Gene

KWMTBOMO09560

Annotation

PREDICTED:_structure-specific_endonuclease_subunit_SLX1_homolog_[Amyelois_transitella]

Location

Bomo_Chr16(+):4188456-4193837      View in EpiBrowser

Full name

Structure-specific endonuclease subunit SLX1 homolog       + More
Structure-specific endonuclease subunit SLX1      

Alternative Name

GIY-YIG domain-containing protein 1

Location in the cell

Nuclear   Reliability : 2.057

CDS

ATGGTGCTTATTGTCCACGGTTTTCCTAATAATATTTCAGCACTAAGGTTTGAATGGGCCTGGCAGAATCCAACAAAAACAACAAGACTGCAACATTTATATCTCAAAAAGATACCTCGTCAAGAATCCGAATTCCAGTTTAAACTAAGGGTACTCAGTGAAATGCTGAGAGTTGGACCTTGGTGTCGATTGCCATTACTAATTAGATGGCTTGAGAAAGAATATTTTGAAGAATTTCCAGTGACGAGAAAACCACCGGAACACATGAAAATCTGCTACGGACCTGTCAAAATTAAAAACTTAAAGAAAATCGATAATGTTGGTTATGAAGATAAATCTGAAGAATGCATCATATGTTGCCGCCTAATAAAAAGCTATCAATCAAAAATTAAATGTTTAAATCAATTCTGTGTGTTAGTTTGTCATATTAGTTGCTTAGCTGATCGGTTTTTGGAGCCAGGGGAGTACATTCCTATACAAGGTTCTTGCCCTTTATGCGATATCAAGTTGAAATGGGGTGACCTTATCAGAAAGATAAAGGGATGCAGCCTGGATTTAAATGGTGATTGTGGTGTGACAGATGAGACTTTATCTGGAAATGATGAGGTTATCCCTAGTAATGTAGCTGATGAAATTGACGATGAACAACCCAGTTGGTTTTTGGACTGTAAAGAAGATTTATGA

Protein

MVLIVHGFPNNISALRFEWAWQNPTKTTRLQHLYLKKIPRQESEFQFKLRVLSEMLRVGPWCRLPLLIRWLEKEYFEEFPVTRKPPEHMKICYGPVKIKNLKKIDNVGYEDKSEECIICCRLIKSYQSKIKCLNQFCVLVCHISCLADRFLEPGEYIPIQGSCPLCDIKLKWGDLIRKIKGCSLDLNGDCGVTDETLSGNDEVIPSNVADEIDDEQPSWFLDCKEDL

Description

Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

Cofactor

a divalent metal cation

Subunit

Forms a heterodimer with a member of the SLX4 family.
Forms a heterodimer with SLX4.

Similarity

Belongs to the SLX1 family.

Keywords

Complete proteome   DNA damage   DNA recombination   DNA repair   Endonuclease   Hydrolase   Metal-binding   Nuclease   Nucleus   Reference proteome   Zinc   Zinc-finger  

Feature

chain  Structure-specific endonuclease subunit SLX1 homolog

Uniprot

A0A2A4JM45   A0A2H1VAA6   A0A3S2LJD0   A0A2W1BK04   A0A1E1W695   A0A194Q1X7   + More
A0A194R1H1   A0A212FMH0   A0A1Y1KKA0   A0A1Y1KMM0   A0A2P8XGJ4   U5EYN8   A0A1W4WSL2   A0A1J1JAG4   A0A2J7QZB8   A0A2G8L0H0   H3A9L3   A0A2Z5TRH2   A0A0L8HJC1   A0A154P0R2   A0A310SCS3   A0A369RTN8   A0A3Q1ICQ7   A0A087TPZ8   H9GM13   K1QSF5   S4RDE7   A0A0L7RFK6   A0A067QIH0   A0A336LU56   A0A2S2PWI2   A0A1B6JSZ3   A0A293N6Y4   A0A2H8TQG0   A0A2S2PVL2   A0A2H6MW14   A0A0N0BHH2   A0A2U9AVS3   A0A210Q0J8   A0A336KCT8   A0A402FCY7   A0A336K8D7   A0A3Q3KMM9   A0A1B0CVF7   C4WWR2   A0A2D4LWM1   C1C1X5   A0A2A3E887   A0A423TM63   A0A3B3ZKS1   A0A3B5KX41   D2A4Q1   E2BL80   J9KAZ3   R7T845   A0A3B4CGA3   A0A3S2MII6   W5N6V0   A0A3Q1BE41   A0A3P8SS82   A0A087ZVQ2   A0A3B3BGH1   B7PW25   A0A3Q1GDM3   A0A3P9N9P5   A0A3Q2ZUQ3   A0A1A8MLA9   A0A3B3D3L5   A0A3Q3ND61   A0A433U7M1   A0A1B6L835   A0A087Y802   A0A3B3UNM8   M3ZZU9   A0A1A8KVW9   A0A1Z5L7E4   A0A1A8PYN4   A0A1A8IFW2   A0A0F8BIL3   A0A1A8GI54   A0A1A8QV72   A0A315V765   A0A1A8CVV6   A0A1A8TYL8   A0A3P8WDA0   A0A1I8MSR6   A0A3Q1G4R0   A0A3B3WNB1   V5HTC3   A0A026WCK2   A0A3P8WAG5   A0A1A7YQR5   A0A2I4AJ26   A0A1W4YAX5   E9IA79   Q5TXB2   A0A164N9Z9   W5KIV9   A0A3P9HTU0   A0A3B1KLL7  

EC Number

3.1.-.-

Pubmed

28756777    26354079    22118469    28004739    29403074    29023486    + More
9215903    26760975    30042472    21881562    22992520    24845553    28812685    25463417    18362917    19820115    20798317    23254933    29451363    23542700    28528879    25835551    29703783    24487278    25315136    25765539    24508170    21282665    12364791    25329095    17554307   

EMBL

NWSH01001060    PCG72856.1    ODYU01001496    SOQ37783.1    RSAL01000093    RVE47942.1    + More
KZ150230    PZC72003.1    GDQN01008542    JAT82512.1    KQ459582    KPI98999.1    KQ460878    KPJ11643.1    AGBW02007651    OWR54927.1    GEZM01081172    JAV61832.1    GEZM01081175    JAV61828.1    PYGN01002217    PSN31119.1    GANO01000230    JAB59641.1    CVRI01000075    CRL08550.1    NEVH01009070    PNF33927.1    MRZV01000274    PIK53764.1    AFYH01166822    FX985823    BBA93710.1    KQ418005    KOF89326.1    KQ434791    KZC05412.1    KQ769895    OAD52766.1    NOWV01000214    RDD37819.1    KK116251    KFM67187.1    AAWZ02023122    JH817795    EKC31875.1    KQ414599    KOC69762.1    KK853329    KDR08427.1    UFQS01000197    UFQT01000197    SSX01196.1    SSX21576.1    GGMS01000702    MBY69905.1    GECU01005372    JAT02335.1    GFWV01023241    MAA47968.1    GFXV01004316    MBW16121.1    GGMR01020277    MBY32896.1    IACI01012526    LAA18903.1    KQ435750    KOX76254.1    CP026243    AWO95687.1    NEDP02005302    OWF42235.1    SSX01195.1    SSX21575.1    BDOT01000199    GCF54333.1    SSX01194.1    SSX21574.1    AJWK01030488    AK342220    BAH72332.1    IACM01048084    LAB25480.1    BT080854    ACO15278.1    KZ288327    PBC27967.1    QCYY01001512    ROT77529.1    KQ971344    EFA05251.1    GL448949    EFN83566.1    ABLF02028893    AMQN01003600    KB312243    ELT87595.1    CM012454    RVE60161.1    AHAT01030154    ABJB010064586    DS804579    EEC10797.1    HAEF01016459    SBR57618.1    RQTK01000046    RUS89840.1    GEBQ01020161    JAT19816.1    AYCK01012130    HAEE01016497    SBR36547.1    GFJQ02003637    JAW03333.1    HAEG01010137    SBR86343.1    HAED01009835    SBQ96047.1    KQ042851    KKF09520.1    HAEB01011878    HAEC01002621    SBQ70698.1    HAEH01013552    HAEI01017236    SBR97685.1    NHOQ01002757    PWA14774.1    HADZ01018880    HAEA01002213    SBP82821.1    HADY01024564    HAEJ01000448    SBS40905.1    GANP01002849    JAB81619.1    KK107274    EZA53653.1    HADW01010313    HADX01010291    SBP32523.1    GL761987    EFZ22540.1    AAAB01008799    LRGB01002864    KZS05770.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    UP000245037    + More
UP000192223    UP000183832    UP000235965    UP000230750    UP000008672    UP000053454    UP000076502    UP000253843    UP000265040    UP000054359    UP000001646    UP000005408    UP000245300    UP000053825    UP000027135    UP000053105    UP000246464    UP000242188    UP000288954    UP000261640    UP000092461    UP000242457    UP000283509    UP000261520    UP000261380    UP000007266    UP000008237    UP000007819    UP000014760    UP000261440    UP000018468    UP000257160    UP000265080    UP000005203    UP000261560    UP000001555    UP000257200    UP000242638    UP000264800    UP000261660    UP000271974    UP000028760    UP000261500    UP000002852    UP000265120    UP000095301    UP000261480    UP000053097    UP000192220    UP000192224    UP000007062    UP000076858    UP000018467    UP000265200   

Pfam

PF01541   GIY-YIG        + More
PF11793   FANCL_C
PF13855   LRR_8

Interpro

IPR000305   GIY-YIG_endonuc        + More
IPR027520   Slx1       
IPR013083   Znf_RING/FYVE/PHD       
IPR035901   GIY-YIG_endonuc_sf       
IPR026850   FANCL_C       
IPR001611   Leu-rich_rpt       
IPR011011   Znf_FYVE_PHD       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR032675   LRR_dom_sf       
IPR019786   Zinc_finger_PHD-type_CS       
IPR001841   Znf_RING       
IPR001965   Znf_PHD       

SUPFAM

SSF82771   SSF82771        + More
SSF57903   SSF57903       

Gene 3D

3.30.40.10     3.40.1440.10     3.80.10.10    

ProteinModelPortal

A0A2A4JM45   A0A2H1VAA6   A0A3S2LJD0   A0A2W1BK04   A0A1E1W695   A0A194Q1X7   + More
A0A194R1H1   A0A212FMH0   A0A1Y1KKA0   A0A1Y1KMM0   A0A2P8XGJ4   U5EYN8   A0A1W4WSL2   A0A1J1JAG4   A0A2J7QZB8   A0A2G8L0H0   H3A9L3   A0A2Z5TRH2   A0A0L8HJC1   A0A154P0R2   A0A310SCS3   A0A369RTN8   A0A3Q1ICQ7   A0A087TPZ8   H9GM13   K1QSF5   S4RDE7   A0A0L7RFK6   A0A067QIH0   A0A336LU56   A0A2S2PWI2   A0A1B6JSZ3   A0A293N6Y4   A0A2H8TQG0   A0A2S2PVL2   A0A2H6MW14   A0A0N0BHH2   A0A2U9AVS3   A0A210Q0J8   A0A336KCT8   A0A402FCY7   A0A336K8D7   A0A3Q3KMM9   A0A1B0CVF7   C4WWR2   A0A2D4LWM1   C1C1X5   A0A2A3E887   A0A423TM63   A0A3B3ZKS1   A0A3B5KX41   D2A4Q1   E2BL80   J9KAZ3   R7T845   A0A3B4CGA3   A0A3S2MII6   W5N6V0   A0A3Q1BE41   A0A3P8SS82   A0A087ZVQ2   A0A3B3BGH1   B7PW25   A0A3Q1GDM3   A0A3P9N9P5   A0A3Q2ZUQ3   A0A1A8MLA9   A0A3B3D3L5   A0A3Q3ND61   A0A433U7M1   A0A1B6L835   A0A087Y802   A0A3B3UNM8   M3ZZU9   A0A1A8KVW9   A0A1Z5L7E4   A0A1A8PYN4   A0A1A8IFW2   A0A0F8BIL3   A0A1A8GI54   A0A1A8QV72   A0A315V765   A0A1A8CVV6   A0A1A8TYL8   A0A3P8WDA0   A0A1I8MSR6   A0A3Q1G4R0   A0A3B3WNB1   V5HTC3   A0A026WCK2   A0A3P8WAG5   A0A1A7YQR5   A0A2I4AJ26   A0A1W4YAX5   E9IA79   Q5TXB2   A0A164N9Z9   W5KIV9   A0A3P9HTU0   A0A3B1KLL7  

PDB

4XM5     E-value=0.000466407,     Score=100

KEGG

NA   

GO

GO:0006281   GO:0017108   GO:0006310   GO:0033557   GO:0004520   GO:0046872   GO:0004519   GO:1904431   GO:0000724   GO:0008821   GO:0090656  

Subcellular location

Nucleus  

Length:

227

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00213

Exp number, first 60 AAs:

0.00096

Total prob of N-in:

0.01174

outside

1  -  227

 

 

Pi

148.939719

Theta

156.834584

Tajima's D

0.042817

CLR

2.250543

CSRT

0.382980850957452

Interpretation

Uncertain