISKFSSKNLEDVIRRANNTEYGLASGVFTRDVSRALQFAERIDAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGQDALNEYLKTKCVTIEY

Catalytic Activity

(6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH

Subunit

Homotetramer.

Similarity

Belongs to the aldehyde dehydrogenase family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
In the N-terminal section; belongs to the GART family.

Keywords

Complete proteome   Cytoplasm   NADP   One-carbon metabolism   Oxidoreductase   Phosphopantetheine   Phosphoprotein   Reference proteome  

Feature

chain  Cytosolic 10-formyltetrahydrofolate dehydrogenase

Uniprot

A0A2H1W8W8   A0A2A4J0X0   A0A212FMM3   A0A194PRS4   A0A437BIX8   A0A1L8D6P4   + More
A0A194RER6   D2A5X9   A0A154PHP2   A0A411G7T9   A0A0M9A4E9   A0A2J7Q7B7   A0A067QH51   F4W7E1   A0A087ZYB7   A0A2L2Y5D2   A0A1Y1LFN3   A0A2L2Y5B9   A0A195DSU2   A0A151X8P0   A0A3R7PD39   A0A151JT46   A0A232FKK8   A0A151IHD6   A0A158NPV3   K7ILV9   A0A195ATU6   E2A3S4   A0A0L7R0K3   A0A026WU32   A0A3L8D917   A0A1Z5KX88   E9IC80   A0A0N8CK90   A0A1L8D6Q1   A0A0P5QMT0   A0A1B0GMU0   A0A0Q9X4L0   B4KEZ9   A0A1B0EY70   A0A3S3PF55   A0A2P2HYA6   T1JDA6   A0A1B6F6T2   A0A2H8TLQ5   A0A0K8WIE2   A0A0C9RMA6   W8BRG1   A0A3B0JV67   X1WIZ3   B4M9T3   A0A0M4EA78   A0A3Q1BVF1   Q63ZT8   A0A3P8TBZ4   E9H8V6   A0A0P5ZGX4   B4GT55   A0A443SUZ4   A0A3Q1HEV9   Q6GNL7   Q29KL6   A0A1S3IEW6   A0A1L8GPP8   A0A3Q2QVF3   A0A3B4Z686   A0A3Q1G9C9   A0A3B4U107   A0A146ZX33   A0A3P9QAE5   I3J595   A0A3P9BES5   B0WX46   A0A0P5QR58   B4Q4E1   A0A3B4XY61   A0A3B4FIR4   B3MMB2   B4N7Q7   A0A1W4VAS3   B4JPX0   B4IFN9   B3NLW9   A0A3Q2WDL4   Q16RZ0   A0A182MKG5   Q9VIC9   A0A3Q3NF04   Q6NNU7   A0A182WHJ5   A0A0P7YKU6   A0A0L0CLW3   A0A3Q2Z4G1   A0A1S3P7F6   A0A164XG39   A0A1W4Y042   A0A182RRH5   A0A182Q3G5   A0A2Z5UMA5   B4P6W5  

EC Number

1.5.1.6

Pubmed

22118469    26354079    18362917    19820115    24845553    21719571    + More
26561354    28004739    28648823    21347285    20075255    20798317    24508170    30249741    28528879    21282665    17994087    24495485    21292972    15632085    27762356    25186727    22936249    17510324    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26108605    17550304   

EMBL

ODYU01007067    SOQ49510.1    NWSH01004073    PCG65509.1    AGBW02007651    OWR54998.1    + More
KQ459595    KPI96012.1    RSAL01000051    RVE50258.1    GEYN01000007    JAV02122.1    KQ460323    KPJ15954.1    KQ971345    EFA05437.1    KQ434912    KZC11396.1    MH366154    QBB01963.1    KQ435760    KOX75639.1    NEVH01017446    PNF24469.1    KK853412    KDR07781.1    GL887844    EGI69814.1    IAAA01004539    LAA03364.1    GEZM01057134    JAV72434.1    IAAA01004538    LAA03361.1    KQ980487    KYN15913.1    KQ982409    KYQ56732.1    QCYY01002845    ROT67137.1    KQ982014    KYN30626.1    NNAY01000091    OXU31070.1    KQ977606    KYN01418.1    ADTU01022757    ADTU01022758    KQ976745    KYM75482.1    GL436457    EFN71966.1    KQ414670    KOC64382.1    KK107105    EZA59493.1    QOIP01000011    RLU16408.1    GFJQ02007217    JAV99752.1    GL762206    EFZ21820.1    GDIP01123527    JAL80187.1    GEYN01000008    JAV02121.1    GDIQ01112119    JAL39607.1    AJVK01003753    AJVK01003754    CH933807    KRG03008.1    EDW11968.2    AJWK01015367    NCKU01000824    RWS14003.1    IACF01001021    LAB66751.1    JH432102    GECZ01024196    JAS45573.1    GFXV01002797    MBW14602.1    GDHF01001500    JAI50814.1    GBYB01008111    GBYB01008114    JAG77878.1    JAG77881.1    GAMC01010719    JAB95836.1    OUUW01000010    SPP85985.1    ABLF02036745    ABLF02036754    ABLF02058045    ABLF02059108    CH940654    EDW57959.1    CP012523    ALC39251.1    CR926185    CR926221    BC082822    GL732606    EFX71787.1    GDIP01043744    JAM59971.1    CH479189    EDW25564.1    NCKV01000190    RWS31346.1    BC073490    CH379061    EAL33158.1    CM004472    OCT85802.1    GCES01015798    JAR70525.1    AERX01016021    AERX01016022    DS232158    EDS36307.1    GDIQ01113524    JAL38202.1    CM000361    CM002910    EDX05738.1    KMY91348.1    CH902620    EDV31872.1    CH964214    EDW80396.1    CH916372    EDV98950.1    CH480833    EDW46461.1    CH954179    EDV54435.2    CH477692    EAT37219.1    AXCM01000826    AE014134    BT150324    AAF53994.3    AGW25606.1    BT011186    AAR88547.1    JARO02004610    KPP68208.1    JRES01000198    KNC33358.1    LRGB01001005    KZS14195.1    AXCN02000752    AP017524    BBB06877.1    CM000158    EDW89934.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000283053    UP000053240    UP000007266    + More
UP000076502    UP000053105    UP000235965    UP000027135    UP000007755    UP000005203    UP000078492    UP000075809    UP000283509    UP000078541    UP000215335    UP000078542    UP000005205    UP000002358    UP000078540    UP000000311    UP000053825    UP000053097    UP000279307    UP000092462    UP000009192    UP000092461    UP000285301    UP000268350    UP000007819    UP000008792    UP000092553    UP000257160    UP000008143    UP000265080    UP000000305    UP000008744    UP000288716    UP000265040    UP000001819    UP000085678    UP000186698    UP000265000    UP000261400    UP000257200    UP000261420    UP000242638    UP000005207    UP000265160    UP000002320    UP000000304    UP000261360    UP000261460    UP000007801    UP000007798    UP000192221    UP000001070    UP000001292    UP000008711    UP000264840    UP000008820    UP000075883    UP000000803    UP000261640    UP000075920    UP000034805    UP000037069    UP000264820    UP000087266    UP000076858    UP000192224    UP000075900    UP000075886    UP000002282   

PRIDE

Q63ZT8    Q6GNL7    Q9VIC9    Q6NNU7   

Pfam

PF00550   PP-binding        + More
PF02911   Formyl_trans_C
PF00551   Formyl_trans_N
PF00171   Aldedh

Interpro

IPR009081   PP-bd_ACP        + More
IPR016161   Ald_DH/histidinol_DH       
IPR037022   Formyl_trans_C_sf       
IPR036736   ACP-like_sf       
IPR016160   Ald_DH_CS_CYS       
IPR016163   Ald_DH_C       
IPR036477   Formyl_transf_N_sf       
IPR002376   Formyl_transf_N       
IPR016162   Ald_DH_N       
IPR029510   Ald_DH_CS_GLU       
IPR005793   Formyl_trans_C       
IPR015590   Aldehyde_DH_dom       
IPR011407   10_FTHF_DH       
IPR011034   Formyl_transferase-like_C_sf       
IPR001555   GART_AS       
IPR006162   Ppantetheine_attach_site       
IPR020806   PKS_PP-bd       

SUPFAM

SSF47336   SSF47336        + More
SSF53720   SSF53720       
SSF50486   SSF50486       
SSF53328   SSF53328       

Gene 3D

1.10.1200.10     3.10.25.10     3.40.309.10     3.40.605.10    

ProteinModelPortal

A0A2H1W8W8   A0A2A4J0X0   A0A212FMM3   A0A194PRS4   A0A437BIX8   A0A1L8D6P4   + More
A0A194RER6   D2A5X9   A0A154PHP2   A0A411G7T9   A0A0M9A4E9   A0A2J7Q7B7   A0A067QH51   F4W7E1   A0A087ZYB7   A0A2L2Y5D2   A0A1Y1LFN3   A0A2L2Y5B9   A0A195DSU2   A0A151X8P0   A0A3R7PD39   A0A151JT46   A0A232FKK8   A0A151IHD6   A0A158NPV3   K7ILV9   A0A195ATU6   E2A3S4   A0A0L7R0K3   A0A026WU32   A0A3L8D917   A0A1Z5KX88   E9IC80   A0A0N8CK90   A0A1L8D6Q1   A0A0P5QMT0   A0A1B0GMU0   A0A0Q9X4L0   B4KEZ9   A0A1B0EY70   A0A3S3PF55   A0A2P2HYA6   T1JDA6   A0A1B6F6T2   A0A2H8TLQ5   A0A0K8WIE2   A0A0C9RMA6   W8BRG1   A0A3B0JV67   X1WIZ3   B4M9T3   A0A0M4EA78   A0A3Q1BVF1   Q63ZT8   A0A3P8TBZ4   E9H8V6   A0A0P5ZGX4   B4GT55   A0A443SUZ4   A0A3Q1HEV9   Q6GNL7   Q29KL6   A0A1S3IEW6   A0A1L8GPP8   A0A3Q2QVF3   A0A3B4Z686   A0A3Q1G9C9   A0A3B4U107   A0A146ZX33   A0A3P9QAE5   I3J595   A0A3P9BES5   B0WX46   A0A0P5QR58   B4Q4E1   A0A3B4XY61   A0A3B4FIR4   B3MMB2   B4N7Q7   A0A1W4VAS3   B4JPX0   B4IFN9   B3NLW9   A0A3Q2WDL4   Q16RZ0   A0A182MKG5   Q9VIC9   A0A3Q3NF04   Q6NNU7   A0A182WHJ5   A0A0P7YKU6   A0A0L0CLW3   A0A3Q2Z4G1   A0A1S3P7F6   A0A164XG39   A0A1W4Y042   A0A182RRH5   A0A182Q3G5   A0A2Z5UMA5   B4P6W5  

PDB

4GO2     E-value=0,     Score=1964

KEGG

101747054    K00289 formyltetrahydrofolate dehydrogenase [EC:1.5.1.6] | (RefSeq) cytosolic 10-formyltetrahydrofol

PATHWAY

00670    One carbon pool by folate - Bombyx mori (domestic silkworm)

GO

GO:0006730   GO:0016155   GO:0009258   GO:0005737   GO:0009058   GO:0016620   GO:0016742   GO:0004029   GO:0031177   GO:0016491   GO:0008168   GO:0048703   GO:0016787   GO:0007507   GO:0007369   GO:0048885   GO:0001755   GO:0008152   GO:0003824   GO:0055114  

Subcellular location

Cytoplasm  

Length:

926

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01671

Exp number, first 60 AAs:

0.00205

Total prob of N-in:

0.00017

outside

1  -  926

 

 

Pi

214.644463

Theta

156.794111

Tajima's D

1.048323

CLR

0.474256

CSRT

0.675066246687666

Interpretation

Uncertain