Gene

KWMTBOMO09456

Pre Gene Modal

BGIBMGA012788

Annotation

Collagenase_[Papilio_machaon]

Location

Bomo_Chr16(+):1487631-1490365      View in EpiBrowser

Full name

Acrosin      

Location in the cell

Extracellular   Reliability : 2.093

CDS

ATGGCACAGTGGGCGGTTTTGCTTCTGGTAGCGATTGCTGGAGTGGCTGTGGTGTCTGCGGATCCGGCTCTGACCTTCGTCGAAAATGTCAGGGCCGGCGCCAGGATCGTATCAGGATGGGAAGCAGAAGAAGGACAGTTCCCTTACCAGCTGTCACTGCGCATGGTGAACCCTGAGGGAGCAGTCAACGCTTGTGGAGCCACCATCATCCACAGCGATTGGGGACTCACGGCTGCTCATTGCACTGCTACGTAA

Protein

MAQWAVLLLVAIAGVAVVSADPALTFVENVRAGARIVSGWEAEEGQFPYQLSLRMVNPEGAVNACGATIIHSDWGLTAAHCTAT

Description

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Subunit

Heavy chain (catalytic) and a light chain linked by two disulfide bonds.

Similarity

Belongs to the peptidase S1 family.

Feature

chain  Acrosin

Uniprot

A0A2H1VYC8   A0A2H1VXG7   A0A0N0PCI5   A0A194Q123   E7D010   J7FDV5   + More
A0A2A4K409   A0A2A4K3D4   A0A2A4K426   A0A2A4K3B1   B1NLE3   A0A2W1BQ29   A0A2A4K2C1   H9JTC5   A0A2W1BZC6   Q9XY10   B6D1R0   A0A2A4K2C9   J7FCI3   A0A2A4K3S1   B6D1Q9   A0A410KK64   C9W8I8   A0A2H1V7W1   A0A3S2LZV4   A0A212FMW9   A0A2W1BS57   A0A2H1V7Z9   A0A0X9I156   C9W8F4   A0A212F859   A0A2A4K4P0   T1QDG4   A0A194Q024   J7FDE1   A0A194RS93   A0PGD9   A0A0K8S2W5   A0A2W1BWI0   A0A3S2NJF1   B4X992   A0A2H1VV70   A0A437BBW9   H9JTB5   A0A2H1VV25   A0A2A4K3Y4   A0A109P6B5   A0A2H1WBT2   Q296D1   B4GFB5   A0A3Q2XDK3   T1GQY2   B6D5J3  

EC Number

3.4.21.10

Pubmed

26354079    22228503    18314941    28756777    19121390    19133073    + More
20824821    22118469    23955944    15632085    17994087    18689890   

EMBL

ODYU01005031    SOQ45512.1    ODYU01005032    SOQ45513.1    KQ460651    KPJ13055.1    + More
KQ459582    KPI99023.1    HM990180    ADT80828.1    JN252040    AFM28253.1    NWSH01000207    PCG78410.1    PCG78414.1    PCG78412.1    PCG78408.1    EF600058    ABU98623.1    KZ149935    PZC77162.1    PCG78411.1    BABH01004141    PZC77163.1    AB026735    BAA77401.1    EU673453    ACI45416.1    PCG78415.1    JN252039    AFM28252.1    PCG78413.1    EU673452    ACI45415.1    MH201547    QAR48640.1    FJ205435    ACR16001.2    ODYU01001144    SOQ36940.1    RSAL01000093    RVE47905.1    AGBW02007651    OWR55096.1    PZC77161.1    ODYU01001143    SOQ36937.1    KP690084    ALO61086.1    FJ205398    ACR15967.2    AGBW02009787    OWR49920.1    NWSH01000176    PCG78733.1    JQ429439    AFW03964.1    KPI98932.1    JN252043    AFM28256.1    KQ459700    KPJ20347.1    AY618894    AAV33657.1    GBRD01018206    JAG47621.1    PZC77160.1    RSAL01000071    RVE49104.1    EF531628    ABR88239.1    ODYU01004626    SOQ44698.1    RVE47909.1    BABH01004171    BABH01004172    SOQ44697.1    PCG78736.1    KP690083    ALO61085.1    ODYU01007484    SOQ50292.1    CM000070    EAL28527.2    CH479182    EDW34300.1    CAQQ02394015    EU836256    ACI22824.1   

Proteomes

UP000053240    UP000053268    UP000218220    UP000005204    UP000283053    UP000007151    + More
UP000001819    UP000008744    UP000264820    UP000015102   

PRIDE

H9JTC5    Q9XY10    H9JTB5   

Pfam

PF00089   Trypsin        + More
PF00057   Ldl_recept_a
PF00431   CUB
PF01390   SEA

Interpro

IPR009003   Peptidase_S1_PA        + More
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR001314   Peptidase_S1A       
IPR033116   TRYPSIN_SER       
IPR000082   SEA_dom       
IPR035914   Sperma_CUB_dom_sf       
IPR036055   LDL_receptor-like_sf       
IPR002172   LDrepeatLR_classA_rpt       
IPR000859   CUB_dom       
IPR036364   SEA_dom_sf       
IPR012267   Pept_S1A_acrosin       

SUPFAM

SSF50494   SSF50494        + More
SSF57424   SSF57424       
SSF82671   SSF82671       
SSF49854   SSF49854       

Gene 3D

2.60.120.290     3.30.70.960     4.10.400.10    

CDD

cd00190  Tryp_SPc
cd00041  CUB
cd00112  LDLa

ProteinModelPortal

A0A2H1VYC8   A0A2H1VXG7   A0A0N0PCI5   A0A194Q123   E7D010   J7FDV5   + More
A0A2A4K409   A0A2A4K3D4   A0A2A4K426   A0A2A4K3B1   B1NLE3   A0A2W1BQ29   A0A2A4K2C1   H9JTC5   A0A2W1BZC6   Q9XY10   B6D1R0   A0A2A4K2C9   J7FCI3   A0A2A4K3S1   B6D1Q9   A0A410KK64   C9W8I8   A0A2H1V7W1   A0A3S2LZV4   A0A212FMW9   A0A2W1BS57   A0A2H1V7Z9   A0A0X9I156   C9W8F4   A0A212F859   A0A2A4K4P0   T1QDG4   A0A194Q024   J7FDE1   A0A194RS93   A0PGD9   A0A0K8S2W5   A0A2W1BWI0   A0A3S2NJF1   B4X992   A0A2H1VV70   A0A437BBW9   H9JTB5   A0A2H1VV25   A0A2A4K3Y4   A0A109P6B5   A0A2H1WBT2   Q296D1   B4GFB5   A0A3Q2XDK3   T1GQY2   B6D5J3  

PDB

3HKI     E-value=1.01506e-05,     Score=110

KEGG

101738003    no KO assigned | (RefSeq) collagenase-like

GO

GO:0004252   GO:0008236   GO:0016021   GO:0001669   GO:0006508   GO:0005515   GO:0008299   GO:0008152   GO:0016301   GO:0016773   GO:0006418   GO:0000049   GO:0016876  

SignalP

Position:   1 - 20,         Likelihood:  0.996821

 

 

Length:

84

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.06282

Exp number, first 60 AAs:

22.01811

Total prob of N-in:

0.33626

POSSIBLE N-term signal

sequence

outside

1  -  4

TMhelix

5  -  27

inside

28  -  84

 

 

Pi

188.979766

Theta

147.35863

Tajima's D

0.816871

CLR

2.874074

CSRT

0.601069946502675

Interpretation

Uncertain