Gene

KWMTBOMO09553  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013021

Annotation

fructose_1?6-bisphosphate_aldolase_[Bombyx_mori]

Location

Bomo_Chr16(-):4089144-4106035      View in EpiBrowser

Full name

Fructose-bisphosphate aldolase      

Location in the cell

Cytoplasmic   Reliability : 1.363 Mitochondrial   Reliability : 1.577

CDS

ATGTCCACCTACTTTCAATACCCAACTCCTGAGCTGCAGGAGGAGCTCAAGAAGATCGCTCAAGCAATTGTAGCTCCCGCAAAGGGTATCCTGGCCGCTGACGAATCCACCGGTACAATGGGCAAGCGTTTGCAGGACATCGGCGTGGAGAACACAGAGGAGAACCGTCGTCGTTATCGCCAACTGCTATTCAGCTCTGACGCTGTGCTCTCCGAGAACATCTCTGGTGTGATCCTGTTCCACGAGACCCTTTACCAGAAGGCTGACGATGGAACCCCTCTGGTCTCCCTGCTGGAGAAGAAGGGCATCATCCCCGGCATCAAGGTCGACAAGGGTGTCGTCCCGCTGTTCGGATCGGAAGACGAATGCACCACCCAGGGTCTGGACGACCTCGCCCAGCGCTGCGCCCAGTACAAGAAGGACGGCTGCCACTTCGCCAAGTGGCGTTGCGTGCTGAAGATTGGCCGCAACACCCCCTCGTACCAAGCTATCCAGGAAAACGCCAATGTTCTCGCCCGCTACGCCTCCATCTGTCAGAGCCAACGCATCGTGCCAATTGTCGAGCCCGAAGTCTTACCTGATGGCGAGCACGACCTGGACCGCGCCCAGAAGGTGACTGAGGTCGTTCTGGCCGCCGTGTATAAGGCGCTGAACGACCACCACGTGTACCTCGAGGGGACACTCCTCAAGCCCAACATGGTGACGGCCGGTCAGTCGTGCAAGAAGACGTACACTCCCAACGACGTCGCGCGCGCCACCGTCACCGCCCTCCTCCGCACCGTGCCCGCCGCAGTCCCCGGAGTGACATTCCTCTCCGGTGGTCAGTCCGAAGAGGAGGCCTCGGTGCATCTGAACGCTATCAACGCTGTGGACCTCAAGAGGCCCTGGGTTCTGACGTTCAGCTACGGGCGCGCCCTCCAGGCTTCGGTGCTCCGCGCCTGGGGAGGGAAGACCGAGAACATTCTCGCCGGACAGCAGGAGCTGATCAAGCGTGCTAAGGCCAACGGTCTCGCAGCAGTCGGCAAATACGTTGCCGGCTCTATTCCTTCGCTGGCCGCTTCTAAATCGAACTTTGTCAAATCTCACGCTTATTAA

Protein

MSTYFQYPTPELQEELKKIAQAIVAPAKGILAADESTGTMGKRLQDIGVENTEENRRRYRQLLFSSDAVLSENISGVILFHETLYQKADDGTPLVSLLEKKGIIPGIKVDKGVVPLFGSEDECTTQGLDDLAQRCAQYKKDGCHFAKWRCVLKIGRNTPSYQAIQENANVLARYASICQSQRIVPIVEPEVLPDGEHDLDRAQKVTEVVLAAVYKALNDHHVYLEGTLLKPNMVTAGQSCKKTYTPNDVARATVTALLRTVPAAVPGVTFLSGGQSEEEASVHLNAINAVDLKRPWVLTFSYGRALQASVLRAWGGKTENILAGQQELIKRAKANGLAAVGKYVAGSIPSLAASKSNFVKSHAY

Description

May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases).

Catalytic Activity

beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

Biophysicochemical Properties

Optimum pH is 7.2-7.8 for isozyme alpha, and 7.2-7.5 for isozymes beta and gamma.

Subunit

Homotetramer.

Similarity

Belongs to the class I fructose-bisphosphate aldolase family.

Keywords

3D-structure   Acetylation   Alternative splicing   Complete proteome   Direct protein sequencing   Glycolysis   Lyase   Reference proteome   Schiff base  

Feature

chain  Fructose-bisphosphate aldolase
splice variant  In isoform Beta.

Uniprot

Q1HPN7   Q75PQ3   A0A1E1W008   S4PKR2   A0A194R6Y9   A0A2A4K0C6   + More
A0A1E1WFZ0   A0A194Q080   I4DS64   I4DIX5   A0A2W1BGR3   A0A437BC03   A0A212EN62   A0A222AJC5   Q6PPI0   A0A0A1WLY1   Q5XXS8   A0A034W0D2   A0A0C9RLK5   A0A1I8MI51   T1PF08   W8BB97   A0A034VYR0   A0A1L8EHG5   A0A1I8MI52   A0A0A1XBW0   A0A1I8Q820   A0A0L0CB25   A0A2J7Q6X2   A0A1L8EEB3   A0A1L8EEC0   A0A0Q9WWZ4   A0A2J7Q6X5   A0A2P0XIZ4   G9C5D5   A0A1B0CFJ1   A0A3B0JS88   A0A1L8E1Y6   A0A0P8Y2A2   A0A0Q9WQB4   A0A067QX08   A0A3B0KE28   D3TPU5   A0A0Q9XD95   A0A1W4VKK0   A0A1A9WAA9   A0A1I8JU48   A0A182YQJ6   A0A1I8JV83   Q178U8   A0A1B6E5I5   A0A1I8JV79   A0A182P065   E0W3R5   A0A182H5C4   A0A182Q2N0   E9GJ13   A0A1Y9IY90   U5EXS9   A0A182TX64   A0A182UVD5   Q7PGI9   A0A182HSP3   A0A1A9ULU3   A0A2M3ZZ82   A0A182JDC8   A0A2M3YXN1   A0A182FNW4   A0A182K296   A0A182LER9   A0A1Y1MII1   A0A068FCL9   A0A182MF90   A0A1Q3G4B3   A0A182VWX4   A0A0P6HXA7   A0A0M4ENX9   W5JKF9   P07764-3   B4NKQ7   F3YDE2   A0A3R7PR20   B4ICK7   B4QW40   A0A226E871   A0A0P5MZC0   A0A1B0GEZ8   F3YDB5   A0A2R7X4P6   A0A3B0JQQ2   A0A0P4WTD2   Q297A9   A0A0P5G3E3   D3TPV3   A0A0P5Y3V4   A0A1A9ZP50   P07764-2   A4V3G1   A0A0P5Y3V0   A5XCY1  

EC Number

4.1.2.13

Pubmed

19121390    23622113    26354079    22651552    28756777    22118469    + More
25830018    25348373    25315136    24495485    26108605    17994087    21835214    18057021    24845553    20353571    25244985    17510324    20566863    26483478    21292972    12364791    14747013    17210077    20966253    28004739    20920257    23761445    1339430    1740444    1732743    7487099    17379620    10731132    12537572    12537569    3918528    3140728    6805442    8537310    1959612    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15632085   

EMBL

BABH01003873    BABH01003874    BABH01003875    DQ443365    LC316985    ABF51454.1    + More
BBA26324.1    AB166792    BAD12426.1    GDQN01010734    JAT80320.1    GAIX01004365    JAA88195.1    KQ460878    KPJ11631.1    NWSH01000318    PCG77509.1    GDQN01005165    JAT85889.1    KQ459582    KPI98987.1    AK405438    BAM20754.1    AK401243    BAM17865.1    KZ150073    PZC74008.1    RSAL01000093    RVE47930.1    AGBW02013713    OWR42930.1    KY609709    ASO76464.1    AY588066    AAT01078.1    GBXI01014752    JAC99539.1    AY725784    AAU95197.1    GAKP01011764    JAC47188.1    GBYB01007841    JAG77608.1    KA647331    AFP61960.1    GAMC01016134    JAB90421.1    GAKP01011765    JAC47187.1    GFDG01000766    JAV18033.1    GBXI01016995    GBXI01005856    JAC97296.1    JAD08436.1    JRES01000664    KNC29432.1    NEVH01017450    PNF24336.1    GFDG01001747    JAV17052.1    GFDG01001742    JAV17057.1    CH964272    KRF99976.1    PNF24337.1    KY661328    AVA17415.1    HQ851376    AEV89754.1    AJWK01010111    AJWK01010112    AJWK01010113    AJWK01010114    OUUW01000007    SPP83282.1    GFDF01001353    JAV12731.1    CH902617    KPU80854.1    CH940650    KRF83012.1    KK853259    KDR09236.1    SPP83281.1    EZ423447    ADD19723.1    CH933806    KRG01699.1    CH477359    EAT42703.1    GEDC01009708    GEDC01004098    JAS27590.1    JAS33200.1    DS235882    EEB20271.1    JXUM01025903    JXUM01025904    KQ560737    KXJ81075.1    AXCN02000003    GL732547    EFX80562.1    GANO01000784    JAB59087.1    AAAB01008859    EAA44916.4    APCN01000316    GGFK01000449    MBW33770.1    GGFM01000272    MBW21023.1    GEZM01032210    JAV84768.1    KJ686589    MH675996    AID61753.1    QBO59887.1    AXCM01006740    GFDL01000393    JAV34652.1    GDIP01252032    GDIP01169946    GDIP01095311    GDIQ01037424    JAI71369.1    JAN57313.1    CP012526    ALC45697.1    ADMH02000939    ETN64621.1    D10446    M98351    X60064    D10762    DQ864133    DQ864134    DQ864135    DQ864136    DQ864137    DQ864138    DQ864139    DQ864140    DQ864141    DQ864142    DQ864143    DQ864144    AE014297    AY058667    AY128452    EDW84118.2    BT126303    AEB39664.1    AGB96365.1    QCYY01001906    ROT74380.1    CH480828    EDW45103.1    CM000364    EDX14539.1    LNIX01000006    OXA52856.1    GDIQ01160575    JAK91150.1    CCAG010012689    BT126276    AEB39637.1    KK856759    PTY26380.1    SPP83283.1    GDIP01251088    JAI72313.1    CM000070    EAL28297.4    GDIQ01251700    JAK00025.1    EZ423455    ADD19731.1    GDIP01063363    JAM40352.1    BT126163    AAN14383.3    ADZ99415.1    GDIP01063362    JAM40353.1    DQ864132    ABH06767.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000053268    UP000283053    UP000007151    + More
UP000095301    UP000095300    UP000037069    UP000235965    UP000007798    UP000092461    UP000268350    UP000007801    UP000008792    UP000027135    UP000009192    UP000192221    UP000091820    UP000075900    UP000076408    UP000075903    UP000008820    UP000075885    UP000009046    UP000069940    UP000249989    UP000075886    UP000000305    UP000076407    UP000075902    UP000007062    UP000075840    UP000078200    UP000075880    UP000069272    UP000075881    UP000075882    UP000075883    UP000075920    UP000092553    UP000000673    UP000000803    UP000283509    UP000001292    UP000000304    UP000198287    UP000092444    UP000001819    UP000092445   

PRIDE

Q1HPN7    Q75PQ3    P07764   

Pfam

PF00274   Glycolytic

Interpro

IPR029768   Aldolase_I_AS        + More
IPR013785   Aldolase_TIM       
IPR000741   FBA_I       

Gene 3D

3.20.20.70    

ProteinModelPortal

Q1HPN7   Q75PQ3   A0A1E1W008   S4PKR2   A0A194R6Y9   A0A2A4K0C6   + More
A0A1E1WFZ0   A0A194Q080   I4DS64   I4DIX5   A0A2W1BGR3   A0A437BC03   A0A212EN62   A0A222AJC5   Q6PPI0   A0A0A1WLY1   Q5XXS8   A0A034W0D2   A0A0C9RLK5   A0A1I8MI51   T1PF08   W8BB97   A0A034VYR0   A0A1L8EHG5   A0A1I8MI52   A0A0A1XBW0   A0A1I8Q820   A0A0L0CB25   A0A2J7Q6X2   A0A1L8EEB3   A0A1L8EEC0   A0A0Q9WWZ4   A0A2J7Q6X5   A0A2P0XIZ4   G9C5D5   A0A1B0CFJ1   A0A3B0JS88   A0A1L8E1Y6   A0A0P8Y2A2   A0A0Q9WQB4   A0A067QX08   A0A3B0KE28   D3TPU5   A0A0Q9XD95   A0A1W4VKK0   A0A1A9WAA9   A0A1I8JU48   A0A182YQJ6   A0A1I8JV83   Q178U8   A0A1B6E5I5   A0A1I8JV79   A0A182P065   E0W3R5   A0A182H5C4   A0A182Q2N0   E9GJ13   A0A1Y9IY90   U5EXS9   A0A182TX64   A0A182UVD5   Q7PGI9   A0A182HSP3   A0A1A9ULU3   A0A2M3ZZ82   A0A182JDC8   A0A2M3YXN1   A0A182FNW4   A0A182K296   A0A182LER9   A0A1Y1MII1   A0A068FCL9   A0A182MF90   A0A1Q3G4B3   A0A182VWX4   A0A0P6HXA7   A0A0M4ENX9   W5JKF9   P07764-3   B4NKQ7   F3YDE2   A0A3R7PR20   B4ICK7   B4QW40   A0A226E871   A0A0P5MZC0   A0A1B0GEZ8   F3YDB5   A0A2R7X4P6   A0A3B0JQQ2   A0A0P4WTD2   Q297A9   A0A0P5G3E3   D3TPV3   A0A0P5Y3V4   A0A1A9ZP50   P07764-2   A4V3G1   A0A0P5Y3V0   A5XCY1  

PDB

1FBA     E-value=4.71209e-162,     Score=1465

KEGG

778467    K01623 fructose-bisphosphate aldolase, class I [EC:4.1.2.13] | (RefSeq) fructose 1,6-bisphosphate al

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00030    Pentose phosphate pathway - Bombyx mori (domestic silkworm)
00051    Fructose and mannose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0004332   GO:0006096   GO:0005829   GO:0030388   GO:0007498   GO:0042593   GO:0030018   GO:0031430   GO:0003824   GO:0050113   GO:0016740   GO:0006108   GO:0030060   GO:0016615   GO:0000049   GO:0016876  

Length:

364

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.08109

Exp number, first 60 AAs:

0.00024

Total prob of N-in:

0.01222

outside

1  -  364

 

 

Pi

224.458604

Theta

176.254075

Tajima's D

1.134993

CLR

0.201982

CSRT

0.698315084245788

Interpretation

Uncertain