Gene

KWMTBOMO09538  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012816

Annotation

PREDICTED:_TBC1_domain_family_member_10B_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr16(+):3484630-3513398      View in EpiBrowser

Full name

TBC1 domain family member whacked      

Location in the cell

Mitochondrial   Reliability : 1.562 Nuclear   Reliability : 1.529

CDS

ATGTCTCTACAGAAGAGCGTGAAGAGTTCAGGAGATCGAAGCGAGCAGGCGGATACCACATCAATATGTTCATCGGTGACTACCCAACCGGACAGACACGGTTTTTTCGGAGGTGCCCAATACAGTCCAGAACCTAAAAGAACTGTCTCGCCGAGTACGATATTGAAGAGAGAACAGAAATGGCTTCGTATGCTCGACAACTGGGAAGCGTTTATGAGCAAGAACTACAAGAAAGTACGAGAAAGATGTCGAAAAGGTATACCAGCATCAGTGAGGCCGAAAGCATGGTTGTACCTGTGCGGGGGACAGCTCCTGCTCGAAAAACATCCGAACGAATACGAGGAATTGCTCCAAGCGCCCGGTGACCCTAAATGCATGGAGGACATAAGGAAGGACCTGCACAGGCAGTTCCCGTACCACGAAATGTTTATAAGAGAGGAGGGATTAGGGCAACAAGAATTATTTTCAGTTCTGAAAGCATATTCAGTGCTGAATCCAAAAGTTGGGTACTTCCAAGCACAAGCCCCGGTGGCGGCGTTCCTCCTCATGCATATGCCCGCGGTGCAAGCATTCTGGTGTCTCGTCAGCATCAGCGATAAATACCTGAGCGGCTACTACAATCCCGGTCTCGAGGTGCTCCAACGCGACGGCGACATTCTTCACGCGCTGCTTCGTCGGACCGCGCCTGCCGTGCACCGGCACCTCGTCAAGCACAAAGTGGAGCCGGTGCTGTACGCTACAGAATGGTTCTTGTGTGCATTAACGCGCACGCTGCCCTGGGACAGTCTGCTCAGGGTCTGGGACTGCTTCCTCTGCGAAGGCGTAAAGGTGCTGTTCAAGGCGGCGTTAGTAGTTCTGGCGGGTGCCCTCGGGCCGGCCAAGGTCCGCAAGCGCGCTTGCGGCCTCTGCGAGACTCTGGAGGTGCTACGACACCCCCCCGAGAACATCCTCGGGGAGGAATACCTCGTGTACCACATGCAAAGACTTAGCCTAACCGAGGAAGACTTTGAGTTCGAACACCAGCGCCAGACCGCGCGACGGAGAGCAATGGCCAACAGGAGTGGCAGCTGA

Protein

MSLQKSVKSSGDRSEQADTTSICSSVTTQPDRHGFFGGAQYSPEPKRTVSPSTILKREQKWLRMLDNWEAFMSKNYKKVRERCRKGIPASVRPKAWLYLCGGQLLLEKHPNEYEELLQAPGDPKCMEDIRKDLHRQFPYHEMFIREEGLGQQELFSVLKAYSVLNPKVGYFQAQAPVAAFLLMHMPAVQAFWCLVSISDKYLSGYYNPGLEVLQRDGDILHALLRRTAPAVHRHLVKHKVEPVLYATEWFLCALTRTLPWDSLLRVWDCFLCEGVKVLFKAALVVLAGALGPAKVRKRACGLCETLEVLRHPPENILGEEYLVYHMQRLSLTEEDFEFEHQRQTARRRAMANRSGS

Description

Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of elongating terminal cell branches thus providing a continuous supply of apical membrane components as the lumen grows. Whereas when Rab35-GDP is inactivated, presumably by this GAP, apical membrane vesicles are transported to a central location adjacent to the terminal cell nucleus.

Keywords

Cell membrane   Cell projection   Complete proteome   Cytoplasmic vesicle   GTPase activation   Membrane   Reference proteome  

Feature

chain  TBC1 domain family member whacked

Uniprot

A0A2A4IZ03   A0A2W1BQ99   A0A212FMR2   A0A194Q0L9   A0A0N1I8V4   A0A2H1VFN5   + More
A0A3S2TL55   H9JTF4   A0A1Y1LU98   A0A1W4WWN5   A0A2J7Q6W6   A0A232FBA6   K7IVX1   A0A0J7KRZ9   A0A026WUA8   A0A067QGT1   A0A158NNE3   A0A195CEB9   F4WD34   A0A151JZ00   A0A151I1A7   A0A151WUC7   D2A652   E2BAG1   T1PDP5   B4KE05   A0A1I8PU16   A0A0K8TNZ1   A0A1I8N288   A0A1B6J199   A0A1B6FL80   U5EQ40   A0A0L0CRZ2   A0A3B0KWQ4   A0A3B0K2H9   A0A1A9W8A9   A0A1B6KEX6   A0A151J5B2   A0A1Q3FII5   A0A1A9YK96   A0A1Q3FIQ3   A0A1B0G6W1   A0A1Q3FI40   B4NHU2   A0A1B0AAB1   A0A0R3NJJ3   B4GMI9   B0WWQ2   N6TXE4   Q17DK0   A0A1A9UN87   B4HI08   B4JSW3   B3P4I9   Q9VGL8   A0A1S4F6R7   B4QU23   A0A0R1E3V2   A0A1W4WDF1   B4M5E2   A0A1B6CLH1   B5DTM4   Q294W3   B4PU46   A0A0Q9W1U5   A0A182GT75   B3M0Y6   A0A0K8UQ09   A0A1L8DVD1   A0A0K8TYM1   A0A034W1F3   W8BHT0   E9J5R9   A0A1J1IHX7   A0A0L7QQP6   A0A310SU19   A0A154P727   A0A1B0BRH2   E0VK29   A0A182MIC0   A0A182QEK2   A0A182SIR7   A0A2A3E8K4   A0A088A8F1   W5JDD1   A0A182PQU8   A0A084VS50   A0A2M4BQT2   A0A182XBG6   A0A182V844   A0A182KLY0   Q7PYI3   A0A182JDF4   A0A182UIQ1   A0A182YG94   A0A2M4BRP3   A0A182I0A6   A0A2M3Z664   A0A182RXJ8   A0A0M9A3L2  

Pubmed

28756777    22118469    26354079    19121390    28004739    28648823    + More
20075255    24508170    30249741    24845553    21347285    21719571    18362917    19820115    20798317    17994087    18057021    26369729    25315136    26108605    15632085    23537049    17510324    10731132    12537572    22407366    17550304    26483478    25348373    24495485    21282665    20566863    20920257    23761445    24438588    20966253    12364791    14747013    17210077    25244985   

EMBL

NWSH01005013    PCG64494.1    KZ150081    PZC73863.1    AGBW02007651    OWR55036.1    + More
KQ459582    KPI99101.1    KQ460651    KPJ12982.1    ODYU01002046    SOQ39064.1    RSAL01000071    RVE49110.1    BABH01003939    GEZM01046441    JAV77234.1    NEVH01017450    PNF24323.1    NNAY01000548    OXU27743.1    LBMM01003773    KMQ93157.1    KK107109    QOIP01000008    EZA59246.1    RLU19177.1    KK853478    KDR07322.1    ADTU01021331    KQ977935    KYM98576.1    GL888082    EGI67891.1    KQ981453    KYN41579.1    KQ976589    KYM79686.1    KQ982730    KYQ51510.1    KQ971346    EFA05467.1    GL446721    EFN87323.1    KA646038    AFP60667.1    CH933806    EDW16026.1    KRG01868.1    KRG01869.1    GDAI01001725    JAI15878.1    GECU01014748    JAS92958.1    GECZ01018835    JAS50934.1    GANO01004474    JAB55397.1    JRES01000091    KNC34194.1    OUUW01000014    SPP88468.1    SPP88467.1    GEBQ01029955    JAT10022.1    KQ980036    KYN18153.1    GFDL01007743    JAV27302.1    GFDL01007650    JAV27395.1    CCAG010013874    GFDL01007846    JAV27199.1    CH964272    EDW84702.1    CM000070    KRT01122.1    CH479185    EDW38063.1    DS232151    EDS36144.1    APGK01047547    APGK01047548    KB741084    KB632329    ENN73990.1    ERL92545.1    CH477293    EAT44501.1    CH480815    EDW42590.1    CH916373    EDV94853.1    CH954181    EDV49504.1    AE014297    BT010263    AAQ23581.1    CM000364    EDX13354.1    CM000160    KRK03920.1    CH940652    EDW59853.1    KRF79112.1    GEDC01022984    JAS14314.1    CH476004    EDY71265.2    EAL28850.2    EDW97696.2    KRF79113.1    JXUM01086408    KQ563565    KXJ73657.1    CH902617    EDV43215.1    GDHF01023869    JAI28445.1    GFDF01003702    JAV10382.1    GDHF01032735    JAI19579.1    GAKP01010795    JAC48157.1    GAMC01017299    GAMC01017298    GAMC01017296    GAMC01017295    JAB89259.1    GL768176    EFZ11840.1    CVRI01000054    CRK99863.1    KQ414786    KOC60950.1    KQ759883    OAD62168.1    KQ434820    KZC06998.1    JXJN01019082    JXJN01025871    DS235237    EEB13735.1    AXCM01003378    AXCN02000031    KZ288325    PBC28038.1    ADMH02001488    ETN62357.1    ATLV01015810    KE525036    KFB40794.1    GGFJ01006306    MBW55447.1    AAAB01008987    EAA01136.5    GGFJ01006307    MBW55448.1    APCN01002057    GGFM01003249    MBW24000.1    KQ435747    KOX76517.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000283053    UP000005204    + More
UP000192223    UP000235965    UP000215335    UP000002358    UP000036403    UP000053097    UP000279307    UP000027135    UP000005205    UP000078542    UP000007755    UP000078541    UP000078540    UP000075809    UP000007266    UP000008237    UP000009192    UP000095300    UP000095301    UP000037069    UP000268350    UP000091820    UP000078492    UP000092443    UP000092444    UP000007798    UP000092445    UP000001819    UP000008744    UP000002320    UP000019118    UP000030742    UP000008820    UP000078200    UP000001292    UP000001070    UP000008711    UP000000803    UP000000304    UP000002282    UP000192221    UP000008792    UP000069940    UP000249989    UP000007801    UP000183832    UP000053825    UP000076502    UP000092460    UP000009046    UP000075883    UP000075886    UP000075901    UP000242457    UP000005203    UP000000673    UP000075885    UP000030765    UP000076407    UP000075903    UP000075882    UP000007062    UP000075880    UP000075902    UP000076408    UP000075840    UP000075900    UP000053105   

PRIDE

H9JTF4    Q9VGL8   

Pfam

PF00566   RabGAP-TBC

Interpro

IPR000195   Rab-GTPase-TBC_dom        + More
IPR035969   Rab-GTPase_TBC_sf       

SUPFAM

SSF47923   SSF47923       

ProteinModelPortal

A0A2A4IZ03   A0A2W1BQ99   A0A212FMR2   A0A194Q0L9   A0A0N1I8V4   A0A2H1VFN5   + More
A0A3S2TL55   H9JTF4   A0A1Y1LU98   A0A1W4WWN5   A0A2J7Q6W6   A0A232FBA6   K7IVX1   A0A0J7KRZ9   A0A026WUA8   A0A067QGT1   A0A158NNE3   A0A195CEB9   F4WD34   A0A151JZ00   A0A151I1A7   A0A151WUC7   D2A652   E2BAG1   T1PDP5   B4KE05   A0A1I8PU16   A0A0K8TNZ1   A0A1I8N288   A0A1B6J199   A0A1B6FL80   U5EQ40   A0A0L0CRZ2   A0A3B0KWQ4   A0A3B0K2H9   A0A1A9W8A9   A0A1B6KEX6   A0A151J5B2   A0A1Q3FII5   A0A1A9YK96   A0A1Q3FIQ3   A0A1B0G6W1   A0A1Q3FI40   B4NHU2   A0A1B0AAB1   A0A0R3NJJ3   B4GMI9   B0WWQ2   N6TXE4   Q17DK0   A0A1A9UN87   B4HI08   B4JSW3   B3P4I9   Q9VGL8   A0A1S4F6R7   B4QU23   A0A0R1E3V2   A0A1W4WDF1   B4M5E2   A0A1B6CLH1   B5DTM4   Q294W3   B4PU46   A0A0Q9W1U5   A0A182GT75   B3M0Y6   A0A0K8UQ09   A0A1L8DVD1   A0A0K8TYM1   A0A034W1F3   W8BHT0   E9J5R9   A0A1J1IHX7   A0A0L7QQP6   A0A310SU19   A0A154P727   A0A1B0BRH2   E0VK29   A0A182MIC0   A0A182QEK2   A0A182SIR7   A0A2A3E8K4   A0A088A8F1   W5JDD1   A0A182PQU8   A0A084VS50   A0A2M4BQT2   A0A182XBG6   A0A182V844   A0A182KLY0   Q7PYI3   A0A182JDF4   A0A182UIQ1   A0A182YG94   A0A2M4BRP3   A0A182I0A6   A0A2M3Z664   A0A182RXJ8   A0A0M9A3L2  

PDB

3HZJ     E-value=5.57976e-25,     Score=283

KEGG

101744901    K19944 TBC1 domain family member 10 | (RefSeq) TBC1 domain family member 10B

GO

GO:0005096   GO:0006886   GO:0005623   GO:0017137   GO:0090630   GO:0035149   GO:0010085   GO:0005737   GO:0098592   GO:0030175   GO:0031410   GO:0043087  

Subcellular location

Apical cell membrane   Restricted to the lumenal membrane of tracheal terminal cells with increased accumulation at the growing tips of seamless tubes. Colocalizes with Rab35 at the apical membrane, cytoplasmic puncta (likely to be vesicles) and filopodia.   With evidence from 2 publications.
Cytoplasmic vesicle   Restricted to the lumenal membrane of tracheal terminal cells with increased accumulation at the growing tips of seamless tubes. Colocalizes with Rab35 at the apical membrane, cytoplasmic puncta (likely to be vesicles) and filopodia.   With evidence from 2 publications.
Cell projection   Restricted to the lumenal membrane of tracheal terminal cells with increased accumulation at the growing tips of seamless tubes. Colocalizes with Rab35 at the apical membrane, cytoplasmic puncta (likely to be vesicles) and filopodia.   With evidence from 2 publications.
Filopodium   Restricted to the lumenal membrane of tracheal terminal cells with increased accumulation at the growing tips of seamless tubes. Colocalizes with Rab35 at the apical membrane, cytoplasmic puncta (likely to be vesicles) and filopodia.   With evidence from 2 publications.

Length:

356

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.75539

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04265

outside

1  -  356

 

 

Pi

191.263161

Theta

169.40558

Tajima's D

0.475247

CLR

0.265939

CSRT

0.506874656267187

Interpretation

Uncertain