Gene

KWMTBOMO09571

Pre Gene Modal

BGIBMGA012834

Annotation

PREDICTED:_NAD-dependent_protein_deacylase_Sirt4_[Amyelois_transitella]

Location

Bomo_Chr16(+):4503482-4505894      View in EpiBrowser

Full name

NAD-dependent protein deacylase       + More
NAD-dependent protein deacylase Sirt4      

Alternative Name

Regulatory protein SIR2 homolog
Regulatory protein SIR2 homolog 4

Location in the cell

Nuclear   Reliability : 2.792

CDS

ATGTTAAAAAGATTTATACCGTTTAATAATAACGCTATTAGCAGACACATAGTGTGTGTTCCGAAACATAAACCACCCGAAAAAAAAGATTTTGACGTTTTGAAAGAGTTCTTAACAAACCATAACAAAATTTTAATTTTGACTGGTGCTGGCATTTCTACTGAATCAGGTATTCCTGACTACAGATCGGAGGATGTTGGTCTGTATGCCCGTAGTAATCACAAACCTATACAGTATCAAGAATTTGTGAAGTATCCGAAAGTAAGGCAAAGGTACTGGGCAAGAAATTATATAGGTTGGCCGAGATTCAGTTGTGTGCAACCGAACGTCACACATCTCTGTATTCGAGAACTAGAGAAGAAGGGAAAAGTGACATCTATAGTGACACAGAATGTGGATAGATTACACCACAAAGCTGGTTCTGAAAAAGTGATTGAATTACATGGGACAAGCTACTTAGTTCAATGTCTCAAATGCCCCTATGAAATAGACAGACATGAACTCCAAGAAATATTAACAGAGAATAATCCAGATATGGAAAGTAGTTTCTCCATGATAAGACCGGATGGCGATGTTGAATTGTCGAGGGAACAAGTAGAAAAATTCCGAGCTCCACTCTGCCCAAAGTGTGAAGGGCCTTTGAAACCAGATATAGTGTTTTTTGGTGACAATGTACCCAAATATCGCGTGGAACAAGTCAGAAAAGAAGTGACTAGCAGTGATGCTGTATTTGTAATGGGATCAAGCCTCACAGTTTATTCTAGCTATAGAATTATATTGCAAGCCAGAGATGAACACAAAAACATAGCTATATTAAATATTGGACCTACTAGAGCAGATGATATTGTTAATATAAAAGTATCTACAAAATGTGGTGATGTTTTACCTGAATTATGTAAATCTTTAAATTAA

Protein

MLKRFIPFNNNAISRHIVCVPKHKPPEKKDFDVLKEFLTNHNKILILTGAGISTESGIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPNVTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGPTRADDIVNIKVSTKCGDVLPELCKSLN

Description

NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

Catalytic Activity

H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide

Cofactor

Zn(2+)

Similarity

Belongs to the sirtuin family. Class II subfamily.

Keywords

Alternative splicing   Complete proteome   Hydrolase   Metal-binding   Mitochondrion   NAD   Reference proteome   Transit peptide   Zinc  

Feature

chain  NAD-dependent protein deacylase Sirt4
splice variant  In isoform a.

Uniprot

H9JTH2   A0A2H1VEA1   A0A2A4J2K7   A0A194RDQ5   A0A194QIB3   A0A0L7L9D9   + More
A0A3S2M3T3   A0A212FMM6   A0A139WG94   A0A2J7PRA2   A0A1S4ELI4   E2ADS2   E9J587   A0A1Y1M4Y1   A0A0T6B3I2   A0A0K8UKC0   A0A1Y1M0E0   A0A067R0A4   A0A2S2NA90   A0A182JVE2   A0A182XXF5   A0A034WQI7   A0A182P7A2   A0A182H5D4   A0A195EUE3   A0A1B6H4G9   E2BN27   A0A182H3G2   A0A1I8MSC8   A0A182I8V4   A0A182WV79   A0A182J7Z3   F5HJ98   B0W3I7   A0A182R5U9   A0A158NR58   A0A3F2Z106   A0A182QZ02   A0A182SLH5   A0A182UTK3   A0A2A3EB70   A0A182N4G3   A0A1B6KFT4   A0A182MJ25   A0A1B6K1X5   A0A182F7P2   A0A1Q3F775   Q17DV2   W5JBK9   A0A1S4F6N7   A0A310SR36   A0A195E5T4   A0A2M4ATK5   A0A195B0X7   J9K8C7   F4WPE5   A0A336LMW1   A0A151I6S8   A0A1I8PPI2   A0A423TP43   A0A088A4P0   A0A151WMA8   B3MRX4   T1JHL2   A0A1A9XC19   A0A1W4VF60   B3NV66   B4L644   A0A1A9VB17   B4R505   A0A0C9PWP9   B4PZD0   W8ANG2   Q8IRR5   B4I0M1   B4M804   A0A1W4XD59   C4WX51   A0A0M3QZM2   A0A0M8ZU10   A0A026WFF3   A0A0P5PRC6   A0A1B6BZS2   B4MSG3   A0A0P5ATX6   E9G957   A0A0P5II33   T1PB20   K7IS10   A0A1W4X3M4   N6TQF1   A0A0K8TT56   B4JKI2   A0A232EES1   K1R299   A0A0P5MKR8   A0A1Y1M5X7   Q29I14   B4H4G5   A0A2C9JZL2  

EC Number

3.5.1.-

Pubmed

19121390    26354079    26227816    22118469    18362917    19820115    + More
20798317    21282665    28004739    24845553    25244985    25348373    26483478    25315136    12364791    14747013    17210077    21347285    17510324    20920257    23761445    21719571    17994087    17550304    24495485    10731132    12537572    24508170    21292972    20075255    23537049    26369729    28648823    22992520    15632085    15562597   

EMBL

BABH01003834    ODYU01002091    SOQ39163.1    NWSH01003390    PCG66387.1    KQ460323    + More
KPJ15973.1    KQ458756    KPJ05257.1    JTDY01002148    KOB72000.1    RSAL01000051    RVE50273.1    AGBW02007651    OWR55014.1    KQ971348    KYB26875.1    NEVH01022362    PNF18868.1    GL438820    EFN68434.1    GL768124    EFZ12017.1    GEZM01043124    GEZM01043121    GEZM01043114    GEZM01043113    JAV79325.1    LJIG01016066    KRT81717.1    GDHF01025180    JAI27134.1    GEZM01043119    JAV79312.1    KK852802    KDR16289.1    GGMR01001253    MBY13872.1    GAKP01002365    JAC56587.1    JXUM01027346    KQ560787    KXJ80886.1    KQ981965    KYN31868.1    GECZ01000219    JAS69550.1    GL449382    EFN82931.1    JXUM01024572    KQ560694    KXJ81246.1    APCN01003125    AAAB01008844    EGK96359.1    DS231832    EDS31773.1    ADTU01023713    AXCN02000040    KZ288295    PBC28968.1    GEBQ01029684    JAT10293.1    AXCM01002816    GECU01002265    JAT05442.1    GFDL01011625    JAV23420.1    CH477290    EAT44649.1    ADMH02001961    ETN60235.1    KQ760801    OAD58981.1    KQ979608    KYN20446.1    GGFK01010805    MBW44126.1    KQ976691    KYM77945.1    ABLF02021374    GL888243    EGI64040.1    UFQS01000065    UFQT01000065    SSW98920.1    SSX19306.1    KQ978459    KYM93810.1    QCYY01001410    ROT78235.1    KQ982944    KYQ48986.1    CH902622    EDV34529.1    JH431506    CH954180    EDV45914.1    CH933812    EDW05840.1    CM000366    EDX17154.1    GBYB01005933    JAG75700.1    CM000162    EDX01097.1    GAMC01016215    JAB90340.1    AE014298    BT011040    BT099555    BT100157    CH480819    EDW53052.1    CH940653    EDW62280.1    AK342451    BAH72471.1    CP012528    ALC49663.1    KQ435885    KOX69603.1    KK107273    EZA53754.1    GDIQ01130949    GDIQ01089516    JAL20777.1    GEDC01030535    JAS06763.1    CH963851    EDW75052.1    GDIP01194148    JAJ29254.1    GL732535    EFX84150.1    GDIQ01214469    JAK37256.1    KA645951    AFP60580.1    APGK01055725    APGK01055726    APGK01055727    KB741269    ENN71465.1    GDAI01000272    JAI17331.1    CH916370    EDW00085.1    NNAY01005248    OXU16828.1    JH817068    EKC35255.1    GDIQ01155137    JAK96588.1    GEZM01043122    GEZM01043118    JAV79306.1    CH379064    EAL31592.1    CH479209    EDW32716.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000037510    UP000283053    + More
UP000007151    UP000007266    UP000235965    UP000079169    UP000000311    UP000027135    UP000075881    UP000076408    UP000075885    UP000069940    UP000249989    UP000078541    UP000008237    UP000095301    UP000075840    UP000076407    UP000075880    UP000007062    UP000002320    UP000075900    UP000005205    UP000075920    UP000075886    UP000075901    UP000075903    UP000242457    UP000075884    UP000075883    UP000069272    UP000008820    UP000000673    UP000078492    UP000078540    UP000007819    UP000007755    UP000078542    UP000095300    UP000283509    UP000005203    UP000075809    UP000007801    UP000092443    UP000192221    UP000008711    UP000009192    UP000078200    UP000000304    UP000002282    UP000000803    UP000001292    UP000008792    UP000192223    UP000092553    UP000053105    UP000053097    UP000007798    UP000000305    UP000002358    UP000019118    UP000001070    UP000215335    UP000005408    UP000001819    UP000008744    UP000076420   

PRIDE

H9JTH2    Q8IRR5   

Pfam

PF02146   SIR2        + More
PF05485   THAP
PF03184   DDE_1
PF05225   HTH_psq

Interpro

IPR029035   DHS-like_NAD/FAD-binding_dom        + More
IPR026591   Sirtuin_cat_small_dom_sf       
IPR003000   Sirtuin       
IPR026590   Ssirtuin_cat_dom       
IPR026587   Sirtuin_class_II       
IPR006612   THAP_Znf       
IPR038441   THAP_Znf_sf       
IPR009057   Homeobox-like_sf       
IPR007889   HTH_Psq       
IPR006600   HTH_CenpB_DNA-bd_dom       
IPR004875   DDE_SF_endonuclease_dom       

SUPFAM

SSF52467   SSF52467        + More
SSF46689   SSF46689       

Gene 3D

3.30.1600.10     3.30.40.180    

ProteinModelPortal

H9JTH2   A0A2H1VEA1   A0A2A4J2K7   A0A194RDQ5   A0A194QIB3   A0A0L7L9D9   + More
A0A3S2M3T3   A0A212FMM6   A0A139WG94   A0A2J7PRA2   A0A1S4ELI4   E2ADS2   E9J587   A0A1Y1M4Y1   A0A0T6B3I2   A0A0K8UKC0   A0A1Y1M0E0   A0A067R0A4   A0A2S2NA90   A0A182JVE2   A0A182XXF5   A0A034WQI7   A0A182P7A2   A0A182H5D4   A0A195EUE3   A0A1B6H4G9   E2BN27   A0A182H3G2   A0A1I8MSC8   A0A182I8V4   A0A182WV79   A0A182J7Z3   F5HJ98   B0W3I7   A0A182R5U9   A0A158NR58   A0A3F2Z106   A0A182QZ02   A0A182SLH5   A0A182UTK3   A0A2A3EB70   A0A182N4G3   A0A1B6KFT4   A0A182MJ25   A0A1B6K1X5   A0A182F7P2   A0A1Q3F775   Q17DV2   W5JBK9   A0A1S4F6N7   A0A310SR36   A0A195E5T4   A0A2M4ATK5   A0A195B0X7   J9K8C7   F4WPE5   A0A336LMW1   A0A151I6S8   A0A1I8PPI2   A0A423TP43   A0A088A4P0   A0A151WMA8   B3MRX4   T1JHL2   A0A1A9XC19   A0A1W4VF60   B3NV66   B4L644   A0A1A9VB17   B4R505   A0A0C9PWP9   B4PZD0   W8ANG2   Q8IRR5   B4I0M1   B4M804   A0A1W4XD59   C4WX51   A0A0M3QZM2   A0A0M8ZU10   A0A026WFF3   A0A0P5PRC6   A0A1B6BZS2   B4MSG3   A0A0P5ATX6   E9G957   A0A0P5II33   T1PB20   K7IS10   A0A1W4X3M4   N6TQF1   A0A0K8TT56   B4JKI2   A0A232EES1   K1R299   A0A0P5MKR8   A0A1Y1M5X7   Q29I14   B4H4G5   A0A2C9JZL2  

PDB

5OJN     E-value=3.26209e-78,     Score=741

KEGG

101742457    K11414 NAD-dependent deacetylase sirtuin 4 [EC:3.5.1.-] | (RefSeq) NAD-dependent protein deacetylase

GO

GO:0034979   GO:0005759   GO:0070403   GO:0006471   GO:0008270   GO:0016740   GO:0003677   GO:0004407   GO:0016575   GO:0005739   GO:0003950  

Subcellular location

Mitochondrion matrix  

Length:

303

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.20358

Exp number, first 60 AAs:

0.00098

Total prob of N-in:

0.01471

outside

1  -  303

 

 

Pi

20.231867

Theta

17.77057

Tajima's D

0.218922

CLR

1.516999

CSRT

0.44302784860757

Interpretation

Uncertain