Gene

KWMTBOMO09561  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012831

Annotation

aldo-keto_reductase_AKR2E4_[Bombyx_mori]

Location

Bomo_Chr16(+):4210436-4221669      View in EpiBrowser

Full name

Aldo-keto reductase AKR2E4      

Alternative Name

3-dehydroecdysone reductase
Aldo-keto reductase 2E

Location in the cell

Cytoplasmic   Reliability : 1.798

CDS

ATGGCGGTGCAAGCGCCTTGCATACAACTGAACGATGGTAATACTATACCCATAGTAGCTTTGGGAACTGGACGAGGAACAGCTAAGGAGTCTGACTCAATAGACGAGGTCCGCCAAGCAGTATATTGGGCAATCGAAGCTGGATACAGACATATCGACACGGCTGCCGTATACCAGGACGAGGAGCAAGTCGGTCAGGGTATAGCTGAAGCCATTGCCAATGGACTGGTCACTAGAGAAGAGCTGTTTGTTACTACTAAATTGTGGAACGACAAACACGCTCGCGACCAGGTTGTACCTGCTCTCCAAGAGTCACTCAAGAAACTTGGATTGGACTACATTGATCTATATCTCATTCATTTCCCCATAGCTACAAAGCCTGACGATTCTCCTGATAACATCGACTATCTGGAAACCTGGCAAGGCATGCAGGACGCGCGGCAGCTGGGTCTGGCCAGGTCCATTGGAGTATCCAACTTCAACGCTACGCAGATCACGAGATTGGTCAGCAACAGTTACATCAGGCCTGTTATTAACCAGATTGAGGTGAATCCTACAAACACACAAGAGCCGCTAGTGGCACACTGCCAGAGTCTCGGTATCGCCGTGATGGCGTACAGTCCGTTCGGCACTCGCTAA

Protein

MAVQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEEQVGQGIAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHFPIATKPDDSPDNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVSNSYIRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGTR

Description

NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. May play a role in the regulation of molting. Has lower activity with phenylglyoxal and isatin (in vitro). Has no activity with NADH as cosubstrate. Has no activity with nitrobenzaldehyde and 3-hydroxybenzaldehyde.

Biophysicochemical Properties

0.0044 mM for 3-dehydroecdysone

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

3D-structure   Complete proteome   Lipid metabolism   NADP   Oxidoreductase   Reference proteome   Steroid metabolism  

Feature

chain  Aldo-keto reductase AKR2E4

Uniprot

H9JTG9   A0A291P0T7   A0A2A4JMB2   A0A2W1BC51   A0A212FML6   A0A2H1VAA3   + More
A0A2H1WAV6   B2DBM2   A0A291P0X3   A0A3S2LZY0   A0A194R6Z8   A0A194Q090   G9F9G0   A0A0L7LKQ3   A0A2H1VGR3   A0A2H1VAB6   A0A2A4JM15   I4DP16   A0A291P0W3   A0A291P0U1   A0A437BCA7   A0A2W1BGS7   Q8WRT0   U5KC22   A0A1L8D6L9   U5KBY4   A0A3S2TM02   A0A291P0Y9   A0A291P0U2   A0A0F6Q2W6   A0A2A4IYA3   D2SNM4   A0A2H1V815   G9F9F4   A0A3S2LEX1   A0A2W1BLQ6   A0A194PSF7   S4PY90   A0A291P0Y7   A0A291P0V1   S4P5J6   G9D4S7   A0A194PKB3   A0A194QT42   A0A291P0Z6   G9D4S4   H9IVT6   A0A194QCQ5   G9D4S6   G9D4T5   A0A1L8D6N6   A0A2A4JDC7   A0A3S2NPB4   G9D4T3   A0A3S2TJM5   G9D4T6   G9D4T2   A0A194RJ39   A0A1I1AK31   G9D4S9   G9D4T1   D9HQ59   D2A296   G9F9F8   G9D4T4   A0A2H1WKT0   G9D4S5   A0A3E0E726   A0A212F4I6   A0A212F244   L7M8R1   A0A3S2M2X1   G9D4T0   A0A2A4IZB1   A0A1L8D6N3   A0A232EMX7   A0A131YR32   A0A1I7DMB9   A0A224YH56   A0A2W7RB29   A0A0N1IF51   A0A2A4K2R0   A0A2A4IW06   A0A212FE89   A0A437BH13   A0A088AGI5   A0A131XMC9   A0A194PUL9   A0A1B2G267   I4DKQ3   A0A2A4JAY8   G3MFC0   D6WCX8   V9IFI2   U5KCB8   A0A212FE35   A0A327PS09   A0A212EU63  

EC Number

1.1.1.-

Pubmed

24012638    19121390    28986331    28756777    22118469    18712529    + More
26354079    26227816    22651552    12110290    24053512    20074338    23622113    21967427    20375075    18362917    19820115    25576852    28648823    26830274    28797301    28049606    22216098   

EMBL

AB701383    MF687576    ATJ44502.1    NWSH01001060    PCG72858.1    KZ150230    + More
PZC72001.1    AGBW02007651    OWR54929.1    ODYU01001496    SOQ37780.1    ODYU01007438    SOQ50215.1    AB264706    BAG30781.1    MF687617    ATJ44543.1    RSAL01000093    RVE47941.1    KQ460878    KPJ11641.1    KQ459582    KPI98997.1    JN033705    AEW46858.1    JTDY01000749    KOB76022.1    ODYU01002492    SOQ40039.1    SOQ37779.1    PCG72859.1    AK403246    BAM19656.1    MF687607    ATJ44533.1    MF687570    ATJ44496.1    RVE47938.1    PZC72000.1    AF409102    AAL73387.1    KC007348    AGQ45613.1    GEYN01000020    JAV02109.1    KC007350    AGQ45615.1    RSAL01000058    RVE49735.1    MF687608    ATJ44534.1    MF687572    ATJ44498.1    KP237872    AKD01725.1    NWSH01005088    PCG64446.1    EZ407153    ACX53715.1    ODYU01001161    SOQ36985.1    JN033699    JN033700    RSAL01000051    AEW46852.1    AEW46853.1    RVE50216.1    RSAL01000168    RVE45243.1    KZ150094    PZC73640.1    KQ459593    KPI96371.1    GAIX01003703    JAA88857.1    MF687609    ATJ44535.1    MF687580    ATJ44506.1    GAIX01005504    JAA87056.1    JF777330    AEU11675.1    KQ459602    KPI93169.1    KQ461155    KPJ08170.1    MF687618    ATJ44544.1    JF777327    AEU11672.1    BABH01038068    BABH01038069    BABH01038070    KQ459232    KPJ02765.1    JF777329    AEU11674.1    JF777338    AEU11683.1    GEYN01000021    JAV02108.1    NWSH01001964    PCG69554.1    RSAL01000916    RVE41050.1    JF777336    AEU11681.1    RVE47940.1    JF777339    AEU11684.1    JF777335    AEU11680.1    KQ460152    KPJ17355.1    FOKK01000008    SFB36800.1    JF777332    AEU11677.1    JF777334    AEU11679.1    HM023814    ADJ58547.1    KQ971338    EFA02158.1    JN033703    AEW46856.1    JF777337    AEU11682.1    ODYU01009309    SOQ53638.1    JF777328    AEU11673.1    QUNF01000002    REG92796.1    AGBW02010353    OWR48651.1    AGBW02010783    OWR47810.1    GACK01005535    JAA59499.1    RVE49736.1    JF777333    AEU11678.1    NWSH01004698    PCG64758.1    GEYN01000016    JAV02113.1    NNAY01003257    OXU19723.1    GEDV01008001    JAP80556.1    FPBF01000007    SFU12766.1    GFPF01005872    MAA17018.1    QKZU01000009    PZX55450.1    KQ460773    KPJ12435.1    NWSH01000243    PCG78063.1    NWSH01006101    PCG63656.1    AGBW02008974    OWR52018.1    RVE49724.1    GEFH01001890    JAP66691.1    KPI96444.1    KU233524    ANZ02995.1    AK401871    BAM18493.1    NWSH01002278    PCG68704.1    JO840571    AEO32188.1    KQ971311    EEZ99072.1    JR040675    AEY59236.1    KC007356    AGQ45621.1    OWR52019.1    QLLK01000002    RAI94101.1    AGBW02012481    OWR44997.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053240    UP000053268    + More
UP000037510    UP000198790    UP000007266    UP000256405    UP000215335    UP000199673    UP000249115    UP000005203    UP000249610   

PRIDE

H9JTG9    H9IVT6    G3MFC0   

Pfam

PF00248   Aldo_ket_red

Interpro

IPR018170   Aldo/ket_reductase_CS        + More
IPR020471   Aldo/keto_reductase       
IPR036812   NADP_OxRdtase_dom_sf       
IPR023210   NADP_OxRdtase_dom       
IPR036691   Endo/exonu/phosph_ase_sf       

SUPFAM

SSF51430   SSF51430       

Gene 3D

3.20.20.100     3.60.10.10    

CDD

cd06660  Aldo_ket_red

ProteinModelPortal

H9JTG9   A0A291P0T7   A0A2A4JMB2   A0A2W1BC51   A0A212FML6   A0A2H1VAA3   + More
A0A2H1WAV6   B2DBM2   A0A291P0X3   A0A3S2LZY0   A0A194R6Z8   A0A194Q090   G9F9G0   A0A0L7LKQ3   A0A2H1VGR3   A0A2H1VAB6   A0A2A4JM15   I4DP16   A0A291P0W3   A0A291P0U1   A0A437BCA7   A0A2W1BGS7   Q8WRT0   U5KC22   A0A1L8D6L9   U5KBY4   A0A3S2TM02   A0A291P0Y9   A0A291P0U2   A0A0F6Q2W6   A0A2A4IYA3   D2SNM4   A0A2H1V815   G9F9F4   A0A3S2LEX1   A0A2W1BLQ6   A0A194PSF7   S4PY90   A0A291P0Y7   A0A291P0V1   S4P5J6   G9D4S7   A0A194PKB3   A0A194QT42   A0A291P0Z6   G9D4S4   H9IVT6   A0A194QCQ5   G9D4S6   G9D4T5   A0A1L8D6N6   A0A2A4JDC7   A0A3S2NPB4   G9D4T3   A0A3S2TJM5   G9D4T6   G9D4T2   A0A194RJ39   A0A1I1AK31   G9D4S9   G9D4T1   D9HQ59   D2A296   G9F9F8   G9D4T4   A0A2H1WKT0   G9D4S5   A0A3E0E726   A0A212F4I6   A0A212F244   L7M8R1   A0A3S2M2X1   G9D4T0   A0A2A4IZB1   A0A1L8D6N3   A0A232EMX7   A0A131YR32   A0A1I7DMB9   A0A224YH56   A0A2W7RB29   A0A0N1IF51   A0A2A4K2R0   A0A2A4IW06   A0A212FE89   A0A437BH13   A0A088AGI5   A0A131XMC9   A0A194PUL9   A0A1B2G267   I4DKQ3   A0A2A4JAY8   G3MFC0   D6WCX8   V9IFI2   U5KCB8   A0A212FE35   A0A327PS09   A0A212EU63  

PDB

3WCZ     E-value=6.57817e-119,     Score=1090

KEGG

101743035    K00011 aldehyde reductase [EC:1.1.1.21] | (RefSeq) AKR2E4, akr2e; aldo-keto reductase AKR2E4

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00051    Fructose and mannose metabolism - Bombyx mori (domestic silkworm)
00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0008202   GO:0008106   GO:0004032   GO:0005829   GO:0005488   GO:0006096   GO:0050113   GO:0016740   GO:0006108   GO:0030060   GO:0016615   GO:0000049   GO:0016876   GO:0055114  

PANTHER

PTHR11732  

Length:

212

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0283

Exp number, first 60 AAs:

0.0008

Total prob of N-in:

0.06375

outside

1  -  212

 

 

Pi

185.476456

Theta

18.012847

Tajima's D

0.149759

CLR

1.781719

CSRT

0.413779311034448

Interpretation

Uncertain