Gene

KWMTBOMO09492  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012807

Annotation

PREDICTED:_carboxypeptidase_D_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr16(+):2452228-2485847      View in EpiBrowser

Full name

Carboxypeptidase D      

Alternative Name

Metallocarboxypeptidase D
Protein silver

Location in the cell

Cytoplasmic   Reliability : 1.25 Nuclear   Reliability : 1.135

CDS

ATGTATCGCTGGATTCGCATGTTGATACTGCTGTTTTCTCTAACAATCGCCAAAGCACAAGTTTCAGCAGTCACAAATGAGGACGAATCCTTTCTAAAGACATCAAATTATACGAAATACGACCAACTTGGTATTCTATTTGACAAACTCGAAAGCACCTATCCGGATCTGGCGAAGTTATATTCGATTGGGAATTCCGTCGAAGGTAGGAAGTTGCTGGTACTACAAATAACGCAGGACGTGCAGAATGAACACCCGGAACGTCCAGCGTTTAAATACGTGGCAAATATGCACGGCGATGAATCGATTGGAAGACAAATAGTGATATATTTGGCTCAGTACTTGTTATTGAACTATGGTAAAAATGAAAGGGTCACGAAGCTGGTGAACAGCACAGATATACACTTGATGCCATCTCTGAACCCGGATGGGTTTGAGGCTAGTGAGGAAGGAAACTGCGAATCGTTAAGAGGCTACGTCGGTCGTAGTAATGCAAACGGCGTGGACTTGAACCGCGATTTTCCCGACCAGTTCGACAAGAATCATGCGAACGATGACGAATATTTATATAGCGGACGGCAACCGGAGACCGTGGCCCTCATCCGGTGGGTCCTGAACAAACAGTTTGTGCTGTCGGCTAACCTTCATGGAGGGGCTATTGTGGCGAGCTATCCATACGACGACGTAGGGCACGGAAAGAACAACGGGAAGGATTGTTGCGAAGAGAGCAGGTCGCCCGACGATGCCGTGTTCAGACACCTGGCCAATTCGTACGCGTCTAGGAACGCGGACATGAGGGCCGGGGACCGATGTAAGCCGGAGAACTTCACTAATGGCATCACCAACGGCGCTAACTGGTATTTCGTGCAGGGTGGAATGCAAGACTTTAATTACATCCACTCGAACTGCTTCGAGGTGACCTTCGAGCTCTCCTGCTGCAAGTACCCGCGCGCCGAGGAACTGCCCTCGTATTGGCACATGAACAAGGAGGCGATGGTCGCGTTCGTCGAGCAGGCTCACATCGGCATCAGCGGCGTGGTGCTGGACGAGGACGGCGCACCTGTGAAGGACGCGCATATCTTAGTGGACGGCATCAAACACCCGGTCAGCACCACGCAGCACGGCCGCTACTGGCGACTCCTCACTCCCGGACAGTACAATGTCACTGTCAAAGCTTCAGGGTTCGTTTCCCCACCGCCCACAACGGTGACCGTCCCAGAAAACCAGACCGCCGCCGTCCCGCTCAATCTGACCGTCCACCGTCGGCCGCGTTCGATAGTCGACGAGGATTTTGTCCATCACAATTACGAGAAGATGGAGTCTTACCTCAAGGACCTCAACGCGATGTACTCCAATATCACGAAGCTGACCAGCATCGGCAAATCGGTGCAAGGAAGAGAGTTATACGTACTGGAGGTTACCAGAGATCCAGGCGTGCATATTCCCGGGAAACCGGAATTCAAGTACGTAGCCAATATGCATGGAAACGAAGCCGTCGGACGCGAACTTCTGCTGTTGTTAGCGAAGTACTTGTGTCAGCAGTACGTCGCCGGCGATGAACGAATACAGAACATGCTGAACAACACGAGGATCCACTTGCTGCCGAGCATGAACCCTGACGGCTACGAGACTGCCAGACCTGGTGATTTCGATGGTTTGAAGGGTCGCACTAATGCACACGATGTTGACTTGAACAGGAATTTCCCCGATCAGTTTGGAAGTACCGAGGAAAATGAAGTCCAAGAGCCGGAGACGTCGGCGGTGATGAAGTGGTCGCAGTCGATCCCGTTCGTGCTGTCGGCCAACCTGCACGGCGGCGCGCTGGTCGCCAACTACCCCTACGACGACAACCCTAGCATGCGCAGCGGGAAGGAGTTCCTGTCTCCCGACAACCCTGTCTTCGTCCATCTCGCTCATGTTTACTCGGACGCCCACCTCAAGATGCACTTAGGGAAGCCCTGCAAGAACTACTCCAGGGAAATGTTCCCGGACGGCACCACGAACGGAGCTAAGTGGTACGTGCTCGCGGGCGGCATGCAAGATTGGAACTACCTGCACACAGACGACATGGAGCTCACGCTAGAGCTGGGCTGCTACAAGTTCCCTCCTGCCGCGGACCTTCCCACCTACTGGCAGGACAACAGGGAAGCTCTCTTGCAGTACATAGAACAGGTCCACACCGGAGTCCACGGCTTCGTCTATAGCCACATAGGTCACGGCTTGTCCAACGCCACGATAACTGTGTCCGGGATCAAGCACGCGGTCCACACGGCCCGGGCCGGCGACTACTGGCGGCTGCTGAGGCCGGGCGTGTACAACGTCACCGCCAGCAGACAGGGTTATGAGAGTGTGACGGAGGAGGTGACGGTCCCTCCCGCCGGCGCGGTCAGCCTCAACTTCACGCTGATGGCGGACGACTCGCAGCACTGGTCCTCCGCCTACGACTTCCGTATATTGGATAACGTTTTGAACACGATGTACCACACCCCTCTGCAAATGTACGCGGCCCTATCTGAATTGGAGAACAAGTATCCGAGCATAGCGGAGTTCCGGGCCGGGGACAGCCTGGTCACCTCCAAGTTCCATCAGCTCAAGATGACTTCGAATGTCGGCTCTCCAGAGGAGACCAAATTCCACATTGCGATAATGAGCAGCCTGTACGCGACCCAGCCTCTGGGCCGGGAGATGCTTCTGAACTTTGCACGTCACATCGCCACCGCCTACACCATCGGCGAACCGAAACACCAACGCCTACTGAACAACACCGTCCTCCACTTCATACCGAACATCGACCCGCTCAACTCGAAGATAATCAAGCAATACGACGGCACCGACAAGTGCGACCTCACCGCCCTCGAGGAAGAGTTCGGCGATAGCCTGTACAACTACCTGACGAAGACCAACATGAACCCACTCTCGAATTACACCAGCGAAACGGCCTTCATCGAAATGCTCAAATCGGAGAAGTACGACTTGATTCTAGAACTCTCTTCCGGCACAGAAGACGTGTCTTACCCTGAAGCTTCGAAGGAACTGTACGAGAAATACGCCCGGACGTACCAGGACCACAGGAACCCAAGCGATAAGTACGAGTGTCGGCCGTTGGACAGCAGTGTCCACGGTCAGCTCGTGGACTTGCTGTGCGAGCGGCTCGACGTGCCCGTGGTGTCCGTGGGGTTGAGCTGCTGCAGGATGCCCGTCGCCGACCAGATCGGCTGGGTCTGGAGAGACAACCTGGGCGGCATCATGAAGTTCGTCGAGCAAGCCAATACCGGCGTCGTGGGATACGTAAAGAACGAGATGGGAAAGCCGGTCCGCGACGCCACCATAGCCATCACCAGCTTCTCGAAGCAGTACCGGGTGACGAGCAACATGGCGCACTACCACGTGATGCTGCCCGCGGGCGTCTACAAGGTCATCGTGCGCGCTCACAACTACAAGGATCGGATCCTAACTTGGAACGTCCTGGACTCCAAACTGAAGCAAATCGACATAATACTGCAGAGGACGAATGCGGAGAGGATATCTGGTGGTCAATTCGAGGACATCCAAGTTCCAGAGGATCCTAATGTCGTTTATACCATGGGGCTGGTCCTGTCCCGCAGCAGCGAGCCGCTGGGCGGGGCCGAGCTGGCGGTGCGCGGGGCGCGCGCGGGCGGCGTGCTGGCGCGCAACACCAGCGACGCGCACGGCCGCTTCGTGCTCGCGCTGCCCGCCGGGTACAAGGGGAAGCAGGTCGCGATATCCGCCGCCTCCGACGGATACGTCACCAAGCAGATGGACGTCTTGATCAACAGCGTGGACAACTTAACGCCCAATTTGATATTTAAGCTGGACAGCGACGACAATGTTCTAGGGATGCCACGTCTCGTTTTCGTCATGTTGTCTGGCGTGGTGGGCGTGTCGCTGGTGGTGCTGGGGGCGTGGTGCTTCAGCTGCCGCGAGCGCGCCCGCCACTCGCGCCGCGACTACCTGTTCACGCAGCTGCCCGGGGACGACAAGCGCCCGCTCTGCGAGCCTGATTTGATCCGCAAGCCGTTCTACGACGAGGAGGACATCCCGTTGACGGAGACCGACTCAGAGGAAGATGTCGTGCTGCTGCAGACCGGACGAGAGCAATGA

Protein

MYRWIRMLILLFSLTIAKAQVSAVTNEDESFLKTSNYTKYDQLGILFDKLESTYPDLAKLYSIGNSVEGRKLLVLQITQDVQNEHPERPAFKYVANMHGDESIGRQIVIYLAQYLLLNYGKNERVTKLVNSTDIHLMPSLNPDGFEASEEGNCESLRGYVGRSNANGVDLNRDFPDQFDKNHANDDEYLYSGRQPETVALIRWVLNKQFVLSANLHGGAIVASYPYDDVGHGKNNGKDCCEESRSPDDAVFRHLANSYASRNADMRAGDRCKPENFTNGITNGANWYFVQGGMQDFNYIHSNCFEVTFELSCCKYPRAEELPSYWHMNKEAMVAFVEQAHIGISGVVLDEDGAPVKDAHILVDGIKHPVSTTQHGRYWRLLTPGQYNVTVKASGFVSPPPTTVTVPENQTAAVPLNLTVHRRPRSIVDEDFVHHNYEKMESYLKDLNAMYSNITKLTSIGKSVQGRELYVLEVTRDPGVHIPGKPEFKYVANMHGNEAVGRELLLLLAKYLCQQYVAGDERIQNMLNNTRIHLLPSMNPDGYETARPGDFDGLKGRTNAHDVDLNRNFPDQFGSTEENEVQEPETSAVMKWSQSIPFVLSANLHGGALVANYPYDDNPSMRSGKEFLSPDNPVFVHLAHVYSDAHLKMHLGKPCKNYSREMFPDGTTNGAKWYVLAGGMQDWNYLHTDDMELTLELGCYKFPPAADLPTYWQDNREALLQYIEQVHTGVHGFVYSHIGHGLSNATITVSGIKHAVHTARAGDYWRLLRPGVYNVTASRQGYESVTEEVTVPPAGAVSLNFTLMADDSQHWSSAYDFRILDNVLNTMYHTPLQMYAALSELENKYPSIAEFRAGDSLVTSKFHQLKMTSNVGSPEETKFHIAIMSSLYATQPLGREMLLNFARHIATAYTIGEPKHQRLLNNTVLHFIPNIDPLNSKIIKQYDGTDKCDLTALEEEFGDSLYNYLTKTNMNPLSNYTSETAFIEMLKSEKYDLILELSSGTEDVSYPEASKELYEKYARTYQDHRNPSDKYECRPLDSSVHGQLVDLLCERLDVPVVSVGLSCCRMPVADQIGWVWRDNLGGIMKFVEQANTGVVGYVKNEMGKPVRDATIAITSFSKQYRVTSNMAHYHVMLPAGVYKVIVRAHNYKDRILTWNVLDSKLKQIDIILQRTNAERISGGQFEDIQVPEDPNVVYTMGLVLSRSSEPLGGAELAVRGARAGGVLARNTSDAHGRFVLALPAGYKGKQVAISAASDGYVTKQMDVLINSVDNLTPNLIFKLDSDDNVLGMPRLVFVMLSGVVGVSLVVLGAWCFSCRERARHSRRDYLFTQLPGDDKRPLCEPDLIRKPFYDEEDIPLTETDSEEDVVLLQTGREQ

Description

Required for the proper melanization and sclerotization of the cuticle.

Catalytic Activity

Releases C-terminal Arg and Lys from polypeptides.

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M14 family.

Keywords

Alternative splicing   Carboxypeptidase   Complete proteome   Cuticle   Glycoprotein   Hydrolase   Membrane   Metal-binding   Metalloprotease   Phosphoprotein   Protease   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix   Zinc  

Feature

chain  Carboxypeptidase D
splice variant  In isoform 3, isoform 4 and isoform 6.

Uniprot

H9JTE5   A0A3S2M1L9   A0A212FMU7   A0A1Y1NB52   A0A1L8DR43   A0A1L8DQU3   + More
A0A1W6EVY0   A0A182P717   A0A2J7RM97   F4X480   W4VRN2   A0A067RRP6   A0A151I9W8   A0A3L8E7V4   A0A348G601   A0A1V1FVK8   A0A182QQ91   A0A158N9I3   E2AE72   A0A151I452   A0A182VX80   A0A026WDN1   A0A0L7R5M1   A0A182YKF6   A0A2A3EQH4   A0A087ZRN5   A0A0J7KJS1   A0A151JV41   A0A151XGD6   A0A0M3QZA1   A0A182HT57   A0A182NA58   A0A182UMV6   Q7QC23   A0A182XI70   A0A195E1K9   A0A182RI04   E2BNR3   A0A0Q9WMF1   J9HJF8   A0A1W4UVK5   A0A0L0BTV6   A0A1I8Q4W2   A0A182J566   B4PX05   B4MEQ9   B4R7E8   A0A182F709   A0A1Q3G2F0   B3P973   A0A1Q3G2L4   W5JS53   A0A154PFK1   A0A1Q3G2Y6   A0A1Q3G2Y9   A0A1Q3G243   A0A2M4B9D9   P42787-5   A0A1Q3G254   X2J9Z1   A0A2M4B9F1   A0A2M4A298   A0A0P8ZHH2   A0A2M4A2G0   B4L2T3   A0A2M4B9B6   P42787   A0A1W4V999   A0A3B0KTY1   A0A0A1XAK1   A0A1A9UUA2   B4JNA3   B5DMP1   A0A1J1IBI2   A0A0R1EF72   B4GY07   A0A1B6LU96   A0A0K8VVD6   V9IFV8   A0A0Q5SRQ2   A0A1B6BYT4   P42787-4   P42787-3   B4N2H9   B3MYX9   A0A0Q9W7V5   A0A1I8MWK5   A0A2M3YZY6   A0A2M3YZV8   A0A310SMJ0   A0A0R3P055   A0A1B6GCF9   A0A0Q9WRL3   A0A182LF97   A0A1A9X7X2   B4I929   A0A182MWJ3  

EC Number

3.4.17.22

Pubmed

19121390    22118469    28004739    21719571    24845553    30249741    + More
28410430    21347285    20798317    24508170    25244985    12364791    14747013    17210077    17994087    17510324    26108605    17550304    20920257    23761445    12393882    10731132    12537572    10731137    7568156    8000074    17893096    18327897    12537568    12537573    12537574    16110336    17569856    17569867    25830018    15632085    25315136    20966253   

EMBL

BABH01004042    BABH01004043    RSAL01000071    RVE49138.1    AGBW02007651    OWR55065.1    + More
GEZM01007557    JAV95093.1    GFDF01005237    JAV08847.1    GFDF01005236    JAV08848.1    KY563465    ARK19874.1    NEVH01002568    PNF41963.1    GL888628    EGI58748.1    GANO01001118    JAB58753.1    KK852507    KDR22449.1    KQ978264    KYM95838.1    QOIP01000001    RLU27578.1    FX985540    BBF97874.1    FX985405    BAX07418.1    AXCN02000215    ADTU01009655    GL438827    EFN68305.1    KQ976461    KYM84710.1    KK107260    EZA54200.1    KQ414648    KOC66182.1    KZ288202    PBC33522.1    LBMM01006597    KMQ90474.1    KQ981713    KYN37346.1    KQ982169    KYQ59464.1    CP012528    ALC49063.1    APCN01000420    AAAB01008859    EAA07478.5    KQ979814    KYN19013.1    GL449444    EFN82672.1    CH933810    KRF93869.1    CH478029    EJY58039.1    JRES01001349    KNC23482.1    CM000162    EDX00791.1    CH940664    EDW63034.2    CM000366    EDX16759.1    GFDL01001037    JAV34008.1    CH954183    EDV45369.2    GFDL01001024    JAV34021.1    ADMH02000331    ETN66931.1    KQ434886    KZC10088.1    GFDL01000919    JAV34126.1    GFDL01000936    JAV34109.1    GFDL01001158    JAV33887.1    GGFJ01000481    MBW49622.1    AF545816    AF545817    AF545818    AF545819    AF545820    AE014298    AL009147    BT029935    BT099720    BT100310    U29591    U29592    U03883    GFDL01001161    JAV33884.1    AHN59215.1    GGFJ01000480    MBW49621.1    GGFK01001615    MBW34936.1    CH902632    KPU74157.1    GGFK01001601    MBW34922.1    EDW06900.1    GGFJ01000482    MBW49623.1    OUUW01000019    SPP89266.1    GBXI01006341    JAD07951.1    CH916371    EDV92196.1    CH379064    EDY72721.1    CVRI01000047    CRK97571.1    KRK05786.1    CH479196    EDW27634.1    GEBQ01012730    JAT27247.1    GDHF01024787    GDHF01009789    JAI27527.1    JAI42525.1    JR040581    AEY59194.1    KQS25945.1    GEDC01031153    JAS06145.1    CH963925    EDW78568.2    EDV32823.2    KRF80877.1    GGFM01001055    MBW21806.1    GGFM01001058    MBW21809.1    KQ759874    OAD62352.1    KRT06602.1    GECZ01009642    JAS60127.1    KRF98900.1    CH480825    EDW43710.1    AXCM01008467   

Proteomes

UP000005204    UP000283053    UP000007151    UP000075885    UP000235965    UP000007755    + More
UP000027135    UP000078542    UP000279307    UP000075886    UP000005205    UP000000311    UP000078540    UP000075920    UP000053097    UP000053825    UP000076408    UP000242457    UP000005203    UP000036403    UP000078541    UP000075809    UP000092553    UP000075840    UP000075884    UP000075903    UP000007062    UP000076407    UP000078492    UP000075900    UP000008237    UP000009192    UP000008820    UP000192221    UP000037069    UP000095300    UP000075880    UP000002282    UP000008792    UP000000304    UP000069272    UP000008711    UP000000673    UP000076502    UP000000803    UP000007801    UP000268350    UP000078200    UP000001070    UP000001819    UP000183832    UP000008744    UP000007798    UP000095301    UP000075882    UP000092443    UP000001292    UP000075883   

PRIDE

H9JTE5    P42787    X2J9Z1   

Pfam

PF00246   Peptidase_M14

Interpro

IPR015567   Pept_M14B_carboxypept_D2        + More
IPR000834   Peptidase_M14       
IPR008969   CarboxyPept-like_regulatory       
IPR034241   M14_CPD_I       

SUPFAM

SSF49464   SSF49464       

CDD

cd03868  M14_CPD_I

ProteinModelPortal

H9JTE5   A0A3S2M1L9   A0A212FMU7   A0A1Y1NB52   A0A1L8DR43   A0A1L8DQU3   + More
A0A1W6EVY0   A0A182P717   A0A2J7RM97   F4X480   W4VRN2   A0A067RRP6   A0A151I9W8   A0A3L8E7V4   A0A348G601   A0A1V1FVK8   A0A182QQ91   A0A158N9I3   E2AE72   A0A151I452   A0A182VX80   A0A026WDN1   A0A0L7R5M1   A0A182YKF6   A0A2A3EQH4   A0A087ZRN5   A0A0J7KJS1   A0A151JV41   A0A151XGD6   A0A0M3QZA1   A0A182HT57   A0A182NA58   A0A182UMV6   Q7QC23   A0A182XI70   A0A195E1K9   A0A182RI04   E2BNR3   A0A0Q9WMF1   J9HJF8   A0A1W4UVK5   A0A0L0BTV6   A0A1I8Q4W2   A0A182J566   B4PX05   B4MEQ9   B4R7E8   A0A182F709   A0A1Q3G2F0   B3P973   A0A1Q3G2L4   W5JS53   A0A154PFK1   A0A1Q3G2Y6   A0A1Q3G2Y9   A0A1Q3G243   A0A2M4B9D9   P42787-5   A0A1Q3G254   X2J9Z1   A0A2M4B9F1   A0A2M4A298   A0A0P8ZHH2   A0A2M4A2G0   B4L2T3   A0A2M4B9B6   P42787   A0A1W4V999   A0A3B0KTY1   A0A0A1XAK1   A0A1A9UUA2   B4JNA3   B5DMP1   A0A1J1IBI2   A0A0R1EF72   B4GY07   A0A1B6LU96   A0A0K8VVD6   V9IFV8   A0A0Q5SRQ2   A0A1B6BYT4   P42787-4   P42787-3   B4N2H9   B3MYX9   A0A0Q9W7V5   A0A1I8MWK5   A0A2M3YZY6   A0A2M3YZV8   A0A310SMJ0   A0A0R3P055   A0A1B6GCF9   A0A0Q9WRL3   A0A182LF97   A0A1A9X7X2   B4I929   A0A182MWJ3  

PDB

3MN8     E-value=9.42672e-115,     Score=1063

KEGG

101735927    K07752 carboxypeptidase D [EC:3.4.17.22] | (RefSeq) carboxypeptidase D

GO

GO:0016021   GO:0008270   GO:0004181   GO:0005615   GO:0016485   GO:0006518   GO:0048471   GO:0042302   GO:0030838   GO:0005576   GO:0004180   GO:0012505   GO:0007476   GO:0007616   GO:0001933   GO:0006508   GO:0019752   GO:0016491   GO:0006108   GO:0030060   GO:0016615   GO:0000049   GO:0016876  

PANTHER

PTHR11532:SF73  

Subcellular location

Membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.997669

 

 

Length:

1373

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.58262

Exp number, first 60 AAs:

0.89644

Total prob of N-in:

0.04760

outside

1  -  1289

TMhelix

1290  -  1312

inside

1313  -  1373

 

 

Pi

225.566724

Theta

176.771585

Tajima's D

0.731334

CLR

0.338524

CSRT

0.583220838958052

Interpretation

Uncertain