Gene

KWMTBOMO09475  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012797

Annotation

PREDICTED:_vacuolar_protein_sorting-associated_protein_45_[Bombyx_mori]

Location

Bomo_Chr16(+):1974903-1985067      View in EpiBrowser

Full name

Vacuolar protein sorting-associated protein 45      

Location in the cell

Cytoplasmic   Reliability : 1.348 Mitochondrial   Reliability : 1.246 Nuclear   Reliability : 1.536

CDS

ATGAATGTGATACAAGCAGTTAAAATGTACATTACTAAAATGACGGAAGAGAGCGGCCCTGGAATGAAAGTGATATTAATGGATAAAGAAACTACCAGCATAGTGAGTATGGTGTACAGTCAATCGGAAATCTTACAGAAGGAAGTTTACTTATTCGAGAGGATAGACAGTCATGCCAAATGGGATAACATGAAACACATGAAATGCATAGTTTTTATACGTCCAACATCAGAGAACATAGCTCTGTTGTCACGGGAACTGAGAGATCCTAAATATGGTGTTTACTTTATATATTTCAGTAATGTAGTTTCTAAGGCAGACATCAAAACTTTGGCCGAATGTGATGAAGAGGAGGCTGTCAGAGAGGTCCAGGAAGTTTTTGCTGACTACCTGGCTGTGGACAGACACCTGTTCTCTTTCAATATTGTTGGATGCCTCCAAGGTCGGGTGTGGAACCAACAGCATCTCCAACGAGTTTCTCAAGGTCTGCTGGCGCTCCTCCTGTCTCTGAAGCGGCGAGCCTGCGTTCGCTACGAGGCAGCATCAGAACCCTGCGCTCGTCTCGCGGAGAGGGTCCGCGATCTGCTGAGGAGGGAGGCTGTGCTCATAGATAATAGCATCCCTTATAACGGAGAGCTGCCCCCTACTCAGCTGCTGATCATCGATAGGAGAAATGATCCCGTCACGCCCCTATTGAGTCAGTGGACCTACCAGGCGATGGTGCACGAGCTGCTGACGATAAACAACAACCGCGTGAGCCTGGCGCACGTGCCCGACGTGCCCAAGGACTTCAGGGAGGTGGTGCTCTCCTCGGAGCAGGACGACTTCTACGCGAAGAATCTTTACTCCAACTTCGGCGAGATCGGGCAAACCATCAAGTCTCTGATGGAGGAGTTTCAGACGAAAGCGAAGAGCAACCAGAAAGTGGAGAGCATCAGCGATATGAAAAATTTCGTGGAACAGTACCCACTCTTCAAGAAAATGTCTGGCACGGTGACGAAGCACGTGACCGTGGTGGGGGAGCTCTCGGCCTGTGTCGGCCGCCACAAGCTGCTCGAGGTCTCCGAGCTGGAGCAGGAGATCGTCTGCCAGTCAGACCACTCTAAACACCTGCAGCGGCTGAAGGCGCTGCTGGCGGACGGCGCGCTGCGGGACAGCGACGCGGCGCGGCTGGCGAGCCTGTACGCGCTGCGCTACGAGAAGCACGCGGGGCAGGGGGTGGGGGCGGCGCTGGAGCTGCTGCGGGCGCGGGGGGCGGCGGACGGGGCTCCGCTGGCCGCGCTCGAGTACGGGGGGGCGCACGCGCGACACGGGGACCTCTTCGGTCTGCAGGACGCGGTCAAGATCACCAACAGGCTCTTCAAGGGTCTGAACGGCGTCGAAAACATATACACGCAACACACGCCCCCCCTGAAGGACACGATCGAGGATCTGTTGAGGGGCAAGCTGCGTGAGGCCCAGTACCCCACGCTGGGCGGGGACGACGGCCGCCGCCCCACGCACGTCGTCGTGTTCGTGGTGGGCGGGGCCACGTACGAGGAGTCGCTGTGCGTGCACCAGATCAACAAGGCCAACCCGGGGGCCAAGGTGGTGCTCGGCGGGACCACCATACATAACTCGGCGTCATTCTTCGAAGAAATAAAGTCGGCTATGCAGGGCGTGCACAGGACGCACACCAAACATATTAGGAATGTTTAG

Protein

MNVIQAVKMYITKMTEESGPGMKVILMDKETTSIVSMVYSQSEILQKEVYLFERIDSHAKWDNMKHMKCIVFIRPTSENIALLSRELRDPKYGVYFIYFSNVVSKADIKTLAECDEEEAVREVQEVFADYLAVDRHLFSFNIVGCLQGRVWNQQHLQRVSQGLLALLLSLKRRACVRYEAASEPCARLAERVRDLLRREAVLIDNSIPYNGELPPTQLLIIDRRNDPVTPLLSQWTYQAMVHELLTINNNRVSLAHVPDVPKDFREVVLSSEQDDFYAKNLYSNFGEIGQTIKSLMEEFQTKAKSNQKVESISDMKNFVEQYPLFKKMSGTVTKHVTVVGELSACVGRHKLLEVSELEQEIVCQSDHSKHLQRLKALLADGALRDSDAARLASLYALRYEKHAGQGVGAALELLRARGAADGAPLAALEYGGAHARHGDLFGLQDAVKITNRLFKGLNGVENIYTQHTPPLKDTIEDLLRGKLREAQYPTLGGDDGRRPTHVVVFVVGGATYEESLCVHQINKANPGAKVVLGGTTIHNSASFFEEIKSAMQGVHRTHTKHIRNV

Subunit

Interacts with STX6 and ZFYVE20.
Interacts with ZFYVE20 (By similarity). Interacts with STX6.

Similarity

Belongs to the STXBP/unc-18/SEC1 family.

Keywords

Complete proteome   Endosome   Golgi apparatus   Membrane   Phosphoprotein   Protein transport   Reference proteome   Transport  

Feature

chain  Vacuolar protein sorting-associated protein 45

Uniprot

A0A2H1V8P9   A0A437BBZ3   A0A194Q137   A0A2W1BU52   A0A212FMV9   A0A2A4JJS5   + More
A0A067RVQ6   A0A2J7R528   A0A1B6FE66   A0A2A3ECD9   A0A088AER4   A0A151JQR5   F4WRE8   A0A195FIX5   A0A0C9RL68   A0A195BF99   A0A026W5U0   A0A2J7R520   A0A151IGB2   A0A232F3X6   A0A433T7Z4   A0A1S3GYE5   N6TUZ7   A0A0J7KBP7   A0A1B6CKF1   S4RHQ9   A0A1B0CL37   A0A158NUK8   E2AFV3   E9IRW2   A0A0L0C014   K7FKQ5   U4TYV2   Q9VHB5   B3M2G2   A0A452J4B8   B4PUQ8   Q295J1   A0A218UEV6   B4QWK4   A0A0K8V5C0   A0A3B0KCF9   A0A034VHX4   A0A1S3F3K4   A0A1U7R2D6   A0A250Y2Y1   A0A1I8ME64   O08700   A0A1W4VZM3   P97390   T1PJ43   Q0D2D9   Q3THX4   W8BJG9   B3NZQ1   A0A1A9W462   A0A087UGW9   H3AZF0   D3TNU1   A0A1A9Z521   B4NB39   Q5XHB0   A0A1U7SKM3   A0A293LGR7   G3TKR4   D7EHQ8   A0A2Y9E9K1   G3VWS6   A0A3Q2HGR5   M3WCQ2   A0A1S3A9R4   F6W1A0   U3BRW1   F7AE31   A0A1D5R9F9   F1SDG5   U6CVG7   A0A2Y9L6K3   G9KXF7   M3Y200   F7ILP1   U3EPE1   A0A2I2Y2Z4   A0A2K5EN41   A0A2Y9GWN4   A0A3Q7QXK1   A0A383ZSF3   G3H2U9   G3SCA3   A0A452E4J0   A0A340XW22   A0A2K6U2P4   V4AN63   A0A3P8SYD4   L8IKS5   A0A3Q7N361   A0A2R9BUS7   A0A2R9BVC6   A0A096N7B5   A0A2Y9EX89  

Pubmed

26354079    28756777    22118469    24845553    21719571    24508170    + More
30249741    28648823    23537049    21347285    20798317    21282665    26108605    17381049    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17994087    28562605    17550304    15632085    25348373    28087693    25315136    9106478    15489334    22673903    9045632    21183079    10349636    11042159    11076861    11217851    12466851    16141073    24495485    9215903    20353571    27762356    18362917    19820115    21709235    19892987    17975172    25243066    17495919    17431167    23236062    22398555    21804562    23254933    22751099    22722832   

EMBL

ODYU01001242    SOQ37187.1    RSAL01000093    RVE47892.1    KQ459582    KPI99038.1    + More
KZ149935    PZC77185.1    AGBW02007651    OWR55084.1    NWSH01001250    PCG71978.1    KK852433    KDR23959.1    NEVH01007395    PNF35935.1    GECZ01021253    JAS48516.1    KZ288301    PBC28846.1    KQ978660    KYN29396.1    GL888285    EGI63219.1    KQ981522    KYN40615.1    GBYB01007699    GBYB01008985    GBYB01008987    JAG77466.1    JAG78752.1    JAG78754.1    KQ976504    KYM82867.1    KK107390    QOIP01000007    EZA51435.1    RLU20929.1    PNF35933.1    KQ977771    KYN00033.1    NNAY01001090    OXU25170.1    RQTK01000564    RUS77638.1    APGK01053605    KB741231    ENN72221.1    LBMM01010090    KMQ87679.1    GEDC01027041    GEDC01023406    JAS10257.1    JAS13892.1    AJWK01016879    ADTU01026591    ADTU01026592    GL439158    EFN67702.1    GL765283    EFZ16590.1    JRES01001097    KNC25576.1    AGCU01163926    AGCU01163927    AGCU01163928    KB631770    ERL86007.1    AE014297    AY119186    AAF54403.1    AAM51046.1    CH902617    EDV43415.1    CM000160    EDW96675.1    CM000070    EAL28720.1    MUZQ01000382    OWK52000.1    CM000364    EDX13608.1    GDHF01018549    JAI33765.1    OUUW01000008    SPP83879.1    GAKP01016848    JAC42104.1    GFFV01001974    JAV37971.1    U81160    BC081705    U66865    BC012691    BC058528    KA648704    AFP63333.1    BC121938    AAI21939.1    AK146190    AK168101    BAE26966.1    BAE40072.1    GAMC01007663    JAB98892.1    CH954181    EDV49761.1    KK119738    KFM76608.1    AFYH01122252    AFYH01122253    AFYH01122254    AFYH01122255    AFYH01122256    CCAG010000864    CCAG010006733    EZ423093    ADD19369.1    CH964232    EDW81003.1    BC084162    CM004481    AAH84162.1    OCT66501.1    GFWV01002338    MAA27068.1    KQ973114    EFA12148.2    AEFK01176820    AEFK01176821    AEFK01176822    AEFK01176823    AANG04001280    GAMT01007483    GAMS01007423    GAMR01010755    GAMQ01001506    JAB04378.1    JAB15713.1    JAB23177.1    JAB40345.1    JSUE03002352    JSUE03002353    AEMK02000022    HAAF01002600    CCP74426.1    JP020988    AES09586.1    AEYP01089787    GAMP01008601    JAB44154.1    CABD030006308    CABD030006309    CABD030006310    CABD030006311    CABD030006312    JH000120    EGV94786.1    LWLT01000004    KB199650    ESP05609.1    JH881048    ELR56931.1    AJFE02058615    AJFE02058616    AJFE02058617    AJFE02058618    AJFE02058619    AJFE02058620    AJFE02058621    AJFE02058622    AHZZ02016811   

Proteomes

UP000283053    UP000053268    UP000007151    UP000218220    UP000027135    UP000235965    + More
UP000242457    UP000005203    UP000078492    UP000007755    UP000078541    UP000078540    UP000053097    UP000279307    UP000078542    UP000215335    UP000271974    UP000085678    UP000019118    UP000036403    UP000245300    UP000092461    UP000005205    UP000000311    UP000037069    UP000007267    UP000030742    UP000000803    UP000007801    UP000291020    UP000002282    UP000001819    UP000197619    UP000000304    UP000268350    UP000081671    UP000189706    UP000095301    UP000002494    UP000192221    UP000000589    UP000008711    UP000091820    UP000054359    UP000008672    UP000092444    UP000092445    UP000007798    UP000186698    UP000189705    UP000007646    UP000007266    UP000248480    UP000007648    UP000002281    UP000011712    UP000079721    UP000008225    UP000002280    UP000006718    UP000008227    UP000248482    UP000000715    UP000001519    UP000233020    UP000248481    UP000286640    UP000261681    UP000001075    UP000291000    UP000265300    UP000233220    UP000030746    UP000265080    UP000286641    UP000240080    UP000028761    UP000248484   

PRIDE

Q9VHB5    O08700    P97390    Q3THX4    F1SDG5    G3H2U9    + More

Pfam

PF00995   Sec1

Interpro

IPR027482   Sec-1-like_dom2        + More
IPR036045   Sec1-like_sf       
IPR001619   Sec1-like       

SUPFAM

SSF56815   SSF56815       

Gene 3D

3.40.50.1910    

ProteinModelPortal

A0A2H1V8P9   A0A437BBZ3   A0A194Q137   A0A2W1BU52   A0A212FMV9   A0A2A4JJS5   + More
A0A067RVQ6   A0A2J7R528   A0A1B6FE66   A0A2A3ECD9   A0A088AER4   A0A151JQR5   F4WRE8   A0A195FIX5   A0A0C9RL68   A0A195BF99   A0A026W5U0   A0A2J7R520   A0A151IGB2   A0A232F3X6   A0A433T7Z4   A0A1S3GYE5   N6TUZ7   A0A0J7KBP7   A0A1B6CKF1   S4RHQ9   A0A1B0CL37   A0A158NUK8   E2AFV3   E9IRW2   A0A0L0C014   K7FKQ5   U4TYV2   Q9VHB5   B3M2G2   A0A452J4B8   B4PUQ8   Q295J1   A0A218UEV6   B4QWK4   A0A0K8V5C0   A0A3B0KCF9   A0A034VHX4   A0A1S3F3K4   A0A1U7R2D6   A0A250Y2Y1   A0A1I8ME64   O08700   A0A1W4VZM3   P97390   T1PJ43   Q0D2D9   Q3THX4   W8BJG9   B3NZQ1   A0A1A9W462   A0A087UGW9   H3AZF0   D3TNU1   A0A1A9Z521   B4NB39   Q5XHB0   A0A1U7SKM3   A0A293LGR7   G3TKR4   D7EHQ8   A0A2Y9E9K1   G3VWS6   A0A3Q2HGR5   M3WCQ2   A0A1S3A9R4   F6W1A0   U3BRW1   F7AE31   A0A1D5R9F9   F1SDG5   U6CVG7   A0A2Y9L6K3   G9KXF7   M3Y200   F7ILP1   U3EPE1   A0A2I2Y2Z4   A0A2K5EN41   A0A2Y9GWN4   A0A3Q7QXK1   A0A383ZSF3   G3H2U9   G3SCA3   A0A452E4J0   A0A340XW22   A0A2K6U2P4   V4AN63   A0A3P8SYD4   L8IKS5   A0A3Q7N361   A0A2R9BUS7   A0A2R9BVC6   A0A096N7B5   A0A2Y9EX89  

PDB

4CCA     E-value=2.68387e-17,     Score=219

KEGG

101744133    K12479 vacuolar protein sorting-associated protein 45 | (RefSeq) vacuolar protein sorting-associated

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0006904   GO:1902746   GO:0000139   GO:0010008   GO:0048227   GO:0008021   GO:0016192   GO:0034058   GO:0016082   GO:0005769   GO:0006897   GO:0007269   GO:0000149   GO:0016021   GO:0005794   GO:0015031   GO:0016616   GO:0019752   GO:0016491   GO:0006108   GO:0030060   GO:0016615   GO:0000049   GO:0016876  

PANTHER

PTHR11679  

Subcellular location

Golgi apparatus membrane   Associated with Golgi/endosomal vesicles and the trans-Golgi network.   With evidence from 2 publications.
Endosome membrane   Associated with Golgi/endosomal vesicles and the trans-Golgi network.   With evidence from 2 publications.

Length:

565

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00617

Exp number, first 60 AAs:

0.00056

Total prob of N-in:

0.00441

outside

1  -  565

 

 

Pi

18.723674

Theta

20.908079

Tajima's D

-1.308068

CLR

2021.112215

CSRT

0.0839958002099895

Interpretation

Possibly Positive selection