Gene

KWMTBOMO09555  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012827

Annotation

PREDICTED:_fructose-bisphosphate_aldolase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr16(+):4111576-4120215      View in EpiBrowser

Full name

Fructose-bisphosphate aldolase      

Location in the cell

Mitochondrial   Reliability : 2.962

CDS

ATGGATGGGACAACAAAGACTGCCAGTTCATCATGCAGATATGTCTTCGTGGGTCGGCTAGGGATTGTGCGATACACCACCGCAACTATACTACACATCCGCGAATGGCTACCACATGGAGAAGAGAAGGTGCTGTTGCTCCAGTTGCAAGAGGGACCGACTTTCAACCAAAGAAATGTTACGCCTGCCGAAGAGAAGGTCATGAAACAAAGAACTGCAAGGAGCCGCGCTGCGAGGTGTGCCATCGCCCGGGACACACGTCGGTCAGCTGATGGTATGCGGCCAGCTCTTCACACCCAAAATATGACAACTTACTTCTCACGATTAGACGTTCAACTGCAAGAGGAGTTGAAAAAGACAGCCGAAGCTATATTAGCTTCAGGCAAAGGCATCCTTGCTGTTGATGAAACTAACGAGGGCATTGGAAAGCTACTGAAGAATGTCGGTTTGGAGAACACTGAAAATAATAGGCGAAGATACAGAGAGTTGCTGTTCACAACCCCCGATTTAGCTGAACATATTTCTGCTGTAATTCTTTACGATGAGACCGTTTATCAAAAAACTGATGACGGTACACCGTTTATAGAGCTCTTAAATAAGCTAAATATCATACCTGGAATTAAAGTAGATAAGGATGTCACGGCGTTGTTCCTTTCCGAAGATGAAATGACTACTCAAGGCTTAGATGATTTAGGTAAACGTTGCGCGGCGTACAAAAAGCAGGGATGCCGATTTGCAAAATGGCGTTGTCCGGTCAAAATAGGACTGAACACGCCCTCCGTTCGGGCTATCAACGATACAGCCACAATCCTGGCACGGTATGCGTCTATATGCCAAAGCGAAGGCTTGGTGCCGATTGTGGAACCCGACGTTCTGTTAGATGGTGACCACGATATAGAGAGAGCCCAAAAAGTGACTGAAGTAGTACTAGCGGCCGTCTACAAGGCATTGAATGACCACCATGTGTTTCTAGAGGGAACGCTGCTTAAGCCTAATATGGTAACGCCTGGACAGGGATGTACTAAGAAAAGTACGCCTAAAGAAATCGCTATTGCAACTAGAACAGCCCTATTGAGGGGAGTGCCAGCTGCCGTACCAGGTATAGCTTTTCTTTCCGGTGGTCAAACAGAAGAGGAAGCGACTTTGAATTTAAATGAAATTAACAAGGTTCAAGGTAAAAAGCCATGGATCCTTACGTTTAGTTATGGCAGAGCTCTACAAGCATCTGTCTGGCAGACGTGGGCAGGTAAAGATGAAAATCTTGTGAAGGCGCAAAAGGAATTACTGAAACGGACCAAGGCTAACGGTCTCGCGTCGCTCGGAAACTACGAAGCTGGTACCGCTATTTCTGCAGCTGGTGACGAAACAAATTACAGTGCCAATTATAAGTATTAA

Protein

MDGTTKTASSSCRYVFVGRLGIVRYTTATILHIREWLPHGEEKVLLLQLQEGPTFNQRNVTPAEEKVMKQRTARSRAARCAIARDTRRSADGMRPALHTQNMTTYFSRLDVQLQEELKKTAEAILASGKGILAVDETNEGIGKLLKNVGLENTENNRRRYRELLFTTPDLAEHISAVILYDETVYQKTDDGTPFIELLNKLNIIPGIKVDKDVTALFLSEDEMTTQGLDDLGKRCAAYKKQGCRFAKWRCPVKIGLNTPSVRAINDTATILARYASICQSEGLVPIVEPDVLLDGDHDIERAQKVTEVVLAAVYKALNDHHVFLEGTLLKPNMVTPGQGCTKKSTPKEIAIATRTALLRGVPAAVPGIAFLSGGQTEEEATLNLNEINKVQGKKPWILTFSYGRALQASVWQTWAGKDENLVKAQKELLKRTKANGLASLGNYEAGTAISAAGDETNYSANYKY

Description

May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases).

Catalytic Activity

beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

Biophysicochemical Properties

Optimum pH is 7.2-7.8 for isozyme alpha, and 7.2-7.5 for isozymes beta and gamma.

Subunit

Homotetramer.

Similarity

Belongs to the class I fructose-bisphosphate aldolase family.

Keywords

3D-structure   Acetylation   Alternative splicing   Complete proteome   Direct protein sequencing   Glycolysis   Lyase   Reference proteome   Schiff base  

Feature

chain  Fructose-bisphosphate aldolase
splice variant  In isoform Beta.

Uniprot

A0A286NZX0   H9JTG5   A0A2A4K1G9   A0A2H1V1S8   A0A2H1WTY8   A0A194Q0Z6   + More
A0A2W1BFW6   A0A212ENA4   A0A0L0CB25   E0W3R5   Q75PQ3   T1PF08   A0A1I8MI51   A0A1L8EHG5   A0A2R7X4P6   A0A1I8Q820   G9C5D5   A0A1L8EEC0   Q6PPI0   A0A0A1XBW0   A0A034W0D2   A0A0C9RLK5   A0A1L8EEB3   Q5XXS8   A0A034VYR0   A0A0A1WLY1   A0A1I8MI52   Q1HPN7   A0A2W1BGR3   W8BB97   B4LYD3   B4JG48   A0A1B0CFJ1   A0A0Q9X9A9   A0A2A4K0C6   S4PKR2   A0A194R6Y9   A0A1Y1MII1   A0A0Q9XD95   A0A2J7Q6X5   A0A0Q9WQB4   I4DS64   I4DIX5   A0A437BC03   A0A1B6E5I5   A0A1E1W008   A0A1E1WFZ0   A0A1A9ULU3   A0A194Q080   A0A2J7Q6X2   A0A1L8E1Y6   D3TPU5   A0A1Y1NCD5   A0A1A9WAA9   B4KB24   A0A1B0GEZ8   V5SHY6   A0A067QX08   A0A0K8S3Z1   D3TPV3   A0A1A9ZP50   A0A0A9VWY6   A0A0T6B775   A0A0Q9WWZ4   B3M1S3   A0A0M4ENX9   A5XD00   A5XCZ4   T1I0J6   A0A3B0JQQ2   Q297A9   A0A0Q9WRY5   P07764-2   A4V3G1   A0A2P0XIZ4   A0A023F8I6   A0A3B0KE28   A0A1B0C7D4   B3P686   A0A1A9YIR0   R4G5J0   A0A2H8TJD7   J9K2N4   A0A3B0JS88   A0A0G3YKZ4   A5XCY1   A0A1W4VKK0   A0A310STW3   A0A0P8Y2A2   B4PSV1   A0A0A1XQY1   P07764-3   F3YDE2   B4ICK7   Q5XUB0   J3JXD3   B4QW40   B4NKQ7   F3YDB5  

EC Number

4.1.2.13

Pubmed

19121390    26354079    28756777    22118469    26108605    20566863    + More
25315136    21835214    25830018    25348373    24495485    17994087    23622113    28004739    18057021    22651552    20353571    24845553    26823975    25401762    17379620    15632085    1339430    1740444    1732743    7487099    10731132    12537572    12537569    3918528    3140728    6805442    8537310    1959612    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25474469    25702953    17550304    22516182   

EMBL

LC316986    BBA26325.1    BABH01003868    BABH01003869    NWSH01000318    PCG77510.1    + More
ODYU01000076    SOQ34224.1    ODYU01011045    SOQ56535.1    KQ459582    KPI98988.1    KZ150073    PZC74009.1    AGBW02013713    OWR42931.1    JRES01000664    KNC29432.1    DS235882    EEB20271.1    AB166792    BAD12426.1    KA647331    AFP61960.1    GFDG01000766    JAV18033.1    KK856759    PTY26380.1    HQ851376    AEV89754.1    GFDG01001742    JAV17057.1    AY588066    AAT01078.1    GBXI01016995    GBXI01005856    JAC97296.1    JAD08436.1    GAKP01011764    JAC47188.1    GBYB01007841    JAG77608.1    GFDG01001747    JAV17052.1    AY725784    AAU95197.1    GAKP01011765    JAC47187.1    GBXI01014752    JAC99539.1    BABH01003873    BABH01003874    BABH01003875    DQ443365    LC316985    ABF51454.1    BBA26324.1    PZC74008.1    GAMC01016134    JAB90421.1    CH940650    EDW66929.1    CH916369    EDV93615.1    AJWK01010111    AJWK01010112    AJWK01010113    AJWK01010114    CH933806    KRG01700.1    PCG77509.1    GAIX01004365    JAA88195.1    KQ460878    KPJ11631.1    GEZM01032210    JAV84768.1    KRG01699.1    NEVH01017450    PNF24337.1    KRF83012.1    AK405438    BAM20754.1    AK401243    BAM17865.1    RSAL01000093    RVE47930.1    GEDC01009708    GEDC01004098    JAS27590.1    JAS33200.1    GDQN01010734    JAT80320.1    GDQN01005165    JAT85889.1    KPI98987.1    PNF24336.1    GFDF01001353    JAV12731.1    EZ423447    ADD19723.1    GEZM01006940    JAV95541.1    EDW15728.1    CCAG010012689    KF647618    AHB50480.1    KK853259    KDR09236.1    GBRD01017869    GDHC01013986    JAG47958.1    JAQ04643.1    EZ423455    ADD19731.1    GBHO01044881    JAF98722.1    LJIG01009459    KRT83038.1    CH964272    KRF99976.1    CH902617    EDV44403.1    KPU80852.1    CP012526    ALC45697.1    DQ864151    DQ864152    DQ864153    DQ864154    DQ864155    DQ864156    ABH06786.1    ABH06787.1    ABH06788.1    ABH06789.1    ABH06790.1    ABH06791.1    DQ864145    DQ864146    DQ864147    DQ864148    DQ864149    DQ864150    ABH06780.1    ABH06781.1    ABH06782.1    ABH06783.1    ABH06784.1    ABH06785.1    ACPB03008738    OUUW01000007    SPP83283.1    CM000070    EAL28297.4    KRF83013.1    D10446    M98351    X60064    D10762    DQ864133    DQ864134    DQ864135    DQ864136    DQ864137    DQ864138    DQ864139    DQ864140    DQ864141    DQ864142    DQ864143    DQ864144    AE014297    AY058667    AY128452    BT126163    AAN14383.3    ADZ99415.1    KY661328    AVA17415.1    GBBI01001026    GEMB01001498    JAC17686.1    JAS01658.1    SPP83281.1    JXJN01028174    JXJN01028175    JXJN01028176    CH954182    EDV53556.1    GAHY01000515    JAA76995.1    GFXV01002458    MBW14263.1    ABLF02022004    SPP83282.1    KM507102    AKM28426.1    DQ864132    ABH06767.1    KQ760241    OAD61299.1    KPU80854.1    CM000160    EDW98638.2    GBXI01000573    JAD13719.1    BT126303    AEB39664.1    AGB96365.1    CH480828    EDW45103.1    AY737544    AAU84937.1    BT127902    AEE62864.1    CM000364    EDX14539.1    EDW84118.2    BT126276    AEB39637.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000037069    UP000009046    + More
UP000095301    UP000095300    UP000008792    UP000001070    UP000092461    UP000009192    UP000053240    UP000235965    UP000283053    UP000078200    UP000091820    UP000092444    UP000027135    UP000092445    UP000007798    UP000007801    UP000092553    UP000015103    UP000268350    UP000001819    UP000000803    UP000092460    UP000008711    UP000092443    UP000007819    UP000192221    UP000002282    UP000001292    UP000000304   

PRIDE

H9JTG5    Q75PQ3    Q1HPN7    B4KB24    P07764   

Pfam

PF00274   Glycolytic

Interpro

IPR029768   Aldolase_I_AS        + More
IPR000741   FBA_I       
IPR013785   Aldolase_TIM       

Gene 3D

3.20.20.70    

ProteinModelPortal

A0A286NZX0   H9JTG5   A0A2A4K1G9   A0A2H1V1S8   A0A2H1WTY8   A0A194Q0Z6   + More
A0A2W1BFW6   A0A212ENA4   A0A0L0CB25   E0W3R5   Q75PQ3   T1PF08   A0A1I8MI51   A0A1L8EHG5   A0A2R7X4P6   A0A1I8Q820   G9C5D5   A0A1L8EEC0   Q6PPI0   A0A0A1XBW0   A0A034W0D2   A0A0C9RLK5   A0A1L8EEB3   Q5XXS8   A0A034VYR0   A0A0A1WLY1   A0A1I8MI52   Q1HPN7   A0A2W1BGR3   W8BB97   B4LYD3   B4JG48   A0A1B0CFJ1   A0A0Q9X9A9   A0A2A4K0C6   S4PKR2   A0A194R6Y9   A0A1Y1MII1   A0A0Q9XD95   A0A2J7Q6X5   A0A0Q9WQB4   I4DS64   I4DIX5   A0A437BC03   A0A1B6E5I5   A0A1E1W008   A0A1E1WFZ0   A0A1A9ULU3   A0A194Q080   A0A2J7Q6X2   A0A1L8E1Y6   D3TPU5   A0A1Y1NCD5   A0A1A9WAA9   B4KB24   A0A1B0GEZ8   V5SHY6   A0A067QX08   A0A0K8S3Z1   D3TPV3   A0A1A9ZP50   A0A0A9VWY6   A0A0T6B775   A0A0Q9WWZ4   B3M1S3   A0A0M4ENX9   A5XD00   A5XCZ4   T1I0J6   A0A3B0JQQ2   Q297A9   A0A0Q9WRY5   P07764-2   A4V3G1   A0A2P0XIZ4   A0A023F8I6   A0A3B0KE28   A0A1B0C7D4   B3P686   A0A1A9YIR0   R4G5J0   A0A2H8TJD7   J9K2N4   A0A3B0JS88   A0A0G3YKZ4   A5XCY1   A0A1W4VKK0   A0A310STW3   A0A0P8Y2A2   B4PSV1   A0A0A1XQY1   P07764-3   F3YDE2   B4ICK7   Q5XUB0   J3JXD3   B4QW40   B4NKQ7   F3YDB5  

PDB

1FBA     E-value=1.25e-117,     Score=1083

KEGG

101743550    K01623 fructose-bisphosphate aldolase, class I [EC:4.1.2.13] | (RefSeq) fructose-bisphosphate aldola

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00030    Pentose phosphate pathway - Bombyx mori (domestic silkworm)
00051    Fructose and mannose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0004332   GO:0006096   GO:0030018   GO:0031430   GO:0005829   GO:0007498   GO:0042593   GO:0003824   GO:0050113   GO:0016740   GO:0006108   GO:0030060   GO:0016615   GO:0000049   GO:0016876  

Length:

464

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.59452

Exp number, first 60 AAs:

0.57512

Total prob of N-in:

0.04254

outside

1  -  464

 

 

Pi

370.310335

Theta

206.648762

Tajima's D

2.294302

CLR

0.04272

CSRT

0.918954052297385

Interpretation

Uncertain