Gene

KWMTBOMO09445

Pre Gene Modal

BGIBMGA013075

Annotation

PREDICTED:_mevalonate_kinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr16(-):1341435-1372700      View in EpiBrowser

Full name

Mevalonate kinase       + More
Alpha-1,3-glucosyltransferase      

Location in the cell

Mitochondrial   Reliability : 1.901

CDS

ATGTTGACGGCCGTCGATAATTTGTTTACGGTGAGCGTTTCCGCGCCGGGGAAAGTCATCTTGCATGGAGAGCATTCGGTCGTGTACGGAAAAACTGCGATCGCTGTCAGCCTCGGCCTAAGGAGCTCCATAGTGATAAAGGAAGTAAACACTCCACACGAACCAGCAGTCCACATACATTTGCCGTGCGTGGATCTACAGGAGACCATTCCATTGGAGCCGACAGTCAAAAGTCTGTTCCATCCTAAACTGGCACCAGGGATAACCGGCAAATTCTCTTGGAGATTACCCCACAAAATCGACCATGACTATCACTTGCGAAGGGTGGAGGAATACCTGCATTTGATCAAGCCTAACTTTGACTCGTTGCCCAACAATCAAAAGAATTCCTTGCGTAGTTTCCTATACGTGTTTTCCGGGATTTTCGGTAGCACATATCTACCGGTAAAGTCTATGGATATTTCGATGGGATCTGAGCTCACCATTGGCGCGGGTACTGGCAGTTCGGCGTCTTTTGCCGTCTGTCTAGCAGGAGCATTGATACAGCTGTTGAAATTGAAGAGTTCTTCGGGGAATTTCGATGCATATTACGATCAGAGCAGCCAAGATTTTACGGATACCGAAAAGGAGATTATATCGGAATGGGCCTTCAATTGTGAGAAGATAATGCACGGAACACCTTCAGGTATTGACAACGCGACCTGCACATTCGGGAACTTGGTATCGTTCAAGAAAGGCGCTAAACCACGTCATCTCGACATAAGGATGGAGCTGCGCGTGTTGCTGGTCGATTCGCGGGTGTCCAGAGAAACGAGGACCCTGGTCGTTCGTGTGGCGGCCCTAAGGCAAAGGAACACGGCCGCCGTGGACCACATCATGGAGGCCTGTGAACACGTTGCGCACACTGCCACTCAGGTTTTAGAGAAACTTTCCAGCGGCAAGTGTGACCCCGATACGGAGGCGGACTATCAACATTTATCAGAGCTTTGGGACATGAACCACTGTCTGCTGTCGGCTCTGGGCGTGTCTCATCCCTCTCTCGAGGTGATCCGAGCGGCGGCCAAGAGCAAGGGGCTCGCCTGCAAGCTCACCGGAGCCGGAGGTGGAGGATACGCCATGATCTTAATTCCACCATCGACTCCTCGTTCGACGATAGACTCGCTGTCCGGCCAGCTGCTGCAGAACGGTTTCCGGGTCACGGAGACGAGGCTCGGTGGACCGGGCGTCTCCATAGAGATGTGA

Protein

MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQDFTDTEKEIISEWAFNCEKIMHGTPSGIDNATCTFGNLVSFKKGAKPRHLDIRMELRVLLVDSRVSRETRTLVVRVAALRQRNTAAVDHIMEACEHVAHTATQVLEKLSSGKCDPDTEADYQHLSELWDMNHCLLSALGVSHPSLEVIRAAAKSKGLACKLTGAGGGGYAMILIPPSTPRSTIDSLSGQLLQNGFRVTETRLGGPGVSIEM

Description

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.

Catalytic Activity

(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)

Similarity

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Belongs to the ALG6/ALG8 glucosyltransferase family.

Feature

chain  Alpha-1,3-glucosyltransferase

Uniprot

A5A7A0   A0A2H1VIA5   A0A2A4K2D1   A0A2H4UZK0   H9JU63   A0A437BC38   + More
A0A212FMY0   I4DKG6   A0A194Q6I9   A0A194R717   A0A0H4IUW0   A0A2P8Z343   A0A067RSI1   A0A0L7REB1   A0A310SIZ3   A0A2J7PTV6   K7IN15   A0A088A8H7   A0A1B0CYD0   A0A2A3EGN3   I1VX02   A0A0G3F5W2   A0A1L8DZ74   A0A1W4XCS0   I1VJ72   A0A232F1I2   A0A1B6IB16   A0A1Y1MYH1   D2A4R0   A0A1B6C337   E2AQ72   A0A0J7L7Q1   A0A195FPX4   U4UN04   A0A195CCX2   A0A154PLJ5   Q176C1   A0A077WT23   U5EVK9   A0A1A7WQ55   A0A0A9XFL2   A0A0P4VUR7   A0A1S3HMS2   N6UI58   A0A3L8D9P7   A0A1J7JK90   E2BLU0   A0A0V0G886   A0A023ESL4   A0A158NEU5   A0A1Y2U394   A0A1Y2USH0   A0A151WSI6   B4MJK1   C1BQV3   A0A162NK42   T1PGP7   V4A0T9   A0A168QSE1   A0A2T7PHZ0   A0A1I8N5P9   F4WJE7   T1IDA7   A0A1A8FM48   E9IEK9   A0A1B0AAW7   A0A194X6X2   A0A165I9M8   A0A1Y2W8M0   A0A397TW19   A0A1A9V2U3   D3TMC0   B2B6Y4   A0A146P6P7   A0A3Q4BQL6   A0A2N1MUP2   A0A3Q3JIA9   F7VU92   A0A0S7I2W7   A0A3P8XDF1   A0A367JTM1   A0A0A1N2Y4   A0A1B5L0M7   A0A1A8BX20   A7SJK4   A0A096M390   A0A3B3V7P1   A0A015L7P9   G2Q8J6   A0A3B5AZV0   A0A146P4D7   B3NRX6   A0A146NPZ2   A0A3B5MEV8   A0A3Q2CCL6   A0A2H5TIE6   A0A0F4ZDB1   A0A0F8AY33   A0A3B5KC85  

EC Number

2.7.1.36
2.4.1.-

Pubmed

17628279    29185447    19121390    22118469    22651552    26354079    + More
26899871    29403074    24845553    20075255    22516182    28648823    28004739    18362917    19820115    20798317    23537049    17510324    25401762    26823975    27129103    30249741    24945155    21347285    28078400    17994087    23254933    25315136    21719571    21282665    26693682    20353571    18460219    24558260    20386741    25069045    29674435    27956601    17615350    21964414    25835551    21551351   

EMBL

AB274991    BAF62109.1    ODYU01002714    SOQ40569.1    NWSH01000207    PCG78421.1    + More
KY971768    AUA18035.1    BABH01004151    RSAL01000093    RVE47914.1    AGBW02007651    OWR55101.1    AK401784    BAM18406.1    KQ459582    KPI99015.1    KQ460878    KPJ11661.1    KP689338    AKO63320.1    PYGN01000219    PSN50908.1    KK852445    KDR23770.1    KQ414609    KOC69312.1    KQ767320    OAD53412.1    NEVH01021221    PNF19768.1    AJVK01000004    AJVK01000005    AJVK01000006    KZ288254    PBC30887.1    JQ413984    AFI55100.1    KP420146    AKJ80166.1    GFDF01002340    JAV11744.1    JQ855693    AFI45056.1    NNAY01001310    OXU24402.1    GECU01023571    JAS84135.1    GEZM01023419    JAV88397.1    KQ971344    EFA05256.2    GEDC01029638    JAS07660.1    GL441701    EFN64406.1    LBMM01000361    KMQ99398.1    KQ981335    KYN42645.1    KB632429    ERL95469.1    KQ978023    KYM97933.1    KQ434972    KZC12739.1    CH477390    EAT41980.1    LK023335    CDS10404.1    GANO01001816    JAB58055.1    HADW01006478    SBP07878.1    GBHO01024840    GBRD01003593    GDHC01015377    JAG18764.1    JAG62228.1    JAQ03252.1    GDKW01000132    JAI56463.1    APGK01019085    KB740092    ENN81425.1    QOIP01000011    RLU17056.1    KV875097    OIW30256.1    GL449036    EFN83424.1    GECL01002003    JAP04121.1    GAPW01001827    JAC11771.1    ADTU01013171    KZ111238    OTA67866.1    KZ112560    OTA87273.1    KQ982769    KYQ50869.1    CH963846    EDW72290.1    BT076982    ACO11406.1    KV440988    OAD70414.1    KA647874    AFP62503.1    KB201305    ESO97418.1    LT554468    SAM05448.1    PZQS01000004    PVD33046.1    GL888182    EGI65725.1    ACPB03002946    HAEB01013294    SBQ59821.1    GL762647    EFZ20993.1    KQ947418    KUJ15552.1    KV407456    KZF24589.1    KZ111538    OTB06135.1    QKYT01000007    RIA99064.1    CCAG010016559    EZ422572    ADD18848.1    CU640366    FO904937    CAP73562.1    CDP25965.1    GCES01146804    JAQ39518.1    LLXL01001281    PKK65339.1    CABT02000007    CCC09080.1    GBYX01434783    JAO46546.1    PJQL01000712    RCH93322.1    CDGI01000202    KV921481    CEI93702.1    ORE14256.1    BBTG02000044    GAO16958.1    HADZ01007412    SBP71353.1    DS469678    EDO36115.1    AYCK01007734    AYCK01007735    JEMT01029766    EXX50833.1    CP003003    AEO56245.1    GCES01147491    JAQ38831.1    CH954179    EDV56278.1    GCES01152463    JAQ33859.1    BDIQ01000130    GBC42215.1    LAEV01001554    KKA27858.1    KQ042291    KKF16217.1   

Proteomes

UP000218220    UP000005204    UP000283053    UP000007151    UP000053268    UP000053240    + More
UP000245037    UP000027135    UP000053825    UP000235965    UP000002358    UP000005203    UP000092462    UP000242457    UP000192223    UP000215335    UP000007266    UP000000311    UP000036403    UP000078541    UP000030742    UP000078542    UP000076502    UP000008820    UP000085678    UP000019118    UP000279307    UP000182658    UP000008237    UP000005205    UP000194279    UP000194361    UP000075809    UP000007798    UP000077315    UP000030746    UP000078561    UP000245119    UP000095301    UP000007755    UP000015103    UP000092445    UP000070700    UP000076632    UP000242955    UP000265703    UP000078200    UP000092444    UP000001197    UP000261620    UP000233469    UP000261600    UP000001881    UP000265140    UP000252139    UP000038169    UP000242381    UP000001593    UP000028760    UP000261500    UP000022910    UP000007322    UP000261400    UP000008711    UP000261380    UP000265020    UP000236242    UP000005226   

PRIDE

A5A7A0    H9JU63   

Pfam

PF08544   GHMP_kinases_C        + More
PF00288   GHMP_kinases_N
PF03155   Alg6_Alg8
PF10509   GalKase_gal_bdg

Interpro

IPR020568   Ribosomal_S5_D2-typ_fold        + More
IPR006205   Mev_gal_kin       
IPR013750   GHMP_kinase_C_dom       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR006204   GHMP_kinase_N_dom       
IPR036554   GHMP_kinase_C_sf       
IPR039488   ALG6       
IPR004856   Glyco_trans_ALG6/ALG8       
IPR006203   GHMP_knse_ATP-bd_CS       
IPR019539   GalKase_gal-bd       
IPR007397   F-box-assoc_dom       
IPR001202   WW_dom       

SUPFAM

SSF54211   SSF54211        + More
SSF55060   SSF55060       

Gene 3D

3.30.230.10     3.30.70.890    

CDD

cd00201  WW

ProteinModelPortal

A5A7A0   A0A2H1VIA5   A0A2A4K2D1   A0A2H4UZK0   H9JU63   A0A437BC38   + More
A0A212FMY0   I4DKG6   A0A194Q6I9   A0A194R717   A0A0H4IUW0   A0A2P8Z343   A0A067RSI1   A0A0L7REB1   A0A310SIZ3   A0A2J7PTV6   K7IN15   A0A088A8H7   A0A1B0CYD0   A0A2A3EGN3   I1VX02   A0A0G3F5W2   A0A1L8DZ74   A0A1W4XCS0   I1VJ72   A0A232F1I2   A0A1B6IB16   A0A1Y1MYH1   D2A4R0   A0A1B6C337   E2AQ72   A0A0J7L7Q1   A0A195FPX4   U4UN04   A0A195CCX2   A0A154PLJ5   Q176C1   A0A077WT23   U5EVK9   A0A1A7WQ55   A0A0A9XFL2   A0A0P4VUR7   A0A1S3HMS2   N6UI58   A0A3L8D9P7   A0A1J7JK90   E2BLU0   A0A0V0G886   A0A023ESL4   A0A158NEU5   A0A1Y2U394   A0A1Y2USH0   A0A151WSI6   B4MJK1   C1BQV3   A0A162NK42   T1PGP7   V4A0T9   A0A168QSE1   A0A2T7PHZ0   A0A1I8N5P9   F4WJE7   T1IDA7   A0A1A8FM48   E9IEK9   A0A1B0AAW7   A0A194X6X2   A0A165I9M8   A0A1Y2W8M0   A0A397TW19   A0A1A9V2U3   D3TMC0   B2B6Y4   A0A146P6P7   A0A3Q4BQL6   A0A2N1MUP2   A0A3Q3JIA9   F7VU92   A0A0S7I2W7   A0A3P8XDF1   A0A367JTM1   A0A0A1N2Y4   A0A1B5L0M7   A0A1A8BX20   A7SJK4   A0A096M390   A0A3B3V7P1   A0A015L7P9   G2Q8J6   A0A3B5AZV0   A0A146P4D7   B3NRX6   A0A146NPZ2   A0A3B5MEV8   A0A3Q2CCL6   A0A2H5TIE6   A0A0F4ZDB1   A0A0F8AY33   A0A3B5KC85  

PDB

2R3V     E-value=6.69709e-40,     Score=412

KEGG

100101205    K00869 mevalonate kinase [EC:2.7.1.36] | (RefSeq) Mk, Mk_bm; mevalonate kinase

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0019287   GO:0004496   GO:0016126   GO:0005524   GO:0016021   GO:0008299   GO:0005789   GO:0042281   GO:0006488   GO:0006695   GO:0005829   GO:0010142   GO:0006696   GO:0005534   GO:0005840   GO:0008152   GO:0016301   GO:0016773   GO:0006418   GO:0000049   GO:0016876  

PANTHER

PTHR12413:SF1   PTHR12413  

Subcellular location

Cytoplasm  
Endoplasmic reticulum membrane  

Length:

413

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

9.74325

Exp number, first 60 AAs:

0.08355

Total prob of N-in:

0.18636

outside

1  -  413

 

 

Pi

21.046323

Theta

21.680505

Tajima's D

0.472764

CLR

1.043936

CSRT

0.508574571271436

Interpretation

Uncertain