Gene

KWMTBOMO09572  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013010

Annotation

PREDICTED:_serine/threonine-protein_phosphatase_4_catalytic_subunit_[Papilio_polytes]

Location

Bomo_Chr16(-):4514253-4518831      View in EpiBrowser

Full name

Serine/threonine-protein phosphatase       + More
Serine/threonine-protein phosphatase 4 catalytic subunit      

Location in the cell

Cytoplasmic   Reliability : 3.618

CDS

ATGTCTGATACGAGCGATCTCGATCGTCAGATCGAACAGCTGAAAAGATGTGAGATTATAATGGAAGCAGAAGTAAAAGCCCTATGCGCTAAAGCTCGAGAAATTTTGGTAGAAGAAAGTAACGTTCAAAGAGTGGATTCGCCCGTAACGGTTTGTGGAGACATACATGGACAGTTTTATGATCTAAAGGAACTTTTCAAAGTTGGAGGTGATGTACCCGAAACAAATTATTTATTTATGGGAGACTTTGTGGACAGAGGATTTTATTCTGTTGAAACTTTCTTATTGTTACTTGCACTAAAGGTTAGGTATCCAGATCGCATAACACTCATCAGAGGAAATCATGAATCGAGACAAATCACACAGGTTTATGGTTTCTACGATGAGTGCCTTAGGAAATATGGTTCCATCACTGTGTGGAGATACTGTACAGAAATATTTGACTATTTATCACTGTCAGCCATTATCGATGGAAGGATATTCTGCGTACACGGCGGTCTAAGTCCGTCGATACACACCCTAGATCAGATTCGTACTATTGATCGAAAGCAGGAAGTTCCTCACGACGGACCAATGTGTGACTTGTTGTGGAGTGATCCTGAAGATACACAAGGTTGGGGTGTTTCACCAAGAGGAGCTGGCTATCTCTTTGGCTCAGATGTAGTCGCTCAATTCAACGTGTCAAATGATATTGATATGATCTGTCGAGCTCATCAGCTTGTCATGGAGGGCTACAAATGGCATTTCAACGAGACCGTGTTGACTGTATGGTCTGCACCTAATTATTGTTACAGATGCGGAAACGTAGCTGCTATATTAGAGTTAAACGAAAATCTTCAACGTGAATTCACAATATTCGAGGCAGCACCGCAGGAATCTCGAGGAGTACCATCAAAGAAACCCCTAGCCGAATACTTCTTATAA

Protein

MSDTSDLDRQIEQLKRCEIIMEAEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGRIFCVHGGLSPSIHTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTQGWGVSPRGAGYLFGSDVVAQFNVSNDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELNENLQREFTIFEAAPQESRGVPSKKPLAEYFL

Description

Protein phosphatase that regulates many processes such as microtubule organization at centrosomes.

Catalytic Activity

H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate

Cofactor

Mn(2+)

Subunit

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

Similarity

Belongs to the PPP phosphatase family.
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Keywords

Complete proteome   Cytoplasm   Cytoskeleton   Hydrolase   Manganese   Metal-binding   Methylation   Nucleus   Protein phosphatase   Reference proteome  

Feature

chain  Serine/threonine-protein phosphatase 4 catalytic subunit

Uniprot

A0A194QI71   H9JTZ8   A0A3S2TMQ0   S4NTS7   W0FXD7   A0A2H1VFZ6   + More
A0A212FMR1   A0A1W4X3S5   A0A1Y1LF77   A0A0T6B5N1   A0A2A3E6V7   A0A2P8ZKU5   A0A0M8ZQ07   E2BG17   A0A026WTC5   A0A067R9J3   A0A0L7R7J4   A0A195CAX7   A0A1B6LT81   A0A1B6FPR2   A0A1B6DB90   A0A1B6IDC0   A0A0P4VSS2   R4FQ69   J3JUU2   A0A0V0GB03   A0A0A9YME3   D2A3N9   E0VUA3   A0A3L8DGV6   A0A023F9I3   A0A2J7PRC5   A0A154PJH8   A0A2P6L3P2   A0A087T7N9   A0A151MLQ0   A0A232FDP6   K7IW68   A0A1B0CHA3   A0A1L8DM77   A0A1S3DDC7   A0A2D4N923   H9GLS6   A0A0B8RQ64   A0A2D4PU58   A0A1W7RDE0   T1DL23   J3S0W2   U3FW05   A0A1Q3EYE1   A0A293N2E6   A0A1Z5LGG9   A0A182VXX1   N6TSX8   C3YD79   B0W3I5   Q17DV3   A0A023EQE1   A0A0N7ZB77   A0A1B8XWE3   A0A2F0BKD2   U5EML5   A0A0P6IJL7   A0A336KW22   Q6P861   Q6IP91   A0A1S3ES28   A0A1A6FWL7   A0A0P6J9H0   I3NEE9   A0A1U7QEI8   A0A250YF14   A0A286X9T2   G3V8M5   G3I4H5   Q3UNF2   L5KGY6   K9IJ28   G3QZX1   E2QU52   G1QNR3   A0A341BBL0   A0A2K5ZTN4   A0A0D9R1H7   A0A452FMX8   G3TJQ8   F6X854   A0A2Y9E4A4   A0A2R9AX24   G3WAW3   A0A2K5DQ44   A0A096NHQ5   A0A2Y9ER69   F7E0S5   A0A2K6PQI7   A0A2Y9I334   M3WK76   A0A2K5NZ13   A0A2Y9LK47   A0A3Q7U0G8  

EC Number

3.1.3.16

Pubmed

26354079    19121390    23622113    22118469    28004739    29403074    + More
20798317    24508170    24845553    27129103    22516182    25401762    26823975    18362917    19820115    20566863    30249741    25474469    22293439    28648823    20075255    21881562    25476704    26358130    23758969    23025625    23915248    28528879    23537049    18563158    17510324    24945155    26483478    20431018    28087693    21993624    15057822    15632090    21804562    23929341    29704459    10349636    11042159    11076861    11217851    12466851    12040188    16141073    21183079    23258410    22398555    16341006    19892987    22722832    21709235    17495919    25362486    17975172   

EMBL

KQ458756    KPJ05258.1    BABH01003834    RSAL01000051    RVE50272.1    GAIX01012111    + More
JAA80449.1    KF255600    AHF45927.1    ODYU01002091    SOQ39164.1    AGBW02007651    OWR55013.1    GEZM01057486    JAV72309.1    LJIG01009656    KRT82643.1    KZ288349    PBC27445.1    PYGN01000027    PSN57122.1    KQ435916    KOX68760.1    GL448096    EFN85419.1    KK107109    EZA59315.1    KK852802    KDR16288.1    KQ414642    KOC66741.1    KQ978023    KYM97962.1    GEBQ01013096    JAT26881.1    GECZ01017630    JAS52139.1    GEDC01014344    JAS22954.1    GECU01035605    GECU01022768    JAS72101.1    JAS84938.1    GDKW01000954    JAI55641.1    ACPB03013340    GAHY01000569    JAA76941.1    BT127007    AEE61969.1    GECL01000968    JAP05156.1    GBHO01012930    GBHO01012929    GBHO01012928    GBHO01012926    GBRD01015031    GDHC01018633    GDHC01010298    JAG30674.1    JAG30675.1    JAG30676.1    JAG30678.1    JAG50795.1    JAP99995.1    JAQ08331.1    KQ971348    EFA05539.2    DS235784    EEB16959.1    QOIP01000008    RLU19546.1    GBBI01000551    JAC18161.1    NEVH01022362    PNF18869.1    KQ434924    KZC11634.1    MWRG01002005    PRD33201.1    KK113836    KFM61128.1    AKHW03005789    KYO25456.1    NNAY01000414    OXU28579.1    AJWK01012153    GFDF01006526    JAV07558.1    IACM01161255    LAB41493.1    AAWZ02023118    AAWZ02023119    GBSH01002511    JAG66515.1    IACN01095786    LAB61490.1    GDAY02002276    JAV49156.1    GAAZ01002322    JAA95621.1    JU175900    GBEX01003153    AFJ51424.1    JAI11407.1    GAEP01001500    GBEW01000957    JAB53321.1    JAI09408.1    GFDL01014735    JAV20310.1    GFWV01022567    MAA47294.1    GFJQ02000505    JAW06465.1    APGK01055712    APGK01055713    KB741269    KB632330    ENN71451.1    ERL92576.1    GG666503    EEN61690.1    EEN61710.1    DS231832    EDS31771.1    CH477290    EAT44648.1    JXUM01024567    JXUM01024568    JXUM01024569    JXUM01024570    JXUM01024571    JXUM01024572    JXUM01027345    JXUM01027346    GAPW01002814    KQ560787    KQ560694    JAC10784.1    KXJ80885.1    KXJ81245.1    GDRN01088299    JAI60880.1    KV461036    OCA14984.1    NTJE010258005    MBW03461.1    GANO01000974    JAB58897.1    GDIQ01003379    JAN91358.1    UFQS01001066    UFQT01001066    SSX08822.1    SSX28734.1    BC061369    BC072026    LZPO01117055    OBS57587.1    GEBF01004401    JAN99231.1    AGTP01031133    GFFW01002555    JAV42233.1    AAKN02007766    AABR07005779    CH473956    EDM17392.1    JH001251    KE671503    RAZU01000108    EGW09866.1    ERE80201.1    RLQ72104.1    AK144244    CH466531    BAE25795.1    EDL17438.1    KB030715    ELK10929.1    GABZ01007138    JAA46387.1    CABD030100171    CABD030100172    AAEX03004404    ADFV01133303    ADFV01133304    AQIB01118678    AQIB01118679    AQIB01118680    LWLT01000031    AJFE02028760    AJFE02028761    AEFK01080624    AHZZ02018583    AANG04004202   

Proteomes

UP000053268    UP000005204    UP000283053    UP000007151    UP000192223    UP000242457    + More
UP000245037    UP000053105    UP000008237    UP000053097    UP000027135    UP000053825    UP000078542    UP000015103    UP000007266    UP000009046    UP000279307    UP000235965    UP000076502    UP000054359    UP000050525    UP000215335    UP000002358    UP000092461    UP000079169    UP000001646    UP000075920    UP000019118    UP000030742    UP000001554    UP000002320    UP000008820    UP000069940    UP000249989    UP000008143    UP000081671    UP000092124    UP000005215    UP000189706    UP000005447    UP000002494    UP000001075    UP000030759    UP000273346    UP000010552    UP000001519    UP000002254    UP000001073    UP000252040    UP000233140    UP000029965    UP000291000    UP000007646    UP000002281    UP000248480    UP000240080    UP000007648    UP000233020    UP000028761    UP000248484    UP000002280    UP000233200    UP000248481    UP000011712    UP000233060    UP000248482    UP000286640   

PRIDE

H9JTZ8    Q6P861    Q6IP91    G3I4H5   

Pfam

PF00149   Metallophos

Interpro

IPR004843   Calcineurin-like_PHP_ApaH        + More
IPR006186   Ser/Thr-sp_prot-phosphatase       
IPR029052   Metallo-depent_PP-like       

Gene 3D

3.60.21.10    

ProteinModelPortal

A0A194QI71   H9JTZ8   A0A3S2TMQ0   S4NTS7   W0FXD7   A0A2H1VFZ6   + More
A0A212FMR1   A0A1W4X3S5   A0A1Y1LF77   A0A0T6B5N1   A0A2A3E6V7   A0A2P8ZKU5   A0A0M8ZQ07   E2BG17   A0A026WTC5   A0A067R9J3   A0A0L7R7J4   A0A195CAX7   A0A1B6LT81   A0A1B6FPR2   A0A1B6DB90   A0A1B6IDC0   A0A0P4VSS2   R4FQ69   J3JUU2   A0A0V0GB03   A0A0A9YME3   D2A3N9   E0VUA3   A0A3L8DGV6   A0A023F9I3   A0A2J7PRC5   A0A154PJH8   A0A2P6L3P2   A0A087T7N9   A0A151MLQ0   A0A232FDP6   K7IW68   A0A1B0CHA3   A0A1L8DM77   A0A1S3DDC7   A0A2D4N923   H9GLS6   A0A0B8RQ64   A0A2D4PU58   A0A1W7RDE0   T1DL23   J3S0W2   U3FW05   A0A1Q3EYE1   A0A293N2E6   A0A1Z5LGG9   A0A182VXX1   N6TSX8   C3YD79   B0W3I5   Q17DV3   A0A023EQE1   A0A0N7ZB77   A0A1B8XWE3   A0A2F0BKD2   U5EML5   A0A0P6IJL7   A0A336KW22   Q6P861   Q6IP91   A0A1S3ES28   A0A1A6FWL7   A0A0P6J9H0   I3NEE9   A0A1U7QEI8   A0A250YF14   A0A286X9T2   G3V8M5   G3I4H5   Q3UNF2   L5KGY6   K9IJ28   G3QZX1   E2QU52   G1QNR3   A0A341BBL0   A0A2K5ZTN4   A0A0D9R1H7   A0A452FMX8   G3TJQ8   F6X854   A0A2Y9E4A4   A0A2R9AX24   G3WAW3   A0A2K5DQ44   A0A096NHQ5   A0A2Y9ER69   F7E0S5   A0A2K6PQI7   A0A2Y9I334   M3WK76   A0A2K5NZ13   A0A2Y9LK47   A0A3Q7U0G8  

PDB

3P71     E-value=2.78003e-124,     Score=1138

KEGG

101742306    K15423 serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] | (RefSeq) serine/thre

GO

GO:0004721   GO:0016787   GO:0005886   GO:0010569   GO:0004722   GO:0005634   GO:0005829   GO:0030289   GO:0046872   GO:0005737   GO:0005815   GO:0000166   GO:0007608   GO:0016020   GO:0016740   GO:0006108   GO:0030060   GO:0016615   GO:0000049   GO:0016876  

Subcellular location

Cytoplasm  
Nucleus  
Cytoskeleton  
Microtubule organizing center  
Centrosome  

Length:

307

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.20607

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04674

outside

1  -  307

 

 

Pi

24.260358

Theta

201.289432

Tajima's D

0.770017

CLR

0.492759

CSRT

0.594620268986551

Interpretation

Uncertain