Gene

KWMTBOMO09474  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013063

Annotation

PREDICTED:_malate_dehydrogenase?_mitochondrial_[Amyelois_transitella]

Location

Bomo_Chr16(-):1966502-1973832      View in EpiBrowser

Full name

Malate dehydrogenase      

Location in the cell

Mitochondrial   Reliability : 3.115

CDS

ATGTTCTCCCGCGCCCTAAAACCTGCCGCCCTTGCTGTACAAAATGGTGCAAAGAACTTTTCCACCACATCACAGAGGAACTTTAAAGTGGTGGTCGCTGGTGCCGCCGGTGGTATCGGCCAGCCTTTGGCCCTTCTACTGAAGCAGAATCCTCTGGTGACCAGGCTGGCTTTATACGACATAGCGCCTGTGACCCCCGGCGTCGCAGCCGACCTTTCCCACATGAACACCCCAGCCAAGGTCAGCGGCCACAAGGGACCTGAGGAGCTATCAGCAGCCATCAAAGATGCTGATGTTGTAGTCATCCCAGCAGGAGTACCCCGTAAACCGGGAATGACCCGTGATGACCTATTCAACACTAATGCTTCCATTGTCCGTGACATTGCTTTGTCCATTGCTCAGAATGCACCCAAAGCTATTGTGGCCATCATCACAAACCCTGTTAACTCTACAGTGCCTATTGCCTCTGAAGTGCTCAAGAAGGCGGGAGTGTACGACCCGAACCGCGTGCTCGGCGTCACCACTCTGGACGTAGTCCGCGCTGCCACCTTCGTCGGCGAGATCAATGGCGTGGACCCGACCTCCGTCGCCGTCCCCGTCATCGGCGGTCACTCCGGCATCACCATCATCCCCATCCTGTCCCAGTGCCAGCCGGCCCTCAAGCTGAGTGACCCGGCCAAGATCAAGGCGCTCACCGAAAGGATCCAGGAGGCTGGTACCGAAGTTGTGAAGGCGAAGGCCGGCGGCGGCTCCGCGACCCTCTCCATGGCGTACGCCGGCGCGCGGCTCACGGCCTCCGTGCTCAGGGGACTGAAGGGCGAGTCCAACGTGGTGGAGTGCGCCTACGTCAAATCGAGCCTCACGGAGGCCACGTACTTCGCCAGCCCCGTGGTGCTCGGCAAGAGCGGCGTCGAGAAGGTCCTCGGCTACGGGACCCTCAACGAATTCGAGCAGCAACTCCTGAAGGCGGCCCTCCCTGAACTCGCCAAGAACATCAAGACCGGCGAGGACTTCGCCAAGAAGTAA

Protein

MFSRALKPAALAVQNGAKNFSTTSQRNFKVVVAGAAGGIGQPLALLLKQNPLVTRLALYDIAPVTPGVAADLSHMNTPAKVSGHKGPEELSAAIKDADVVVIPAGVPRKPGMTRDDLFNTNASIVRDIALSIAQNAPKAIVAIITNPVNSTVPIASEVLKKAGVYDPNRVLGVTTLDVVRAATFVGEINGVDPTSVAVPVIGGHSGITIIPILSQCQPALKLSDPAKIKALTERIQEAGTEVVKAKAGGGSATLSMAYAGARLTASVLRGLKGESNVVECAYVKSSLTEATYFASPVVLGKSGVEKVLGYGTLNEFEQQLLKAALPELAKNIKTGEDFAKK

Catalytic Activity

(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate

Similarity

Belongs to the LDH/MDH superfamily.

Uniprot

H9JU51   A0A3S2NCY2   A0A212FMW7   A0A0N1IFM5   A0A194Q0C9   A0A2A4K4Z0   + More
A0A2W1BWY1   I4DQC2   A0A2H1V8P8   A0A232F4J8   K7J833   A0A2P8YT87   A0A411G6K4   E2B525   E9IT62   A0A1L8EI00   A0A195E5P6   E2ADN0   A0A195C8W5   A0A0J7NNS3   A0A2Z5RE49   A0A2J7Q6U6   F4WPA4   A0A1D1XXI6   Q4PP90   A0A0L0BXC1   A0A336KS61   A0A1Y1KFL2   D2A663   A0A026WP45   A0A154PN63   A0A2P0XJ03   U5EL58   A0A182JME3   A0A0K8TPD6   A0A158NR67   A0A182PC32   A0A084VRY1   N6TTQ3   A0A1I9WLG5   J3JXT9   A0A182NZ02   A0A182MFG3   A0A182R1J5   A0A182QV09   A0A182VQY7   A0A0P6AFG0   A0A1B6JRY2   A0A1B6F1E5   A0A182S6J7   A0A2Y9D3K4   A0A182UXV3   A0A182U2M5   A0A182KM35   Q7PYE7   A0A182IIP6   A0A0P5EE84   A0A0A1XDJ4   A0A1B6LGI7   A0A151WME8   A0A182JQR4   A0A0P5L8R4   T1DMZ1   A0A2M4A2E0   A0A2M4BTF4   W5J4N2   A0A182FQJ7   A0A2M4CT91   W8BVV6   A0A2M4BT81   A0A0P6DCQ6   V5SJ21   A0A1L8EEQ2   A0A2M3YZS5   A0A1J1IGX3   A0A2M3YZM4   E9HGX0   A0A182GNQ1   A0A1L8EEK1   A0A1I8PUI8   T1PH40   A0A0K8VWB8   A0A0C9QFA6   A0A034VDU0   A0A023EQ02   B4JI52   A0A1S4FIY1   A0A1A9YNS9   A0A131XGD2   B3MTR2   Q293U0   B4GLM6   B4M0W4   A0A310SPT5   B4K7H4   A0A1B0BFC4   A0A3B0KCD1   B0WMC8   A0A0M4EPV2   Q16ZI5  

EC Number

1.1.1.37

Pubmed

19121390    22118469    26354079    28756777    22651552    28648823    + More
20075255    29403074    20798317    21282665    26760975    21719571    26108605    28004739    18362917    19820115    24508170    26369729    21347285    24438588    23537049    27538518    22516182    20966253    12364791    14747013    17210077    25830018    20920257    23761445    24495485    21292972    26483478    25315136    25348373    24945155    17994087    28049606    15632085    17510324   

EMBL

BABH01004084    BABH01004085    RSAL01000093    RVE47895.1    AGBW02007651    OWR55085.1    + More
KQ460651    KPJ13039.1    KQ459582    KPI99037.1    NWSH01000176    PCG78732.1    KZ149935    PZC77186.1    AK404038    BAM20112.1    ODYU01001242    SOQ37186.1    NNAY01000986    OXU25605.1    PYGN01000374    PSN47461.1    MH365706    QBB01515.1    GL445685    EFN89233.1    GL765434    EFZ16256.1    GFDG01000570    JAV18229.1    KQ979608    KYN20488.1    GL438820    EFN68392.1    KQ978081    KYM97140.1    LBMM01002952    KMQ94145.1    FX983743    BAX07242.1    NEVH01017450    PNF24298.1    GL888243    EGI64085.1    GDJX01020827    JAT47109.1    DQ062223    AAY63978.1    JRES01001197    KNC24655.1    UFQS01000662    UFQT01000490    UFQT01000662    SSX05893.1    SSX24725.1    GEZM01087903    JAV58405.1    KQ971346    EFA04972.1    KK107139    EZA57723.1    KQ434960    KZC12660.1    KY661311    AVA17398.1    GANO01001560    JAB58311.1    GDAI01001597    JAI16006.1    ADTU01023767    ATLV01015785    KE525036    KFB40725.1    APGK01019088    KB740092    KB632429    ENN81433.1    ERL95462.1    KU932349    APA33985.1    BT128060    AEE63021.1    AXCM01001692    AXCN02000191    GDIQ01191327    GDIP01043456    GDIQ01037520    LRGB01000626    JAK60398.1    JAM60259.1    KZS17437.1    GECU01005761    JAT01946.1    GECZ01025697    JAS44072.1    AAAB01008987    EAA01572.4    APCN01002072    GDIQ01270961    JAJ80763.1    GBXI01004828    JAD09464.1    GEBQ01017166    JAT22811.1    KQ982944    KYQ49026.1    GDIQ01178465    JAK73260.1    GAMD01003320    JAA98270.1    GGFK01001594    MBW34915.1    GGFJ01007143    MBW56284.1    ADMH02002134    GGFL01004373    ETN58378.1    MBW68551.1    GGFL01004365    MBW68543.1    GAMC01003193    JAC03363.1    GGFJ01007144    MBW56285.1    GDIQ01082614    JAN12123.1    KF647639    AHB50501.1    GFDG01001643    JAV17156.1    GGFM01000967    MBW21718.1    CVRI01000051    CRK99511.1    GGFM01000971    MBW21722.1    GL732643    EFX69032.1    JXUM01076841    JXUM01076842    KQ562972    KXJ74736.1    GFDG01001652    JAV17147.1    KA647450    AFP62079.1    GDHF01009138    JAI43176.1    GBYB01013203    JAG82970.1    GAKP01018685    GAKP01018684    JAC40267.1    GAPW01002460    JAC11138.1    CH916369    EDV92933.1    GEFH01002017    JAP66564.1    CH902623    EDV30193.1    CM000070    EAL29124.1    CH479185    EDW38450.1    CH940650    EDW68423.1    KQ761246    OAD57934.1    CH933806    EDW15318.1    JXJN01013365    OUUW01000008    SPP83849.1    DS231997    EDS30985.1    CP012526    ALC47877.1    CH477489    EAT40089.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053240    UP000053268    UP000218220    + More
UP000215335    UP000002358    UP000245037    UP000008237    UP000078492    UP000000311    UP000078542    UP000036403    UP000235965    UP000007755    UP000037069    UP000007266    UP000053097    UP000076502    UP000075880    UP000005205    UP000075885    UP000030765    UP000019118    UP000030742    UP000075884    UP000075883    UP000075900    UP000075886    UP000075920    UP000076858    UP000075901    UP000076407    UP000075903    UP000075902    UP000075882    UP000007062    UP000075840    UP000075809    UP000075881    UP000000673    UP000069272    UP000183832    UP000000305    UP000069940    UP000249989    UP000095300    UP000095301    UP000001070    UP000092443    UP000007801    UP000001819    UP000008744    UP000008792    UP000009192    UP000092460    UP000268350    UP000002320    UP000092553    UP000008820   

PRIDE

H9JU51    B3MTR2   

Pfam

PF02866   Ldh_1_C        + More
PF00056   Ldh_1_N
PF17917   RT_RNaseH
PF17921   Integrase_H2C2

Interpro

IPR022383   Lactate/malate_DH_C        + More
IPR015955   Lactate_DH/Glyco_Ohase_4_C       
IPR001557   L-lactate/malate_DH       
IPR010097   Malate_DH_type1       
IPR001236   Lactate/malate_DH_N       
IPR001252   Malate_DH_AS       
IPR036291   NAD(P)-bd_dom_sf       
IPR036397   RNaseH_sf       
IPR041588   Integrase_H2C2       
IPR041373   RT_RNaseH       

SUPFAM

SSF51735   SSF51735        + More
SSF56327   SSF56327       

Gene 3D

3.90.110.10     3.30.420.10    

ProteinModelPortal

H9JU51   A0A3S2NCY2   A0A212FMW7   A0A0N1IFM5   A0A194Q0C9   A0A2A4K4Z0   + More
A0A2W1BWY1   I4DQC2   A0A2H1V8P8   A0A232F4J8   K7J833   A0A2P8YT87   A0A411G6K4   E2B525   E9IT62   A0A1L8EI00   A0A195E5P6   E2ADN0   A0A195C8W5   A0A0J7NNS3   A0A2Z5RE49   A0A2J7Q6U6   F4WPA4   A0A1D1XXI6   Q4PP90   A0A0L0BXC1   A0A336KS61   A0A1Y1KFL2   D2A663   A0A026WP45   A0A154PN63   A0A2P0XJ03   U5EL58   A0A182JME3   A0A0K8TPD6   A0A158NR67   A0A182PC32   A0A084VRY1   N6TTQ3   A0A1I9WLG5   J3JXT9   A0A182NZ02   A0A182MFG3   A0A182R1J5   A0A182QV09   A0A182VQY7   A0A0P6AFG0   A0A1B6JRY2   A0A1B6F1E5   A0A182S6J7   A0A2Y9D3K4   A0A182UXV3   A0A182U2M5   A0A182KM35   Q7PYE7   A0A182IIP6   A0A0P5EE84   A0A0A1XDJ4   A0A1B6LGI7   A0A151WME8   A0A182JQR4   A0A0P5L8R4   T1DMZ1   A0A2M4A2E0   A0A2M4BTF4   W5J4N2   A0A182FQJ7   A0A2M4CT91   W8BVV6   A0A2M4BT81   A0A0P6DCQ6   V5SJ21   A0A1L8EEQ2   A0A2M3YZS5   A0A1J1IGX3   A0A2M3YZM4   E9HGX0   A0A182GNQ1   A0A1L8EEK1   A0A1I8PUI8   T1PH40   A0A0K8VWB8   A0A0C9QFA6   A0A034VDU0   A0A023EQ02   B4JI52   A0A1S4FIY1   A0A1A9YNS9   A0A131XGD2   B3MTR2   Q293U0   B4GLM6   B4M0W4   A0A310SPT5   B4K7H4   A0A1B0BFC4   A0A3B0KCD1   B0WMC8   A0A0M4EPV2   Q16ZI5  

PDB

2DFD     E-value=1.74789e-100,     Score=934

KEGG

101736985    K00026 malate dehydrogenase [EC:1.1.1.37] | (RefSeq) malate dehydrogenase, mitochondrial

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0006099   GO:0006108   GO:0030060   GO:0019752   GO:0005739   GO:0005737   GO:0006919   GO:0035209   GO:0035071   GO:0035096   GO:0003824   GO:0016616   GO:0016491   GO:0016615   GO:0000049   GO:0016876   GO:0055114  

Length:

341

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.52991

Exp number, first 60 AAs:

1.50838

Total prob of N-in:

0.08734

outside

1  -  341

 

 

Pi

59.606838

Theta

53.850191

Tajima's D

-0.680244

CLR

2273.954092

CSRT

0.199890005499725

Interpretation

Possibly Positive selection