Gene

KWMTBOMO09480

Pre Gene Modal

BGIBMGA012800

Annotation

PREDICTED:_protein_I'm_not_dead_yet_isoform_X1_[Papilio_xuthus]

Location

Bomo_Chr16(+):2083438-2141987      View in EpiBrowser

Full name

Protein I'm not dead yet      

Alternative Name

INDY transporter protein
drIndy

Location in the cell

PlasmaMembrane   Reliability : 4.92

CDS

ATGTCTACCGCCGTGGTTGAGAATGGACAAAATGTTAATGATGAAATTAGGGGTCAAACATACTACTTCCCTGGGGGTGGGTCGAGTGCATCGCTATGGCAACGGATAAATTTATTTATATCTATTTACTGGAAGTCTATAATAGTAGTGCTAACACCACTGCTACTGCTGCCCATACCGATCTTGAATAATGGACCAGCCTACAGATGTATGTACGTGGTCCTAATCATGGCAGTGTTTTGGGTCCTCGAACTCCTCCCCCTACCGGTAACTTCAATGTTGCCGATCGTCCTGTTCCCGACTATGGGCATCTTGGATTCGGATAAGACCTGCGCGGCCTACATGAAGGAAACCAACATGATGTTCATGGGAGGCTTGATGATTGCTGCTGGGGTGCAGCACTCCAAGTTGCCAAAGAGGGTTGCACTATGGACAGTTCAAGTCGTAGGCTGTTCACATAGAAGGTTGAACTTTGGATTGACGTTTGTGACTATGTTCATATCTATGTGGGTATCTAATGCAGCTGCCACGACCATGATGGTGCCAATCGTAGATGCCATACTCGAAGTTTTGGAACAGCAAGGCCTAGGTGACGTGTACATAAATAAGAAGAATCAGCCAACAGAAAATGGTAAAGAAGCGAAGGCCAGTGGACCAGTAAAGAACACTGATGATGAAGCACCAATGCCAAGTAACATAACTATATGCTACTACCTAAGCATTGCCTATGCCTCGACCCTTGGCGGTTGCGGCACTCTGGTCGGGACAGCAACGAATTCTGCGTTCAAAGGAATTTTTGATTCTGAGTTTCCTGAGTACTCGAGTTCGGTGAACTTCTTCTGGTTCATGGCGTACAGCACTCCGCCGATGCTGCTGATGCAGTTCCTCGTGTGGATGTCGTTACAGATCACCTTCATGGGAATGTTCAGACCTAACAGCGAAGCCGCCAAGGCAGTGAACCTCGCCAGCTCCGGCTCCACGAATACCATGAAGGTTATCAAGGAGACGTACAGGAGTCTAGGACCCATCACTTTCCATGAAAAAGCTTCAGGTTTCCTGTTCATCTTTGCGGTGCTCCTGTACATCTTGAGGAAGCCAGGCTTCATGCCGGGCTGGGCTGACGTCCTCACCGCCATGAAAGTGAAAGACGGCGTGACGTCAATGTTCATAGTGATCCTGATGATCATACTGCCCATGTCCACGGACTTCCTCAAGTTCTTCTCATCTAACGCTTCTTACGAGGAGCTGGCGGCCTCCAAGCCGTCGCCCAGCATCGTCACGTGGAACATCCTCAAGGAGAAGATTCCCTGGGGATTACTGTTCTTGTTGGGCGGAGGGTTCGCGCTGGCGGAGGGCAGCAAGGCGACGGGCTTGTCGTCCATGATCGGCAGCTCGCTGCAGGGGCTCGCCGGGCAGCCGCACTGGCTCGTGCTGCTCGTCGTGGTGCTCGTCATCCAGTTCATCACCGAGTTCACCTCCAACGTGGCCATCGCCAACCTCACCCTGCCCGTGCTGGCCAACATGGCTCGCGTTCTGAGGATAGACCCGCGCTACCTGATGGTCCCGGCCACGCTGGCGTGCTCCATGGCCTTCCACATGCCCGTGGGCACGCCGCCCAACGCCATCGTGGCCGGGGTCGCACACATCCCCACCGCCAGAATGGCCGTCGGCGGGATCGGACCTAAGATTATAACGACATTAATAGTGTGGGGCTCGTACCTGACTTGGGGCTCGGTGATATTCCCGGTCGGGGACGCGCCGACCGCGCTGTACAACGCCACCGCGACCGCGCTCTCCGCCAACGTGACCCTGGGCTGCGACATCGCCTACTCCTCGCTGCCGGCCGCCGGACGCTTCAACTGTACCGTCCCCGGGAACGGGACCGCGCTGGCCGAAGTCGCCAAGGGACTCTTCAGATGCGACTACCTGCCCTACGACAGTTGA

Protein

MSTAVVENGQNVNDEIRGQTYYFPGGGSSASLWQRINLFISIYWKSIIVVLTPLLLLPIPILNNGPAYRCMYVVLIMAVFWVLELLPLPVTSMLPIVLFPTMGILDSDKTCAAYMKETNMMFMGGLMIAAGVQHSKLPKRVALWTVQVVGCSHRRLNFGLTFVTMFISMWVSNAAATTMMVPIVDAILEVLEQQGLGDVYINKKNQPTENGKEAKASGPVKNTDDEAPMPSNITICYYLSIAYASTLGGCGTLVGTATNSAFKGIFDSEFPEYSSSVNFFWFMAYSTPPMLLMQFLVWMSLQITFMGMFRPNSEAAKAVNLASSGSTNTMKVIKETYRSLGPITFHEKASGFLFIFAVLLYILRKPGFMPGWADVLTAMKVKDGVTSMFIVILMIILPMSTDFLKFFSSNASYEELAASKPSPSIVTWNILKEKIPWGLLFLLGGGFALAEGSKATGLSSMIGSSLQGLAGQPHWLVLLVVVLVIQFITEFTSNVAIANLTLPVLANMARVLRIDPRYLMVPATLACSMAFHMPVGTPPNAIVAGVAHIPTARMAVGGIGPKIITTLIVWGSYLTWGSVIFPVGDAPTALYNATATALSANVTLGCDIAYSSLPAAGRFNCTVPGNGTALAEVAKGLFRCDYLPYDS

Description

Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.

Miscellaneous

The life-extending effect of mutations is likely caused by an alteration in energy balance caused by a decrease in transport function.

Similarity

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Protein I'm not dead yet
splice variant  In isoform B.

Uniprot

H9JTD8   A0A437BBV8   A0A2A4JY85   A0A194Q6M0   A0A212FMX4   A0A0N1IP13   + More
W5J711   A0A1L8DES5   A0A1L8DEL7   A0A182WWT0   A0A182JDR1   A0A182PTK9   Q7QIT2   A0A182VBY4   A0A182L392   A0A182UAV5   A0A182HWF9   A0A2M4BIC4   A0A182NZ46   A0A2M4BIG4   A0A182Q6Q6   A0A2M3ZG83   A0A1B0CAN5   A0A023EVA1   A0A182JX44   Q16UM3   A0A084WJU2   A0A182Y266   U5EXM5   B0WCP1   A0A2M4A456   A0A1Q3FNV3   A0A2M4A4T9   A0A182RMY3   T1E8N6   A0A1L8DE76   A0A182PF37   A0A1L8DE04   A0A336KWG5   A0A182TLR4   A0A182HWF8   A0A182WL11   A0A182UXA5   Q5TWN3   A0A182WWS9   A0A336KDB7   A0A182QCM8   A0A182L390   A0A0L0C679   A0A182GSH1   A0A182J1X2   A0A0P8XVW7   A0A084WJU3   B3M868   A0A182FER4   A0A1B0GFN7   A0A0A1WUW7   A0A182NZ47   A0A1B0A737   A0A1A9XD94   A0A1B0C4D6   A0A1A9V5X8   A0A034WH82   A0A1I8M3N9   A0A1Q3FP35   A0A2M3ZGA1   A0A1S4FNY7   Q16UM0   A0A0K8WEA4   Q16UM1   W5J5N2   B4J1T3   W8BH49   A0A1L8ECM3   E2AWA1   A0A1I8QD75   A0A2M4BIE2   A0A0M4EI95   A0A1L8E9V4   A0A0R3P3N0   B5DPF3   B4N4U3   A0A182SQS9   B4LFX1   A0A0Q9WVC4   A0A0Q9WUJ9   A0A0Q5UJB0   B3NHN6   B4IFW0   A0A1W4UPB0   A0A0J9RXY5   A0A1W4UP31   A0A0R1DXX2   B4PIY5   A0A0J9RXQ8   K7IW72   Q9VVT2-2   E1JI19   D0IQJ2   Q9VVT2  

Pubmed

19121390    26354079    22118469    20920257    23761445    12364791    + More
14747013    17210077    20966253    24945155    26483478    17510324    24438588    25244985    26108605    17994087    25830018    25348373    25315136    24495485    20798317    15632085    22936249    17550304    20075255    12186628    10731132    12537572    12537569    10581279    11118146    12391301    12537568    12537573    12537574    16110336    17569856    17569867   

EMBL

BABH01004073    RSAL01000093    RVE47888.1    NWSH01000386    PCG76769.1    KQ459582    + More
KPI99045.1    AGBW02007651    OWR55077.1    KQ460651    KPJ13032.1    ADMH02002049    ETN59761.1    GFDF01009207    JAV04877.1    GFDF01009206    JAV04878.1    AAAB01008807    EAA03999.4    APCN01001489    GGFJ01003664    MBW52805.1    GGFJ01003663    MBW52804.1    AXCN02000497    GGFM01006709    MBW27460.1    AJWK01004128    AJWK01004129    JXUM01002643    GAPW01000677    KQ560143    JAC12921.1    KXJ84193.1    CH477618    EAT38219.1    EAT38220.1    ATLV01024071    KE525348    KFB50486.1    GANO01002475    JAB57396.1    DS231889    EDS43692.1    GGFK01002181    MBW35502.1    GFDL01005766    JAV29279.1    GGFK01002411    MBW35732.1    GAMD01002603    JAA98987.1    GFDF01009399    JAV04685.1    GFDF01009398    JAV04686.1    UFQS01001198    UFQT01001198    SSX09649.1    SSX29445.1    EAL41887.3    UFQS01000322    UFQT01000322    SSX02866.1    SSX23233.1    JRES01000836    KNC27883.1    JXUM01002647    KXJ84195.1    CH902618    KPU78880.1    ATLV01024072    KFB50487.1    EDV41007.1    CCAG010022811    GBXI01012064    JAD02228.1    JXJN01025422    GAKP01005451    GAKP01005450    GAKP01005449    GAKP01005447    JAC53505.1    GFDL01005799    JAV29246.1    GGFM01006846    MBW27597.1    EAT38223.1    GDHF01015246    GDHF01009568    GDHF01002892    GDHF01001470    JAI37068.1    JAI42746.1    JAI49422.1    JAI50844.1    EAT38222.1    ETN59762.1    CH916366    EDV98013.1    GAMC01008483    JAB98072.1    GFDG01002319    JAV16480.1    GL443269    EFN62291.1    GGFJ01003685    MBW52826.1    CP012525    ALC44427.1    GFDG01003239    JAV15560.1    CH379069    KRT07809.1    EDY73532.1    CH964101    EDW79382.1    CH940647    EDW70370.1    KRF84878.1    KRF84879.1    CH954178    KQS43994.1    EDV51831.1    CH480834    EDW46547.1    CM002912    KMZ00448.1    CM000159    KRK01936.1    EDW94576.1    KMZ00449.1    AF509505    AE014296    AY102686    AF217399    AAF73384.1    AAM27515.1    ACZ94736.1    BT100230    ACY56898.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000007151    UP000053240    + More
UP000000673    UP000076407    UP000075880    UP000075885    UP000007062    UP000075903    UP000075882    UP000075902    UP000075840    UP000075884    UP000075886    UP000092461    UP000069940    UP000249989    UP000075881    UP000008820    UP000030765    UP000076408    UP000002320    UP000075900    UP000075920    UP000037069    UP000007801    UP000069272    UP000092444    UP000092445    UP000092443    UP000092460    UP000078200    UP000095301    UP000001070    UP000000311    UP000095300    UP000092553    UP000001819    UP000007798    UP000075901    UP000008792    UP000008711    UP000001292    UP000192221    UP000002282    UP000002358    UP000000803   

PRIDE

H9JTD8    Q9VVT2    D0IQJ2   

Pfam

PF00939   Na_sulph_symp

Interpro

IPR001898   SLC13A/DASS        + More
IPR031312   Na/sul_symport_CS       

ProteinModelPortal

H9JTD8   A0A437BBV8   A0A2A4JY85   A0A194Q6M0   A0A212FMX4   A0A0N1IP13   + More
W5J711   A0A1L8DES5   A0A1L8DEL7   A0A182WWT0   A0A182JDR1   A0A182PTK9   Q7QIT2   A0A182VBY4   A0A182L392   A0A182UAV5   A0A182HWF9   A0A2M4BIC4   A0A182NZ46   A0A2M4BIG4   A0A182Q6Q6   A0A2M3ZG83   A0A1B0CAN5   A0A023EVA1   A0A182JX44   Q16UM3   A0A084WJU2   A0A182Y266   U5EXM5   B0WCP1   A0A2M4A456   A0A1Q3FNV3   A0A2M4A4T9   A0A182RMY3   T1E8N6   A0A1L8DE76   A0A182PF37   A0A1L8DE04   A0A336KWG5   A0A182TLR4   A0A182HWF8   A0A182WL11   A0A182UXA5   Q5TWN3   A0A182WWS9   A0A336KDB7   A0A182QCM8   A0A182L390   A0A0L0C679   A0A182GSH1   A0A182J1X2   A0A0P8XVW7   A0A084WJU3   B3M868   A0A182FER4   A0A1B0GFN7   A0A0A1WUW7   A0A182NZ47   A0A1B0A737   A0A1A9XD94   A0A1B0C4D6   A0A1A9V5X8   A0A034WH82   A0A1I8M3N9   A0A1Q3FP35   A0A2M3ZGA1   A0A1S4FNY7   Q16UM0   A0A0K8WEA4   Q16UM1   W5J5N2   B4J1T3   W8BH49   A0A1L8ECM3   E2AWA1   A0A1I8QD75   A0A2M4BIE2   A0A0M4EI95   A0A1L8E9V4   A0A0R3P3N0   B5DPF3   B4N4U3   A0A182SQS9   B4LFX1   A0A0Q9WVC4   A0A0Q9WUJ9   A0A0Q5UJB0   B3NHN6   B4IFW0   A0A1W4UPB0   A0A0J9RXY5   A0A1W4UP31   A0A0R1DXX2   B4PIY5   A0A0J9RXQ8   K7IW72   Q9VVT2-2   E1JI19   D0IQJ2   Q9VVT2  

PDB

5ULE     E-value=6.23516e-10,     Score=156

KEGG

101743692    K14445 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 | (RefSeq

GO

GO:0006814   GO:0005215   GO:0016021   GO:0055085   GO:0015746   GO:0015137   GO:0015141   GO:0050833   GO:0005887   GO:0008340   GO:0010889   GO:0016323   GO:0006848   GO:0005886   GO:0015744   GO:0016020   GO:0019752   GO:0016491   GO:0006108   GO:0030060   GO:0016615   GO:0000049   GO:0016876  

Subcellular location

Basolateral cell membrane  

Length:

647

Number of predicted TMHs:

10

Exp number of AAs in TMHs:

243.21861

Exp number, first 60 AAs:

20.78

Total prob of N-in:

0.49786

POSSIBLE N-term signal

sequence

inside

1  -  39

TMhelix

40  -  62

outside

63  -  76

TMhelix

77  -  99

inside

100  -  155

TMhelix

156  -  178

outside

179  -  232

TMhelix

233  -  255

inside

256  -  275

TMhelix

276  -  298

outside

299  -  340

TMhelix

341  -  363

inside

364  -  383

TMhelix

384  -  401

outside

402  -  474

TMhelix

475  -  497

inside

498  -  517

TMhelix

518  -  537

outside

538  -  551

TMhelix

552  -  574

inside

575  -  647

 

 

Pi

249.664836

Theta

179.441101

Tajima's D

0.91475

CLR

0.67606

CSRT

0.635218239088046

Interpretation

Uncertain